e-ISSN: Pending

Browse the failure-mode index

21,277 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Do Respiratory Viruses Cause Leaky Gut Syndrome?

Karataş ŞN, Çağan E, Demirören K et al. · 2025 · Turkish archives of pediatrics

Objective Increased intestinal permeability is associated with the development of allergic and autoinflammatory diseases. Zonulin is a key physiological regulator of tight junctions in the intestinal epithelium. Thymus-expressed chemokine…

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Replication FailureMedicine

Maternal hypertensive disorders of pregnancy and childhood neurodevelopmental disorders: A two-sample Mendelian randomization.

Zhang B, Shi H, Cai W et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective To investigate the association between maternal hypertensive disorders of pregnancy (HDP) and childhood neurodevelopmental disorders (NDD) by Mendelian randomization (MR). Methods A two-sample MR analysis was conducted to…

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Negative / Null Result ReportMedicine

Clinical utility of post-GnRH agonist trigger serum hormonal testing and effect on the incidence of empty follicle syndrome: a single-center retrospective cohort study.

Kloosterman R, Dinh T, Michaeli J · 2026 · Journal of assisted reproduction and genetics

Purpose The purpose of this study is to assess whether discontinuing routine serum hormone testing following gonadotropin-releasing hormone (GnRH) agonist trigger affects the incidence of empty follicle syndrome (EFS) and embryological…

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Negative / Null Result Report

Effect of insect exclusion screens on insect pests in high tunnels

Quesada CR, Batson C, Holaskova I et al. · 2025 · Preprint

Abstract High tunnels can use insect exclusion screens as a mechanical pest control method within integrated pest management (IPM) programs. The impact of insect screens was evaluated on several tomato pests in commercial high tunnels. The…

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Negative / Null Result ReportMedicine

Immune Checkpoint Inhibitors Did Not Exacerbate Autoimmune Rheumatic Disease Activity in Patients With Cancer.

Tsai PH, Hsieh CI, Kuo YC et al. · 2026 · Journal of the National Comprehensive Cancer Network : JNCCN

Background The safety of immune checkpoint inhibitors (ICIs) in patients with cancer and preexisting or acquired autoimmune rheumatic diseases (ARDs) remains unclear. This study aimed to evaluate the safety of ICIs in patients with cancer…

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Negative / Null Result ReportMedicine

Evaluation of a web-based self-monitoring application (MyRA) to empower people with rheumatoid arthritis in daily life.

Hochstenbach LMJ, Verbeek JGE, Brokken-Peters MBJ et al. · 2026 · Rheumatology (Oxford, England)

Objectives To evaluate MyRA, a web-based self-monitoring application for RA, on patient empowerment, usability and perceived usefulness. Methods MyRA was co-developed with patients and used at their own discretion during a 4-month…

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Negative / Null Result ReportMedicine

[Deep learning-based assessment of periodontal ligament area changes in maxillary central incisors under different orthodontic regimens using cone beam CT images].

Li RQ, Su S, Zhan LP et al. · 2026 · Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

Objective: To investigate the differences in the changes of periodontal ligament area (PDLA) and related clinical indicators before and after maxillary central incisor movement under different orthodontic treatment regimens. Methods: This…

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Negative / Null Result ReportMedicine

Using Social Media to Increase Participation in Universal Free School Meal Programs: An RCT With Parents of Elementary-Aged Children.

Grummon AH, Zeitlin AB, Lee CJY et al. · 2026 · American journal of preventive medicine

Introduction As of 2025, 9 states have adopted Universal Free School Meal programs. The success of these programs depends in part on high participation. This study tested whether a social media campaign promoting school meal participation…

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Failed Experiment ReportOpen accessMedicine

An Exploratory Retrospective Study on the Association of Radiotherapy with the Risk of Immune-Related Adverse Events in Esophageal and Esophagogastric Junction Cancer Patients Receiving Immunotherapy.

Hokamura N, Fukagawa T, Fukushima R et al. · 2025 · Cancers

Background Radiotherapy (RT) combined with immune checkpoint inhibitors (ICIs) has shown therapeutic benefits, and the potential for enhanced immune activation has raised concerns about increased immune-related adverse events (irAEs). The…

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Negative / Null Result ReportOpen accessMedicine

Multidisciplinary prospective study of standardized pelvic lymph-node dissection focusing on the dorsal obturator nerve region.

Sazuka T, Habu Y, Matsusaka K et al. · 2026 · International journal of clinical oncology

Background Pelvic lymph-node dissection is performed across multiple surgical specialties. However, inconsistent terminology and unclear anatomical boundaries hinder standardization. This study established a multidisciplinary team with a…

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Negative / Null Result ReportMedicine

Effects of two longevity interventions, calorie restriction and rapamycin treatment, on the kynurenine-aryl hydrocarbon receptor pathway in aging skeletal muscle.

Hamrick MW, Fulzele S, Isales CM et al. · 2025 · Biochimie

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is thought to play important roles in aging, oxidative stress, and cellular senescence. We have previously shown that the AhR agonist kynurenine (Kyn), a…

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