Negative / Null Result ReportOpen accessMedicine
Nilsson KH, Henning P, Lagerquist MK et al. · 2026 · Calcified tissue international
Osteoporosis is characterized by an imbalance in bone remodeling, resulting in bone loss and increased fracture risk. Inflammatory diseases, such as rheumatoid arthritis, are strongly associated with secondary osteoporosis due to…
View details →Negative / Null Result ReportOpen accessMedicine
Leal R, Fragoso P, Venda J et al. · 2025 · Renal failure
Background The optimal immunosuppressive (IS) withdrawal strategy after kidney allograft failure remains unclear. This study evaluated the effects of prolonged calcineurin inhibitor (CNI) therapy on HLA sensitization, graft intolerance…
View details →Negative / Null Result ReportMedicine
Krikelis M, Gazi S, Trovas G et al. · 2024 · Joint bone spine
Introduction Denosumab (Dmab) is widely used for the treatment of post-menopausal osteoporosis. Its discontinuation is sometimes accompanied by multiple vertebral fractures. Romosozumab (Rmab) has not been tested for its ability to prevent…
View details →Negative / Null Result ReportMedicine
Zhou AL, Ward RE · 2024 · Journal of dairy science
The focus of this work is the role milk polar lipids play in affecting gut permeability, systemic inflammation, and lipid metabolism during acute and chronic inflammation induced by a single subcutaneous injection of lipopolysaccharide.…
View details →Negative / Null Result ReportOpen accessMedicine
Karp Z, Czarny J, Adamczewska-Wawrzynowicz K et al. · 2026 · Children (Basel, Switzerland)
Background : Infantile hepatic hemangiomas (IHH) are common benign vascular tumors in infancy with diverse presentations. Methods : We report a 7-week-old infant presenting with hepatosplenomegaly, multiple skin and hepatic hemangiomas,…
View details →Negative / Null Result ReportOpen accessMedicine
Shunyakova J, Reynolds M, Taylor A et al. · 2025 · Frontiers in ophthalmology
Background Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache (ROSAH) syndrome is an autosomal dominant disorder caused by a heterozygous missense mutation in alpha kinase 1 (ALPK1). This series reports the…
View details →Negative / Null Result ReportMedicine
Frouin M, Cavalerie R, Piazza S et al. · 2024 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
A 2.5-year-old spayed female Chihuahua dog was presented with chronic cervical pain and exhibited a "prayer-like position" following a history of a 4-meter fall. CT and MRI revealed a moderate right-sided enlargement of the subdural space…
View details →Negative / Null Result ReportOpen accessMedicine
Le Corre E, Jousserand N, Maurey C et al. · 2026 · Journal of veterinary internal medicine
Background Subclinical bacteriuria (SBU) is frequently encountered in cats with chronic kidney disease (CKD), but it remains unclear if it is associated with survival and disease progression. Hypothesis/objectives To determine the…
View details →Negative / Null Result ReportOpen accessMedicine
Villanova S, Gatti M, Colosio M et al. · 2026 · Nutrients
Background: Astragali radix is a traditional herb known for its antioxidant, anti-inflammatory, and immunomodulatory properties and has gained attention for its potential to support post-exercise recovery. However, the effects of long-term…
View details →Negative / Null Result Report
Chitolina R, Reis CG, Stahlhofer-Buss T et al. · 2023 · Preprint
Epilepsy is a prevalent neurological disorder, affecting approximately 1 to 2% of the global population. The hallmark of epilepsy is the occurrence of epileptic seizures, which are characterized by predictable behavioral changes reflecting…
View details →Negative / Null Result ReportOpen accessMedicine
Hotz JF, Kaindl L, Krebs S et al. · 2026 · European journal of neurology
Introduction Hemiplegic migraine (HM) is a rare subtype of migraine with aura, characterized by transient, unilateral motor weakness. Due to its rarity, treatment strategies are lacking. Monoclonal antibodies targeting the calcitonin…
View details →Negative / Null Result ReportMedicine
Haddad S, Jacobs E, Núñez-Pereira S et al. · 2025 · Spine
Study design Retrospective analysis of a prospective multicenter adult spinal deformity (ASD) registry. Objective Assess whether spinal alignment deteriorates postsurgery in the absence of mechanical complications and evaluate the…
View details →Negative / Null Result ReportOpen accessMedicine
Wagstaff KM, Stein MS, Herschtal A et al. · 2025 · Pharmaceutics
Background: The efficacy of a single oral dose of Ivermectin as prophylaxis for SARS-CoV-2 is uncertain. This trial sought to evaluate the effectiveness of a single oral low dose of Ivermectin to prevent SARS-CoV-2 infection or reduce…
View details →Negative / Null Result ReportMedicine
Çevik N, Hazar Bodrumlu E · 2024 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
Objective Colour stability is important in the long-term aesthetic success of restorative materials and is affected by both internal and external factors. Internal discolourations are due to the properties of the restorative materials.…
View details →Negative / Null Result ReportMedicine
Taguchi K, Chuang VTG, Ozawa M et al. · 2024 · Die Pharmazie
Urticaria is induced by the histamine released from mast cells which develops wheals (edema) as a visual feature. In clinical practice, second-generation histamine H 1 -receptor blockers are routinely used as the first-line symptomatic…
