e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

21,290 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

[Application of optical genome mapping technology for the detection of chromosomal structural variations].

Zhang Z, He S, Li X et al. · 2024 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To assess the value of optical genome mapping (OGM) for the detection of chromosomal structural abnormalities including ring chromosomes, balanced translocations, and insertional translocations. Methods Clinical data of four…

View details →
Negative / Null Result ReportOpen accessMedicine

Pipeline evaluation of a state-of-the-art AI algorithm for detection of focal cortical dysplasia: insights into potential failure sources.

Esmeraldo MA, Chambers S, Kravutske Y et al. · 2026 · Brain informatics

Purpose MELD Graph is a state-of-the-art artificial intelligence (AI) model for automated detection of focal cortical dysplasia (FCD), but its performance remains limited, highlighting the need to investigate which aspects of the pipeline…

View details →
Negative / Null Result ReportMedicine

Evaluation of the AMP rapid test ROTA/ADENOVIRUS for simultaneous detection of rotavirus and adenovirus in stool samples.

Allahham M, Rennert W, Miller KM et al. · 2025 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Background Rotavirus (RV) and Adenovirus (AdV) gastroenteritis affect children worldwide. The sensitivity and specificity of the AMP Rapid Test ROTA/ADENOVIRUS [AMP-RA] for the detection of RV and AdV were compared against qPCR Allplex™…

View details →
Negative / Null Result ReportMedicine

Twenty-one days of bed rest alter motor unit properties and neuromuscular junction transmission in young adults.

Sarto F, Kalc M, Motanova ES et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)

Previous studies showed that properties of higher-threshold motor units (MUs) and neuromuscular junction (NMJ) function are preserved during short-term disuse. This study aimed to test how a longer disuse period affects MU properties, NMJ…

View details →
Negative / Null Result ReportOpen accessMedicine

Diagnostic Performance of Cardiac CT and Transthoracic Echocardiography in Congenital Heart Disease: A Surgical Correlation Study.

Bakhshaliyev S, Arslanoğlu E, Huseynov H et al. · 2026 · Diagnostics (Basel, Switzerland)

Background : This study evaluated the diagnostic efficacy of transthoracic echocardiography (TTE) and 128-slice multislice computed tomography (MSCT) angiography in congenital heart disease (CHD). Methods : Between January 2018 and August…

View details →
Negative / Null Result ReportOpen accessMedicine

Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor.

Kawamoto S, Horiguchi H, Torigoe D et al. · 2026 · EMBO reports

The discovery of the senescence-associated secretory phenotype (SASP) has reshaped our understanding of cellular senescence, shifting its role from a solely tumor-suppressive mechanism to a potential driver of chronic inflammation and…

View details →
Negative / Null Result ReportMedicine

Post-hoc out-of-distribution detection for cardiac MRI segmentation.

Arega TW, Bricq S, Meriaudeau F · 2025 · Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

In real-world scenarios, medical image segmentation models encounter input images that may deviate from the training images in various ways. These differences can arise from changes in image scanners and acquisition protocols, or even the…

View details →
Negative / Null Result ReportOpen accessMedicine

Establishing population-specific gestational weight gain ranges for twin pregnancies and comparing their performance with IOM recommendations: a retrospective cohort study from central China.

Yang R, Wang Y, Fu Q et al. · 2026 · BMJ open

Objectives To establish optimal pre-pregnancy body mass index (BMI)-specific gestational weight gain (GWG) ranges for twin pregnancies and compare their association with maternal and neonatal adverse outcomes against Institute of Medicine…

View details →
Negative / Null Result ReportOpen accessMedicine

Measured and Estimated Glomerular Filtration Rate to Evaluate Rapid Progression and Changes over Time in Autosomal Polycystic Kidney Disease: Potential Impact on Therapeutic Decision-Making.

Miquel-Rodríguez R, González-Toledo B, Pérez-Gómez MV et al. · 2024 · International journal of molecular sciences

Autosomal polycystic kidney disease (ADPKD) is the most common genetic form of kidney failure, reflecting unmet needs in management. Prescription of the only approved treatment (tolvaptan) is limited to persons with rapidly progressing…

View details →
Failed Experiment ReportOpen accessMedicine

Domain-specific cognitive screening in acute first-ever stroke: a comparative study of the Oxford Cognitive Screen (OCS) and ACE-III.

Tanglay O, Jhunjhnuwala D, Huynh W · 2025 · Frontiers in human neuroscience

Introduction Post-stroke cognitive impairment (PSCI) is common and often under-recognized, particularly in the acute phase. Most cognitive screening tools provide only a global score, overlooking domain-specific deficits that influence…

View details →
Negative / Null Result ReportMedicine

FilmArray® effectively detects all clades of F41 but encounters challenges with other adenovirus species.

Ito S, Takano C, Hoque SA et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

The BioFire FilmArray® Gastrointestinal (GI) Panel, a widely used diagnostic tool, is designed to detect the genetic material of 22 common pathogens responsible for gastroenteritis, including viruses, bacteria, and parasites. It can detect…

View details →
Negative / Null Result ReportOpen accessMedicine

Gastrointestinal cancer with indeterminate <sup>18</sup>F-FDG PET/CT findings: Diagnostic efficacy analysis of <sup>68</sup>Ga-FAPI-04 PET/MRI.

Miao J, Xu Y, Qiao F et al. · 2026 · Oncology letters

The present prospective study aimed to investigate whether gallium-68-labeled fibroblast activation protein inhibitor-04 ( 68 Ga-FAPI-04) positron emission tomography (PET)/magnetic resonance imaging (MRI) could provide notably increased…

View details →
Negative / Null Result ReportOpen accessMedicine

Clinicopathology of adenocarcinoma originating from the anal gland with immunohistochemical expressions of GATA3 and TTF-1: a case report and literature review.

Shi J, Li G, Tang W et al. · 2026 · Frontiers in oncology

Adenocarcinoma originating from the anal gland with immunohistochemical expression of GATA3 and TTF-1 (ACAGGT) is a rare entity. This report describes an 80-year-old female patient who detected a perianal mass without an obvious cause 10…

View details →
Negative / Null Result ReportMedicine

GC-MS quantification of fecal short-chain fatty acids and spectrophotometric detection of indole: Do rectal swabs produce comparable results as stool samples? - A pilot study.

K K V, P R A, Rao BK et al. · 2024 · Rapid communications in mass spectrometry : RCM

Rationale The exploration of the gut microbiome and related metabolites holds an exciting future in health science. The challenges associated with fecal sample testing are proper sample collection, sterile transportation, optimal transport…

View details →
Negative / Null Result ReportOpen accessMedicine

Association between in-hospital antibiotic use and long-term outcomes in critically ill patients.

Burrows P, Brown RA, Samuelsen A et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE

Objective To assess whether antibiotic duration (AD) and one-year antibiotic-free days (AFD) are associated with key in-hospital and post-discharge outcomes among critically ill adults. Design Prospective observational study. Setting…

View details →
Negative / Null Result ReportOpen accessMedicine

Renal safety of postoperative short-term use of flurbiprofen axetil in well-controlled hypertensive patients: a prospective multicenter cohort study.

Sun L, Jiang Y, Ma X et al. · 2026 · Frontiers in pharmacology

Background Currently, postoperative nonsteroidal anti-inflammatory drugs-associated kidney damage in hypertensive patients remains undetermined. This study aimed to examine renal safety of short-term post-surgery use of flurbiprofen axetil…

View details →