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Browse the failure-mode index

21,290 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Klossiella equi, an underreported parasite of equids in the Americas.

Zeldenrust EG, Carlton K, Jenkins EJ et al. · 2026 · Veterinary parasitology

Klossiella equi Baumann, 1946 (Apicomplexa: Coccidia) is a globally distributed adeleorinid parasite that infects the kidneys of equid hosts. Considered an uncommon parasite, when K. equi is detected, it is typically an incidental finding…

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Failed Experiment Report

The cytoplasmic C-terminal domain of the MmpL11 lipid transporter is required for interaction with its co-cistronic partner MSMEG_0240 in Mycobacterium smegmatis

Lecher S, Jaisinghani N, Previti M et al. · 2026 · Preprint

MmpL proteins play an important role in the various mechanisms associated with mycobacterial virulence. Identification of interacting protein partners required for a detailed understanding of their role remains hampered because of their…

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Failed Experiment ReportOpen accessMedicine

Progesterone

· 2006

Because of the low reported levels of progesterone in breastmilk, even with the high-dose products, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. The progesterone…

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Failed Experiment ReportMedicine

YTHDF proteins differentially regulate a subset of m6A-modified transcripts to restrain endothelial inflammation during homeostasis.

Shyam Kumar R, Chakraborty S, Jayakumar H et al. · 2026 · Molecular biology reports

Background N6-methyladenosine (m6A) modification of mRNAs through METTL3 maintains homeostasis in many cell types. The mechanism by which METTL3 complexes together with reader proteins, especially the YTH domain-containing protein, governs…

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Negative / Null Result ReportMedicine

Radiographic Detection of Intrathoracic Lymphadenomegaly in Dogs: How Useful Is It?

Lye G, Pollard RE, Hartman A et al. · 2026 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

The intrathoracic lymph nodes (LN) of clinical interest in dogs are the sternal (STLN), cranial mediastinal (CrMLN), and tracheobronchial (TBLN) groups. Although computed tomography (CT) depicts and measures these nodes well, thoracic…

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Negative / Null Result ReportMedicine

Detection of cross-reactivity of antibodies to the N proteins of feline morbillivirus and canine distemper virus in Japanese cat plasma samples

Khin STMM, Jafar SM, Ju M et al. · 2025 · Journal of virological methods

Feline morbillivirus (FeMV) is a globally emerging virus that has been linked to chronic kidney disease (CKD) in infected cats. Immunological assays, such as enzyme-linked immunosorbent assay (ELISA), are important for studying the virus…

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Negative / Null Result ReportMedicine

Using EEG to detect lapses in sustained attention to moving stimuli.

Lowe BG, Woolgar A, Smit S et al. · 2026 · Cortex; a journal devoted to the study of the nervous system and behavior

Sustaining attention is effortful but crucial for daily life. Despite this, attentional lapses are common and can have fatal consequences (e.g., when driving). The spontaneous nature of these lapses makes studying their underlying…

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Failed Experiment ReportMedicine

Survival outcomes of rectal and head and neck cancer patients receiving radio(chemo)therapy with a ketogenic diet. A post-hoc analysis from the KETOCOMP trial.

Klement RJ, Sweeney RA · 2026 · Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Purpose Ketogenic diets (KDs) have been proposed to target glycolytic cancer metabolism and synergize with radio- and chemotherapy. We herein report survival outcomes of rectal and head and neck cancer (HNC) patients who followed a KD…

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Failed Experiment ReportMedicine

Aztreonam plus ceftazidime/avibactam broth disk elution test: failure to detect Escherichia coli with PBP-3 insertions.

Peirano G, Walker SD, Duong MS et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Introduction Metallo-β-lactamase (MBL)-producing Enterobacterales are increasing in frequency and treatment options are limited. Aztreonam/avibactam (AZA) and aztreonam (ATM) plus ceftazidime/avibactam (CZA) showed activities against these…

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Negative / Null Result Report

Explainable Deep Learning for Lesion-Level Detection of Diabetic Retinopathy: A Segmentation Approach Using Fundus Images Graded as Mild-to-Moderate Nonproliferative Diabetic Retinopathy

Sato T, Nishitsuka K, Itoh T et al. · 2025 · Preprint

Deep learning has shown promise in diabetic retinopathy screening using fundus images. However, many existing models operate as “black boxes,” providing limited interpretability at the lesion level. This study aimed to develop an…

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Negative / Null Result ReportOpen accessMedicine

AcrIIA8 is a putative phage structural protein of the HTJ2 family that does not inhibit Streptococcus pyogenes Cas9.

An SY, Kim I, Hong SH et al. · 2026 · Protein science : a publication of the Protein Society

Anti-CRISPR (Acr) proteins are phage-encoded anti-defense factors that suppress CRISPR-Cas immunity in bacteria. AcrIIA8 was previously identified as an inhibitor of Streptococcus pyogenes Cas9 (SpyCas9) through functional assays of…

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Failed Experiment ReportMedicine

The agony of choice: Advancing sediment hazard assessment by using avoidance behaviour assays with Lumbriculus variegatus.

Hilgendorf J, Calisto V, Cardoso DN et al. · 2025 · Environmental toxicology and pharmacology

Sediments play a key role in chemical partitioning in aquatic ecosystems, acting as sinks for lipophilic and persistent compounds. However, sediment hazard assessment is limited, often underestimating risks by focusing on short-term,…

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