Negative / Null Result ReportOpen accessMedicine
Hackländer RPM, Schlüter H, Rolke AK et al. · 2025 · Experimental psychology
Not all information encountered is equally important to remember. Some information may be valuable, while others may be irrelevant. Importantly, retrieving and acting upon some information may even have negative consequences. Research has…
View details →Negative / Null Result ReportOpen accessMedicine
Robertson I, Taylor D, Chong J · 2025 · Journal of rehabilitation medicine
Background Rehabilitation is vital for optimizing recovery following neurological injuries. However, much of what is done for the paediatric population relies heavily on the adult literature or is based on expert opinion. No previous…
View details →Negative / Null Result ReportMedicine
McDonald A, Corbin W · 2025 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
Objective Building upon prior research, the present study tested coping motives as a mediator of relations between both negative urgency and internalizing symptoms (depression, anxiety, and stress), and alcohol-related consequences using…
View details →Negative / Null Result ReportOpen access
Helder M, Pandeya N, Seviiri M et al. · 2024 · Preprint
ABSTRACT With over 1.5 million new cases annually, skin cancers are the most commonly diagnosed group of cancers worldwide. Among these, melanoma and keratinocyte cancers (KC), comprising squamous cell carcinoma (SCC) and basal cell…
View details →Negative / Null Result ReportMedicine
Snippe E, Elmer T, Ceulemans E et al. · 2024 · Journal of consulting and clinical psychology
Objective Despite the importance for understanding mechanisms of change, little is known about the order of change in daily life emotions, cognitions, and behaviors during treatment of depression. This study examined the within-person…
View details →Abandoned HypothesisOpen accessMedicine
Jones GA · 2025 · Critical criminology
Failure is taboo. Yet as researchers we often encounter failure in the field and engage in confessional conversations with colleagues about 'what went wrong'. Failure is regarded as an unfortunate and unproductive part of research. Better…
View details →Negative / Null Result ReportMedicine
Li C, Li X, Zhang Z · 2024 · Work (Reading, Mass.)
Background The involvement of Perchloroethylene (PCE) in the development of autoimmune diseases has been reported. However, few studies investigated immunotoxicity in PCE-exposed workers. Objective To study changes in the oxidative stress…
View details →Negative / Null Result ReportOpen accessMedicine
Van Dyken PC, Yang K, Faria AV et al. · 2025 · Biological psychiatry global open science
Background White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date…
View details →Methods Dead-End
Zhao y, Xu F · 2023 · Preprint
Abstract Background: A few of cohort studies declared an converse association between pork intake and cardiovascular diseases, but the causal relationship is ambiguous. Objective: To evaluate the causal relationship between pork intake,…
View details →Replication FailureMedicine
McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…
View details →Failed Experiment ReportMedicine
Liu C, Lyu Y, Jiang Y et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To carry out genetic analysis for a fetus with confined placental mosaicism (CPM) for trisomy 2 (T2) in conjunct with fetal uniparental disomy (UPD). Methods Amniocentesis and chromosomal karyotyping was carried out for a…
View details →Replication FailureMedicine
Rehe D, Subashchandran V, Zhang Y et al. · 2025 · Journal of clinical anesthesia
Study objective To determine whether preoperative LDL-C concentration affects the risk of perioperative major adverse cardiovascular or cerebrovascular events (MACCE) after noncardiac surgery. Design Single center retrospective cohort…
View details →Negative / Null Result ReportMedicine
Dickerson JF, Clarke G, Weersing VR et al. · 2025 · American journal of epidemiology
The current study estimated effects of intervention dose (attendance) of a cognitive behavioral prevention (CBP) program on depression-free days (DFDs) in adolescent offspring of parents with a history of depression. As part of secondary…
View details →Negative / Null Result ReportOpen accessMedicine
De Gaudenzi M, Mozun R, Schlapbach LJ et al. · 2026 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives Healthcare improvement studies indicate a potential to reduce cardiac arrests in the PICU through anticipatory care and shared awareness. We developed a structured risk-assessment and anticipation tool (i.e., the Airway,…
View details →Negative / Null Result Report
Yu S, Chen S, Tao T et al. · 2023 · Preprint
Background: Previous observational studies have found that negative moods are associated with cardiovascular diseases (CVDs). However, their causal association remains unclear. We aim to evaluate the causal associations of genetically…
View details →Negative / Null Result ReportMedicine
Scheen AJ · 2023 · Diabetes & metabolism
Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular complication has been less carefully investigated than the risk of cardiovascular mortality, heart failure and renal disease. Some data suggested…
View details →Negative / Null Result ReportMedicine
Inman EM, Inman EM, Ramsammy CW et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)
Background Both HIV and adverse childhood experiences (ACEs) can affect neurocognitive performance. Among youth with perinatal HIV (PHIV), living with a chronic viral infection and experiencing ACEs simultaneously may result in an…
View details →Negative / Null Result ReportOpen accessMedicine
Ray CC, Wolf J, Guillaumin J · 2025 · Frontiers in veterinary science
Introduction Locomotion improvement without serious complications is the main goal of treatment for feline aortic thromboembolism (FATE). We aimed to describe the survival and functional recovery of cardiogenic FATE treated with tissue…
View details →Negative / Null Result ReportOpen accessMedicine
Lee T, Choi B, Choi S et al. · 2026 · Journal of eye movement research
Prior research on lexical elaboration (providing additional information about unfamiliar words) has yielded non-significant effects on incidental vocabulary acquisition. Building on this, the present study used eye-tracking technology to…
View details →Failed Experiment Report
Wöhner S, Luckow J, Brandt M et al. · 2023 · Preprint
Semantic context effects in picture naming and categorization tasks are central to the development and evaluation of current models of word production. When pictures are named in a semantically blocked context, response latencies are…
View details →Negative / Null Result ReportOpen accessMedicine
Kumar SK, Misra S, Behera BK et al. · 2025 · Journal of anaesthesiology, clinical pharmacology
Background and aims No studies have compared the effects of ketamine and dexmedetomidine on bowel recovery. We evaluated the effects of intraoperative low-dose ketamine or dexmedetomidine infusion on postoperative bowel recovery in…
View details →Negative / Null Result ReportMedicine
Lu J, Xing J, Zang L et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there is still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The…
View details →Negative / Null Result ReportOpen accessMedicine
Duy WD, Pajewski NM, Williamson JD et al. · 2025 · The Journal of frailty & aging
Objective To compare the association of glaucoma and glaucoma suspect diagnoses with frailty, quantified via an electronic frailty index (eFI), and to evaluate whether a glaucoma diagnosis moderates the association between frailty and the…
View details →Negative / Null Result ReportMedicine
Metcalf D, Zhang D · 2023 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Objectives This study explores racial and ethnic differences in 1) receiving tissue plasminogen activator (tPA) and endovascular thrombectomy (EVT) as treatment for ischemic stroke and 2) outcomes and quality of care after use of tPA or…
View details →Negative / Null Result Report
Vezirian K, IJzerman H, begue l et al. · 2021 · Preprint
Do colored backgrounds lead to polarized judgments? Zarkadi and Schnall (2013) found in their Study 1 that, indeed, exposing participants to a black-and-white (versus other colored) background polarized participants’ judgments in a moral…
View details →Negative / Null Result ReportOpen accessMedicine
Munder O, Adam GK, Nasralla K et al. · 2025 · SAGE open nursing
Introduction Adolescent pregnancy is considered a global public health problem that affects both developed and developing countries. While the obstetric and perinatal outcomes of adolescent pregnancies have been extensively studied, there…
View details →Failed Experiment ReportOpen accessMedicine
Dameron LS, Bank NC, Raghava N et al. · 2026 · Journal of hand surgery global online
Purpose The primary aim was to compare postoperative complications at 90 days and 1 year following trigger finger release (TFR) in patients with versus without glucagon-like peptide-1 receptor agonist (GLP-1 RA) exposure. GLP-1 RAs are…
View details →Negative / Null Result ReportOpen accessMedicine
Chari HS, Padukone AM, Magazine R et al. · 2026 · The Journal of international medical research
ObjectiveChronic obstructive pulmonary disease is a common condition marked by significant disability and frequent exacerbations. Statins, owing to their anti-inflammatory and immunomodulatory effects, may offer therapeutic benefits in…
View details →Negative / Null Result ReportOpen accessMedicine
Quanz EV, Al-Nosairy KO, Stolle FH et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology
Purpose Quanz et al. (Sci Rep 14:16797, 2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA…
View details →Failed Experiment ReportMedicine
Park EC, Harris LM, Sigel AN et al. · 2023 · Behaviour research and therapy
Existing evidence suggests a link between physical pain and suicide, but the nature of this relationship remains unknown. To address this critical gap in knowledge, the present study leveraged a validated virtual reality (VR) suicide…
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