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Browse the failure-mode index

21,287 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Plasma Neurofilament Light Chain Is Associated with Cognitive Functions but Not Patient-Reported Outcomes in Multiple Sclerosis.

Nicolella V, Novarella F, Falco F et al. · 2025 · Neurology international

Objective We aimed to explore associations between plasma neurofilament light chain (pNfL) and cognition through patient-reported outcomes (PROs) in multiple sclerosis (MS). Methods In this cross-sectional study, we included 211 people…

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Negative / Null Result ReportOpen accessMedicine

Cryoanalgesia to treat phantom limb pain following a trans-femoral (above-knee) amputation: a randomized, sham-controlled pilot study.

Ilfeld BM, Finneran JJ, Abdullah B et al. · 2026 · Regional anesthesia and pain medicine

Background A previous clinical trial applied percutaneous cryoneurolysis to lower limb amputees with phantom pain. The primary outcome measure was negative, but a secondary analysis suggested that patients with a below-knee amputation…

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Negative / Null Result ReportMedicine

Face masks and protection against COVID-19 and other viral respiratory infections: Assessment of benefits and harms in children.

Sandlund J, Duriseti R, Ladhani SN et al. · 2025 · Paediatric respiratory reviews

Mask mandates for children were implemented at schools and childcare centers during the COVID-19 pandemic, and the US continues to recommend masking down to the age of two in certain settings. Medical interventions should be informed by…

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Negative / Null Result ReportOpen accessMedicine

Model-based planning is unaffected by ketamine, antidepressant and internet delivered cognitive behavioural therapy treatments in depression.

Donegan KR, Hossein S, Panny BM et al. · 2025 · Translational psychiatry

Cognitive impairments have been observed in patients with depression. These include deficits in inhibition, shifting, and updating; cognitive processes that are critical for goal-directed control over behavior ('model-based planning').…

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Negative / Null Result ReportOpen accessMedicine

No Impact of COVID-19 Pandemic on Early Mortality for Thyroid Cancer in the US. Comment on Lee et al. Impact of the COVID-19 Pandemic on Thyroid Cancer Surgery. <i>Curr. Oncol.</i> 2024, <i>31</i>, 3579-3590.

Nocini R, Lippi G, Mattiuzzi C · 2024 · Current oncology (Toronto, Ont.)

Thyroid cancer is relatively rare in the general population compared to other malignancies, but its incidence appears to have increased in recent decades [...].

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Negative / Null Result ReportOpen accessMedicine

Cognitive and physiological impacts of psychotherapy incorporating human-equine interactions during substance withdrawal: A scoping review.

Friend MM, Nicodemus MC, Cavinder CA et al. · 2025 · Journal of equine rehabilitation

The use of psychotherapy incorporating equine interaction (PIE) is becoming widely utilized for the treatment of a range of conditions; however, evidence supporting the efficacy of this treatment is highly variable, inconsistently defined,…

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Negative / Null Result ReportMedicine

Synthetic Versus Biologic Mesh for Complex Open Ventral Hernia Repair: 3-Year Follow-Up of a Pilot Randomized Controlled Trial.

Dhanani NH, Lyons NB, Lee KH et al. · 2025 · HCA healthcare journal of medicine

Background Biologic mesh is often used in complex hernia repair, but there has been limited clinical evidence to date to support this practice. The aim of this study was to compare clinical and patient-reported outcomes of biologic versus…

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Negative / Null Result ReportMedicine

Derailment in adolescence: Factor analytic structure and correlates.

Ratner K, Zhu G, Li Q et al. · 2024 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Derailment is the sense of being "off-course" in life. But what could this mean for adolescents, who are often establishing identity and self-direction for the first time? We examined the structure and correlates of the Derailment Scale…

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Negative / Null Result ReportMedicine

Early Sodium Bicarbonate Use in Pediatric In-Hospital Cardiac Arrest: A Single-Center, Retrospective Cohort Study, 2013-2023.

Duster NA, Grossestreuer AV, Sorcher JL et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To explore the association of intra-arrest sodium bicarbonate (SB) use with outcomes in pediatric in-hospital cardiac arrest (p-IHCA) when accounting for the timing of initial SB administration. We hypothesized that…

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Negative / Null Result ReportMedicine

Sudden Sensorineural Hearing Loss Before COVID-19, During COVID-19, and After Inactivated Vaccination: Experience From a Tertiary Referral Center in China.

Cao X, Yi H · 2024 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective The purpose of this study was to investigate the incidence rate and audiological characteristics of sudden sensorineural hearing loss (SSHL) before the COVID-19 pandemic, during the COVID-19 pandemic, and after inactivated…

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Negative / Null Result ReportOpen accessMedicine

Progestogen supplementation to prevent miscarriage: Evidence and controversies.

Saccone G, Berghella V, Gulersen M et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Progesterone plays a key role in the establishment and maintenance of pregnancy and its deficiency has been associated with early pregnancy loss. Progestogen supplementation has therefore been widely investigated as a preventive strategy…

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Negative / Null Result ReportMedicine

Semantic facilitation in blocked picture categorization: Some data and considerations regarding task selection.

Wöhner S, Luckow J, Brandt M et al. · 2024 · Journal of experimental psychology. Human perception and performance

Semantic context effects in picture naming and categorization tasks are central to the development and evaluation of current models of word production. When pictures are named in a semantically blocked context, response latencies are…

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