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Browse the failure-mode index

21,290 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Skeletal muscle index, grip strength, and physical performance as predictors of severe chemotherapy toxicity among older adults with malignancy.

Papadopoulos E, Rozenberg D, Wong AKO et al. · 2025 · PloS one

Background Skeletal muscle index (SMI), grip strength, and physical performance have been shown to predict clinically relevant outcomes in geriatric oncology. However, their predictive ability for chemotherapy toxicity is poorly…

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Failed Experiment ReportMedicine

Testing the effects of pathogen threat and sexual strategies on political ideology.

Shook NJ, Oosterhoff B · 2020 · Politics and the life sciences : the journal of the Association for Politics and the Life Sciences

Disgust has been consistently associated with greater political conservatism. Two explanations have been proposed for this link. According to a pathogen threat model, disgust serves a pathogen-avoidance function, encouraging more…

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Negative / Null Result ReportOpen accessMedicine

Effects of Emergency Department Training on Buprenorphine Prescribing and Opioid Use Disorder-Associated ED Revisits: Retrospective Cohort Study.

Torchiano A, Roberts B, Haroz R et al. · 2025 · The western journal of emergency medicine

Introduction Prescribing patients buprenorphine from the emergency department (ED) is recommended by multiple organizations. However, it is unclear how best to encourage physicians to prescribe buprenorphine from the ED. Our objectives in…

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Replication FailureOpen accessMedicine

At 75 Years, Is Lithium the Gold Standard in Bipolar Disorder?

Belmaker RH · 2025 · Pharmaceuticals (Basel, Switzerland)

Lithium was the first discovered mood stabilizer for bipolar disorder. However, several antiepileptics such as valproate and carbamazepine have also proven to be mood stabilizers in all phases of bipolar disorder with profiles barely…

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Negative / Null Result ReportMedicine

Comparison of CATCH, PECARN and CHALICE rules in children with minor head trauma.

Ferhatlar ME, Cumhur BA, Koca Y et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Purpose The aim of this study is to prospectively compare the diagnostic performance of the PECARN, CATCH, and CHALICE clinical decision rules in pediatric patients presenting with minor head trauma, within a rural secondary-level…

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Negative / Null Result ReportOpen accessMedicine

Computer vision for pain detection during procedural sedation.

Zarghami Y, Rad MG, Mafeld S et al. · 2026 · Scientific reports

Continual automated pain detection from facial expressions using computer vision during procedural sedation could optimize sedation dose titration and minimize pain. A prospective observational study was conducted. Participants' faces were…

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Negative / Null Result ReportMedicine

Unresponsive Systemic Mastocytosis in a Young AML With RUNX1::RUNX1T1 Fusion With Rare KIT c.1255_1257delGAC Mutation: A Clinical Deadlock.

Balraam Kv V, Nayak AR, Dass J et al. · 2026 · Journal of pediatric hematology/oncology

Background Systemic mastocytosis (SM) with associated acute myeloid leukemia (AML) is a rare malignancy usually linked to KIT p.D816V mutations. Observations We report a 17-year-old female with RUNX1::RUNX1T1-positive AML and florid mast…

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Negative / Null Result Report

Multiple evidence supporting a novel species amid complex phylogenomic discordance: a case of Indian Ledebouria based on Angiosperms353 target capture sequencing

Nayak S, Deshmukh P, Yadav SR et al. · 2026 · Preprint

Ledebouria , a geophytic herb native genus to Africa and represented by a few species in the Arabian Peninsula, Madagascar, India and Sri Lanka. For a long time Indian species were named as L. revoluta until recent molecular work clarified…

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Negative / Null Result ReportMedicine

Point-of-Care Ultrasound and Clinical Findings in 14 Cats With High-Rise Syndrome.

Swanstein HKJ, Gommeren K, Langhorn R et al. · 2026 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Objective To describe point-of-care ultrasound (POCUS) and clinical findings in cats with high-rise syndrome. Design Retrospective descriptive study. Setting University hospital. Animals Fourteen cats that fell from a height. Measurements…

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