21,294 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Millington O, Sharma A, Montanaro S et al. · 2023 · Chemical science
In molecular dimers that undergo intramolecular singlet fission (iSF), efficient iSF is typically accompanied by triplet pair annihilation at rates which prohibit effective triplet harvesting. Collisional triplet pair separation and…
View details →Galang CM, Obhi SS · 2023 · Experimental brain research
Previous research has shown that empathic pain observation can lead to motor facilitation in the form of faster reaction times. However, it is unclear whether participants are focusing on the others' pain or simply focusing on their own…
View details →Rosenheck R, Kurtz SG, Anand ST et al. · 2023 · Psychiatry research
Multi-site randomized effectiveness trials evaluate treatments under real-world conditions. Whether results change practice is under-studied. A 6-month 26-site Veterans Health Administration (VHA) cooperative study published in 2011…
View details →Das S, Freedland SJ · 2023 · Cancer prevention research (Philadelphia, Pa.)
Statins are widely prescribed medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase and therefore reduce cholesterol synthesis. Given the key role of cholesterol in cancer, statins may therefore have…
View details →Costa CL, Araujo-Menendez CEE, Lawrence A et al. · 2026 · Frontiers in aging neuroscience
Background High blood pressure (BP) is a known risk factor for dementia, but the relationships between BP and gross brain volumes are mixed and are understudied in groups who are at particularly high risk for dementia, such as…
View details →Chang MJ, Liu MT, Chen MR et al. · 2023 · Journal of medical virology
Systemic lupus erythematosus (SLE) characterized by immune dysfunction is possibly more vulnerable to herpes simplex virus (HSV) infection. The infection has been intensively considered a common onset and exacerbation of SLE. This study is…
View details →Rafiee Y, Jones BC, Shiramizu V · 2022 · Preprint
Objective: The Compensatory Prophylaxis Hypothesis proposes that women will show increased pathogen disgust at points in the menstrual cycle when progesterone is high, compensating for the immunosuppressive effects of progesterone.…
View details →Cotter KN, Crone D, Rodriguez-Boerwinkle R et al. · 2022 · Preprint
Visiting art museums has been associated with a range of flourishing outcomes. But there have been recent shifts towards increasing digital engagement with art, leading to a radical change in how people experience visual art. Given the now…
View details →Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
View details →Kieras DE, Meyer DE · 2026 · Psychonomic bulletin & review
This article concerns simple visual-search tasks that require people to respond "yes" or "no" about whether a specified target object is present in stimulus displays containing relatively small numbers of typically simple objects. The…
View details →Tebib N, Liaudet L, Ltaief Z · 2026 · Journal of intensive care
Background In patients with refractory cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (ECMO) provides temporary circulatory support, but optimal strategies to promote myocardial recovery and facilitate ECMO weaning…
View details →Xu H, Yan Y, Niu J et al. · 2026 · BMC cancer
BACKGROUND: Metastatic colorectal cancer (mCRC) patients who progress following the standard chemotherapy have maintained a favourable performance status. Nevertheless, there are limited effective treatment options, particularly for a…
View details →Shelton RC, Pizzagalli DA, Cohen EA et al. · 2025 · The Journal of clinical psychiatry
Objective: To assess proof-of-concept (PoC) for efficacy, tolerability, and safety of TRPC4/5 inhibitor BI 1358894 vs placebo in patients with major depressive disorder (MDD) with inadequate response to ongoing antidepressants. Methods: In…
View details →Koonrungsesomboon N, Teeyakasem P, Dukaew N et al. · 2025 · International journal of clinical oncology
Background Osteosarcoma is a prevalent and aggressive bone malignancy primarily affecting young adults. Despite advances in standard treatment, the 5-year survival rate remains low, highlighting the need for new chemotherapy options.…
View details →Liu J, Moura DS, Jones RL et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase III ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas…
View details →Bendetowicz D, Fabbri M, Sirna F et al. · 2024 · Current neurology and neuroscience reports
Purpose of review This review summarizes previous and ongoing neuroprotection trials in multiple system atrophy (MSA), a rare and fatal neurodegenerative disease characterized by parkinsonism, cerebellar, and autonomic dysfunction. It also…
View details →Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
View details →Ghimouz A, Dureau S, Carton M et al. · 2026 · Scientific reports
The value of music (MUS) and virtual reality (VR) in reducing pain or anxiety during central venous port implantation (CVPI) is controversial. We conducted a randomised multicenter controlled trial in 127 patients who received either MUS…
View details →Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
View details →Savsani PK, Khan SH, Perkins AJ et al. · 2025 · Critical care medicine
Objectives To describe the performance of the Healthy Aging Brain Care Monitor Self Report (HABC-M SR) in assessment of post-intensive care syndrome (PICS) among Acute Respiratory Failure ICU survivors. Design Secondary data analysis of a…
View details →Chaudhari A, Almajali M, Khan N et al. · 2026 · Stroke (Hoboken, N.J.)
Background Endovascular thrombectomy (EVT) has transformed the management of acute ischemic stroke, but remains inaccessible to many patients due to anatomic, clinical, or logistical limitations. Treatment strategies for patients with…
View details →Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
View details →Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)
With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…
View details →Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry
Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…
View details →Bremhorst A, Mills DS, Würbel H et al. · 2022 · Animal cognition
Facial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System…
View details →Desai R, Tan F, Wu M et al. · 2026 · Arthritis care & research
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been…
View details →Chen H, Colasurdo M, Matsukawa H et al. · 2026 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
View details →Cerbone L, Orecchia S, Bertino P et al. · 2023 · Cancers
Mesothelioma comprises a group of rare cancers arising from the mesothelium of the pleura, peritoneum, tunica vaginalis testis and pericardium. Mesothelioma is generally associated with asbestos exposure and has a dismal prognosis, with…
View details →Pope JE · 2020 · The Lancet. Rheumatology
Strides have been made in the treatment of pulmonary arterial hypertension and interstitial lung disease in patients with systemic sclerosis, with successful trials of combination therapies in pulmonary arterial hypertension and of new…
View details →Persu A, Stoenoiu MS, Maes F et al. · 2023 · Clinical kidney journal
Following second-generation randomized trials, there is evidence that renal denervation (RDN) decreases blood pressure (BP), although to a lesser extent than suggested in the initial controlled and observational studies. The recent…
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