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Browse the failure-mode index

21,290 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Detectability of Automated Tumor-feeder Detection Software Using Angio-computed Tomography in Transarterial Chemoembolization for Hepatocellular Carcinoma.

Ueda M, Mitani H, Nakaki Y et al. · 2025 · Interventional radiology (Higashimatsuyama-shi (Japan)

Purpose: To evaluate the performance of automated tumor-feeder detection software in transarterial chemoembolization for hepatocellular carcinoma using angio-computed tomography. Material and Methods: This was a retrospective study of 107…

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Negative / Null Result ReportMedicine

Optical Genome Mapping in Myelodysplastic Syndromes: Clinical Value and Limitations Derived From a Cohort of 236 Patients.

Wei Q, Wang SA, Garcia-Manero G et al. · 2025 · Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Identification of cytogenetic abnormalities is critical for the classification and risk stratification of myelodysplastic syndromes (MDS). Optical genome mapping (OGM) is an emerging cytogenomic platform that enables high-resolution…

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Negative / Null Result ReportOpen accessMedicine

Comparative Diagnostic Accuracy of MRI and Ultrasound in Meniscal Tear Detection: Evaluating Reliability and Limitations Against Arthroscopic Outcomes.

Noorelahi Y · 2025 · Radiology research and practice

Objective Accurate meniscal tear diagnosis is essential for proper knee injury management. While MRI is the gold standard, ultrasound (US) offers a cost-effective alternative. However, its accuracy compared to arthroscopy remains…

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Negative / Null Result ReportMedicine

Performance of creatinine and cystatin C-based equations to estimate glomerular filtration rate in African children with sickle cell anemia.

Nkoy AB, Mumaka FM, Matoka TT et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Serum creatinine (SCr), the most used biomarker to evaluate glomerular filtration rate (GFR), might be inaccurate in children with sickle cell anemia (SCA). In this context, cystatin C (SCys) could be of interest. This study…

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Negative / Null Result ReportOpen accessMedicine

Genome-resolved metagenomics reveals unexpected diversity and host range of Candidatus Lariskella (Rickettsiales: Midichloriaceae).

Hagenbeek A, Masukagami Y, Palanichamy P et al. · 2026 · BMC genomics

The intracellular endosymbiont Candidatus Lariskella (Alphaproteobacteria, Candidatus Midichloriaceae) has been found across a wide diversity of terrestrial arthropods, including ticks, true bugs, beetles, fleas, wasps and moths. Despite…

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Failed Experiment Report

† Cryptovaranoides is not a squamate

Caldwell MW, Brownstein CD, Meyer DL et al. · 2025 · Preprint

Accurate reconstruction of the timescale of organismal evolution requires placement of extinct representatives among living branches. In this way, the fossil record has the capacity to revise hypotheses of organismal evolution by producing…

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Negative / Null Result ReportMedicine

Polymerase chain reaction fails to detect mixed malaria infections in siblings from Ethiopia.

Hall AD, Whitehurst DA, Mortensen JE et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Malaria remains a significant public health concern in sub-Saharan Africa, particularly in Ethiopia where Plasmodium falciparum and Plasmodium vivax are co-endemic. Most cases in the United States are acquired abroad and imported.…

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Negative / Null Result ReportMedicine

Real-time PCR versus culture of bronchoalveolar lavage fluid for detecting Bordetella bronchiseptica in dogs with persistent lower respiratory signs: a retrospective study of 23 cases.

Atencia S, Mateu N, Rodríguez-Cobos A et al. · 2025 · Veterinary research communications

Bordetella bronchiseptica (Bb) is a frequent pathogen in dogs and a component of the Canine Infectious Respiratory Disease Complex (CIRDC). However, it can also be detected in the lower respiratory tract of healthy animals, complicating…

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Negative / Null Result ReportMedicine

Bactericera maculipennis (Hemiptera: Triozidae) is a vector of "Candidatus Liberibacter solanacearum" to species within the Convolvulaceae (Solanales).

Cooper WR, Ohler B, Wenninger EJ et al. · 2025 · Environmental entomology

Bactericera maculipennis (Crawford) and Bactericera cockerelli (Šulc) (Hemiptera: Triozidae) share hosts within the Solanaceae and Convolvulaceae (Solanales), and both are associated with "Candidatus Liberibacter solanacearum" (Lso). Lso,…

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Negative / Null Result ReportMedicine

Efficacy and safety of chemotherapy combined with iodine-125 seed brachytherapy for intermediate and advanced oncogenic driver gene-negative non-small cell lung cancer.

Xia MH, Liu KC, Zhao W et al. · 2025 · Brachytherapy

Purpose To compare the effectiveness and safety of CT-guided iodine-125 seed brachytherapy in conjunction with chemotherapy against chemotherapy alone for the management of intermediate and advanced non-small cell lung cancer (NSCLC)…

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Negative / Null Result ReportOpen accessMedicine

Phase 1 LITESPARK-001 study of belzutifan in participants with advanced solid tumors: Results of the glioblastoma expansion cohort.

Strowd RE, de la Fuente M, Bauer TM et al. · 2026 · Neuro-oncology advances

Recurrent isocitrate dehydrogenase (IDH) wild-type glioblastoma has no established standard-of-care treatment. Preclinical models have demonstrated that hypoxia-inducible factor-2 alpha (HIF-2α) contributes to stabilizing the hypoxic…

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