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WASTE Journal

Browse the failure-mode index

21,309 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Statistical Learning in Dynamic Assessment to Identify Developmental Language Disorder in Spanish-English-Speaking Preschoolers: A Feasibility Study.

Neiling SL, Alt M, Kapa LL · 2026 · Language, speech, and hearing services in schools

Background The current project was a prospective feasibility study using a dynamic assessment of statistical learning of a novel morpheme for the identification of developmental language disorder (DLD) in Spanish-English-speaking…

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Negative / Null Result ReportMedicine

A cumulative-morbidity plasma proteomic architecture of critical-illness susceptibility: a UK biobank proteome-wide study of critical-care exposure, in-hospital death, and sex-specific signals.

Ren X, Dai Q, Jin C · 2026 · Journal of intensive care

Background Existing biomarker studies profile plasma during acute illness, leaving pre-illness proteomic susceptibility to critical care largely uncharacterised. We mapped the baseline proteomic architecture of critical-care outcomes in UK…

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Negative / Null Result ReportMedicine

Developing and Validating a Machine Learning Model to Predict Brain Injury in Preterm Infants Using Multisource Data from the Early Postnatal Period.

Xu P, Li Y, Chen Y et al. · 2026 · Children (Basel, Switzerland)

Background Moderate-to-severe preterm brain injury (PBI), including intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), remains an important cause of adverse neurodevelopmental outcomes in preterm infants. Early risk…

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Negative / Null Result ReportMedicine

Tailoring Grammatical Test Items in English According to Language Experience for the Classification of Developmental Language Disorder in Bilinguals.

Pratt AS, Ramos MN, Peña ED et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Purpose This study attempts to discriminate developmental language disorder (DLD) in bilinguals using only the child's second language (L2), English. We grouped bilinguals by their current weekly language experience (high English…

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Negative / Null Result ReportMedicine

Molecular Basis of Synergistic Causal Effect of Dual GLP-1R and GIPR Agonists for Risk Reduction in Diabetic Retinopathy, Alzheimer Disease, and Coronary Artery Disease in Diabetic Patients.

Xu J, Ashebir YA, Shao Y · 2026 · Genes

Background: The dual agonism of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) becomes a groundbreaking treatment for type 2 diabetes (T2D) that achieves robust glycemic control…

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Negative / Null Result ReportMedicine

Comparative evaluation of tigecycline susceptibility testing methods for carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii.

Shi Y, Li S, He L et al. · 2026 · Annals of clinical microbiology and antimicrobials

Background In this study, we aimed to evaluate the performance of different tigecycline susceptibility testing methods for CRKP and CRAB using the broth microdilution (BMD) method as the gold standard, under different breakpoint criteria.…

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Negative / Null Result ReportMedicine

The Diagnostic Value of English Language Sample Measures for Identifying Developmental Language Disorder in Bilingual Children.

Ramos MN, Bedore LM, Peña ED · 2026 · American journal of speech-language pathology

Purpose This study examines the diagnostic accuracy of four measures derived from English narrative language samples for identifying developmental language disorder (DLD) in 5- and 6-year-old Spanish-English bilinguals. Method Ninety-two…

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Abandoned HypothesisMedicine

Hermann J. Muller's research swan song: His long-term radiation dose-rate mutation investigations yielded no research publications, leaving questions of scientific misconduct.

Calabrese EJ · 2026 · Chemico-biological interactions

This paper evaluates the final major research effort of Hermann J. Muller, Nobel Laureate, to assess whether radiation displays a dose-rate process for radiation-induced germ cell mutation. Muller tried to extend the dose-rate findings of…

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Abandoned HypothesisOpen accessMedicine

Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors.

Ghosh AK, Bhattacharjee A, Jayashankar U et al. · 2026 · Organic & biomolecular chemistry

We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…

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Methods Dead-End

Comparative Performance of Gaussian Plume and Backward Lagrangian Stochastic Models for Near-Field Methane Emission Estimation Using a Single Controlled Release Experiment

Upreti A, Shonkwiler K, Riddick SN et al. · 2026 · Preprint

Methane (CH4) is a major component of natural gas and a potent greenhouse gas. Increasing atmospheric methane concentrations are attributed to emissive anthropogenic activities by an average of 13 ppb per yr since 2020 and are linked to a…

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Negative / Null Result ReportMedicine

Development of a Prognostic Prediction Model for Clinically Significant Prostate Cancer Based on Lesion Zone and Apparent Diffusion Coefficient Value Quantification.

Ashouri R, Reynolds PS, Rajavel S et al. · 2026 · Urology

Objective To guide biopsy decision making via a predictive model for clinically significant prostate cancer (csPCa) in men with positive imaging (PI-RADS 3-5). We aim to elucidate the influence of zone on the predictive accuracy of PI-RADS…

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Negative / Null Result ReportMedicine

Early psychotherapeutic interventions for posttraumatic stress responses in children and adolescents: A scoping review.

Robinson E, Chapman C, Orchard F et al. · 2026 · Journal of child and adolescent mental health

Background: Exposure of children and young people to potentially traumatic events is common. There is a need for increased access to early interventions following a potentially traumatic event. Objective: This review aimed to identify…

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Negative / Null Result ReportMedicine

Reassessing the Incidence and Risk Factors of Radiation Pneumonitis in Treatment-Naive EGFR-Mutant NSCLC With Concurrent Third-Generation EGFR-TKI and Thoracic Radiotherapy.

Zheng, Jia, Jing et al. · 2026 · International journal of cancer

This single-center retrospective study evaluated radiation pneumonitis (RP) in 209 treatment-naive EGFR-mutant non-small cell lung cancer (NSCLC) patients receiving first-line third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)…

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