21,253 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Li, Tong, Xue et al. · 2026 · Journal of hepatology
Hepatic stellate cells (HSCs) are activated during cholestasis. However, beyond liver fibrosis, whether HSCs influence bile acid (BA) synthesis and homeostasis remain largely unknown. This study investigates the role of activated HSCs…
View details →Li, Zhou, Xu et al. · 2026 · Microorganisms
The present study investigates the effects of tannic acid (TA) on body composition, immune function, and gut microbiota in Brandt's voles ( Lasiopodomys brandtii ); analyzes the gut microbiota-immune parameter associations during their…
View details →Almuraikhi, Alkhamees, Tareen et al. · 2026 · Current issues in molecular biology
Glycogen synthase kinase-3 (GSK3) inhibition is a commonly used approach to promote osteogenic differentiation through activation of Wnt signaling. However, 6-bromoindirubin-3'-oxime (BIO), which is commonly used for GSK3 inhibition, also…
View details →Yıldırım Ş, İnci A, Karaduru Avcı A et al. · 2026 · Biomolecules & biomedicine
Primary membranous nephropathy (pMN) is a principal cause of nephrotic syndrome in adults. The identification of the M-type phospholipase A2 receptor (PLA2R) antigen has significantly advanced non-invasive management; however, the precise…
View details →Aba O, Yalçın Sezen G, Ersoy Karka O · 2026 · BMC anesthesiology
Purpose This study aimed to evaluate perioperative changes in optic nerve sheath diameter (ONSD) and regional cerebral oxygen saturation (rSO₂) using noninvasive monitoring techniques during laparoscopic abdominal surgery, and to assess…
View details →Çetinkaya F, Uslu E · 2026 · Journal of perioperative practice
Objective This study aimed to determine whether there is a relationship between patients' health literacy levels and their preoperative anxiety during the preoperative period. Design An analytical cross-sectional study. Methods The…
View details →Sugiarta AP, Anggani HS, Purbiati M · 2025 · Journal of orthodontic science
Objective This study aims to demonstrate the correlation between anterior tooth retraction and changes in the dimensions of the pharyngeal airway in cases of bimaxillary protrusion. Materials and methods Changes in dental parameters and…
View details →Melnikova, Nechipurenko, Mangin et al. · 2026 · Thrombosis and haemostasis
Subendothelial matrix exhibits a distinctive organization, with collagen fibers beneath the endothelium oriented parallel to the flow and comprising mainly types III and I collagen in arteries and arterioles. However, the significance of…
View details →Ankmnal Veeranna, Chapman · 2026 · American journal of audiology
The purpose of the present study was to determine whether standard and high-frequency transducers influence test scores on clinically used speech-in-noise (SIN) assessments, such as the Word-In-Noise (WIN) and QuickSIN tests. Sixteen…
View details →Wu, Zhang, Wang et al. · 2026 · Frontiers in ophthalmology
To assess central corneal thickness (CCT), as well as the density and morphology of corneal endothelial cells (ECD) in myopic eyes. A total of 400 patients scheduled for myopic refractive surgery were consecutively enrolled in this study.…
View details →Mukhopadhyay, Modgekar, Yang-Hood et al. · 2026 · Scientific reports
Quantal synaptic transmission in vestibular endorgans is glutamatergic. Here, we investigated the vestibular phenotype of deaf Vglut3 -/- (Slc17a8 -/- ) mice from the cellular to behavioral levels. In Vglut3 -/- mice, quantal synaptic…
View details →Li, Peng, Song et al. · 2026 · Poultry science
The development and utilization of unconventional feed such as sprayed corn bran (SCB) have effectively alleviated the shortage of feed raw materials, although its application in meat geese production has rarely been reported. Therefore,…
View details →Dambro, Anderson, Clebak et al. · 2025 · Family medicine
The integration of artificial intelligence (AI) in medical education primarily has focused on clinical applications, with limited investigation into its role in learner assessment. This study explores AI usage among family medicine…
View details →Gayraud, Lequy, Hucteau et al. · 2026 · Ophthalmology science
Age-related macular degeneration (AMD) and cataracts are part of the leading causes of blindness globally, with oxidative stress being a key factor in their development. Air pollution, known to exacerbate oxidative stress, may contribute…
View details →Sai-Ut, Indriani, Srisakultiew et al. · 2026 · Food science of animal resources
Meat tenderness is key to consumer acceptance but is challenged by goat meat's leanness and high connective tissue content. A promising solution is the in-pack combination of ultrasonication (US) and sous-vide (SV) technologies to enhance…
