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Browse the failure-mode index

21,733 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Multidisciplinary prospective study of standardized pelvic lymph-node dissection focusing on the dorsal obturator nerve region.

Sazuka T, Habu Y, Matsusaka K et al. · 2026 · International journal of clinical oncology

Background Pelvic lymph-node dissection is performed across multiple surgical specialties. However, inconsistent terminology and unclear anatomical boundaries hinder standardization. This study established a multidisciplinary team with a…

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Negative / Null Result ReportMedicine

Effects of two longevity interventions, calorie restriction and rapamycin treatment, on the kynurenine-aryl hydrocarbon receptor pathway in aging skeletal muscle.

Hamrick MW, Fulzele S, Isales CM et al. · 2025 · Biochimie

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is thought to play important roles in aging, oxidative stress, and cellular senescence. We have previously shown that the AhR agonist kynurenine (Kyn), a…

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Negative / Null Result ReportMedicine

Factors Affecting the Intrafollicular Transfer of Immature Oocytes in Beef Heifers: Does the Injection Matter?

de Faria OAC, Kussano NR, de Faria LC et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

This study aimed to evaluate whether the quality of injection and number of oocytes injected during Intrafollicular Transfer of Immature Oocytes (IFIOT) affect ovulation timing, follicle dynamics, oocyte recovery, nuclear maturation and in…

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Negative / Null Result ReportMedicine

Effect of hydrogen peroxide on microcystin-LR from Microcystis sp.

Ng PH, St-Hilaire S · 2025 · Diseases of aquatic organisms

Microcystis spp. blooms in fish ponds can lead to fluctuations in water parameters, and the microcystin-LR (MC-LR) toxin they produce may pose health risks for fish, as well as consumers. Hydrogen peroxide (H2O2) treatment has been…

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Negative / Null Result ReportMedicine

A Prospective Interventional Study to Evaluate the Effect of Hypoxia on Healthy Volunteers and Patients With Inflammatory Bowel Disease: The Altitude Inflammatory Bowel Disease Study.

Vavricka SR, Zeitz J, Madanchi M et al. · 2025 · The American journal of gastroenterology

Introduction Retrospective data suggest association of high-altitude exposure and inflammatory bowel disease flares. Knowledge about underlying pathogenesis remains limited. Methods This prospective interventional trial evaluated the…

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Negative / Null Result ReportMedicine

Heavy episodic drinking and intimate partner violence perpetration: Do interpersonal stress perceptions matter?

Hammett JF, Kirwan M, Chen W · 2026 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

Objective Intimate partner violence (IPV) is a major public health concern. Heavy episodic drinking (HED; i.e., drinking 5+ drinks for men or 4+ drinks for women in a 2-hr period) is a contributing cause of IPV, yet HED does not elicit IPV…

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Negative / Null Result ReportMedicine

Decreasing the Use of As-Needed Antihypertensive Therapy in Hospitalized Patients With Asymptomatic Hypertension.

Lipps KM, Samuel AM, Patel D et al. · 2025 · Journal for healthcare quality : official publication of the National Association for Healthcare Quality

Background Hypertension (HTN) is common in the inpatient setting, with many patients receiving as-needed (PRN) antihypertensive medications (anti-HTN) despite lack of benefit and risk of adverse events. We aimed to decrease PRN anti-HTN…

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Negative / Null Result ReportMedicine

Developing more effective phosphorus-loaded iron modified biochar fertilisers for improvement of peanut yield and regulation of soil phosphorus fractions

Zhang J, Wu Q, Chi D et al. · 2025 · Soil & tillage research

Phosphorus-loaded iron-modified biochar (Fe-BP) can be used as farmlands' slow-release phosphorus (P) fertilizer. This study aimed to explore the effects of Fe-BP on soil P composition, phosphatase activity, peanut P accumulation, and P…

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Negative / Null Result ReportMedicine

The influence of the Hunga Tonga-Hunga Ha'apai water vapor on ozone content in the Antarctic and Arctic stratospheric polar vortex in the winter 2023 and 2023–2024

Lukyanov AN, Vargin PN, Yushkov VA · 2025 · Atmospheric research

The eruption of the underwater volcano Hunga Tonga – Hunga Ha'apai (20.54° S, 178.3° W) on January 15, 2022, resulted in the first significant increase in the stratospheric water vapor content in the entire satellite observation era. This…

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Negative / Null Result ReportMedicine

Pictures are not always worth a thousand words: Non-probative pictures did not increase the effectiveness of misinformation corrections.

