21,277 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Vermedal H, Hellings IR, Fretheim-Kelly ZL et al. · 2026 · Equine veterinary journal
Background Exercise-related upper respiratory tract (URT) disorders are frequently diagnosed in racehorses. Treatment recommendations are routinely based on subjective assessment of clinical evaluation and exercising endoscopy findings.…
View details →Okutan AE, Kehribar L, Gürün E et al. · 2026 · International orthopaedics
Purpose To evaluate 1-year clinical and functional outcomes, as well as donor-site morbidity based on quadriceps muscle morphology, after primary single-bundle ACLR using a quadrupled RF tendon autograft. Methods Patients who underwent…
View details →Jabba SV, Erythropel HC, Anastas PT et al. · 2026 · Tobacco prevention & cessation
Since late 2022, the sale of most flavored tobacco products has been prohibited in California, including menthol cigarettes. Tobacco companies responded by introducing 'non-menthol' cigarettes in which menthol was replaced with WS-3, an…
View details →Rehman MU · 2026 · Preprint
Abstract The X-ray repair cross-complementing protein 1 (XRCC1) is a central scaffold protein involved in DNA single-strand break repair (SSBR), coordinating the assembly of multi-protein repair complexes. Its activity is regulated by…
View details →Kaw R, Shekhar S, Mehra R et al. · 2026 · Chest
Background Heart failure (HF) is common in obesity hypoventilation syndrome (OHS). We explored the impact of HF on in-hospital outcomes of patients with or at risk of OHS who were treated with mechanical ventilation (MV), noninvasive…
View details →Jerabek S, Kim J, Sung J et al. · 2026 · Preprint
ABSTRACT Cas9-based tools enable the introduction of genetic lesions to investigate DNA repair outcomes and edit the genome at disease-relevant loci. DNA double-strand breaks (DSBs) induced by CRISPR/Cas9 result in frequent aneuploidy and…
View details →Berge T, Vuletić F, Bøe B · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose To compare clinical and radiological outcomes 1 year after Arthroscopic Latarjet procedure, using two different fixation techniques: screw or suture button fixation. Methods This retrospective comparative cohort study included 75…
View details →Graetz C, Löwe C, Übermuth S et al. · 2026 · International journal of dental hygiene
Objective Bristle splaying may be associated with reduced cleaning efficacy; however, the relationship between the bristle splaying index (BSI) and contact pressure (CP) during brushing with a powered toothbrush (PT) with real-time CP…
View details →Copps M, Solmi F, Viding E et al. · 2026 · Preprint
BackgroundIrritability is a distressing and disabling transdiagnostic symptom of emotion dysregulation. Despite some obvious links between irritability and eating behaviours this relationship is rarely studied.AimsWe examined longitudinal…
View details →Yamaguchi H, Arioka M · 2026 · Preprint
Abstract We previously reported that in the filamentous fungus Aspergillus oryzae entire nuclei were degraded by autophagy when cells are exposed to nutrient starvation. In this study we investigated the roles of vacuolar proteases in…
View details →Vrba J, Havlasek J, Dostalova K et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Cannabidiol (CBD) is known to activate aryl hydrocarbon receptor (AhR) and expression of cytochromes P450 (CYP) 1A. This study examined the effect of cannabigerol (CBG) on the AhR/CYP1A pathway in HepG2 cells, human hepatocytes, and normal…
View details →Negrila A, Radu RA, Terecoasa EO et al. · 2026 · Journal of neurointerventional surgery
Background Endovascular thrombectomy (EVT) is a time-sensitive treatment for acute ischemic stroke, and hub-and-spoke systems have expanded patient access to this intervention. However, overcrowding at comprehensive stroke centers (CSCs)…
View details →Kuznetsova DA, Kuznetsov DM, Lyubina AP et al. · 2026 · Biochimica et biophysica acta. Biomembranes
The design of effective non-viral nucleic acid delivery systems based on cationic amphiphilic compounds remains a major challenge in biomedical research. In this study, cationic benzimidazolium surfactants (BI-n) and cationic liposomes…
View details →Nakagawa A, Matsuoka Y, Seo M et al. · 2026 · Circulation journal : official journal of the Japanese Circulation Society
Background Patients with heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV)-pulmonary arterial (PA) uncoupling, as assessed by a decrease ratio of tricuspid annular plane systolic excursion (TAPSE) to PA…
View details →Hussain SK, Ayoub WS, Cruz-Correa M et al. · 2026 · Cancer prevention research (Philadelphia, Pa.)
