e-ISSN: Pending

Browse the failure-mode index

21,277 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Dietary milk polar lipids modulate gut barrier integrity and lipid metabolism in C57BL/6J mice during systemic inflammation induced by Escherichia coli lipopolysaccharide.

Zhou AL, Ward RE · 2024 · Journal of dairy science

The focus of this work is the role milk polar lipids play in affecting gut permeability, systemic inflammation, and lipid metabolism during acute and chronic inflammation induced by a single subcutaneous injection of lipopolysaccharide.…

View details →
Negative / Null Result ReportOpen accessMedicine

Pulmonary Aspergillosis in an Infant with Multiple Hepatic Hemangiomas.

Karp Z, Czarny J, Adamczewska-Wawrzynowicz K et al. · 2026 · Children (Basel, Switzerland)

Background : Infantile hepatic hemangiomas (IHH) are common benign vascular tumors in infancy with diverse presentations. Methods : We report a 7-week-old infant presenting with hepatosplenomegaly, multiple skin and hepatic hemangiomas,…

View details →
Negative / Null Result ReportMedicine

Presumed post-traumatic subdural hygroma in a 2.5-year-old spayed female Chihuahua.

Frouin M, Cavalerie R, Piazza S et al. · 2024 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

A 2.5-year-old spayed female Chihuahua dog was presented with chronic cervical pain and exhibited a "prayer-like position" following a history of a 4-meter fall. CT and MRI revealed a moderate right-sided enlargement of the subdural space…

View details →
Negative / Null Result ReportOpen accessMedicine

Clinical outcomes and association with disease progression and survival of subclinical bacteriuria in cats with chronic kidney disease: a multicenter retrospective study.

Le Corre E, Jousserand N, Maurey C et al. · 2026 · Journal of veterinary internal medicine

Background Subclinical bacteriuria (SBU) is frequently encountered in cats with chronic kidney disease (CKD), but it remains unclear if it is associated with survival and disease progression. Hypothesis/objectives To determine the…

View details →
Negative / Null Result ReportOpen accessMedicine

<i>Astragalus membranaceus</i> Modulates Inflammatory Markers Without Enhancing Muscle Function Following Intensified Resistance Training.

Villanova S, Gatti M, Colosio M et al. · 2026 · Nutrients

Background: Astragali radix is a traditional herb known for its antioxidant, anti-inflammatory, and immunomodulatory properties and has gained attention for its potential to support post-exercise recovery. However, the effects of long-term…

View details →
Negative / Null Result ReportOpen accessMedicine

A Pilot, Randomised, Placebo-Controlled, Double-Blind Trial of a Single Oral Dose of Ivermectin for Post-Exposure Prophylaxis of SARS-CoV-2.

Wagstaff KM, Stein MS, Herschtal A et al. · 2025 · Pharmaceutics

Background: The efficacy of a single oral dose of Ivermectin as prophylaxis for SARS-CoV-2 is uncertain. This trial sought to evaluate the effectiveness of a single oral low dose of Ivermectin to prevent SARS-CoV-2 infection or reduce…

View details →
Negative / Null Result ReportMedicine

The effect of fluoride varnish application on colour change due to paediatric drug usage in polyacid-modified composite resin: an in vitro study.

Çevik N, Hazar Bodrumlu E · 2024 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Objective Colour stability is important in the long-term aesthetic success of restorative materials and is affected by both internal and external factors. Internal discolourations are due to the properties of the restorative materials.…

View details →
Failed Experiment Report

Effect of Maraviroc and/or Favipiravir plus systemic steroids versus systemic steroids only on the viral load of adults with severe COVID-19: clinical trial

Medina E, Sanchez-Sandoval AL, Barrón-Palma EV et al. · 2024 · Preprint

Background Coronavirus disease 2019 (COVID-19) has created the need to evaluate drugs such as favipiravir (FPV), an antiviral inhibitor of RNA-dependent RNA-polymerase (RdRp), and Maraviroc (MVC), an antiretroviral that antagonizes the…

View details →
Negative / Null Result ReportMedicine

Can a Sacrococcygeal Epidural of 0.25% Bupivacaine Prevent the Activation of the Sympathetic Nervous System during Feline Ovariectomy?

