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Browse the failure-mode index

21,294 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The promise of IL-1β modulation in NSCLC clinical context.

Ghiringhelli F, Rébé C · 2026 · Frontiers in immunology

Emerging preclinical evidence challenges the long-standing assumption that Interleukin-1β (IL-1β) uniformly promotes non-small cell lung cancer (NSCLC). We show that, in the context of chemo-immunotherapy, IL-1β enhances anti-tumor…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the utility of cardiac biomarkers for risk stratification in patients with lower extremity artery disease: A retrospective study.

Schweiger L, Raggam RB, Toth-Gayor G et al. · 2025 · PloS one

Critical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve as an effective tool for risk…

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Negative / Null Result ReportOpen accessMedicine

USP13 Downregulation Distinguishes Malignant from Adjacent Non-Neoplastic Prostate Tissue and Suggests Altered PTEN-Related Regulatory Pathways in a Korean Cohort.

Kim JH, Song M, Lee KW et al. · 2026 · Life (Basel, Switzerland)

Ubiquitin-specific protease 13 (USP13) is a deubiquitinating enzyme that stabilizes phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a well-established tumor suppressor involved in PI3K/AKT signaling. This study aimed to…

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Negative / Null Result ReportMedicine

Pigmented Villonodular Synovitis: A Metastatic Melanoma Imitator.

Fields BC, Jain AJ, Prieto VG et al. · 2024 · The American Journal of dermatopathology

Abstract A 45-year-old woman with a history of previously treated left plantar foot melanoma presented with a left thigh mass. Fine needle aspiration findings were concerning for metastatic melanoma (MM). Imaging was remarkable for…

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Negative / Null Result ReportMedicine

Retrospective Evaluation of Bone Turnover Markers in Serum for the Prediction of Metastases Development in Breast Cancer Patients: A Cohort Study.

Kasoha M, Findeklee S, Nigdelis MP et al. · 2024 · Biomedicines

Background Serum bone turnover markers might play a role in the prediction of the development of bone metastases in breast cancer (BC) patients. We conducted a retrospective cohort study to address the association of serum bone turnover…

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Negative / Null Result ReportOpen accessMedicine

Relationship Between Body Mass Index and the Incidence of Perineal Tears in Primigravid Women: A Retrospective Cross-Sectional Study at a Hospital in Mexico.

Sadek Azar R, Ramirez Roldan JF, Nuñez de la Vega JM · 2026 · Cureus

Introduction Perineal tears represent one of the main complications of vaginal delivery, with immediate and long-term consequences for maternal health. Although several factors have been associated with their occurrence, the role of…

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Replication FailureOpen accessMedicine

Clinical outcome following best medical management in acute stroke with a proximal isolated occlusion of the anterior cerebral artery: an international multicentre study.

Sabben C, Charbonneau F, Obadia M et al. · 2026 · European stroke journal

Introduction Acute ischaemic strokes (AIS) due to proximal anterior cerebral artery (ACA) occlusions are rare. Their clinical outcomes following medical management alone have been scarcely described. Patients and methods We conducted a…

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Negative / Null Result ReportOpen accessMedicine

Metformin Is Associated With a Reduced Risk of Gastric Cancer, but Not Dysplasia, in Patients With Diabetes.

Lee HS, Kang SH, Eun HS et al. · 2026 · The Korean journal of helicobacter and upper gastrointestinal research

Objectives Metformin has been suggested to exert chemopreventive effects against gastric cancer. However, epidemiologic evidence remains inconsistent, and its impact on histologically confirmed precursor lesions, such as gastric dysplasia,…

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Negative / Null Result ReportMedicine

Outcomes of a Foundational Sciences Daily Engagement Game in Medical Education.

Schmidt M · 2026 · Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Daily engagement games are widely used as motivational tools in applications ranging from language learning to medical licensing board preparations. In medical education, continuous engagement with basic science concepts has benefits for…

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Negative / Null Result ReportMedicine

Immune checkpoint inhibitors in pediatric central nervous system tumors: biology, clinical experience, and translational pathways to precision immunotherapy.

Yenidogan I, Tabori U, Das A · 2026 · Journal of neuro-oncology

Purpose Immune checkpoint inhibitors (ICI) have transformed cancer therapy but remain of limited efficacy in pediatric central nervous system tumors, which are characterized by low tumor mutational burden, sparse antigen presentation, and…

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Negative / Null Result ReportMedicine

Endovascular thrombectomy in addition to intravenous thrombolysis versus intravenous thrombolysis alone in medium distal vessel occlusions: Results from the SITS International Stroke Treatment Register.

Keselman B, Mazya MV, Strbian D et al. · 2026 · International journal of stroke : official journal of the International Stroke Society

Background Endovascular thrombectomy (EVT) is the standard of care for large-vessel occlusion stroke. Medium distal vessel occlusions (MDVO) account for 25-40% of acute ischemic stroke cases, but recanalization rates with intravenous…

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Failed Experiment ReportMedicine

Bladder region-specific analysis of the diagnostic performance of oral 5-aminolevulinic acid fluorescence cystoscopy in non-muscle-invasive bladder cancer.

Ishikawa Y, Tanaka H, Kobayashi M et al. · 2026 · Japanese journal of clinical oncology

Background Fluorescence cystoscopy (FL) using 5-aminolevulinic acid (ALA) enhances the detection of urothelial carcinoma compared to white-light endoscopy (WL). The location of bladder tumors may affect the diagnostic performance of FL;…

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Negative / Null Result ReportMedicine

Male partner treatment and the potential sexual transmission of bacterial vaginosis: considerations for patient counseling and clinical application in the United States.

Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology

Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…

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Negative / Null Result ReportMedicine

PACAP and migraine.

Diener HC · 2025 · Brain : a journal of neurology

A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…

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