Negative / Null Result ReportMedicine
Ptáček, Musil, Guarnieri et al. · 2026 · International journal of molecular sciences
Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disorder; to date, there is no long-term effective treatment. Recently, a relationship has been discovered between the human intestinal microbiome and the pathogenesis of…
View details →Negative / Null Result ReportMedicine
Deng, Xiang, Li et al. · 2026 · Animals : an open access journal from MDPI
Due to the lack of corn and soybean meal in animal feeding, rice bran meal (RBM) has been proposed as a beneficial substitute for these feedstocks' ingredients. Its fermentation by using diverse microbes has been adopted as a beneficial…
View details →Negative / Null Result ReportMedicine
Hazell, Khazova, O'Mahoney · 2026 · Antioxidants (Basel, Switzerland)
Conflicting evidence exists on whether blue or red light modulates nitric oxide (NO) release within skin cells. Using environmentally relevant doses, irradiances and spectral distribution akin to low-level sunlight, we provide evidence…
View details →Negative / Null Result ReportMedicine
Tas, Erturk · 2026 · Indian journal of surgical oncology
Due to controversial results, the clinical impact of sex in pancreatic cancer has not been fully clarified. We aimed to investigate the clinical significance of sex in patients with pancreatic cancer in this study. A total of 334…
View details →Negative / Null Result ReportMedicine
Elgayar · 2026 · Scientific reports
This trial aimed to explore the effect of supervised breathing exercises (BEs) on depression, sexual function, and exercise capacity in postmenopausal women. Sixty-four depressed postmenopausal women with associated sexual dysfunction were…
View details →Failed Experiment ReportMedicine
Chen, Liu, Xue et al. · 2026 · Molecular pain
The insular cortex (IC), a critical hub for nociception, emotion, and cognition processing, has emerged as a key role in the descending modulation of spinal cord excitability. Although previous studies have suggested that IC may influence…
View details →Short NoteMedicine
Balducci, Haxhi, Vitale et al. · 2026 · Acta diabetologica
To assess the effect of a 1-year supervised exercise training program on long-term mortality in people with type 2 diabetes. This is a post hoc analysis of the Italian Diabetes and Exercise Study randomized clinical trial, which enrolled…
View details →Methods Dead-EndMedicine
Zhang, Song, Ji et al. · 2026 · Ecotoxicology and environmental safety
The rise in electronic waste from the electronics industry has increased environmental and health risks. Pollutants like tris(2-chloroethyl) phosphate (TCEP) and lead (Pb) are particularly concerning for their harmful effects on…
View details →Negative / Null Result ReportMedicine
Rezaeinejad, Sepidarkish, Moini et al. · 2026 · Pregnancy hypertension
While cigarette smoking has been paradoxically associated with a reduced risk of preeclampsia, the effect of waterpipe (WP) smoking, an increasingly prevalent form of tobacco use remains poorly understood. This study aimed to investigate…
View details →Negative / Null Result ReportMedicine
Ehne, Kastensson, Wedin et al. · 2026 · Journal of bone oncology
The use of postoperative radiotherapy (PORT) as an adjunct to orthopaedic surgery of the long bones is widely recommended. Evidence of the benefits is however sparse. The primary research question of this study was whether PORT reduces the…
View details →Negative / Null Result ReportMedicine
Karunayawong, Sukmanee, Butchon et al. · 2026 · BMJ open
Since 1985, the international healthcare community has recommended the ideal rate of caesarean section (CS) to be 10%-15% at the national level. The literature has reported that overused CS without necessary medical indications can be…
View details →Abandoned HypothesisMedicine
Li, Hou, Li et al. · 2026 · Chemistry & biodiversity
Two new pyrrole alkaloids, asiaticain A (1) and asiaticain B (2), two aromatic compounds 3-4, and one steroid 5 were isolated from Lanmaoa asiatica. The structural elucidation of the isolated compounds was determined by using NMR, MS, IR,…
View details →Negative / Null Result ReportMedicine
Rodrigues, Macedo, de Paulo et al. · 2026 · Oral surgery, oral medicine, oral pathology and oral radiology
To evaluate the effects of sticky bone a biomaterial composed of Solid-PRF (S-PRF), a variant of platelet-rich fibrin (PRF), and deproteinized bovine bone-on bone formation after tooth extraction performed prior to radiotherapy, with…
View details →Negative / Null Result ReportMedicine
Olivieri, Amatori, Battocchio et al. · 2026 · Nanomaterials (Basel, Switzerland)
Gold nanorods (AuNRs) were synthesized and optimized with the aim of obtaining strongly hydrophilic nanomaterials, suitable as a drug delivery system (DDS) for copper-based drugs. After careful purification, AuNRs were characterized by…
View details →Methods Dead-EndMedicine
Vrinzen, Stadhouders, Bloemendal et al. · 2026 · BMJ open
Concentration of care and collaborations between hospitals increasingly reorganise oncological care into Comprehensive Cancer Networks (CCNs), aiming to improve care outcomes and reduce costs. This study aims to evaluate the effect of four…
View details →Short NoteMedicine
Pellerito, Dowling, Luke et al. · 2026 · Thrombosis research
Post thrombotic syndrome is a fibrotic disease related to inflammation resolution. There are no direct therapies that can ameliorate this disease. Monocyte/macrophages (Mo/MØ) are the primary leukocyte involved with later venous…
View details →Negative / Null Result ReportMedicine
Bregen, de Buhr, Strutzberg-Minder et al. · 2026 · Veterinary sciences
The reasons for disease outbreaks caused by Actinobacillus pleuropneumoniae (APP) in vaccinated pigs are often unknown and remain a challenge for farmers and veterinarians. One hypothesis for APP vaccine failure is the timing of APP…
View details →Negative / Null Result ReportMedicine
Wang, Ouyang, Chen et al. · 2026 · Scientific reports
This study aims to explore the impact of wearing Defocus Incorporated Multiple Segments (DIMS) spectacle lenses on astigmatism in myopic children. This study included 396 myopic children and divided the participants into two groups:the…