View details →Savaş, Kavrut, Engin · 2026 · Foods (Basel, Switzerland)
In the study, the effects of adding sour cheery seed powder at different concentrations (0%, 0.5%, 1%, and 1.5%) on the pH, water content, lipid oxidation, cooking loss, color, TPC, antioxidant activity (DPPH and ABTS), texture, and…
View details →Tian, Zhao, Huang et al. · 2026 · Foods (Basel, Switzerland)
This study focuses on the storage process of coffee beans, employing electron beam irradiation (EBI) to investigate the comprehensive effects of different irradiation doses on coffee beans and their storage process, including…
View details →Celik · 2026 · Applied clinical informatics
This study applies object-centric process mining (OCPM) techniques to analyze laparoscopic cholecystectomy (LC) procedures. Traditional process mining techniques are limited in analyzing workflows involving multiple interacting entities…
View details →Storck, Schönefeld, Bellstedt et al. · 2026 · Journal of surgical education
Prior knowledge activation (PKA) has long been considered a cornerstone of surgical education, yet recent meta-analyses reveal conflicting evidence regarding its effectiveness. This study examined when PKA enhances surgical education by…
View details →Manikanta, Kumar, Mani et al. · 2026 · Scientific reports
Distributed generators (DGs) are recent emerging technologies which are executed in distribution system (DS) to reduce power losses (PLs). However, optimal location and sizing of DG (OLSDG) remain a challenging combinatorial optimization…
View details →Wu, Zhang, Xi et al. · 2026 · Critical reviews in oncology/hematology
Ovarian cancer remains an immunologically "cold" tumor, with early all-comer immune checkpoint inhibitor (ICI) trials largely negative despite underlying immunogenicity. This review takes a clinician-centric, stage-specific view linking…
View details →Partlova, Comley, Haigh et al. · 2026 · Experimental neurology
Spinal muscular atrophy (SMA) is characterized by motor neuron loss and neuromuscular junction (NMJ) pathology. Although SMN-upregulating therapies such as Nusinersen markedly improve survival and motor function for many patients,…
View details →Li, Nelson, Li et al. · 2026 · Cancer research
Synovial sarcoma (SyS) incorporates the SS18::SSX fusion oncoprotein into GLTSCR1-containing BRG1/BRM and associated factors (GBAF) complexes, which confers a dependency on the GBAF subunit BRD9. However, SyS clinical trials with multiple…
View details →Khairil, Benny, Jerry et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
The integration of artificial intelligence (AI) into the life sciences has accelerated significantly between 2022 and 2026, accompanied by global investment exceeding USD 100 billion and widespread expectations of a transformative impact…
View details →Lee · 2026 · Journal of clinical medicine
Hypoxic-ischemic brain injury remains the leading cause of death and neurological disability after cardiac arrest. Although targeted temperature management (TTM) and other neuroprotective strategies have demonstrated promising results in…
View details →Wu, Li, Zhu et al. · 2026 · Microorganisms
The gut microbiome, often termed the human "second genome", profoundly influences host physiology through metabolic interactions, immune modulation, and gut-brain axis signaling. Dysbiosis is implicated in the pathogenesis of obesity,…
View details →Mulita, Kouroupi, Verras et al. · 2026 · Diagnostics (Basel, Switzerland)
Background and Clinical Significance: Ganglioneuromas are rare benign tumors of neural crest origin, with gastrointestinal involvement being uncommon and ampullary localization exceptionally rare. Pancreatic neuroendocrine tumors (NETs)…
View details →Mangano, Lerner, Mangano · 2026 · Journal of dentistry
To evaluate the 2-year clinical, radiographic, and prosthetic outcomes of 3D printed porous titanium implants supporting single crowns. This retrospective study included 70 patients (31 males, 39 females; mean age 58.4 ± 12.1 years)…
View details →Xu, Hu, Cai · 2026 · PloS one
The layout of the image and the positional distribution of the objects directly affect the audience's visual focus and the effect of the message conveyed. By setting up a specific layout structure, the viewer's attention can be more…
View details →Van Rompay, Tabury, Rehnberg et al. · 2026 · Cells
Three-dimensional (3D) cardiac models, including spheroids, organoids, and organ-on-chips, are advanced systems for studying human physiology, disease, and drug responses with greater biological relevance than 2D models. As their use…
View details →