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Browse the failure-mode index

21,165 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessPhysics and Astronomy

First results from the DarkSide-50 dark matter experiment at Laboratori Nazionali del Gran Sasso

P. Agnes, T. Alexander, A. Alton et al. · 2015 · Physics Letters B

We report the first results of DarkSide-50, a direct search for dark matter operating in the underground Laboratori Nazionali del Gran Sasso (LNGS) and searching for the rare nuclear recoils possibly induced by weakly interacting massive particles (WIMPs). The dark matter detector is a Liquid Argon Time Projection Chamber with a ( 46.4 ± 0.7 ) kg active mass, operated inside a 30 t organic liquid scintillator neutron veto, which is in turn installed at the center of a 1 kt water Cherenkov veto for the residual flux of cosmic rays. We report here the null results of a dark matter search for a (

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Negative / Null Result ReportOpen accessEnvironmental Science

Why do several small patches hold more species than few large patches?

Lenore Fahrig · 2020 · Global Ecology and Biogeography

Abstract Background The principle that a single large habitat patch should hold more species than several small patches totalling the same area (SL > SS) is used by conservation agencies to favour protection of large, contiguous areas.…

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Negative / Null Result ReportOpen accessEnvironmental Science

Meta‐analysis supports further refinement of eDNA for monitoring aquatic species‐specific abundance in nature

Matthew C. Yates, Dylan J. Fraser, Alison M. Derry · 2019 · Environmental DNA

Abstract The use of eDNA to detect the presence/absence of rare or invasive species is well documented and its use in biodiversity monitoring is expanding. Preliminary laboratory research has also shown a positive correlation between the concentration of species‐specific eDNA particles and the density/biomass of a species in a given environment. However, the extent to which these results can be extended to natural environments has yet to be formally quantified. We collated data from experiments that examined the correlation between eDNA and two metrics of abundance (biomass and density) and, u

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Negative / Null Result ReportOpen accessBusiness, Management and Accounting

CEO Preferences and Acquisitions

Dirk Jenter, Katharina Lewellen · 2015 · The Journal of Finance

ABSTRACT This paper explores the impact of target CEOs’ retirement preferences on takeovers. Using retirement age as a proxy for CEOs’ private merger costs, we find strong evidence that target CEOs’ preferences affect merger activity. The…

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Decision Making Under the Gambler’s Fallacy: Evidence from Asylum Judges, Loan Officers, and Baseball Umpires*

Daniel L. Chen, Tobias J. Moskowitz, Kelly Shue · 2016 · The Quarterly Journal of Economics

Abstract We find consistent evidence of negative autocorrelation in decision making that is unrelated to the merits of the cases considered in three separate high-stakes field settings: refugee asylum court decisions, loan application…

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Negative / Null Result ReportOpen accessEnvironmental Science

Aerosols enhance cloud lifetime and brightness along the stratus-to-cumulus transition

Matthew W. Christensen, William K. Jones, Philip Stier · 2020 · Proceedings of the National Academy of Sciences

Anthropogenic aerosols are hypothesized to enhance planetary albedo and offset some of the warming due to the buildup of greenhouse gases in Earth's atmosphere. Aerosols can enhance the coverage, reflectance, and lifetime of warm low-level clouds. However, the relationship between cloud lifetime and aerosol concentration has been challenging to measure from polar orbiting satellites. We estimate two timescales relating to the formation and persistence of low-level clouds over [Formula: see text] spatial domains using multiple years of geostationary satellite observations provided by the Clouds

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Negative / Null Result ReportOpen accessSocial Sciences

How will climate change shape climate opinion?