Whitehead PS, Davis CP, Park JS et al. · 2025 · Journal of applied research in memory and cognition

Much research has focused on the language used for debunking false beliefs: communications should lead with facts, label misinformation as false, and reinforce true information. Pictures are used in debunking messages, but it remains…

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Negative / Null Result ReportMedicine

Evaluating Text Messaging Approaches to Promote Enrollment in Smoking Cessation Treatment Among Latino Adults: A Pragmatic Randomized Clinical Trial.

Cartujano-Barrera F, Catley D, Chávez-Iñiguez A et al. · 2026 · Chest

Background Little is known about the use of text messages to promote enrollment in smoking cessation treatment. Research question What is the impact of the number of outreach messages and monetary incentives on enrollment in smoking…

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Negative / Null Result ReportMedicine

Clinical efficacy and safety of long-term treatment, discontinuation, and extended dosing intervals of denosumab treatment for solid cancer bone metastasis: A retrospective study.

Mihara A, Iwanaga R, Muramatsu K et al. · 2025 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Metastatic bone tumors in solid cancer often induce excessive local bone resorption leading to skeletal related events (SRE) which may impact patients' quality of life and survival of the primary cancer. Denosumab, a bone…

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Negative / Null Result ReportMedicine

Development and testing of implementation strategies to increase the use of midline catheters in a paediatric intensive care unit.

Weber MD, Frankenberger W, Ullman AJ et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Paediatric critically ill patients are at risk of harm from central venous catheter overuse. We applied an implementation science approach to promote appropriate use of midline catheters. The aim of this study was to evaluate…

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Negative / Null Result ReportOpen accessMedicine

First report of bilateral Bronchial Rheoplasty for treating chronic bronchitis performed in a single procedure.

Jensen K, Secher EL, Libermann RH et al. · 2025 · European clinical respiratory journal

Introduction The RheOx system delivers brief, high-voltage electrical pulses to the airway lining, promoting the regeneration of healthy tissue and reducing mucus production in COPD patients with chronic bronchitis. The procedure, called…

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Negative / Null Result ReportOpen accessMedicine

Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study.

Tsujio G, Yashiro M, Miki Y et al. · 2026 · PloS one

Background Our group revealed that the combination of intra-operative stamp cytology and peritoneal lavage cytology (CY) improved the identification of individuals with high risk of peritoneal metastasis. In this exploratory Phase II…

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Negative / Null Result ReportMedicine

Associations between paracetamol administration and delayed intravenous antibiotic administration among patients with in-hospital sepsis.

Senangkhanikorn S, Morapun N, Samansee A et al. · 2026 · Journal of hospital medicine

Background Timely antibiotic administration is crucial for improving sepsis outcomes, but delays are common and multifactorial. Fever, a key feature of sepsis, is often treated with paracetamol, which may mask the condition and contribute…

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Negative / Null Result ReportMedicine

Effects of replacing porcine blood meal with rumen-protected lysine, while maintaining metabolizable methionine supply, on performance, nitrogen use efficiency, and nutrient partitioning in dairy cows.

Arshad U, Johnson SJ, Fukumori R et al. · 2026 · Journal of dairy science

The objectives of this experiment were to determine the effects of replacing metabolizable Lys from porcine blood meal (PBM) with rumen-protected (RP) Lys (RPL) on lactation performance, ECM/DMI, N use efficiency (NUE; milk N/N intake),…

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