Martins J, Eliseu A, Campos S et al. · 2024 · Animals : an open access journal from MDPI

The ovariectomy (OVE) procedure can trigger somatosensory and visceral peritoneal nociception. Sacrococcygeal epidural (ScE) anesthesia may complement or replace systemic analgesia used for feline OVE, reducing opioid consumption and their…

View details →
Negative / Null Result ReportMedicine

Prevalence, risk factors and the impact of tenofovir treatment in SARS-CoV-2 infection and COVID-19 disease among people living with HIV: A cross-sectional population-based study.

de Lazzari E, Nomah DK, Blanco JL et al. · 2024 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives The prevalence and risk factors of SARS-CoV-2 infection among unvaccinated people living with HIV (PWH) are not well understood, and the protective role of tenofovir remains controversial. This study aimed to assess the…

View details →
Negative / Null Result ReportOpen accessMedicine

Aicardi-Goutières syndrome type 6: report of ADAR variant and clinical outcome after ruxolitinib treatment in the neonatal period.

Gabaldon-Albero A, Martin-Grau C, Marti-Masanet M et al. · 2024 · Pediatric rheumatology online journal

Background Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage. Approximately 7% of Aicardi-Goutières Syndrome cases are caused by pathogenic…

View details →
Negative / Null Result Report

Magnesium supplementation may not be protective against carboplatin induced nephrotoxicity but may be beneficial for children suffering malignancies : a Randomized Clinical Trial

Eghbali A, Ghaffari K, Eghbali A et al. · 2024 · Preprint

Background: Magnesium oxide is proposed to be effective in prevention of nephrotoxic impact of carboplatin therapy. The aim was to evaluate the magnesium oxide supplementation effect on serum creatinine, blood urea nitrogen (BUN) and…

View details →
Negative / Null Result ReportMedicine

Towards maintaining canine training aid integrity: Effects of environmental factors and operational use on the triacetone triperoxide polymer odor capture-and-release system.

Cropper E, Riley P, Simon AG · 2024 · Journal of forensic sciences

There are many factors that may affect the longevity of or guide the use of canine training aids. Literature to date has mainly focused on identifying the headspace volatiles associated with training aids or odors and only minimal research…

View details →
Negative / Null Result ReportOpen accessMedicine

Impaired envelope integrity in the absence of SanA is linked to increased lipid II availability and an imbalance of septal peptidoglycan synthesis.

Carr JF, Basurto De Santiago C, Bhut SA et al. · 2026 · mBio

In gram-negative bacteria, the outer membrane (OM) acts in conjunction with the peptidoglycan (PG) cell wall as a barrier against physical, osmotic, and chemical environmental stressors, including antibiotics. SanA, an inner membrane…

View details →
Negative / Null Result ReportMedicine

Dynamic inflation prevents and standardized lung recruitment reverts volume loss associated with percutaneous tracheostomy during volume control ventilation: results from a Neuro-ICU population.

Bastia L, Garberi R, Querci L et al. · 2024 · Journal of clinical monitoring and computing

To determine how percutaneous tracheostomy (PT) impacts on respiratory system compliance (C rs ) and end-expiratory lung volume (EELV) during volume control ventilation and to test whether a recruitment maneuver (RM) at the end of PT may…

View details →
Negative / Null Result ReportMedicine

Effects of mindfulness-based stress reduction on levels of depression, anxiety, stress, and hopelessness in parents of children with autism: A randomized controlled trial.

Yurttutan S, Geçkil E · 2026 · Journal of pediatric nursing

Aim This study aimed to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on depression, anxiety, stress, and hopelessness among parents of children with autism (Autism Spectrum Disorder [ASD]). Method A…

View details →