Failed Experiment ReportOpen accessMedicine
Coker JA, Sun R, Polzer PM et al. · 2026 · ACS chemical biology
Point mutations in the exonuclease (ExoN) site of nonstructural protein 14 (NSP14) compromise the fitness of betacoronaviruses such as SARS-CoV-2, implicating NSP14 ExoN inhibition as an antiviral strategy. However, there are no advanced…
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Ye S, Wu M, Yao C et al. · 2024 · eNeuro
Visual working memory (VWM) requires precise feature binding. Previous studies have revealed a close relationship between the posterior parietal cortex (PPC) and feature binding during VWM; this study further examined their causal…
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Yao Q, Yao Y, Liao Z et al. · 2026 · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
BackgroundSepsis and its complications pose a major global health burden. Mendelian randomization (MR) provides a genetic approach to assess causality.MethodsWe conducted a two-sample Mendelian randomization (MR) study using data from…
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Allard A, Clavien C · 2023 · PloS one
The recent replicability crisis in social and biomedical sciences has highlighted the need for improvement in the honest transmission of scientific content. We present the results of two studies investigating whether nudges and soft social…
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Weilnhammer V · 2024 · Neuroscience of consciousness
The neurobiology of conscious experience is one of the fundamental mysteries in science. New evidence suggests that transcranial magnetic stimulation of the parietal cortex does not modulate bistable perception. What does this mean for the…
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Ramaswamy A, Yamamori Y, Vivekananda U et al. · 2026 · Computational psychiatry (Cambridge, Mass.)
Anhedonia, a transdiagnostic symptom marked by diminished reward sensitivity, is often linked to impairments in reinforcement learning (RL). Standard tasks (e.g., the 4-arm bandit) can place substantial demands on participants and may blur…
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Burkard T, Holmberg D, Thorell A et al. · 2022 · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Background Obesity is considered a risk factor for cataracts. The association between weight loss and a cataract among patients with obesity has not been assessed to date. Objectives To assess the association between weight loss following…
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Cassar A, Hobbs A, Anttila-Hughes J et al. · 2026 · PNAS nexus
A consistent finding regarding human societies is that higher temperatures lead to antisocial behavior, including more crime, violence, aggression, and civil conflict. A large body of research documents this relationship at the societal…
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Li ZL, Zou YW, Jia PW et al. · 2026 · Food science & nutrition
Growing research implicates the diet-microbiota-joint axis plays a key role in joint health. The Dietary Index for Gut Microbiota (DI-GM) is a novel metric evaluating dietary effects on microbial communities, yet its potential link to…
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Wu J, Hang R, Xin P et al. · 2026 · Brain sciences
Background: Proficient second language (L2) reading relies on complex neurocognitive processes. Neuroimaging studies have identified key brain regions recruited during L2 reading, including the left inferior parietal lobule (LIPL) and the…
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Rajaraman R, Kassaye I, Sharma SS et al. · 2026 · Antimicrobial agents and chemotherapy
The aim of this study was to determine the antiamoebic efficacy of povidone-iodine when used as an adjunct to topical biguanide therapy for Acanthamoeba keratitis. Patients with smear- or culture-positive Acanthamoeba keratitis received…
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Makin AD, Rahman A, Bertamini M · 2020 · Preprint
Previous work has shown that symmetrical or regular stimuli are judged as lasting longer than asymmetrical or irregular ones, even when actual duration is matched. This effect has been replicated with different methods and stimuli types,…
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Pinto R, Ferreira R, Alves P et al. · 2025 · Healthcare (Basel, Switzerland)
Background : Healthcare-associated infection drives morbidity and unplanned hospital use in haemodialysis. We aimed to determine whether an adapted British Renal Society Infection Risk Screening Tool, applied during a nurse-led vascular…
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Andrade G, Gamboa L, Campo-Redondo M · 2026 · Frontiers in psychology
Background Beliefs about free will are central to philosophical and scientific conceptions of agency, and experimental work suggests that weakening such beliefs can reduce honesty, self-control, and helping. Yet little is known about how…
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Chen C, Zhang W, Chu C et al. · 2026 · Gland surgery
Background Thyroid malignancies pose a significant global health burden, especially in women. Sex hormones are crucial for thyroid function, but their relationship with thyroid malignancy remains unclear. This study investigates the causal…
