Negative / Null Result ReportOpen accessMedicine
Ghiringhelli F, Rébé C · 2026 · Frontiers in immunology
Emerging preclinical evidence challenges the long-standing assumption that Interleukin-1β (IL-1β) uniformly promotes non-small cell lung cancer (NSCLC). We show that, in the context of chemo-immunotherapy, IL-1β enhances anti-tumor…
View details →Negative / Null Result ReportOpen accessMedicine
Schweiger L, Raggam RB, Toth-Gayor G et al. · 2025 · PloS one
Critical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve as an effective tool for risk…
View details →Negative / Null Result ReportOpen accessMedicine
Bespalov A, Swartz J, Knowles N et al. · 2025 · Alzheimer's research & therapy
Agitation is one of the most prevalent neuropsychiatric symptoms leading to institutionalization in individuals with Alzheimer's disease (AD) dementia. It is associated with poor outcomes, including reduced functional ability, reduced…
View details →Negative / Null Result ReportOpen accessMedicine
Kim JH, Song M, Lee KW et al. · 2026 · Life (Basel, Switzerland)
Ubiquitin-specific protease 13 (USP13) is a deubiquitinating enzyme that stabilizes phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a well-established tumor suppressor involved in PI3K/AKT signaling. This study aimed to…
View details →Negative / Null Result ReportMedicine
Fields BC, Jain AJ, Prieto VG et al. · 2024 · The American Journal of dermatopathology
Abstract A 45-year-old woman with a history of previously treated left plantar foot melanoma presented with a left thigh mass. Fine needle aspiration findings were concerning for metastatic melanoma (MM). Imaging was remarkable for…
View details →Negative / Null Result ReportOpen accessMedicine
Misawa A, Kimura E, Inoue M et al. · 2025 · Journal of surgical case reports
Tension-free vaginal mesh repair surgery (TVM) has decreased due to complications related to mesh use and the lack of superiority compared to native tissue repair (NTR). In japan it is still performed as a treatment for pelvic organ…
View details →Negative / Null Result ReportMedicine
Kasoha M, Findeklee S, Nigdelis MP et al. · 2024 · Biomedicines
Background Serum bone turnover markers might play a role in the prediction of the development of bone metastases in breast cancer (BC) patients. We conducted a retrospective cohort study to address the association of serum bone turnover…
View details →Negative / Null Result ReportOpen accessMedicine
Samatoshenkov I, Zakirova E, Samatoshenkova J et al. · 2026 · Cells
Peripheral arterial disease and critical limb-threatening ischemia remain major clinical challenges, particularly in patients who are not candidates for surgical or endovascular revascularization. These limitations have stimulated…
View details →Negative / Null Result ReportOpen accessMedicine
Sadek Azar R, Ramirez Roldan JF, Nuñez de la Vega JM · 2026 · Cureus
Introduction Perineal tears represent one of the main complications of vaginal delivery, with immediate and long-term consequences for maternal health. Although several factors have been associated with their occurrence, the role of…
View details →Replication FailureMedicine
Sonnick MA, Laothamatas K, Furfaro D et al. · 2024 · Transplantation proceedings
Background In lung transplant, the United Network for Organ Sharing (UNOS) contains a diagnosis of secondary pulmonary hypertension (SPH). SPH and pulmonary arterial hypertension are treated the same in the allocation scoring system. It is…
View details →Replication FailureMedicine
Pradhan A, Bhandari M, Vishwakarma P et al. · 2024 · European review for medical and pharmacological sciences
Heart failure (HF) is a condition with growing morbidity and mortality. Dyslipidemia in HF is not concentrated around hypercholesterolemia as in coronary artery disease. As a corollary, the robust benefits seen with statins across the…
View details →Replication FailureOpen accessMedicine
Sabben C, Charbonneau F, Obadia M et al. · 2026 · European stroke journal
Introduction Acute ischaemic strokes (AIS) due to proximal anterior cerebral artery (ACA) occlusions are rare. Their clinical outcomes following medical management alone have been scarcely described. Patients and methods We conducted a…
View details →Negative / Null Result ReportOpen accessMedicine
Lee HS, Kang SH, Eun HS et al. · 2026 · The Korean journal of helicobacter and upper gastrointestinal research
Objectives Metformin has been suggested to exert chemopreventive effects against gastric cancer. However, epidemiologic evidence remains inconsistent, and its impact on histologically confirmed precursor lesions, such as gastric dysplasia,…
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Ion RM, Hutanu A, Sala DT et al. · 2024 · Preprint
Abstract Background: Bariatric surgery plays an impotant role in immnological modulation by reducing levels of systemic inflammatory markers, such as interkleukin-6 and tumor necrosis factor alpha. The goal of this study is to establish…
View details →Negative / Null Result ReportOpen accessMedicine
Dong X, Liu Y, Chu X et al. · 2024 · CNS neuroscience & therapeutics
