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Browse the failure-mode index

21,287 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Do uncontrolled processes contribute to evaluative learning? Insights from a new two-US process dissociation procedure and ambivalence measures.

Béna J, Lacassagne D, Corneille O · 2025 · Quarterly journal of experimental psychology (2006)

The contribution of uncontrolled processes to evaluative learning has been examined in evaluative conditioning procedures by comparing evaluations of conditioned stimuli between tasks or within tasks but between learning instruction…

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Negative / Null Result ReportOpen accessMedicine

Same Sentences, Different Grammars, Different Brain Responses?: An MEG Study on Case and Agreement Encoding in Hindi and Nepali Split-Ergative Structures.

Chacón DA, Shrestha S, Dillon BW et al. · 2026 · Neurobiology of language (Cambridge, Mass.)

At first glance, the brain's language network appears to be universal, but languages clearly differ. Does the brain adapt to the specific details of individual grammatical systems? Here, we present a magnetoencephalography (MEG) study on…

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Negative / Null Result ReportMedicine

Does sensitive skin lie in epidermal barrier impairment or abnormalities? Results from an observational study assessing biophysical parameters.

Borghi A, Guarneri F, Pacetti L et al. · 2024 · Italian journal of dermatology and venereology

Background The pathophysiology of sensitive skin is largely unknown and no univocal data on the role of the epidermal barrier impairment have been identified. The aim of this study was to assess whether subjects with or without sensitive…

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Negative / Null Result ReportOpen accessMedicine

An Exploratory Pilot Study to Investigate the Potential Relationship Between Porcine Reproductive and Respiratory Syndrome (PRRS) Virus Viremia Changes and Barn Manure Pit Management Procedures.

Melini CM, Kikuti M, Yue X et al. · 2026 · Pathogens (Basel, Switzerland)

Porcine reproductive and respiratory syndrome virus (PRRSV)-positive pigs can be exposed to high concentration of gases, such as ammonia and hydrogen sulfide when manure and urine stored in the pits beneath them is agitated and pumped.…

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Negative / Null Result ReportOpen accessMedicine

Parent emotion regulation difficulties statistically mediate the association between parental adverse childhood experiences and child emotion regulation.

Freeman SE, Staples AD, Loverich TM et al. · 2025 · Frontiers in global women's health

Introduction Emotion regulation (ER) abilities predict positive outcomes among children. While parenting behaviors that promote young children's ER development have been widely studied, less is known about how a parent's history of early…

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Negative / Null Result ReportOpen accessMedicine

Less Than Zero?

Hackländer RPM, Schlüter H, Rolke AK et al. · 2025 · Experimental psychology

Not all information encountered is equally important to remember. Some information may be valuable, while others may be irrelevant. Importantly, retrieving and acting upon some information may even have negative consequences. Research has…

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Negative / Null Result ReportMedicine

Internalizing symptoms, negative urgency, and coping motives: Potential pathways to alcohol consequences.

McDonald A, Corbin W · 2025 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

Objective Building upon prior research, the present study tested coping motives as a mediator of relations between both negative urgency and internalizing symptoms (depression, anxiety, and stress), and alcohol-related consequences using…

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Negative / Null Result ReportOpen access

No evidence that retinol is protective for skin cancer

Helder M, Pandeya N, Seviiri M et al. · 2024 · Preprint

ABSTRACT With over 1.5 million new cases annually, skin cancers are the most commonly diagnosed group of cancers worldwide. Among these, melanoma and keratinocyte cancers (KC), comprising squamous cell carcinoma (SCC) and basal cell…

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Abandoned HypothesisOpen accessMedicine

Finding Ramón: Navigating Failure and Luck in Mexico.

Jones GA · 2025 · Critical criminology

Failure is taboo. Yet as researchers we often encounter failure in the field and engage in confessional conversations with colleagues about 'what went wrong'. Failure is regarded as an unfortunate and unproductive part of research. Better…

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Negative / Null Result ReportOpen accessMedicine

Overconfidence, Time-on-Task, and Medical Errors: Is There a Relationship?

Al-Maghrabi M, Mamede S, Schmidt HG et al. · 2024 · Advances in medical education and practice

Background Literature suggest that physicians' high level of confidence has a negative impact on medical decisions, and this may lead to medical errors. Experimental research is lacking; however, this study investigated the effects of high…

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Negative / Null Result ReportMedicine

Relationship between facility type and bulk tank milk bacteriology, udder health, udder hygiene, and milk production on Vermont organic dairy farms.

Jeffrey CE, Andrews T, Godden SM et al. · 2024 · Journal of dairy science

The primary objective of this cross-sectional observational study was to determine whether bulk tank milk quality, udder health, udder hygiene, and milk production outcomes were associated with facility type on organic dairies. A secondary…

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Failed Experiment ReportOpen accessMedicine

Clinical efficacy of subsensory sacral neuromodulation in adults with faecal incontinence: The SUBSoNIC crossover randomised controlled trial and cohort follow-up study.

Vollebregt PF, Goh YL, Bagul A et al. · 2025 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Aim Sacral neuromodulation (SNM) is considered the first-line surgical treatment in adults with refractory faecal incontinence (FI). However, its clinical efficacy has not been rigorously tested in a trial setting. Method Randomised,…

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Negative / Null Result ReportOpen accessMedicine

Quick returns, sleep, sleepiness and stress - An intra-individual field study on objective sleep and diary data.

Öster K, Tucker P, Söderström M et al. · 2024 · Scandinavian journal of work, environment & health

Objectives Quick returns ( Methods Of 225 nurses and assistant nurses who wore actigraphy wristbands and kept a diary of work and sleep for seven days, a subsample of 90 individuals with one observation of both a quick return and a control…

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Negative / Null Result ReportMedicine

Serum heat shock protein concentrations are not associated with amyotrophic lateral sclerosis risk or survival in three European populations.

Rooney JPK, Geoghegan G, O'Reilly F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration

Introduction : Serum heat shock protein (HSP) concentrations have been reported as potential biomarkers for amyotrophic lateral sclerosis (ALS). Here, we investigate the role of serum HSP70, HSP90, and DNAJC7 as biomarkers for ALS. Methods…

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Negative / Null Result ReportMedicine

Social Determinants of Health and Health-Related Quality of Life Following Pediatric Septic Shock: Secondary Analysis of the Life After Pediatric Sepsis Evaluation Dataset, 2014-2017.

Lenz KB, McDade J, Petrozzi M et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives Social determinants of health (SDOH) are associated with disparities in disease severity and in-hospital outcomes among critically ill children. It is unknown whether SDOH are associated with later outcomes. We evaluated…

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Negative / Null Result ReportOpen accessMedicine

Stable White Matter Structure in the First Three Years After Psychosis Onset.

Van Dyken PC, Yang K, Faria AV et al. · 2025 · Biological psychiatry global open science

Background White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date…

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Replication FailureMedicine

Targeted Temperature Management After Pediatric Cardiac Arrest: A Quality Improvement Program With Multidisciplinary Implementation in the PICU.

McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…

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Failed Experiment ReportMedicine

[Study of a fetus with confined placental mosaicism for trisomy 2 in conjunct with fetal uniparental disomy and a literature review].

Liu C, Lyu Y, Jiang Y et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To carry out genetic analysis for a fetus with confined placental mosaicism (CPM) for trisomy 2 (T2) in conjunct with fetal uniparental disomy (UPD). Methods Amniocentesis and chromosomal karyotyping was carried out for a…

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