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Browse the failure-mode index

21,277 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Wildflower strips enhance pest regulation services in citrus orchards

Mockford A, Urbaneja A, Ashbrook K et al. · 2024 · Agriculture, Ecosystems and Environment.

Contemporary approaches to agriculture must be reimaged to include ecological techniques that maximise ecosystem services, so that food can be produced sustainably whilst simultaneously meeting yield demands. Pest regulation services,…

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Negative / Null Result ReportOpen accessMedicine

Effects of supplementing crude protein to feedlot bison heifers using canola meal or wheat-based distillers' grains with solubles on feed intake, performance and carcass traits.

Alcivar de Lucca J, McKinnon JJ, Feist MS et al. · 2025 · Translational animal science

This study evaluated how varying crude protein levels in rations that incorporated canola meal or wheat-based dried distillers' grains with solubles as alternative protein sources affected growth performance, carcass traits, and liver…

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Negative / Null Result ReportOpen accessMedicine

A Phase 2a Study of the Early Bactericidal Activity of Rifampicin in Combination With Meropenem Plus Amoxicillin/Clavulanate Among Adults With Rifampicin-Resistant Pulmonary Tuberculosis.

de Jager V, Mockeliunas L, You H et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background In vitro, meropenem is shown to restore the activity of rifampicin in rifampicin-resistant Mycobacterium tuberculosis strains. This phase 2a trial aimed to determine if addition of rifampicin increases the early bactericidal…

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Negative / Null Result ReportMedicine

Extended Reichardt's Dye-Synthesis and Solvatochromic Properties.

Franzese S, Saker Neto N, Wong WWH · 2024 · Chemistry (Weinheim an der Bergstrasse, Germany)

Three new pyridinium-phenolate dyes based on the benchmark solvatochromic dye Betaine 30 were synthesised. The dyes contained phenylene spacers between the donor and acceptor groups. Their UV-Vis absorption spectra were measured, with the…

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Negative / Null Result ReportMedicine

Investigating the impact of surface treatments on tensile bond strength between pediatric prefabricated zirconia crowns and primary maxillary incisors with various types of luting cement: an in vitro study.

Chinadet W, Pengpue P, Chaijareenont P · 2024 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Purpose This study aimed to evaluate the effects of two surface treatments on the tensile bond strength of prefabricated zirconia crowns (PZCs) using bioactive and resin cements. Methods Forty extracted human primary maxillary incisors…

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Negative / Null Result ReportMedicine

Rheological properties, microstructure, and encapsulation efficiency of inulin-type dietary fiber-based gelled emulsions at different concentrations.

Gomes A, Costa ALR, Fasolin LH et al. · 2025 · Carbohydrate polymers

Gelled emulsion systems offer promising matrices for encapsulating bioactive compounds, enhancing stability, bioavailability, and controlled release. Incorporating inulin-type dietary fibers into emulsion-filled gels can innovate food…

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Negative / Null Result ReportOpen accessMedicine

Randomized Phase I/II Clinical Trial of a Melanoma Helper Peptide Vaccine with or without Systemic Agonistic Anti-CD27 Antibody (Varlilumab).

Ninmer EK, Petroni GR, Gaughan E et al. · 2026 · Cancer research communications

Purpose This randomized phase I/II clinical trial (NCT03617328) was designed to test whether administration of systemic agonistic anti-CD27 antibody (varlilumab) concurrent with a melanoma vaccine is safe and enhances vaccine…

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Negative / Null Result ReportOpen accessMedicine

Long-Term Outcomes of Trauma Patients After Treatment With Prehospital Tranexamic Acid: A Subgroup Analysis From the PATCH-Trauma Trial.

Mitra B, MacKenzie S, Bourke EM et al. · 2026 · Journal of the American College of Emergency Physicians open

Objectives The aim of this study was to assess 24-month functional outcomes of patients randomly assigned to prehospital tranexamic acid (TXA) compared with those assigned to placebo. Methods The PATCH-Trauma trial assessed administration…

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Negative / Null Result ReportMedicine

Targeting Oral Tissue Regeneration With Standardized Centella asiatica Extract: Experimental Insights From Human Fibroblast Cultures.

Değirmenci A, Bayar Muluk N, Budak Z et al. · 2026 · The Journal of craniofacial surgery

Objectives The possible cytotoxic effect of Centella asiatica extract on human dermal fibroblast cells was examined in this cell culture experiment. The main objective was to determine its basic safety for potential use in oral tissue…

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Negative / Null Result ReportMedicine

The Effect of 6 Months of Dietary Counselling on Sleep Outcomes Among Patients With Cardiovascular Diseases: A Randomised Controlled Trial.

Verkaar AJCF, van Damme I, van Veldhuisen ER et al. · 2026 · Journal of sleep research

Sleep problems are highly prevalent among patients with cardiovascular diseases (CVD). We examined the effect of dietary counselling on sleep outcomes among patients with CVD. We performed secondary analyses within a previously conducted…

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Negative / Null Result ReportMedicine

Volume-Stable Collagen Matrix With or Without Platelet-Rich Fibrin Impregnation for Multiple Gingival Recessions: A Randomized Clinical Trial.

Magrin GL, Michels R, Gil ACK et al. · 2026 · Journal of periodontal research

Aim This split-mouth randomized clinical trial aimed to assess whether incorporating platelet-rich fibrin (PRF) into a volume-stable collagen matrix results in superior reduction of recession depth after 6 months of healing in the…

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Replication FailureMedicine

Evidence of a limit to benefits from culling lionfish.

Hyman AC, Albins MA, Curtis JS et al. · 2026 · Scientific reports

Biological invasions threaten ecosystems worldwide, with invasive predators such as lionfish (Pterois spp.) altering marine communities through predation, competition, and habitat disruption. Since their introduction to the western…

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Replication FailureMedicine

Implementation of a New MRI Contrast Policy at a Large Hospital System: Access to Contrast-Enhanced MRI and Development of NSF in Patients with Renal Insufficiency.

Ludwig DR, Zhang F, Minor B et al. · 2026 · Academic radiology

Rationale and objectives To evaluate access to contrast-enhanced MRI among patients with acute or chronic renal failure after implementation of a more permissive contrast policy and determine whether any patients developed nephrogenic…

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Negative / Null Result ReportMedicine

Photobiomodulation for Pain, Healing, and Analgesic Use after Perineal Lacerations: A Double-Blind Randomized Controlled Trial.

de Castro T, Viana LH, Botelho S et al. · 2026 · International urogynecology journal

Introduction and hypothesis Approximately 60% of women experience some degree of perineal laceration following vaginal delivery. Although there is evidence supporting the use of photobiomodulation (PBM) for pain relief and wound healing in…

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