Background The ideal blood pressure (BP) target in patients who undergo endovascular thrombectomy (EVT) with successful reperfusion is uncertain. Observational studies show that elevated BP during this period is associated with a higher…
View details →Negative / Null Result ReportMedicine
Wilmshurst P, Pearson M, Walsh K et al. · 2026 · Diving and hyperbaric medicine
Introduction Transoesophageal echocardiography (TOE) is claimed to be the investigation of choice for detecting a persistent foramen ovale (PFO) with almost 100% diagnostic accuracy. If true, TOE would detect all large/clinically…
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Lalaurie CJ, Dalby PA, McDonnell T · 2026 · Scientific reports
Beta-2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid syndrome (APS). β2GPI can adopt a number of structures; an extended J-shape, an O-shape and a transitional S-shape. It has also been shown previously that…
View details →Negative / Null Result ReportMedicine
Schmidt M · 2026 · Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
Daily engagement games are widely used as motivational tools in applications ranging from language learning to medical licensing board preparations. In medical education, continuous engagement with basic science concepts has benefits for…
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Demin K, Hwang JS, Che W et al. · 2026 · Preprint
Previous brain decoding studies indicate that an individual’s pain experience can be robustly predicted from distributed patterns of brain activity. Two brain decoders have notably been associated respectively with the nociceptive and…
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Lee HJ, Bae Y, Woo JU et al. · 2026 · Preprint
Abstract Background Surgical success after the Maze procedure is conventionally defined as “freedom from atrial fibrillation (AF),” often grouping junctional rhythm (JR) with normal sinus rhythm (NSR). However, the specific hemodynamic…
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Park Y, Chae H, Yoon E et al. · 2026 · GeroScience
Gamma entrainment shows promise for Alzheimer's disease (AD) treatment in preclinical models, but human trials have yielded heterogeneous results. We hypothesized that the clinical efficacy of gamma entrainment depends on individual…
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Isono S, Kajikawa K, Oseki Y et al. · 2025 · Preprint
Memory limitations have been assumed to be a major factor shaping human sentence comprehension, but characterizing memory-demanding structures in a broad-coverage and cross-linguistic manner has remained a challenge. A recent study…
View details →Negative / Null Result ReportMedicine
Yenidogan I, Tabori U, Das A · 2026 · Journal of neuro-oncology
Purpose Immune checkpoint inhibitors (ICI) have transformed cancer therapy but remain of limited efficacy in pediatric central nervous system tumors, which are characterized by low tumor mutational burden, sparse antigen presentation, and…
View details →Negative / Null Result ReportMedicine
Keselman B, Mazya MV, Strbian D et al. · 2026 · International journal of stroke : official journal of the International Stroke Society
Background Endovascular thrombectomy (EVT) is the standard of care for large-vessel occlusion stroke. Medium distal vessel occlusions (MDVO) account for 25-40% of acute ischemic stroke cases, but recanalization rates with intravenous…
View details →Failed Experiment ReportMedicine
Srivastava A, Renna HA, Hossain T et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives : Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder. Current AD therapies offer minimal benefits and do not prevent or repair neuronal damage. More effective therapeutic approaches…
View details →Failed Experiment ReportMedicine
Ishikawa Y, Tanaka H, Kobayashi M et al. · 2026 · Japanese journal of clinical oncology
Background Fluorescence cystoscopy (FL) using 5-aminolevulinic acid (ALA) enhances the detection of urothelial carcinoma compared to white-light endoscopy (WL). The location of bladder tumors may affect the diagnostic performance of FL;…
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Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology
Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…
View details →Negative / Null Result ReportMedicine
Xue J, Ye J, Han P et al. · 2025 · The journal of gene medicine
Background Synovial mesenchymal stem cell-derived exosomes (SMSC-Exos) can regulate macrophage polarization and alleviate knee osteoarthritis (KOA). However, the underlying mechanisms remain unclear. This study explored the role of…
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Diener HC · 2025 · Brain : a journal of neurology
A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…
View details →Negative / Null Result ReportOpen accessMedicine
Park SK, Chung Y, Oh CM et al. · 2026 · Global heart
Background There have been inconsistent findings regarding the effects of high sodium intake on coronary artery disease (CAD). This study therefore aimed to investigate the relationship between sodium intake and the coronary artery calcium…
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