Negative / Null Result ReportOpen accessMedicine
Sun Y, Yang X, Zhu Q et al. · 2026 · Drug design, development and therapy
Autoimmune thyroiditis (AIT) is a chronic immune-mediated thyroid disorder characterized by lymphocytic infiltration, follicular epithelial injury, autoantibody production, and variable progression to thyroid dysfunction. Because current…
View details →Failed Experiment ReportMedicine
Wikkeling OR, VAN Rijn MJ, Witte ME et al. · 2026 · The Journal of cardiovascular surgery
Background Pelvic venous disease (PeVD) and lymphedema are traditionally regarded as distinct clinical entities and are usually investigated and managed within separate clinical frameworks. However, both conditions may coexist in patients…
View details →Failed Experiment Report
Ley Urzaiz L, Carrasco Moro R · 2026 · Preprint
Background: /Objectives: Trigeminal neuralgia associated with multiple sclerosis (TN-MS) is a secondary facial pain syndrome whose clinical and therapeutic features differ substantially from those of classical TN. Although the literature…
View details →Failed Experiment ReportMedicine
Huang J, Deng X, Zhou L et al. · 2026 · BMC medical research methodology
Background Evidence quality assessment is critical for informed public health decision-making, but manual approaches are time-consuming and subject to variability. Automated support tools have been proposed to improve efficiency and…
View details →Negative / Null Result ReportMedicine
Aubret A, Triesch J · 2026 · Developmental science
There is strong and diverse evidence for mental rotation (MR) abilities in adults. However, current evidence for MR in children rests on just a few behavioral paradigms adapted from the adult literature. Here, we leverage recent…
View details →Failed Experiment Report
Dias Maile AA, Andronova E, Ball F et al. · 2026 · Preprint
Decision making often requires the integration of noisy bottom-up sensory evidence with top-down prior expectations learned from past experiences. Acetylcholine and noradrenaline have been proposed to shape these computations, yet it…
View details →Failed Experiment Report
Tan S, Teoh TT, Joseph P et al. · 2026 · Preprint
Abstract Scenarios involving concealed-cavity fire spread has contributed to major facade fires, dating from Knowsley Heights (1991) to Grenfell Tower (2017). However, post-Grenfell regulatory responses diverged widely, and no study has…
View details →Negative / Null Result ReportMedicine
Yu J, Eyles JP, Moreti Cabral Silveira A et al. · 2026 · BMC health services research
Background Evidence based medicine is a critical cornerstone in contemporary medicine, yet uptake and adoption of evidence remain suboptimal. This is prominent in many fields of healthcare, including musculoskeletal health and surgery.…
View details →Abandoned HypothesisMedicine
Iuliano L, Veritti D, Lanzetta P · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Iridology is an alternative diagnostic practice that claims to identify systemic diseases and organ dysfunction through visual inspection of iris features, including pigmentation patterns, crypts, furrows, and discolorations. Despite its…
View details →Methods Dead-EndMedicine
Simão AC, de Oliveira MBG, Menezes Junior ADS · 2026 · Cardiology
Introduction This umbrella review aims to evaluate the certainty and consistency of the available evidence rather than to provide a new procedural comparison. We combined systematic reviews that looked at surgical septal myectomy (SM) and…
View details →Methods Dead-EndOpen accessMedicine
Han LJ, Pan XW, Zhu J et al. · 2026 · Journal of multidisciplinary healthcare
Purpose Acute pancreatitis has complex causes, and traditional Chinese medicine plays a significant role in its treatment. However, there is a lack of standardized protocols and a comprehensive best evidence summary for rhubarb…
View details →Failed Experiment ReportMedicine
Melendez Vassall I, Mannino JE, Watters P et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses
Metabolic bone disease (MBD) is a disorder affecting bone mineralization that leads to short and long-term consequences. A daily exercise regimen consisting of passive range of motion (ROM) and gentle compression of upper and lower…
View details →Methods Dead-EndMedicine
Fontanier V, Delforge E, Opplert J et al. · 2026 · Physical therapy
Importance Evidence-based practice (EBP) is a core competency in physical therapy. In 2015, France implemented a major reform of physical therapist education, extending training from 3 to 5 years and embedding EBP throughout the…
View details →Negative / Null Result Report
Parisien C, Ho-El Abidi N, Khalaf E et al. · 2026 · Preprint
Addiction is a chronic, relapsing disorder comprising three stages: binge, withdrawal, and preoccupation. Preclinical evidence suggests that the habenula, a small epithalamic region, is involved across these stages and may contribute to…
View details →Failed Experiment ReportMedicine
Williams T, Phillips NJ, Stein DJ et al. · 2026 · The Cochrane database of systematic reviews
Background Posttraumatic stress disorder (PTSD) is a prevalent and disabling disorder. Evidence that PTSD is characterised by specific psychobiological dysfunctions has contributed to a growing interest in the use of medication in its…
View details →Failed Experiment ReportOpen accessMedicine
