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Browse the failure-mode index

21,707 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Liquid Chromatography-High-Resolution Mass Spectrometric Determination of Nitrite Ion Concentration in the Natural Water Resources.

Ganji SK, Talari K, Maloth RK et al. · 2026 · Rapid communications in mass spectrometry : RCM

Rationale Nitrite anion is among the highly reactive anions and converts the secondary amines to their corresponding carcinogenic N-nitroso metabolites in the human body. Nitrite ion is highly abundant in natural waters and enters the body…

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Negative / Null Result ReportMedicine

Exploratory comparative analysis of automated morphologic and perfusion features derived from one-stop computed tomography angiography and computed tomography perfusion in large unruptured intracranial aneurysms.

Niu J, Huang W, Zou J · 2026 · Clinical neurology and neurosurgery

Purpose To compare rupture-related signals captured by automatically extracted computed tomography angiography (CTA) morphologic features and threshold-based computed tomography perfusion (CTP) metrics in large unruptured intracranial…

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Failed Experiment ReportMedicine

Dentin Bond Strength of Resin Cements Under Simulated Intraoral Humidity Conditions.

Washino T, Nikaido T, Burrow MF et al. · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Background/aims Adhesive procedures performed after dental trauma are often carried out in emergency settings with compromised isolation due to bleeding, limited access, and patient cooperation. This study evaluated how variation in…

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Failed Experiment ReportOpen accessMedicine

Dried Black Soldier Fly (<i>Hermetia illucens</i>) Larvae in a Sustainable Diet for Laying Hens: Effects on Welfare and Behavior.

Znazen Y, Gaddes M, Janssens GPJ et al. · 2026 · Animals : an open access journal from MDPI

This study evaluated the effects of locally sourced ingredient dietary, with or without supplementation of black soldier fly ( Hermetia illucens ; BSF) larvae, on laying hen welfare. A total of 150 Lohman White hens aged 30 weeks were…

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Negative / Null Result ReportOpen accessMedicine

Non-Essential Element-Based Nanoparticles in Rice: Unraveling the Impacts of Yttrium Oxide and Zirconium Oxide Nanoparticles on Root Accumulation and Antioxidant Responses.

Xie B, Rui Y · 2026 · Plants (Basel, Switzerland)

Nanotechnology has attracted increasing attention in agricultural and environmental research, but the biological effects and potential risks of nanoparticles based on non-essential elements remain insufficiently understood. This study…

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Negative / Null Result ReportMedicine

Current comorbid psychiatric symptoms in the statistical indirect association between childhood attention-deficit/hyperactivity disorder symptoms and functional impairment among university students.

Koyuncu Z, Evcil FY, Kilimci ÖS et al. · 2026 · BMC psychiatry

Objective This study investigated whether current comorbid psychiatric symptoms were involved in statistical indirect associations between childhood attention-deficit/hyperactivity disorder (ADHD) symptoms (CAS) and functional impairment…

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Negative / Null Result Report

High Concordance in Molecular Profiles Between Primary Tumors and Matched Lymph Node Metastases in Differentiated Thyroid Carcinoma: Implications for Clinical Sample Selection

Pan Y, Sun Y, Shi C et al. · 2026 · Preprint

Abstract Genetic testing guides personalized management of differentiated thyroid carcinoma (DTC). However, tumor heterogeneity, including spatial and temporal heterogeneity, has created an unresolved clinical problem. It remains unclear…

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Negative / Null Result ReportMedicine

Influence of inhalation exposure to biogenic volatile organic compounds from Syringa oblata flowers on behavior, spatial working memory, and hematological parameters in mice.

Tuo Y, Yang S, Dai X et al. · 2026 · Journal of ethnopharmacology

Ethnopharmacological relevance Syringa oblata Lindl. emits a variety of biogenic volatile organic compounds (BVOCs) during full bloom, which forms the key chemical basis for its characteristic floral scent. Species of the genus Syringa…

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Negative / Null Result ReportOpen accessMedicine

Anticoccidial efficacy of a cinnamon-Rumex nervosus phytobiotic mixture on growth performance, carcass traits, cecal morphology, and cecal health in Eimeria tenella-challenged broilers.

Qaid MM, Al-Garadi MA, Al-Abdullatif AA et al. · 2026 · Poultry science

Coccidiosis remains a major constraint in poultry production; therefore, this study evaluated the anticoccidial efficacy of a phytogenic blend of cinnamon bark and Rumex nervosus leaf in Eimeria tenella-challenged broilers. Birds were…

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Negative / Null Result ReportOpen accessMedicine

Discrepant Intracranial and Extracranial Responses to Tarlatamab in Relapsed Small-Cell Lung Cancer With Untreated Brain Metastases: A Case Report.

Hayashi E, Kano H, Nakamura K et al. · 2026 · Respirology case reports

Small-cell lung cancer (SCLC) has a poor prognosis, and the efficacy of tarlatamab for untreated brain metastases remains unclear. We report a case demonstrating a discrepant response between extracranial and intracranial lesions after…

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Negative / Null Result ReportMedicine

Utility of ultrasensitive, US Food and Drug Administration-approved κ and λ dual in situ hybridization assay in the diagnosis of Hodgkin lymphomas.

Eltahir M, Young K, Younes S et al. · 2026 · American journal of clinical pathology

Objectives Determination of B-cell clonality in formalin-fixed, paraffin-embedded tissues is challenging, especially in cases where tumor B cells are sparse. Flow cytometry is of limited utility in Hodgkin lymphomas, at least in part due…

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Negative / Null Result ReportMedicine

Performance of a new bone-level tapered two-piece zirconia implant manufactured by injection moulding: A pilot preclinical study in minipig mandibles.

Hauck F, Herber V, Moecke S et al. · 2026 · International journal of oral implantology (Berlin, Germany)

Purpose The aim of this pilot preclinical study was to investigate the performance of a novel double-lead thread, conical bone-level ceramic implant manufactured by injection moulding (test group) in comparison to a well-established…

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Negative / Null Result ReportMedicine

Clinical and Neuroimaging Predictors of Outcome and Impact of Surgical Intervention in Cryptococcal Meningitis: An Observational Study.

Qian MY, He LY, Lan P et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

This study aimed to identify predictors of outcomes and evaluate the therapeutic impact of surgical intervention in CM patients, with a specific focus on the growing HIV-negative population in East Asia. We conducted a single-center…

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