21,266 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Di Cesare B, Mancini GF, Parente M et al. · 2026 · Life sciences
Aims Metabolic syndrome (MetS) is characterized by several metabolic alterations that may increase the risk of memory alterations. While metabolic consequences of MetS are well documented, its memory impact remains underexplored. This…
View details →Leal RMS, Campos MCBP, Copelli FA et al. · 2026 · International endodontic journal
Aim To evaluate the endodontic retreatment of S-shaped mesial root canals of mandibular molars using the Reciproc Blue R25 and R40 instruments, with or without the use of an orange oil solvent, and to assess the effect of additional apical…
View details →Ko E, Kim YH, Lee S et al. · 2025 · The Journal of surgical research
Introduction Sepsis is a severe pathological crisis marked by infection and systemic inflammation with high mortality rates. Sepsis induces microcirculatory dysfunction and oxidative stress, which share pathophysiological features with…
View details →Dong Z, Wu L, Du H et al. · 2026 · Gastroenterology
Background & aims Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lacking. We aimed to explore whether AI can enhance gastric neoplasm detection. Methods…
View details →Greistofer E, Taher F, Assadian A et al. · 2026 · Annals of vascular surgery
Background The objective of this study was to evaluate the prognostic value of routine postoperative laboratory parameters including renal function, inflammatory markers, and hematologic indices in patients undergoing fenestrated…
View details →Lee TY, Hunter DA, Perez R et al. · 2026 · The Journal of hand surgery
Purpose Polyethylene glycol (PEG) fusion has been reported to restore axonal continuity after nerve repair if initiated before Wallerian degeneration (WD). Sterile α and Toll/Interleukin-1 Receptor motif-containing 1 (SARM1) inhibition can…
View details →Umbricht D, Abt M, Derks M et al. · 2026 · The Journal of clinical psychiatry
Objective: Cognitive impairment associated with schizophrenia (CIAS) is a key driver of functional deficits in patients with this disorder. CIAS may involve deficient NMDA receptor-dependent neurotransmission. Negative allosteric…
View details →Toprak HB, Erdemir M, Bilgiç E et al. · 2026 · Preprint
Abstract Background The C-reactive protein–to–albumin ratio has been proposed as a composite inflammatory biomarker associated with adverse outcomes in critically ill patients. However, whether the C-reactive protein–to–albumin ratio…
View details →Liu Y, Wang X, Qian P et al. · 2026 · Preprint
Abstract Background Patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing surgery after neoadjuvant chemotherapy (NCT) or neoadjuvant chemoimmunotherapy (NICT) remain at risk of disease progression. Currently,…
View details →Kitowski A, Heise C, Sperling S et al. · 2026 · British journal of pharmacology
Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to…
View details →Grossmann I, Rudnev M, Clark CJ et al. · 2026 · Preprint
Experts and pundits routinely forecast societal trends, yet these predictions often fall short, leading to poor policy decisions. What distinguishes accurate forecasters? In a three-year longitudinal tournament (N = 520), we tested whether…
View details →Talathi R, Hubbard RA, Somasundar P et al. · 2026 · Surgery
Background The Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (STRASS 2) trial is evaluating the impact of neoadjuvant chemotherapy versus surgery in patients with high-risk, resectable…
View details →Zhao A, Chen W, Liang Y et al. · 2026 · Cancer treatment and research communications
Objective To compare and analyze the efficacy and safety of an overall strategy of immunotherapy combined with chemoradiotherapy in patients with limited-stage small cell lung cancer (LS-SCLC)-including induction immunotherapy plus…
View details →Sarica C, Darmani G, Ramezanpour H et al. · 2026 · Science translational medicine
Transcranial ultrasound stimulation (TUS) is a promising noninvasive technique for modulating deep brain targets and circuits with high spatial precision. For its successful clinical translation, confirmation of target engagement, together…
View details →Riestra JM, Levin-Carrion Y, Sutar R et al. · 2026 · Human psychopharmacology
Treatment-resistant depression (TRD) remains a formidable challenge in psychiatry, with nearly one-third of patients with major depressive disorder (MDD) failing to respond adequately to first-line pharmacological treatments.…
View details →Nandi D, Gajarski RJ, Zhao H et al. · 2026 · Pediatric transplantation