View details →Negative / Null Result ReportMedicine
Ma, Qiu, Liu · 2025 · Frontiers in nutrition
Acute-on-chronic liver failure (ACLF) patients face high risks of nutritional risk and clinical complications, but whether adjuvant nutritional support reduces adverse complications remains unclear. This study included 6,097 hospitalized…
View details →Negative / Null Result ReportMedicine
Kır · 2026 · PeerJ
This research compares the yield and quality of barley ( Hordeum vulgare ), rye ( Secale cereale ), triticale (× Triticosecale Wittmack ), and wheat ( Triticum aestivum ) grown in dry conditions in winter and widely used in producing…
View details →Negative / Null Result ReportMedicine
Cheng, Wang, Liu et al. · 2026 · PloS one
There has been ongoing debate over whether people are intuitively honest or intuitively dishonest. A recent social harm account was proposed to address this debate: dishonesty is intuitive when cheating inflicts harm on an abstract other…
View details →Negative / Null Result ReportMedicine
Li, Wang, Shen et al. · 2026 · International journal of cancer
Gastric carcinoma (GC) with neuroendocrine differentiation (GCNED) is a rare and particular pathological subtype. The survival outcomes and prognosis of patients with GCNED are currently unclear. We conducted a retrospective cohort study…
View details →Negative / Null Result ReportMedicine
Pires Marafon, Reuter, Isola et al. · 2026 · Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
The legal shelf life of platelet concentrates (PCs) has been extended from 5 to 7 days in France since 2018. Our study aimed to determine whether this increase in PC storage time has produced a significant impact on…
View details →Negative / Null Result ReportMedicine
Akkaya, Kosar · 2026 · Journal of endodontics
To investigate the influence of different types of intracanal medicaments and root canal sealers on root dentine fracture resistance at different time intervals. A total of 180 single-rooted human mandibular premolars were used. Samples…
View details →Negative / Null Result ReportMedicine
Liu, Zhang, Yuan et al. · 2026 · Chemical science
Hexafluoropropylene oxide-dimer acid (HFPO-DA) is widely used in food packaging bags, surfactants, lubricants, etc. As a new substitute for the persistent organic pollutant perfluorooctanoic acid (PFOA), it has been proven to have…
View details →Negative / Null Result ReportOpen accessOcean engineering
Jiaxing Xin, Ying Cui, Jun Yang et al. · 2025 · IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The intensification of the urban heat island (UHI) effect poses a serious threat to public health, particularly in cities. Effectively mitigating UHI has been a focus of national and international academic research over the last decades. However, most contemporary research has focused on land use mitigation measures within urban areas, with less emphasis on suburban land use. To address this research gap and explore spatial characteristics, we analyzed the driving mechanism of suburban land use patterns on UHI intensity (UHII) within the main urban area of Shenyang City based on high spatial r
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Bilan Yang, Xiaoli Xi, Hongsheng Yu et al. · 2024 · Cancer Reports
Abstract Background The optimal treatment strategy for early‐stage hepatocellular carcinoma (HCC) remains controversial, specifically in regard to surgical resection (SR) and ablation. The aim of this study was to investigate the impact of SR and ablation on recurrence and prognosis in early‐stage HCC patients, to optimize treatment strategies and improve long‐term survival. Methods A retrospective analysis was conducted on 801 patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) stage 0/A HCC and treated with SR or ablation between January 2015 and December 2019. The effectiveness and
View details →Negative / Null Result ReportOpen accessMedicine
Wade J. Chalker, Anthony J. Shield, David A. Opar et al. · 2018 · PeerJ
Background Hamstring strain injuries (HSI) are one of the most prevalent and serious injuries affecting athletes, particularly those in team ball sports or track and field. Recent evidence demonstrates that eccentric knee flexor weakness and between limb asymmetries are possible risk factors for HSIs. While eccentric hamstring resistance training, e.g. the Nordic hamstring exercise (NHE) significantly increases eccentric hamstring strength and reduces HSI risk, little research has examined whether between limb asymmetries can be reduced with training. As augmented feedback (AF) can produce sig
View details →Negative / Null Result ReportOpen accessMedicine (General)
Wei-Kai Chuang, Skye Hung-Chun Cheng, Chen-Fang Hung et al. · 2022 · Journal of the Formosan Medical Association
Background/purpose: This study aimed to analyze the long-term outcomes of hypofractionated whole-breast irradiation (WBI) (HF-WBI) compared with those of conventionally fractionated WBI (CF-WBI) for early breast cancer treated with breast-conservation surgery (BCS) and adjuvant WBI in Taiwan. Methods: This study included patients treated at our institution between 2012 and 2016. All patients with early breast cancer received BCS (pT1–2, pN0, M0) and adjuvant WBI through one of two treatment schemes. Propensity score matching analysis was conducted to create comparable cohorts. The major result
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Hao WANG, Zhitao GU, Jianyong DING et al. · 2016 · Chinese Journal of Lung Cancer
Background and objective Video-assisted thoracoscopic surgery (VATS) theoretically offers advantages over open thymectomy for clinically early-stage (Masaoka-Koga stage I and II) thymic malignancies. However, longterm outcomes have not been well studied. We compared the postoperative outcomes and survival from a cohort study based on the database of the Chinese Alliance for Research in Thymomas (ChART). Methods Between 1994 and 2012, data of 1,117 patients having surgery for clinically early-stage (Masaoka-Koga stage I and II) tumors were enrolled for the study. Among them, 241 cases underwent
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