Peter D. Howe, Jennifer R. Marlon, Matto Mildenberger et al. · 2019 · Environmental Research Letters

Abstract As climate change intensifies, global publics will experience more unusual weather and extreme weather events. How will individual experiences with these weather trends shape climate change beliefs, attitudes, and behaviors? In this article, we review 73 papers that have studied the relationship between climate change experiences and public opinion. Overall, we find mixed evidence that weather shapes climate opinions. Although there is some support for a weak effect of local temperature and extreme weather events on climate opinion, the heterogeneity of independent variables, dependen

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Negative / Null Result ReportOpen accessComputer Science

The impact of site-specific digital histology signatures on deep learning model accuracy and bias

Frederick M. Howard, James M. Dolezal, Sara Kochanny et al. · 2021 · Nature Communications

The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital histology. Deep learning (DL) models have been trained on TCGA to predict numerous features directly from histology, including survival, gene expression patterns, and driver mutations. However, we demonstrate that these features vary substantially across tissue submitting sites in TCGA for over 3,000 patients with six cancer subtypes. Additionally, we show that histologic image differences between submitting sites can easily be identified with DL. Site detection remains possible despite commonly used color normaliz

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Negative / Null Result ReportOpen accessMedicine

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults

Simon Finfer, Sharon Micallef, Naomi Hammond et al. · 2022 · New England Journal of Medicine

BACKGROUND: Whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution (saline) in critically ill patients reduces the risk of acute kidney injury or death is uncertain. METHODS: In a…

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Negative / Null Result ReportOpen accessMedicine

Association of Umbilical Cord Milking vs Delayed Umbilical Cord Clamping With Death or Severe Intraventricular Hemorrhage Among Preterm Infants

Anup Katheria, Frank Reister, Jochen Essers et al. · 2019 · JAMA

Importance: Umbilical cord milking as an alternative to delayed umbilical cord clamping may provide equivalent benefits to preterm infants, but without delaying resuscitation. Objective: To determine whether the rates of death or severe…

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Firms’ knowledge search and local knowledge externalities in innovation performance

Stephen Roper, James H. Love, Karen Bonner · 2016 · Research Policy

We use an augmented version of the UK Innovation Surveys 4–7 to explore firm-level and local area openness externalities on firms’ innovation performance. We find strong evidence of the value of external knowledge acquisition both through interactive collaboration and non-interactive contacts such as demonstration effects, copying or reverse engineering. Levels of knowledge search activity remain well below the private optimum, however, due perhaps to informational market failures. We also find strong positive externalities of openness resulting from the intensity of local interactive knowledg

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Negative / Null Result ReportOpen accessNursing

Agricultural commercialization and nutrition revisited: Empirical evidence from three African countries

Calogero Carletto, Paul Corral, Anita Guelfi · 2016 · Food Policy

The transition from subsistence to commercial agriculture is key for economic growth. But what are the consequences for nutritional outcomes? The evidence to date has been scant and inconclusive. This study contributes to the debate by revisiting two prevailing wisdoms: (a) market participation by African smallholders remains low; and (b) the impact of commercialization on nutritional outcomes is generally positive. Using nationally representative data from three African countries, the analysis reveals high levels of commercialization by even the poorest and smallest landholders, with rates of

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Evaluating State and Local Business Incentives

Cailin Slattery, Owen Zidar · 2020 · The Journal of Economic Perspectives

This essay describes and evaluates state and local business tax incentives in the United States. In 2014, states spent between $5 and $216 per capita on incentives for firms in the form of firm-specific subsidies and general tax credits,…

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Negative / Null Result ReportBusiness, Management and Accounting

Impression Management in Sustainability Reports: An Empirical Investigation of the Use of Graphs

Charles H. Cho, Giovanna Michelon, Dennis M. Patten · 2012 · Accounting and the Public Interest

ABSTRACT The purpose of this paper is to investigate whether firms use graphs in their sustainability reports in order to present a more favorable view of their social and environmental performance. Further, because prior research…

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Negative / Null Result ReportOpen accessMedicine

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin, Jeannie Callum, Erin Jamula et al. · 2021 · Nature Medicine

The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence patient outcomes. We conducted an open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within 12 d of respiratory symptom onset ( NCT04348656 ). Patients were allocated 2:1 to 500 ml of convalescent plasma or standard of care. The composite primary outcome was intubation or death by 30 d. Exploratory analyses

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Negative / Null Result ReportOpen accessMedicine

Parkin Interacts with Ambra1 to Induce Mitophagy

Cindy Van Humbeeck, Tom Cornelissen, Hilde Hofkens et al. · 2011 · Journal of Neuroscience

Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy).…

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Negative / Null Result ReportOpen accessEarth and Planetary Sciences

Quantifying Environmental Control on Tropical Cyclone Intensity Change

Eric A. Hendricks, Melinda S. Peng, Bing Fu et al. · 2010 · Monthly Weather Review

Abstract Composite analysis is used to examine environmental and climatology and persistence characteristics of tropical cyclones (TCs) undergoing different intensity changes in the western North Pacific (WPAC) and North Atlantic (ATL)…

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Negative / Null Result ReportOpen accessNeuroscience

Empirical failures of the claim that autistic people lack a theory of mind.

