Replication FailureOpen accessMedicine
Connolly CE, Sgier BP, Masser R et al. · 2026 · International journal of breast cancer
Aims This study aimed to compare the performance of immunohistochemistry (IHC)-based luminal subtyping of breast cancer against gene expression panels at our institute and to evaluate a CE-certified artificial intelligence (AI) Ki67 image…
View details →Negative / Null Result ReportOpen accessMedicine
Kasai N, Hayashi K, Kito M et al. · 2025 · Physical activity and nutrition
Purpose Piceatannol, a polyphenolic compound found in high concentrations in passion fruit, has been reported to exert multiple physiological effects in preclinical studies, including vascular relaxation and increased expression of…
View details →Negative / Null Result ReportMedicine
Mockford A, Urbaneja A, Ashbrook K et al. · 2024 · Agriculture, Ecosystems and Environment.
Contemporary approaches to agriculture must be reimaged to include ecological techniques that maximise ecosystem services, so that food can be produced sustainably whilst simultaneously meeting yield demands. Pest regulation services,…
View details →Negative / Null Result ReportMedicine
Yau DKW, Ng FF, Wong MH et al. · 2025 · British journal of anaesthesia
Background Physical prehabilitation can enhance patient resilience to surgical stress, but its effects are unclear in vulnerable and frail patients. We aimed to determine the effect of a structured exercise prehabilitation programme on the…
View details →Negative / Null Result ReportOpen accessMedicine
Hasan A, Mohammad H, Darwish M et al. · 2026 · BMC oral health
BACKGROUND: Enterococcus faecalis (E. faecalis) commonly persists in endodontic infections and shows high resistance to traditional intracanal medicaments like calcium hydroxide [Ca(OH)2]. Alternatives such as chlorhexidine (CHX) and…
View details →Negative / Null Result ReportMedicine
Shahhosseini G, Alirezaei S, Alaee A et al. · 2025 · Journal of lasers in medical sciences
Introduction: Dental caries remains a prevalent oral health issue worldwide, with Lactobacillus acidophilus playing a significant role in its progression. While traditional antimicrobial agents like chlorhexidine are effective, the…
View details →Negative / Null Result ReportOpen accessMedicine
Alcivar de Lucca J, McKinnon JJ, Feist MS et al. · 2025 · Translational animal science
This study evaluated how varying crude protein levels in rations that incorporated canola meal or wheat-based dried distillers' grains with solubles as alternative protein sources affected growth performance, carcass traits, and liver…
View details →Negative / Null Result ReportOpen accessMedicine
de Jager V, Mockeliunas L, You H et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background In vitro, meropenem is shown to restore the activity of rifampicin in rifampicin-resistant Mycobacterium tuberculosis strains. This phase 2a trial aimed to determine if addition of rifampicin increases the early bactericidal…
View details →Negative / Null Result ReportMedicine
Kwak JS, Lee KH, Min WK et al. · 2024 · Plant biology (Stuttgart, Germany)
OsS1Fa1, a homologue of spinach S1Fa, is a small protein in rice that contains four distinct conserved motifs and participates in drought tolerance. However, the biological functions of these conserved motifs have not been characterized to…
View details →Negative / Null Result ReportMedicine
Franzese S, Saker Neto N, Wong WWH · 2024 · Chemistry (Weinheim an der Bergstrasse, Germany)
Three new pyridinium-phenolate dyes based on the benchmark solvatochromic dye Betaine 30 were synthesised. The dyes contained phenylene spacers between the donor and acceptor groups. Their UV-Vis absorption spectra were measured, with the…
View details →Negative / Null Result ReportMedicine
Shelly TE · 2026 · Journal of insect science (Online)
Traps containing food-based attractants are an important component of regional networks operated to detect invasive tephritid fruit flies (Diptera: Tephritidae), which pose a serious threat to fruit and vegetable production worldwide.…
View details →Negative / Null Result ReportMedicine
Chinadet W, Pengpue P, Chaijareenont P · 2024 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
Purpose This study aimed to evaluate the effects of two surface treatments on the tensile bond strength of prefabricated zirconia crowns (PZCs) using bioactive and resin cements. Methods Forty extracted human primary maxillary incisors…
View details →Negative / Null Result ReportMedicine
Gomes A, Costa ALR, Fasolin LH et al. · 2025 · Carbohydrate polymers
Gelled emulsion systems offer promising matrices for encapsulating bioactive compounds, enhancing stability, bioavailability, and controlled release. Incorporating inulin-type dietary fibers into emulsion-filled gels can innovate food…
View details →Negative / Null Result ReportMedicine
Jin P, Wang Y · 2024 · Developmental neurorehabilitation
Objective To evaluate the impact of combining botulinum toxin-A (BoNT-A) injection with robot-assisted gait training (RAGT) on lower limb spasticity and motor function in children with cerebral palsy. Methods A prospective study was…
View details →Negative / Null Result ReportOpen accessMedicine
Ninmer EK, Petroni GR, Gaughan E et al. · 2026 · Cancer research communications
Purpose This randomized phase I/II clinical trial (NCT03617328) was designed to test whether administration of systemic agonistic anti-CD27 antibody (varlilumab) concurrent with a melanoma vaccine is safe and enhances vaccine…