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Hamilton F, Mitchell RE, Constantinescu A et al. · 2023 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Severe malaria remains a deadly disease for many young children in low- and middle-income countries. Levels of interleukin (IL)-6 have been shown to identify cases of severe malaria and associate with severity, but it is unknown…
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Oda T, Houshmand Chatroudi A, Yotsumoto Y · 2026 · Journal of vision
Flicker-induced time dilation refers to the robust illusion whereby temporally modulated visual stimuli are perceived as lasting longer than static stimuli. Although flicker-induced time dilation has been consistently demonstrated, it…
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Xu X, Zang X, Liu H et al. · 2026 · The Journal of international medical research
ObjectiveTo assess the causal effects of specific eating habits on ischemic stroke risk and functional outcomes using Mendelian randomization.MethodsThis two-sample Mendelian randomization study used genetic variants associated with 32…
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Lin WT, Yang JL, Lin CY et al. · 2026 · JAC-antimicrobial resistance
Objectives Among patients with daptomycin-resistant and vancomycin-resistant Enterococcus faecium bloodstream infection (BSI), the optimal definitive therapy is uncertain. We estimated the dose effect of daptomycin (≥11 mg/kg versus 8 to…
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Ünal K, Taş Torun Y, Erol ME et al. · 2026 · World journal of clinical pediatrics
Background Generalized anxiety disorder (GAD) is a prevalent psychiatric condition in children and adolescents, frequently linked to difficulties in daily functioning and academic performance. Increasing evidence suggests that immune…
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Li J, Lee P, Jones BC et al. · 2025 · PloS one
The tendency for men to find younger adult women more attractive has been hypothesised to reflect preferences for cues of reproductive potential. To further test this hypothesis, we investigated the possible relationship between…
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Simpson NH, Bishop DV, Newbury DF · 2021 · Preprint
Language disorders in children are highly heritable, but progress in identifying genetic variants that contribute to language phenotypes has been slow. Here we applied a novel approach by identifying SNPs that are associated with gene…
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McKean J, Underwood P, Yasinzai AQK et al. · 2026 · Cancers
Background/objectives Pancreatic ductal adenocarcinoma is an aggressive malignancy with poor long-term survival. While surgical resection followed by adjuvant chemotherapy remains the standard of care for resectable disease, a substantial…
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Sadil P, Cowell RA, Huber DE · 2024 · Psychonomic bulletin & review
In the "serial dependence" effect, responses to visual stimuli appear biased toward the last trial's stimulus. However, several kinds of serial dependence exist, with some reflecting prior stimuli and others reflecting prior responses.…
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Orhan BE, Karadağ B, Alkasasbeh WJ et al. · 2026 · Frontiers in nutrition
Introduction Problematic social media use (PSMU) and caffeine use disorder (CUD), a behavioral pattern without formal diagnostic status and a DSM-5 condition listed for further study, respectively, share phenomenological features…
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Marshev V, Frey HG, Brascamp J · 2025 · Journal of vision
The pupil constricts in response to visual stimuli that keep net luminance unchanged but that do introduce local luminance increments and decrements-a reaction here called "isoluminant constriction." This response can form a pupillometric…
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Tammurello C, Coelho LA, Amadeo M et al. · 2026 · Scientific reports
In the Somatic Rubber Hand Illusion (SRHI), synchronous brushing of a participant’s hidden hand and a dummy hand induces proprioceptive drift, a shift in perceived position of the hand towards the dummy hand, along with the sensation of…
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Sasidharan S, Philips CA, Philips CA et al. · 2026 · Hepatology communications
Background Fatigue affects 60%-80% of patients with cirrhosis, yet no universally effective pharmacologic therapy exists. Taurine, an amino sulfonic acid with antioxidant and membrane-stabilizing properties, may address metabolic…
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MacAllister S, Miller M, Swanson S · 2025 · Injury epidemiology
Background Recent publications on Child Access Prevention (CAP) laws suggest substantial protective effects on adolescent firearm suicide. However, these studies have also found comparable protective effect estimates on adolescent…
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Ren F, Liu W · 2026 · Behavioral sciences (Basel, Switzerland)
Emotions play an important role in shaping aggressive behavior, and understanding their underlying psychological mechanisms is particularly relevant among college students. However, existing research has predominantly focused on reactive…
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