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Browse the failure-mode index

21,713 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Retrospective study on diagnostic yield and medical impact of diagnostic imaging in dogs with immune-mediated haemolytic anaemia in Belgium.

Vlassenbroek R, Peeters D, Matthewman L et al. · 2026 · The Journal of small animal practice

Objectives To assess the incidence of associative immune-mediated haemolytic anaemia in dogs diagnosed with immune-mediated haemolytic anaemia and to evaluate whether performing diagnostic imaging, specifically thoracic radiographs and…

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Negative / Null Result ReportMedicine

Stabilizing Segmental Le Fort I Osteotomy Using Clear Thermoplastic Retainers Versus Arch Bars With Occlusal Splints: A Retrospective Analysis.

Wu L, Xu X, Liu X et al. · 2026 · The Journal of craniofacial surgery

In patients receiving segmental Le Fort I osteotomy as part of a clear aligner treatment regimen, this study aimed to compare the clinical effectiveness of clear thermoplastic retainers as a postoperative stabilization technique and…

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Negative / Null Result ReportMedicine

Midterm Clinical and Echocardiographic Outcomes After Transcatheter Aortic Valve Replacement in Patients With Severe Bicuspid Aortic Valve Stenosis.

Nienaber S, Krabichler K, Fahlbusch D et al. · 2026 · Journal of the American Heart Association

Background Outcomes >2 years after transcatheter aortic valve replacement (TAVR) for bicuspid aortic valves (BAV) are scarce, and differences between balloon-expandable transcatheter heart valves (THVs) and self-expandable (SE-THVs) are…

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Negative / Null Result ReportMedicine

Increased Retinol Levels in Patients with Cardiac Surgery-Associated Acute Kidney Injury-A Prospective Single-Center Exploratory Study.

Olasińska-Wiśniewska A, Swora-Cwynar E, Urbanowicz T et al. · 2026 · Nutrients

Background Acute kidney injury (AKI) is a frequent and prognostically important complication of cardiac surgery, yet early risk stratification remains challenging. The purpose of this prospective exploratory study was to determine whether…

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Negative / Null Result ReportMedicine

Comparative Analysis of Clinically Meaningful Recovery Trajectories Following Unicompartmental Arthroplasty and Patello-Femoral Arthroplasty.

Singh R, Williams DL, Alexander J et al. · 2026 · The Journal of arthroplasty

Background Medial unicompartmental knee arthroplasty (UKA), lateral UKA, and patello-femoral arthroplasty (PFA) are established treatments for isolated compartmental knee osteoarthritis. Despite its growing popularity, the comparative…

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Negative / Null Result ReportMedicine

No serological association between Porphyromonas gingivalis or Prevotella intermedia and early spondyloarthritis: analysis from the DESIR cohort.

Zekre F, Neel T, Paul M et al. · 2026 · Clinical and experimental medicine

Porphyromonas gingivalis and Prevotella intermedia are key oral pathogens implicated in periodontal disease and have been associated with rheumatoid arthritis and specific categories of juvenile idiopathic arthritis. Whether oral dysbiosis…

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Methods Dead-EndMedicine

Prospective evaluation of the CASST score to guide elective tracheostomy following oral cancer surgery: challenges and clinical misalignment.

Gulamani A, Shamim F, Khan S et al. · 2026 · International journal of oral and maxillofacial surgery

The Clinical Assessment Scoring System for Tracheostomy (CASST) was developed to predict the need for elective tracheostomy in head and neck cancer surgery, but evidence on its external performance remains limited. This prospective study…

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Methods Dead-EndMedicine

Propensity Score-Matched Comparison of Patient-Reported Outcomes Between Crowe I Developmental Dysplasia of the Hip and Primary Osteoarthritis Following Total Hip Arthroplasty.

Saluja A, Eschert J, Ren R et al. · 2026 · The Journal of arthroplasty

Background Total hip arthroplasty (THA) is commonly performed for Crowe I developmental dysplasia of the hip (DDH) and primary osteoarthritis (OA), but comparative survivorship and patient-reported outcome measure (PROM) data remain…

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Negative / Null Result ReportOpen accessMedicine

Residential radon exposure and lung cancer histology and stage: a population-based ecological study in Central Germany.