Petri AC, Martins TB, Martins TB et al. · 2026 · Sports medicine - open
Background Gait retraining has been proposed as a strategy to modify running biomechanics and reduce symptoms in runners with patellofemoral pain (PFP). However, review-level evidence remains heterogeneous regarding clinical effects,…
View details →Negative / Null Result ReportMedicine
Scurich N, Albright TD · 2026 · Proceedings of the National Academy of Sciences of the United States of America
Proficiency testing is widely used to assess expertise in medicine, engineering, and other high-stakes fields. In forensic science, such tests are often cited in court as evidence that pattern-comparison methods are accurate and reliable.…
View details →Negative / Null Result Report
Mahon P, Körtner G · 2026 · Preprint
Abstract Measuring the effectiveness of management programmes for alien invasive predators can be difficult not least because the densities of these species are often hard to estimate. We estimated the proportion of nights ( incursion rate…
View details →Negative / Null Result ReportMedicine
Stewart JJ, Allen BS, Polutchko SK et al. · 2026 · Journal of experimental botany
Refilling of xylem embolism during recovery from drought has been studied for decades, although the legitimacy of supporting evidence has been debated in recent years due to potentially widespread methodological artifacts associated with…
View details →Negative / Null Result ReportOpen accessMedicine
van der Steege AE, Humuza J, Shyirambere C et al. · 2026 · BMJ global health
Introduction The WHO Model Lists of Essential Medicines (MLEM and MLEMc) guide national medicine selection, particularly in low-income and lower middle-income countries (LMICs). Concerns exist about the adequacy and transferability of…
View details →Negative / Null Result ReportMedicine
Ganguly A, Bhowmik S, Hajra A · 2026 · Therapeutic hypothermia and temperature management
Shivering is a common complication of targeted temperature management (TTM), which could undermine its neuroprotective benefits by increasing cerebral oxygen consumption and metabolic demand. Buspirone, a 5-HT1A receptor partial agonist,…
View details →Negative / Null Result ReportMedicine
Simone J, Cooke C, Lee S et al. · 2026 · Sexually transmitted infections
Congenital syphilis (CS) has been rapidly re-emerging as a public health crisis across North America. The present standard of care treatment for CS involves a 10-day hospitalisation for intravenous penicillin G, which is costly for…
View details →Negative / Null Result ReportMedicine
Jin X, Shen T, Wang Y et al. · 2026 · JBI evidence implementation
Introduction Auditory hallucinations, persistent and distressing symptoms in patients with schizophrenia, are often poorly controlled by antipsychotics. Structured non-pharmacological interventions remain limited in routine clinical…
View details →Negative / Null Result ReportMedicine
Black CFD, Phillips C, Sanders IA et al. · 2026 · Child maltreatment
It is unclear whether research has generated causal evidence about the impact of mandatory reporting (MR) policies on reporting outcomes. This scoping review applied concepts from the NIH Stage Model to map and organize five decades of…
View details →Negative / Null Result ReportMedicine
Gao Y, Liu M, Li L et al. · 2026 · The Cochrane database of systematic reviews
Background Triple-negative breast cancer (TNBC), an aggressive subtype lacking oestrogen and progesterone receptors and amplification of HER2 receptors, accounts for 12% to 17% of breast cancers. Adjuvant and neoadjuvant chemotherapy…
View details →Negative / Null Result ReportMedicine
Brock AS · 2026 · American journal of speech-language pathology
Purpose The objective of this review article is to examine and describe the literature on training speech-language pathology students on the principles of evidence-based practice (EBP). Method A scoping literature review was undertaken in…
View details →Negative / Null Result ReportOpen accessMedicine
Yao S, Xu L · 2026 · Frontiers in medicine
Background Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease characterized by a prolonged clinical course with recurrent episodes, and the optimal treatment remains controversial. Multiple systematic…
View details →Negative / Null Result ReportOpen accessMedicine
Gazit N, Ben-Gal G, Eliashar R · 2026 · JMIR medical education
Background Assessment of technical aptitude, cognitive abilities, and personality characteristics is important in selecting candidates for surgical training. Currently, the selection of surgical training candidates does not systematically…
View details →Negative / Null Result ReportOpen accessMedicine
Du Y, Xu Z, Wen T et al. · 2026 · Diabetes, metabolic syndrome and obesity : targets and therapy
Purpose The care of diabetic foot ulcers (DFU) continues to be a notable clinical challenge. The efficacy and safety of stem cell therapies versus conventional treatments for DFU are debated. Cross-sectional analyses of meta-analyses…
View details →Negative / Null Result ReportOpen accessMedicine
Zhang Y, Wu Z · 2026 · Frontiers in public health
Background Digital technologies in oncology require patients and health workers to possess adequate electronic health literacy (eHealth literacy). Yet, the extent to which this literacy influences cancer-specific insights, ranging from…
View details →