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Browse the failure-mode index

21,277 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of choice of instruction language on anatomy learning outcomes.

Alghamdi MA, Almasaad JM, Ahmed ME et al. · 2026 · Anatomical sciences education

The choice of instructional language in medical education continues to be debated across non-English-speaking nations. In Saudi Arabia, medical schools use English as the medium of instruction, which may challenge students who previously…

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Negative / Null Result ReportMedicine

A vest-based sling provides greater hip flexion and abduction than a traditional Ehmer sling, with limited tolerability in healthy dogs.

Huber AL, Picavet PP, Hamon M et al. · 2026 · American journal of veterinary research

Objective To measure hip flexion, abduction, and internal rotation in a static standing position with the limb maintained with a traditional Ehmer sling (TES), compare these with a commercially available vest-based sling (VBS), and…

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Negative / Null Result ReportMedicine

Effect of acupuncture on postoperative nausea and vomiting in lumbar disc herniation surgery.

Erdem G, Kavak Akelma F, Nalbant B et al. · 2026 · Acupuncture in medicine : journal of the British Medical Acupuncture Society

Objective Nausea, vomiting and pain are common postoperative complications. The aim of this study was to evaluate the effects of ondansetron combined with acupuncture at bilateral PC6 during the intraoperative period on the incidence of…

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Replication FailureMedicine

Is Combined Tranexamic Acid Administration Superior to Single-Route Protocols in Primary Total Knee Arthroplasty? A Prospective Cohort Study.

Stepanovic Z, Ristic B, Matic A et al. · 2026 · Journal of clinical medicine

Background : The optimal route of tranexamic acid (TXA) administration remains one of the most debated topics in total knee arthroplasty. This study aimed to compare the effects of intravenous (IV), intra-articular (IA), and combined TXA…

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Negative / Null Result ReportMedicine

Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial.

Østergaard AM, Rosenbæk JB, Ejlersen JA et al. · 2026 · Physiological reports

Inorganic nitrate may lower blood pressure (BP) and enhance natriuresis through nitric oxide (NO) mediated mechanisms. Studies have found inconsistent effects of NO on sodium excretion. Nitric oxide synthase (NOS) inhibition suggests…

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Negative / Null Result ReportMedicine

Assessing the impact of an integrated health-system specialty pharmacy model on clinical disease activity index scores in patients with rheumatoid arthritis.

Phan T, Datt P, Zhao L et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune joint disorder necessitating the use of complex, specialty medications. Health-system specialty pharmacies (HSSPs) operate under closed-loop models that have been shown to minimize…

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Negative / Null Result ReportMedicine

Acute Effects of Taurine Supplementation on Energy Metabolism and Aerobic Capacity in Physically Active Young Adults.

Júnior FC, Santos WRD, Cordeiro Feitosa R et al. · 2026 · Research quarterly for exercise and sport

Taurine (TAU) is a conditionally essential amino acid whose consumption has recently increased, particularly among young people, through supplements and energy drinks. It has potential beneficial effects on physical performance; however,…

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Negative / Null Result ReportMedicine

Effect of horizontal and extended platelet-rich fibrin on soft tissue healing and outcomes after impacted mandibular third molar extraction: a controlled trial.

Haskic A, Hadziabdic N, Miron RJ · 2026 · International journal of oral and maxillofacial surgery

Postoperative sequelae such as pain, swelling, and trismus are common following mandibular third molar surgery. This single-blind controlled trial was performed to evaluate the effects of two newer platelet-rich fibrin (PRF) formulations,…

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Negative / Null Result ReportMedicine

Ensuring continuous buprenorphine access: A multi-component quality improvement initiative in a university-affiliated clinic and outpatient pharmacy.

Choo LY, Zheng W, Wen S et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Patients with opioid use disorder encounter challenges obtaining buprenorphine (BUP) at pharmacies, increasing their risk of treatment non-adherence and illicit drug use. Objectives The purpose of this quality improvement (QI)…

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Negative / Null Result ReportMedicine

Stage-specific disruption of host resistance and metabolic pathways following developmental PFAS exposure in marine medaka.

DiBona ER, Elliott J, Labeille RO et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)

Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with immunotoxic potential, yet impacts on immune development remain poorly defined. We examined effects of developmental PFAS exposure on host resistance and…

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Negative / Null Result ReportMedicine

Superinfection risk in critically ill patients with severe COVID-19: a retrospective analysis of pulse steroid therapy with and without tocilizumab.