Purpose Human Leukocyte Antigen (HLA) sensitization can adversely impact heart transplant (HTx) outcomes. We evaluated the effect of panel-reactive antibody (PRA) and desensitization (DS) strategies on outcomes of pediatric HTx recipients…
View details →Silva-García J, Eurolo I, Fuentes-Flores R et al. · 2026 · Brain research
Ischemic stroke is a leading cause of death and disability worldwide. Among survivors, one-third live with permanent impairments, and two-thirds experience upper limb dysfunction. Despite advances in acute care, no universally effective…
View details →Hayashi T, Go M, Kawasumi K et al. · 2026 · Preprint
Abstract Introduction Maintaining dose intensity is essential for the efficacy of adjuvant S-1 chemotherapy in gastric cancer. Although pharmacist interventions can reduce toxicity and improve adherence, multicenter evidence regarding…
View details →Saloojee H, Gramanie MC, Mwale R et al. · 2026 · Medical teacher
Background Generative artificial intelligence (AI) tools are entering clinical training faster than curricula and assessments can adapt. It is currently unknown whether point-of-care access to large language models (LLMs) improves…
View details →An DW, Wang Y, Cheng YB et al. · 2026 · Hypertension (Dallas, Tex. : 1979)
Background Whether central systolic blood pressure (cSBP) compared with brachial systolic blood pressure (bSBP) improves risk stratification remains debated. This study investigated whether cSBP is more closely associated with total and…
View details →Durmuş Ece BŞ, Yozgat Z, Işık MU et al. · 2026 · Journal francais d'ophtalmologie
Purpose To determine the effect of trabecular meshwork (TM) peeling on gonioscopy-assisted transluminal trabeculotomy (GATT) surgical outcomes in patients with open-angle glaucoma. Methods In this retrospective cross-sectional study,…
View details →Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry
Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…
View details →Vedrenne-Cloquet M, de Montmollin E, Gaudemer A et al. · 2026 · Journal of educational evaluation for health professions
Purpose To assess the effectiveness of a short multimodal workshop, including stress-management and communication-skills training, on objective structured clinical examination (OSCE) performance and exam-related anxiety among medical…
View details →Tortajada M, Rodriguez-Larios J, Martínez-Pérez V et al. · 2026 · Preprint
Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in Working Memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…
View details →Badulescu S, Gill H, Shah H et al. · 2026 · Med (New York, N.Y.)
Background Evidence suggests that glucagon-like peptide 1 receptor agonists (GLP-1RAs) might have pro-cognitive effects. No prior study has evaluated the efficacy and safety of a GLP-1RA for the treatment of cognitive dysfunction in adults…
View details →Muller M, Agrawal A, Thomas N et al. · 2026 · Substance use & addiction journal
Background Patients with opioid use disorder (OUD) are frequently hospitalized and often need post-acute care, but face high rates of rejection from post-acute and long-term care (PALTC) facilities. This study aimed to assess the impact of…
View details →Munazir M, Kausar N, Qureshi R et al. · 2026 · Scientific reports
Untreated municipal wastewater is widely used for irrigation in peri-urban agriculture where freshwater is limited, yet its effects on edible vegetable crops remain context dependent. This study evaluated the morphological, physiological,…
View details →Liang XQ, Han L, Yan T et al. · 2026 · Journal of anesthesia
Purpose Postoperative pulmonary complications are common and associated with worse long-term outcomes. In our previous trial, prophylactic penehyclidine inhalation reduced pulmonary complications in high-risk patients. Herein, we tested…
View details →Toft M, Hansen MS, Vestergaard JD et al. · 2026 · British journal of sports medicine
Objective To evaluate whether individualised treatment using the Copenhagen Achilles Rupture Treatment Algorithm (CARTA) is superior to default operative or non-operative strategies. Methods We conducted a multicentre, three-arm,…
View details →Chau IJ, Dixon PR, Lin V et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective To identify patient characteristics associated with improvements in speech recognition scores (SRS) and Cochlear Implant Quality of Life (CIQOL-35) scores following cochlear implantation. Study design Multi-institutional…
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