View details →Failed Experiment ReportMedicine
Ioannidis K, Katmerou I, Nikolaidis A et al. · 2026 · Journal of endodontics
Introduction The aim of this study was to examine, in vitro, the formation of formaldehyde with the aid of high performance liquid chromatography (HPLC), following the interaction of sodium hypochlorite (NaOCl) 2% w/v and…
View details →Negative / Null Result ReportMedicine
Yang N, Subak LL, Shatkin-Margolis A et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Urinary incontinence (UI) can negatively affect sexual function in women. Although many women with UI seek complementary strategies such as pelvic floor yoga techniques to improve sexual functioning, evidence of their efficacy…
View details →Negative / Null Result ReportOpen accessMedicine
Mitra B, MacKenzie S, Bourke EM et al. · 2026 · Journal of the American College of Emergency Physicians open
Objectives The aim of this study was to assess 24-month functional outcomes of patients randomly assigned to prehospital tranexamic acid (TXA) compared with those assigned to placebo. Methods The PATCH-Trauma trial assessed administration…
View details →Negative / Null Result ReportMedicine
Değirmenci A, Bayar Muluk N, Budak Z et al. · 2026 · The Journal of craniofacial surgery
Objectives The possible cytotoxic effect of Centella asiatica extract on human dermal fibroblast cells was examined in this cell culture experiment. The main objective was to determine its basic safety for potential use in oral tissue…
View details →Negative / Null Result ReportMedicine
Verkaar AJCF, van Damme I, van Veldhuisen ER et al. · 2026 · Journal of sleep research
Sleep problems are highly prevalent among patients with cardiovascular diseases (CVD). We examined the effect of dietary counselling on sleep outcomes among patients with CVD. We performed secondary analyses within a previously conducted…
View details →Negative / Null Result ReportMedicine
Hannig L, Braunger BM, Kleefeldt N et al. · 2026 · Cell and tissue research
CEACAM1 (CC1) is an important mediator of cell proliferation and adhesion and serves as an angiogenic factor through interaction with VEGF. Although the role of CC1 has been extensively studied in organs such as the heart, liver and lung…
View details →Negative / Null Result ReportMedicine
Magrin GL, Michels R, Gil ACK et al. · 2026 · Journal of periodontal research
Aim This split-mouth randomized clinical trial aimed to assess whether incorporating platelet-rich fibrin (PRF) into a volume-stable collagen matrix results in superior reduction of recession depth after 6 months of healing in the…
View details →Negative / Null Result ReportMedicine
Nguyen E, Rusu DN, Dolan JL et al. · 2026 · Practical radiation oncology
Purpose/objective(s) - This retrospective study determines if uniform fasting protocols successfully limit stomach volume variation and proximity to the planning target volume (PTV) throughout radiation treatment. Materials/methods - 74…
View details →Negative / Null Result ReportMedicine
Naemura N, Fukuda Y · 2026 · [Nihon koshu eisei zasshi] Japanese journal of public health
Objectives Improving the screening rates in specific health checkups and guidance represents a challenge for health insurance providers and local governments nationwide. In this study, we evaluated SMS-based health checkup encouragement…
View details →Replication FailureMedicine
Hyman AC, Albins MA, Curtis JS et al. · 2026 · Scientific reports
Biological invasions threaten ecosystems worldwide, with invasive predators such as lionfish (Pterois spp.) altering marine communities through predation, competition, and habitat disruption. Since their introduction to the western…
View details →Replication FailureMedicine
Ludwig DR, Zhang F, Minor B et al. · 2026 · Academic radiology
Rationale and objectives To evaluate access to contrast-enhanced MRI among patients with acute or chronic renal failure after implementation of a more permissive contrast policy and determine whether any patients developed nephrogenic…
View details →Replication FailureMedicine
Islam AM, Baldwin RB, Dyer BJ et al. · 2026 · Facial plastic surgery & aesthetic medicine
Background Patients with orbital floor fractures are frequently transferred between facilities for suspected clinical need, although many of these transfers may be unnecessary. Objective To compare the characteristics among patients with…
View details →Replication FailureMedicine
Pentland DR, Treder N, Najjar S et al. · 2026 · Hearing research
WHRN gene mutations underlie several forms of deafness in humans and mice. It is not known whether WHRN-associated hearing loss can be reversed after its onset and we aimed to address this using a genetic approach. We show that a knockdown…
View details →Replication FailureMedicine
Arslan B, Güdül KF · 2026 · BMC oral health
Aim The aim of this study is to assess whether coloured resin composites undergo greater colour changes following exposure to a colouring solution after the use of a whitening mouthwash. Materials and methods Sixty composite discs (2 × 8…
View details →Negative / Null Result ReportMedicine
de Castro T, Viana LH, Botelho S et al. · 2026 · International urogynecology journal
Introduction and hypothesis Approximately 60% of women experience some degree of perineal laceration following vaginal delivery. Although there is evidence supporting the use of photobiomodulation (PBM) for pain relief and wound healing in…
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