e-ISSN: Pending

Browse the failure-mode index

21,266 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Randomized Phase II Trial of Consolidation Pembrolizumab After Definitive Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: KCSG HN19-09, CONPELAN Study.

Chun SH, Seo S, Cho JH et al. · 2026 · Head & neck

Background The benefit of consolidation programmed cell death protein 1 (PD-1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II-IVB NPC were…

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Negative / Null Result ReportMedicine

Health-Related Quality of Life in People Living with HIV andHypertension: Effects of a Short Message Service-Based Mobile HealthIntervention (MOPHADHIV Trial).

Hongoro DJ, Kengne AP, Peer N et al. · 2026 · AIDS and behavior

Mobile health (mHealth) interventions offer scalable support for adherence and self-management, yet their effects on health-related quality of life (HRQoL) among people living with HIV (PLWH) and comorbid hypertension remain unclear. We…

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Negative / Null Result ReportMedicine

Exercise-nutrition prehabilitation attenuates lean body mass loss before gastrectomy: a randomized controlled trial.

Yamamoto K, Shinno N, Omori T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Background Older patients undergoing gastrectomy frequently exhibit sarcopenia and reduced physiologic reserve, increasing vulnerability to perioperative muscle loss. However, randomized evidence supporting multimodal exercise-nutrition…

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Negative / Null Result ReportMedicine

Impact of fludarabine dosage on outcomes in large B-cell lymphoma patients treated with CAR T-cell therapy: a retrospective study of the CTIWP of the EBMT.

Dachy G, Mooyaart JE, Gabellier L et al. · 2026 · Bone marrow transplantation

Lymphodepleting conditioning (LD) with fludarabine and cyclophosphamide is critical to ensure optimal expansion and persistence of CD19 CAR T-cells. We conducted a retrospective EBMT registry study to assess the impact of fludarabine…

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Negative / Null Result ReportMedicine

High-dose Vitamin D<sub>3</sub> supplementation and glycaemic control in adult males with Type 2 diabetes: a randomised placebo-controlled trial.

Nasr MH, Abdulrasool Hassan B, Othman N et al. · 2026 · Journal of pharmaceutical policy and practice

Background Vitamin D deficiency is common among individuals with type 2 diabetes mellitus (T2DM) and has been linked to insulin resistance and poor glycaemic control. However, findings from randomised controlled trials remain inconsistent.…

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Negative / Null Result ReportMedicine

Flash glucose monitoring addition to self-monitoring of blood glucose and perinatal outcomes in gestational diabetes: a randomized controlled trial.

Zorko K, Munda A, Janež A et al. · 2026 · American journal of obstetrics and gynecology

Background Self-monitoring of blood glucose represents the standard for glycemic monitoring in gestational diabetes mellitus, while the role of continuous glucose monitoring remains uncertain. Objective To assess whether adjunctive flash…

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Negative / Null Result ReportMedicine

Durability and mechanistic performance of aztreonam/avibactam versus aztreonam plus ceftazidime/avibactam against Stenotrophomonas maltophilia complex.

Kunz Coyne AJ, Gray R, Gonnabathula P et al. · 2026 · The Journal of antimicrobial chemotherapy

Background Stenotrophomonas maltophilia complex infections are difficult to treat because of intrinsic resistance mediated by the L1 metallo-β-lactamase and L2 serine β-lactamase. Although aztreonam/avibactam is clinically available,…

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Negative / Null Result ReportMedicine

Switching anti-VEGF agents does not improve visual outcomes in branch retinal vein occlusion-related macular edema.

Peretz-Kahlon M, Wood K, Harris A et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

BACKGROUND: Branch retinal vein occlusion (BRVO) frequently results in macular edema (ME), impairing visual acuity (VA). Intravitreal anti-vascular endothelial growth factor (VEGF) injections are standard first-line therapy but the benefit…

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Negative / Null Result ReportMedicine

Evaluating the efficacy of G12C inhibitors in conjunction with Gamma Knife radiosurgery for KRAS-mutant non-small cell lung cancer brain metastases.

Andrade A, Mureb M, Karaman N et al. · 2026 · Journal of neuro-oncology

PURPOSE: KRAS G12C mutations occur in approximately 11% of non-small-cell lung cancer (NSCLC) patients and are associated with aggressive disease and poor prognosis. Although KRAS G12C-inhibitors are now approved, their impact on Gamma…

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Negative / Null Result ReportMedicine

The Effects of a Powdered Meal Replacement on Inflammation, Gut Microbiota, and Metabolism in People With Excess Body Weight-A Randomized Controlled Trial.

