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Browse the failure-mode index

21,290 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessMedicine

The Causal Effects of Inflammation and Coagulation-Related Biomarkers on Sepsis-Related Complications: A Mendelian Randomization Study.

Yao Q, Yao Y, Liao Z et al. · 2026 · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

BackgroundSepsis and its complications pose a major global health burden. Mendelian randomization (MR) provides a genetic approach to assess causality.MethodsWe conducted a two-sample Mendelian randomization (MR) study using data from…

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Failed Experiment ReportOpen accessMedicine

Nudging accurate scientific communication.

Allard A, Clavien C · 2023 · PloS one

The recent replicability crisis in social and biomedical sciences has highlighted the need for improvement in the honest transmission of scientific content. We present the results of two studies investigating whether nudges and soft social…

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Negative / Null Result ReportOpen accessMedicine

Where is the ghost in the shell?

Weilnhammer V · 2024 · Neuroscience of consciousness

The neurobiology of conscious experience is one of the fundamental mysteries in science. New evidence suggests that transcranial magnetic stimulation of the parietal cortex does not modulate bistable perception. What does this mean for the…

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Negative / Null Result ReportOpen accessMedicine

Anhedonic Traits Do Not Impair Performance in a 3-Arm Bandit Task.

Ramaswamy A, Yamamori Y, Vivekananda U et al. · 2026 · Computational psychiatry (Cambridge, Mass.)

Anhedonia, a transdiagnostic symptom marked by diminished reward sensitivity, is often linked to impairments in reinforcement learning (RL). Standard tasks (e.g., the 4-arm bandit) can place substantial demands on participants and may blur…

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Negative / Null Result ReportMedicine

The association between bariatric surgery and cataract: a propensity score-matched cohort study.

Burkard T, Holmberg D, Thorell A et al. · 2022 · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

Background Obesity is considered a risk factor for cataracts. The association between weight loss and a cataract among patients with obesity has not been assessed to date. Objectives To assess the association between weight loss following…

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Negative / Null Result ReportOpen accessMedicine

Transcranial Magnetic Stimulation over the Left Inferior Parietal Lobule Facilitates Early-Stage Processing During Natural Chinese-English Bilingual Reading.

Wu J, Hang R, Xin P et al. · 2026 · Brain sciences

Background: Proficient second language (L2) reading relies on complex neurocognitive processes. Neuroimaging studies have identified key brain regions recruited during L2 reading, including the left inferior parietal lobule (LIPL) and the…

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Negative / Null Result ReportOpen accessMedicine

Clinical Implementation of an Adapted Infection Risk Screening Tool Following Nurse-Led Haemodialysis Vascular Access Consultation.

Pinto R, Ferreira R, Alves P et al. · 2025 · Healthcare (Basel, Switzerland)

Background : Healthcare-associated infection drives morbidity and unplanned hospital use in haemodialysis. We aimed to determine whether an adapted British Renal Society Infection Risk Screening Tool, applied during a nurse-led vascular…

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Negative / Null Result ReportOpen accessMedicine

The effect of interleukin-6 signaling on severe malaria: A Mendelian randomization analysis.

Hamilton F, Mitchell RE, Constantinescu A et al. · 2023 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Severe malaria remains a deadly disease for many young children in low- and middle-income countries. Levels of interleukin (IL)-6 have been shown to identify cases of severe malaria and associate with severity, but it is unknown…

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Negative / Null Result ReportOpen accessMedicine

Factors underlying flicker-induced time dilation: Temporal frequency, semantic content, and subjective saliency of visual stimuli.

Oda T, Houshmand Chatroudi A, Yotsumoto Y · 2026 · Journal of vision

Flicker-induced time dilation refers to the robust illusion whereby temporally modulated visual stimuli are perceived as lasting longer than static stimuli. Although flicker-induced time dilation has been consistently demonstrated, it…

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Negative / Null Result ReportOpen accessMedicine

Causal effects of 32 eating habits on ischemic stroke risk and post-stroke functional outcome: A Mendelian randomization study.

Xu X, Zang X, Liu H et al. · 2026 · The Journal of international medical research

ObjectiveTo assess the causal effects of specific eating habits on ischemic stroke risk and functional outcomes using Mendelian randomization.MethodsThis two-sample Mendelian randomization study used genetic variants associated with 32…

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Negative / Null Result ReportOpen accessMedicine

Could high serum C-reactive protein levels serve as a biomarker for children and adolescents diagnosed with generalized anxiety disorder?

Ünal K, Taş Torun Y, Erol ME et al. · 2026 · World journal of clinical pediatrics

Background Generalized anxiety disorder (GAD) is a prevalent psychiatric condition in children and adolescents, frequently linked to difficulties in daily functioning and academic performance. Increasing evidence suggests that immune…

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Negative / Null Result Report

Analysis of expression Quantitative Trait Loci for NLGN4X in relation to language and neurodevelopmental function: an exploratory analysis using FUSION and GTEx workflows

Simpson NH, Bishop DV, Newbury DF · 2021 · Preprint

Language disorders in children are highly heritable, but progress in identifying genetic variants that contribute to language phenotypes has been slow. Here we applied a novel approach by identifying SNPs that are associated with gene…

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Negative / Null Result ReportOpen accessMedicine

Neoadjuvant Therapy for Localized Pancreatic Cancer.

McKean J, Underwood P, Yasinzai AQK et al. · 2026 · Cancers

Background/objectives Pancreatic ductal adenocarcinoma is an aggressive malignancy with poor long-term survival. While surgical resection followed by adjuvant chemotherapy remains the standard of care for resectable disease, a substantial…

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Negative / Null Result ReportOpen accessMedicine

Examining the relationship between problematic social media use and caffeine use disorder in the context of physical activity: a cross-sectional moderation study among university students.

Orhan BE, Karadağ B, Alkasasbeh WJ et al. · 2026 · Frontiers in nutrition

Introduction Problematic social media use (PSMU) and caffeine use disorder (CUD), a behavioral pattern without formal diagnostic status and a DSM-5 condition listed for further study, respectively, share phenomenological features…

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