Hepatocellular carcinoma (HCC) is a lethal cancer with rising burden. Few clinical trials have evaluated preventive strategies for HCC in high-risk patients with liver cirrhosis. Observational studies show statins are associated with…
View details →Kumar N, Prasad S, Srivastava MVP et al. · 2026 · The Journal of clinical psychiatry
Background: Negative symptoms remain among the most debilitating and treatment-resistant features of schizophrenia. Repetitive transcranial magnetic stimulation, particularly intermittent theta burst stimulation (iTBS), is emerging as a…
View details →Cowan C, Harmon EY, Melewski M et al. · 2026 · The American journal of occupational therapy : official publication of the American Occupational Therapy Association
Importance Understanding how upper extremity (UE) robotic therapy (RT) affects efficiency and effectiveness of inpatient rehabilitation is important to advancing poststroke treatment and recovery. Objective To determine whether UE RT…
View details →Abdelgaied MY, Abdelgawad O, Rashad MH et al. · 2026 · Journal of neuroimmunology
Background Neurodegeneration and inflammation can accelerate the demyelination process in multiple sclerosis (MS). We aimed to investigate the efficacy and tolerability of metformin as an add-on treatment to interferon Beta 1a (IFNβ-1a) in…
View details →Aust H, Kranke P, Torossian A et al. · 2026 · Cancers
Background Isolated Perfusion Chemotherapy (IPC) with balloon occlusion creates transient ischemic tissue compartments while patients remain exposed to significant perioperative heat loss. Active warming during these phases is commonly…
View details →Xia C, Yang R, Ou S et al. · 2026 · Preprint
Abstract Background Robotic-assisted unicompartmental knee arthroplasty (RA-UKA) improves component alignment; however, improved radiographic precision does not consistently translate into superior clinical outcomes. Nutritional status may…
View details →Mohar S, Crawford AM, Vásquez US et al. · 2026 · BMC medical education
Background Effective airway management is essential for patient safety across prehospital, perioperative, and critical care settings. Traditional training, largely based on lectures and brief skills stations, may be insufficient to develop…
View details →Jeppesen TD, Jedrzejczyk JH, Vingborg AL et al. · 2026 · Cardiovascular engineering and technology
Purpose Freeze-preservation of porcine aortic tissue is often necessary for experimental planning and standardization, but the impact of freezing on aortic root properties has not been systematically investigated. This study evaluated the…
View details →Kretzschmar HA, Abouabdillah A, Bouabid R et al. · 2026 · Potato Res..
The Fès-Meknès region in Morocco is characterized by a typical Mediterranean climate and the cultivation of water-demanding, locally well-established cash crops, such as potato (Solanum tuberosum L.). Therefore, this region is likely to…
View details →Luty M, Borah D, Szafrańska K et al. · 2026 · Preprint
Background and Aims Fenofibrate is widely prescribed for hyperlipidaemia and has been associated with rare but severe cases of drug-induced liver injury (DILI), yet its effects on liver sinusoidal endothelial cells (LSECs) remain to be…
View details →Takahashi K, Kawagoe J, Takehara I et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)
This study examined whether oral administration of individual short-chain fatty acids (SCFAs) alters Treg- and Th17-related immune parameters during the peri-implantation period in pregnant mice. Using a mouse model, the effects of SCFAs…
View details →Choi JY, Yu OJ, Yun JY et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
Purpose The role of deltoid ligament (DL) repair in supination-external rotation (SER)-type trimalleolar equivalent ankle fractures (TEAFs) remains controversial. Additionally, it remains unclear whether posterior malleolar fixation alone…
View details →Mathai SK, Callahan SJ, Chang H et al. · 2026 · Annals of the American Thoracic Society
Rationale The optimal treatment of interstitial lung disease resulting from COVID-19 is unknown. Objectives We sought to investigate the effect of nintedanib, an antifibrotic medication, on interstitial lung disease in participants who…
View details →Peanchitlertkajorn S, Makkasaman K, Neoh SP et al. · 2026 · Journal of the World federation of orthodontists
Background To evaluate the cytotoxicity of direct 3D-printed aligners fabricated from Tera Harz TC-85DAC resin (TC) compared with conventional thermoformed aligners, and to investigate the effect of different post curing durations on TC…
View details →Liu J, Nassrallah W, Quan-Nguyen C et al. · 2026 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
Objective The progression of glaucoma despite adequate intraocular pressure (IOP) control highlights the need for neuroprotective and neuroregenerative therapies. Preclinical studies suggest insulin promotes retinal ganglion cell survival…
View details →Brown JAR, Brewis HT, Kobor MS · 2026 · DNA repair
A range of genome maintenance factors respond to endogenous and exogenous DNA damage to prevent mutations and cell death. The scaffold protein, Rtt107, is important for the growth of cells exposed to DNA-damaging agents in the budding…
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