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Browse the failure-mode index

21,290 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

An investigation of mental rotation in infancy using change detection.

Beckner AG, Voss AT, Phillips L et al. · 2023 · Infant behavior & development

Two experiments were conducted to examine mental rotation in 6- to 12-month-old infants (N = 166) using a change detection task. These experiments were replications of Lauer and Lourenco (Lauer et al., 2015; Lauer & Lourenco, 2016), using…

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Negative / Null Result ReportOpen accessMedicine

Finding the forest in the trees: Using machine learning and online cognitive and perceptual measures to predict adult autism diagnosis.

Van der Burg E, Jertberg RM, Geurts HM et al. · 2026 · Translational psychiatry

Traditional subjective measures are limited in the insight they provide into underlying behavioral differences associated with autism and, accordingly, their ability to predict diagnosis. Performance-based measures offer an attractive…

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Negative / Null Result ReportOpen accessMedicine

The Reproducibility Movement in Psychology: Does Researcher Gender Affect How People Perceive Scientists With a Failed Replication?

Ashburn-Nardo L, Moss-Racusin CA, Smith JL et al. · 2022 · Frontiers in psychology

The reproducibility movement in psychology has resulted in numerous highly publicized instances of replication failures. The goal of the present work was to investigate people's reactions to a psychology replication failure vs. success,…

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Negative / Null Result ReportOpen accessMedicine

Emotional Blunting and Time Estimation in Depression.

Mura F, Catrambone V, Valenza G et al. · 2026 · Biological psychiatry global open science

Background Various cognitive and emotional factors shape our perception of time. Notably, individuals experiencing depressive symptoms often report changes in their time perception, characterized by a phenomenon termed depressive time…

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Negative / Null Result ReportOpen accessMedicine

Enhanced Structural Understanding of Dissolved Organic Matter through Comparative LC/MS2 Analysis with Synthetic Carboxylate Rich Alicyclic Molecules.

Hawkes JA, Flygare AD, Moodie LWK et al. · 2025 · Analytical chemistry

Dissolved organic matter (DOM) is one of the most complex chemical mixtures known, with its chemical composition having long puzzled biogeochemists. Identifying the chemical structures within DOM is essential for unraveling its origins and…

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Negative / Null Result ReportOpen accessMedicine

Alterations in epigenetic marks and expression of genes related to stress regulation: an exploratory study among newborns after fetal repair of spina bifida aperta.

Landolt MA, Strebel NL, Moehrlen U et al. · 2026 · Epigenetics

Fetal repair of spina bifida aperta (fSBA) is an established intervention that improves neurological and neurodevelopmental outcomes. The present exploratory study examines whether molecular signatures related to stress regulation are…

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Negative / Null Result ReportMedicine

Preoperative Use of Glucagon-Like Peptide-1 Receptor Agonists Is Not Protective Against Pseudoarthrosis Following Small Joint Hand Arthrodesis: A Propensity-Matched Analysis.

Stump K, Morar H, Talsania A et al. · 2026 · Hand (New York, N.Y.)

Background Glucagon-like peptide-1 receptor agonist (GLP-1 RA) use has demonstrated positive effects on bone metabolism and pseudoarthrosis following fusion surgery. There is, however, little evidence regarding the preoperative use of…

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Negative / Null Result Report

Second Replication of Finn & Hudson Kam (2008) Experiment 3

Ricketts W, Hartshorne JK · 2022 · Preprint

We replicated Experiment 3 of Finn & Hudson Kam (2008) The curse of knowledge: First language knowledge impairs adult learners' use of novel statistics for word segmentation, Cognition, 108(2), 477-499. This is part of a larger project…

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Negative / Null Result Report

Second Replication of Finn & Hudson Kam (2008) Experiment 1

Ricketts W, Hartshorne JK · 2022 · Preprint

We replicated Experiment 1 of Finn & Hudson Kam (2008) The curse of knowledge: First language knowledge impairs adult learners’ use of novel statistics for word segmentation, Cognition, 108(2), 477-499. This is part of a larger project…

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Negative / Null Result Report

Is musical engagement enough to keep the brain young?

Matziorinis AM, Gaser C, Koelsch S · 2022 · Preprint

Music-making and engagement in music-related activities have shown procognitive benefits for healthy and pathological populations, suggesting reductions in brain aging. A previous brain aging study, using Brain Age Gap Estimation…

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Negative / Null Result ReportOpen accessMedicine

Genome-wide Association Study of Susceptibility to Respiratory Syncytial Virus Hospitalization in Young Children <5 Years of age.

Egeskov-Cavling AM, van Wijhe M, Yakimov V et al. · 2024 · The Journal of infectious diseases

Background Worldwide, respiratory syncytial virus (RSV) infections are among the most common causes of infant hospitalization. Host genetic factors influencing the risk and severity of RSV infection are not well known. Methods We conducted…

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Failed Experiment Report

Engineering Alignment has Mixed Effects on hiPSC-CM Maturation

Kalkunte NG, Delabmbre TE, Sohn S et al. · 2022 · Preprint

The potential of human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CMs) is greatly limited by their functional immaturity. Strong relationships exist between CM structure and function, leading many in the field to…

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Negative / Null Result ReportMedicine

Does interpersonal liking lead to interpersonal synchrony in musical contexts?

Melton ZJ, Chaffin R, Kangas-Dick K et al. · 2023 · Quarterly journal of experimental psychology (2006)

The causal relationship of interpersonal liking affecting interpersonal synchrony is inconsistently documented. This study tests whether (a) interpersonal liking increases both behavioural and perceived synchrony and (b) people will…

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Negative / Null Result ReportMedicine

Genome scan reveals several loci associated with torus palatinus.

Lee MK, El Sergani AM, Herrick N et al. · 2025 · Orthodontics & craniofacial research

Objective Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic…

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Negative / Null Result ReportMedicine

Evaluating factors associated with paediatric cochlear implant outcome in four cochlear implant satellite centres in Malaysia.

Tengku Kamalden TMI, Azali MZ, Chong LC et al. · 2022 · The Medical journal of Malaysia

Introduction Many factors are associated with cochlear implant (CI) outcomes and various methods of assessment for auditory and speech performance outcomes in CI are available globally. The objective of this study is to identify factors…

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Negative / Null Result Report

Genome-wide determination of barriers to horizontal gene transfer

Burch CL, Romanchuk A, Kelly M et al. · 2022 · Preprint

Horizontal gene transfer (HGT) is a major contributor to bacterial genome evolution, generating phenotypic diversity, driving the expansion of protein families, and facilitating the evolution of new phenotypes, new metabolic pathways, and…

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