Ernst P, Rachow T, Henn S et al. · 2026 · Journal of cancer research and clinical oncology

Purpose Residential radon exposure is recognised as one of the leading environmental risk factors for lung cancer and acts synergistically with tobacco smoking. Thuringia, Germany, exhibits high geogenic radon potential; however,…

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Negative / Null Result ReportMedicine

The impact of drains on postoperative seroma and infection after mastectomy: A retrospective study in Danish women with breast cancer.

Palshof FK, Korsholm RHR, Duriaud HM et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Postoperative drains are commonly used after mastectomy to reduce seroma formation, but evidence of the benefit remains unclear. We evaluated the effect of postoperative drains on seroma formation and infection after…

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Negative / Null Result ReportMedicine

Hematopoietic progenitor cells (HPCs) mobilization following high-intensity interval exercise in cancer patients undergoing bone marrow transplantation: preliminary results from a randomized controlled trial.

Zarekar T, Ahmadizad S, Hajifathali A et al. · 2026 · Stem cell research & therapy

Background and objective Hematopoietic progenitor cells (HPCs) mobilization is essential for successful bone marrow transplantation but may be impaired in cancer patients due to prior treatments. High-intensity interval exercise (HIIE) has…

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Negative / Null Result ReportMedicine

Amplicon sequencing reveals impact of imidacloprid residues on diversity profile of grape fructosphere microbiota.

Deore P, Upadhyay A, Thekkumpurath AS et al. · 2026 · World journal of microbiology & biotechnology

In grape, fructosphere microbiota play an important role in nutrient cycling, pathogen suppression, berry quality, and fermentation processes. Insecticide imidacloprid (IM) is used to manage several insect pests of grape. However, the…

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Negative / Null Result ReportMedicine

Clinical Outcome of EMG-Based Pelvic Floor Biofeedback in Patients With Constipation-Impact of Prior Anorectal Manometry/Balloon Expulsion Test for Patient Selection. A Retrospective Study.

Kochhar S, Channapragada T, Shenoy V et al. · 2026 · Neurogastroenterology and motility

Introduction Pelvic floor biofeedback therapy (BFT) is the mainstay treatment for dyssynergic defecation, a condition defined by the Rome criteria. This retrospective study compares outcomes between patients referred for EMG-based BFT…

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Negative / Null Result ReportMedicine

Comparison of Urodynamic Outcomes of Surgery Using the Photoselective Vaporization 180 W XPS System and Transurethral Resection of the Prostate: A Propensity Score-Matched Analysis in Real-World Clinical Practice.

Saito Y, Kyoda Y, Nofuji S et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Objectives No previous studies have directly compared pre- and postoperative pressure flow study (PFS) outcomes between transurethral resection of the prostate (TURP) and photoselective vaporization of the prostate using the GreenLight XPS…

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Negative / Null Result ReportMedicine

Rose danio (Danio roseus): A native Mekong basin alternative to zebrafish for acute, developmental, and neurobehavioral toxicity testing.

Seetapan K, Nobsathian S, Bullangpoti V et al. · 2026 · Environmental toxicology and chemistry

The fish embryo toxicity test is widely used as an alternative to conventional acute fish toxicity assays, but its ecological relevance may be limited when the model species is nonnative to the region of interest. Here, we evaluated rose…

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Negative / Null Result ReportMedicine

Advancements in Breast Lipofilling: A 12-Year Retrospective Comparative Analysis of Patient Satisfaction and Complication Rates across Fat Preparation Methods.

Loucas R, Loucas M, Müller R et al. · 2026 · Plastic and reconstructive surgery

Background Breast lipofilling is a commonly utilized method in plastic surgery for breast reconstruction and augmentation. However, the procedure is often limited by the unpredictable survival of fat grafts, leading to dissatisfied…

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