Morton Ann Gernsbacher, Melanie Yergeau · 2019 · Archives of Scientific Psychology

The claim that autistic people lack a theory of mind-that they fail to understand that other people have a mind or that they themselves have a mind-pervades psychology. This article (a) reviews empirical evidence that fails to support the claim that autistic people are uniquely impaired, much less that all autistic people are universally impaired, on theory-of-mind tasks; (b) highlights original findings that have failed to replicate; (c) documents multiple instances in which the various theory-of-mind tasks fail to relate to each other and fail to account for autistic traits, social interacti

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Negative / Null Result ReportOpen accessEnvironmental Science

Heat-related Emergency Hospitalizations for Respiratory Diseases in the Medicare Population

G. Brooke Anderson, Francesca Dominici, Yun Wang et al. · 2013 · American Journal of Respiratory and Critical Care Medicine

RATIONALE: The heat-related risk of hospitalization for respiratory diseases among the elderly has not been quantified in the United States on a national scale. With climate change predictions of more frequent and more intense heat waves,…

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Negative / Null Result ReportComputer Science

Measuring Perceived Usability: The CSUQ, SUS, and UMUX

James R. Lewis · 2018 · International Journal of Human-Computer Interaction

The primary purpose of this research was to investigate the relationship between two widely used questionnaires designed to measure perceived usability: the Computer System Usability Questionnaire (CSUQ) and the System Usability Scale…

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Negative / Null Result ReportEnvironmental Science

Life histories predict coral community disassembly under multiple stressors

Emily S. Darling, Tim R. McClanahan, Isabelle M. Côté · 2013 · Global Change Biology

Climate change is reshaping biological communities against a background of existing human pressure. Evaluating the impacts of multiple stressors on community dynamics can be particularly challenging in species-rich ecosystems, such as…

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Negative / Null Result ReportEnvironmental Science

Movement responses by wolves to industrial linear features and their effect on woodland caribou in northeastern Alberta

A. David M. Latham, M. Cecilia Latham, Mark S. Boyce et al. · 2011 · Ecological Applications

Woodland caribou (Rangifer tarandus caribou) populations are declining across most of their range. Predation by wolves (Canis lupus) is believed to be the main proximate cause of these declines. However, it has been hypothesized that…

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Negative / Null Result ReportMedicine

Alexithymia and the Recognition of Facial Expressions of Emotion

James D. A. Parker, Graeme J. Taylor, Michael Bagby · 2010 · Psychotherapy and Psychosomatics

Slides of photographs depicting posed facial expressions of nine different emotions were presented to 131 females and 85 males who were asked to identify the emotion(s) being experienced by the person in each photograph. Subjects were then…

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Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Experience, age and exporting performance in UK SMEs

James H. Love, Stephen Roper, Ying Zhou · 2015 · International Business Review

We consider the determinants of SME exporting performance using a survey of internationally engaged UK SMEs. We first develop a model incorporating organisational and prior managerial learning effects. Our empirical analysis then allows us to identify separately the positive effects on exporting from the international experience of the firm and the negative effects of firm age. Positive exporting effects also result from grafted knowledge – acquired by the recruitment of management with prior international experience. Innovation also has positive exporting effects with more radical new-to-the-

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma

Alba A. Brandes, Alain Carpentier, Santosh Kesari et al. · 2016 · Neuro-Oncology

BACKGROUND: The combination of galunisertib, a transforming growth factor (TGF)-β receptor (R)1 kinase inhibitor, and lomustine was found to have antitumor activity in murine models of glioblastoma. METHODS: Galunisertib (300 mg/day) was…

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