Montenegro J, Oliveira CL, Nguyen NK et al. · 2026 · The Journal of nutrition

Background Excess body weight is associated with chronic low-grade inflammation and metabolic abnormalities, such as insulin resistance, and dyslipidemia. Objectives This study aimed to assess the impact of a soy protein-yogurt-honey…

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Negative / Null Result ReportMedicine

Performance, non-carcass components, serum biochemistry panel and intestinal morphology of Texel lambs fed with bioactive peptides.

Nascimento GO, Otávio KS, Ferreira J et al. · 2026 · Tropical animal health and production

Bioactive peptides (BP) have been investigated as potential functional feed additives due to their reported immunomodulatory and metabolic properties. This study evaluated the effects of dietary BP supplementation on growth performance,…

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Negative / Null Result ReportMedicine

Endogenous Theta as a Function of Task Load and Working Memory Capacity: Revisiting the Role of Slower Frequencies in Theta-Gamma Coupling.

Tortajada M, Rodríguez-Larios J, Martínez-Pérez V et al. · 2026 · Journal of cognitive neuroscience

Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in working memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…

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Negative / Null Result ReportMedicine

Real-World Data on Treatment Compliance and Visual Outcomes Between Patients With Diabetic Macular Edema or Retinal Vein Occlusion Receiving Antivascular Endothelial Growth Factor Injections or Intravitreal Corticosteroid Implants.

Kim SB, Lopez A, Gu X et al. · 2026 · Journal of vitreoretinal diseases

Purpose: To evaluate real-world differences in treatment frequency, appointment compliance, and visual outcomes among patients with DME or RVO whose eyes either remained on antivascular endothelial growth factor (anti-VEGF) therapy or were…

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Negative / Null Result ReportMedicine

Testing the efficacy of a defocusing intervention to improve affective forecasting accuracy in younger and older adults.

Sobel Misieczko M, Barber SJ · 2026 · Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

Affective forecasting, the process of predicting future feelings, is key for decision-making, but prone to errors. Prior research suggests that age differences in forecasting accuracy vary by event valence such that older adults tend to be…

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Negative / Null Result Report

Acute profound thrombocytopenia associated with glycoprotein IIb/IIIa receptor inhibitor after percutaneous coronary intervention: therapy insights from a single center 6-year experience

Wu Y, Feng K, Liu L et al. · 2026 · Preprint

Abstract Background Acute profound thrombocytopenia is an infrequent, but potentially serious, even fatal complication associated with intravenous glycoprotein IIb/IIIa receptor inhibitors (GPI), which are widely used in acute coronary…

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Negative / Null Result ReportMedicine

Effects of Dry-Land Versus In-Water Resistance Priming Exercise on Performance Parameters of Young Female Water Polo Players.

Brisola GMP, da Cruz AL, Belorio LGDS et al. · 2026 · Journal of strength and conditioning research

Abstract Brisola, GMP, da Cruz, AL, Belorio, LGdS, Grossi, JP, De Poli, RAB, Zagatto, AM, Esco, MR, and Mendes, OdC. Effects of dry-land versus in-water resistance priming exercise on performance parameters of young female water polo…

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Negative / Null Result ReportMedicine

A single autoregressive integrated moving average with exogenous variable outperforms ensembles of autoregressive models for forecasting influenza hospitalizations in the contiguous United States.

Arraes Rocha Felix V, Rohani P, Drake JM · 2026 · Journal of the Royal Society, Interface

Infectious disease forecasting is important to public health decision-making, particularly for mitigating the burden of seasonal influenza. We propose and evaluate comprehensive autoregressive modelling approaches (autoregressive…

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Negative / Null Result ReportMedicine

Mycorrhizal inoculation and crop rotation as soil sustainable management strategies to reduce fertilizer use and water consumption in horticultural crops

Vargas Ribera PR, Nogales A, Calvet C et al. · 2026 · Applied Soil Ecology.

Crop rotation enhances agroecosystem sustainability by reducing nutrient loss, improving soil fertility, and decreasing crop evapotranspiration. Arbuscular mycorrhizal fungi (AMF) inoculation further supports enhanced nutrient and water…

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