View details →Failed Experiment Report
Medina E, Sanchez-Sandoval AL, Barrón-Palma EV et al. · 2024 · Preprint
Background Coronavirus disease 2019 (COVID-19) has created the need to evaluate drugs such as favipiravir (FPV), an antiviral inhibitor of RNA-dependent RNA-polymerase (RdRp), and Maraviroc (MVC), an antiretroviral that antagonizes the…
View details →Negative / Null Result ReportMedicine
Martins J, Eliseu A, Campos S et al. · 2024 · Animals : an open access journal from MDPI
The ovariectomy (OVE) procedure can trigger somatosensory and visceral peritoneal nociception. Sacrococcygeal epidural (ScE) anesthesia may complement or replace systemic analgesia used for feline OVE, reducing opioid consumption and their…
View details →Negative / Null Result ReportOpen accessMedicine
Wu H, Jin J, Zhou D et al. · 2025 · BMC anesthesiology
Background Liposomal bupivacaine (LB) provides prolonged analgesia, but it remains unclear whether it prevents rebound pain or merely delays its onset. This study investigated the effect of LB on rebound pain in a mouse model of peripheral…
View details →Replication FailureOpen accessMedicine
Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2025 · BMC cancer
Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
View details →Negative / Null Result ReportMedicine
Pintus E, Scaringi M, Engelen J et al. · 2026 · Theriogenology
Impaired seminal redox balance is a main factor that contributes to male fertility disorders and reduced sperm survival during storage. Although several methods are available to measure antioxidant and reactive oxygen species (ROS) levels,…
View details →Negative / Null Result ReportMedicine
de Lazzari E, Nomah DK, Blanco JL et al. · 2024 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives The prevalence and risk factors of SARS-CoV-2 infection among unvaccinated people living with HIV (PWH) are not well understood, and the protective role of tenofovir remains controversial. This study aimed to assess the…
View details →Negative / Null Result ReportOpen accessMedicine
Gabaldon-Albero A, Martin-Grau C, Marti-Masanet M et al. · 2024 · Pediatric rheumatology online journal
Background Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage. Approximately 7% of Aicardi-Goutières Syndrome cases are caused by pathogenic…
View details →Negative / Null Result ReportOpen accessMedicine
Tang F, Zhang L, Lu S et al. · 2026 · Cancer reports (Hoboken, N.J.)
Background Hyperbaric oxygen therapy (HBOT) is widely used as a therapeutic intervention for various types of wounds. Studies have shown that in addition to improving local oxygen supply to the wound site, HBOT can also influence cytokine…
View details →Negative / Null Result Report
Eghbali A, Ghaffari K, Eghbali A et al. · 2024 · Preprint
Background: Magnesium oxide is proposed to be effective in prevention of nephrotoxic impact of carboplatin therapy. The aim was to evaluate the magnesium oxide supplementation effect on serum creatinine, blood urea nitrogen (BUN) and…
View details →Negative / Null Result ReportOpen accessMedicine
Gao J, Mathias RT, Varadaraj K et al. · 2025 · Investigative ophthalmology & visual science
Purpose The lens has a feedback control system made by transient receptor potential vanilloid 4 (TRPV4) and TRPV1 to sense pressure and activate ion transport to maintain intracellular hydrostatic pressure close to zero at the lens…
View details →Negative / Null Result ReportMedicine
Cropper E, Riley P, Simon AG · 2024 · Journal of forensic sciences
There are many factors that may affect the longevity of or guide the use of canine training aids. Literature to date has mainly focused on identifying the headspace volatiles associated with training aids or odors and only minimal research…
View details →Negative / Null Result ReportOpen accessMedicine
Carr JF, Basurto De Santiago C, Bhut SA et al. · 2026 · mBio
In gram-negative bacteria, the outer membrane (OM) acts in conjunction with the peptidoglycan (PG) cell wall as a barrier against physical, osmotic, and chemical environmental stressors, including antibiotics. SanA, an inner membrane…
View details →Negative / Null Result ReportMedicine
Bastia L, Garberi R, Querci L et al. · 2024 · Journal of clinical monitoring and computing
To determine how percutaneous tracheostomy (PT) impacts on respiratory system compliance (C rs ) and end-expiratory lung volume (EELV) during volume control ventilation and to test whether a recruitment maneuver (RM) at the end of PT may…
View details →Negative / Null Result ReportOpen accessMedicine
Nemets VV, Grinevich VP, Petrunina EN et al. · 2025 · Cells
Recent studies indicated a connection between trace amine-associated receptor 5 (TAAR5) and emotional behaviors related to anxiety and depression; however, the neurobiological basis of this link is still unclear. Using mutant TAAR5…
View details →Negative / Null Result ReportMedicine
Yurttutan S, Geçkil E · 2026 · Journal of pediatric nursing
Aim This study aimed to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on depression, anxiety, stress, and hopelessness among parents of children with autism (Autism Spectrum Disorder [ASD]). Method A…
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