Effect of PCC on Thrombin Generation in Patients on FXaI with Bleeding or Needing Urgent Surgery (GAUGE).
Shaw JR; Gray H; Xu Y; Le Gal G; Wang TF; Khalife R; Siegal DM; Castellucci LA · 2026 · Blood advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Prothrombin complex concentrates (PCC) are used off-label to treat direct factor Xa inhibitor (FXaI)-associated bleeding or before urgent surgery. GAUGE was a prospective observational cohort study of the effects of PCC on thrombin…
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Metadata source: Europe PMC · DOI 10.1182/bloodadvances.2026020203