Gok A, Kavakli AS, Sugur T et al. · 2026 · Expert review of anti-infective therapy

Background This study aimed to assess culture positivity rates and the microbiological profile of intensive care unit (ICU)-acquired superinfections in patients with severe COVID-19 pneumonia treated with pulse-dose methylprednisolone,…

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Negative / Null Result ReportMedicine

Does the methane-mitigating feed additive 3-nitrooxypropanol affect additive genetic variance and ranking of methane and yield traits in Holstein dairy cows?

Stephansen RB, Lassen J, Lund MS et al. · 2026 · Journal of dairy science

This study aimed to quantify the effect of the methane-mitigating feed additive 3-NOP on genetic parameters and potential genotype-by-environment (G × E) interaction for gas emission traits, i.e., methane (CH 4 ) and, carbon dioxide (CO 2…

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Negative / Null Result ReportMedicine

Effect of polymerization mode on dentin bond strength of universal adhesives: influence of aging and application strategy.

Yazici Akbiyik S, Yikici Col C, Bakir E · 2026 · Quintessence international (Berlin, Germany : 1985)

Objectives This study evaluated the effect of polymerization mode on dentin bond strength of universal adhesives applied using etch-and-rinse (ER) and self-etch (SE) strategies, before and after thermocycling. Method and materials A total…

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Negative / Null Result ReportMedicine

Leader behaviors to improve teamwork during interprofessional rounds in the NICU.

Traylor AM, Bell EA, Lewis NCM et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective We investigated the impact of leaders' interprofessional teamwork behaviors on NICU staff perceptions of teamwork processes, trust, psychological safety, and voice behavior. Study design To develop a measure of leaders'…

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Negative / Null Result ReportMedicine

Is Seeing Believing and Hearing Trusting? Exploring the Role of Visual and Vocal Cues in Shaping User Trust in VR News Anchors.

Gao Y, Guo Z, Liang HN · 2026 · IEEE transactions on visualization and computer graphics

Amid the global decline in news credibility, immersive journalism in virtual reality (VR) offers opportunities to enhance trust and engagement through presence and interactivity. As the communicators of news, virtual news anchors play a…

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Negative / Null Result ReportMedicine

Mode of delivery among breech presentations with and without External Cephalic Version: A retrospective observational study.

Athiel Y, Goffinet F, Le Ray C et al. · 2026 · Journal of gynecology obstetrics and human reproduction

Objective To compare the mode of delivery among women with singleton breech presentation at 36 weeks who attempted external cephalic version (ECV) with those who declined the procedure, in a tertiary center characterized by a low ECV…

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Negative / Null Result ReportMedicine

Antibacterial activity and multi-target mechanism of naringenin against Alicyclobacillus acidoterrestris and its application in apple juice.

Zhang Y, Zhao N, Hu B et al. · 2026 · International journal of food microbiology

Alicyclobacillus acidoterrestris (A. acidoterrestris) poses a major spoilage risk in pasteurized fruit juices, owing to its thermophilicity and acidophilicity. Naringenin, a natural flavonoid, has been investigated for its potential…

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Negative / Null Result ReportMedicine

A combined Ames and in vivo genotoxicity assessment of dimyricetin-yl-diselenide, a structurally defined organoselenium flavonoid.

Zhang L, Liu X, Zhang C et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Dimyricetin-yl-diselenide (DMS; 3,5,7-trihydroxy-8-[[3,5,7-trihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)chromen-8-yl]diselanyl]-2-(3,4,5-trihydroxyphenyl)chromen-4-one) is a structurally defined organoselenium flavonoid dimer in which two…

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Negative / Null Result ReportMedicine

Adding Self-directed Psychological Support to Usual Rehabilitation Following Anterior Cruciate Ligament Reconstruction Did Not Increase Return-to-Sport Rates at 12 Months. Results From the BAck iN the Game (BANG) Randomized Controlled Trial.

Fältström A, Hedevik H, Ardern CL et al. · 2026 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To evaluate the efficacy of internet-delivered psychological support-the BAck iN the Game (BANG) intervention-after anterior cruciate ligament reconstruction (ACLR) for improving return to sport (RTS). DESIGN: Randomized…

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Negative / Null Result ReportMedicine

Increasing meniscal repair rates during ACL reconstruction did not increase reoperation risk: An analysis of surgical trends from 2015 to 2023.

Kekki C, Essen CV, Cristiani R et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To evaluate surgical trends over time in meniscal procedures during anterior cruciate ligament reconstruction (ACLR) and compare meniscal reoperation rates and subjective outcomes between 2015-2019 and 2020-2023. Methods This study…

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