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Browse the failure-mode index

21,290 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Generalizability and Out-of-Sample Predictive Ability of Associations Between Neuromelanin-Sensitive Magnetic Resonance Imaging and Psychosis in Antipsychotic-Free Individuals.

Wengler K, Baker SC, Velikovskaya A et al. · 2024 · JAMA psychiatry

Importance The link between psychosis and dopaminergic dysfunction is established, but no generalizable biomarkers with clear potential for clinical adoption exist. Objective To replicate previous findings relating neuromelanin-sensitive…

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Negative / Null Result ReportMedicine

Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene-environment interplay with family conflict and parental acceptance.

Jamil B, Su J, Elam K et al. · 2025 · Development and psychopathology

Introduction Past research suggests that polygenic scores for major depressive disorder (MDD-PGS), family conflict, and parental acceptance may all predict depressive outcomes among adolescents. Few studies have examined the interplay of…

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Negative / Null Result Report

Defaults versus framing: Revisiting Default Effect and Framing Effect with replications and extensions of Johnson and Goldstein (2003) and Johnson, Bellman, and Lohse (2002)

Chandrashekar SP, Adelina N, Zeng S et al. · 2022 · Preprint

People tend to stick with a default option instead of switching to another option. For instance, Johnson and Goldstein (2003) found a default effect in an organ donation scenario: if organ donation is the default option, people are more…

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Negative / Null Result ReportOpen accessMedicine

Sequential Versus Non-Sequential Polymyxin B Hemoperfusion in Severe Sepsis and Septic Shock: A Real-World Cohort Analysis of Survival in an Asian ICU.

Chang WH, Hu TY, Kuo LK · 2026 · Diagnostics (Basel, Switzerland)

Background: Severe sepsis and septic shock remain major causes of ICU mortality despite advances in critical care. Polymyxin B hemoperfusion (PMX-HP) is widely used in Asia for refractory endotoxemia, yet the optimal session strategy…

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Negative / Null Result Report

Generalizing the Effect of Lyrics on Emotion Rating

Ma Y, Baker DJ, Vukovics K et al. · 2021 · Preprint

What factors affect listeners’ emotional perception of music? Ali and Peynircioğlu (2006) conducted a series of experiments on the listener's emotional response to melodies and lyrics in songs. Here we present a pre-registered replication…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of antioxidant co-therapy for polymyxin B-associated nephrotoxicity and mortality: a real-World retrospective cohort study.

Qi J, Yin Z, Peng Y et al. · 2025 · Journal of pharmaceutical policy and practice

Background Polymyxin B is increasingly used to treat infections caused by multidrug-resistant gram-negative bacteria; however, its widespread clinical use is hindered by the high incidence of nephrotoxicity. Antioxidants, such as vitamin…

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Negative / Null Result ReportOpen accessMedicine

Temperature and nutrition do not interact to shape the evolution of metabolic rate.

Alton LA, Kutz T, Bywater CL et al. · 2024 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Metabolic cold adaptation, or Krogh's rule, is the controversial hypothesis that predicts a monotonically negative relationship between metabolic rate and environmental temperature for ectotherms living along thermal clines measured at a…

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Negative / Null Result ReportOpen accessMedicine

Combined vaginal progesterone and cervical Pessary effect on preterm birth in Singleton pregnancies with short cervix: a retrospective cohort study.

Eshraghi N, Jayervand F, Hashemi N et al. · 2025 · BMC pregnancy and childbirth

Background To determine whether the combination of vaginal progesterone and cervical pessary initiated during the second trimester reduces the incidence of preterm birth and enhance neonatal outcomes among women diagnosed with singleton…

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Negative / Null Result ReportOpen accessMedicine

The Acute Effect of Consuming Whey Versus a Plant-Based Protein Blend on Postprandial Metabolism and Appetite in a Sample of Healthy Adults.

Petkova YP, Johnston JD, Collins AL · 2026 · Food science & nutrition

There is controversy regarding the differential metabolic effects of proteins from plant and animal sources. Existing literature focuses on a limited range of plant proteins consumed just before, or as part of, a mixed meal, resulting in…

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