21,252 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Arslan Çarpar K, Yılmaz T · 2026 · BMC oral health
BACKGROUND: This study aimed to compare the plaque removal efficacy of manual and powered toothbrushes around attachments in patients undergoing clear aligner therapy under standardized, single-brushing conditions. METHODS: This…
View details →Hakkani Öznay Ç, Findik H, Uzun F et al. · 2026 · Journal of clinical medicine
Objectives : To prospectively compare the outcomes of external dacryocystorhinostomy (EX-DCR), endonasal dacryocystorhinostomy (EN-DCR), and laser-assisted transcanalicular dacryocystorhinostomy (TL-DCR) in patients with nasolacrimal duct…
View details →Sorjonen K, Melin B, Melin M · 2026 · Preprint
Ji et al. recently reported evidence suggesting that marital satisfaction serves as a longitudinal protective factor against postpartum depressive symptoms, basing this conclusion on statistically significant paths estimated with…
View details →Smith A, Dixit I, Zhang L et al. · 2026 · JAMA dermatology
Importance Cardiovascular disease (CVD) is the leading cause of mortality in patients with psoriasis, yet structured CVD prevention is not routinely embedded in dermatology care. Objective To evaluate the effectiveness of a text-messaging…
View details →Parkhoo K, Schmitz LA, Fröb L et al. · 2026 · Dentistry journal
Objectives : Six dentin adhesives were tested in vitro regarding their cytotoxicity toward human fibroblasts. AdheSE, Clearfil SE Bond, Hybrid Bond, One-up Bond F Plus, Optibond Solo Plus, and Syntac were tested using a cell culture model.…
View details →Korodimos N, Wojtyś ME, Kostopanagiotou K et al. · 2026 · Journal of clinical medicine
Background: Non-small-cell lung cancer (NSCLC) is driven by distinct oncogenic alterations with important therapeutic and prognostic implications. Noninvasive biomarkers that predict molecular status in surgically resectable disease may…
View details →Mahajan A, Haideri S, Kumar VVH et al. · 2026 · Journal of education and health promotion
Background The oral health is an integral part of general well-being in children suffering from attention deficit hyperactivity disorder (ADHD). The present study aimed to analyze the impact of oral health education program on children…
View details →Abdi A, Abbasi E, Abazarlou A · 2026 · BMC neurology
Objectives Migraine is a common and disabling neurological disorder in children, often requiring preventive treatment. This study aimed to compare the efficacy and tolerability of cinnarizine and topiramate in the prophylaxis of migraine…
View details →Peker N, Yücetürk A, Tığlı E et al. · 2026 · Journal of ovarian research
Background We aimed to evaluate whether delayed initiation of gonadotropin hormone-releasing hormone (GnRH) antagonist treatment affects premature ovulation and the number of good-quality blastocysts. We retrospectively reviewed the…
View details →Yan Z, Jiang Q, Lu Z et al. · 2026 · International journal of general medicine
Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Observational studies suggest a link with gut microbiota (GM), possibly mediated by systemic inflammation, but causality remains unclear. Objective To…
View details →Conde-Disla E, González-Olmo MJ, Olmos-Valverde M et al. · 2026 · Dentistry journal
Background: Pain during orthodontic debonding is a common clinical concern. Although previous studies have mainly focused on mechanical approaches to reduce discomfort, the influence of emotional characteristics of patients on pain…
View details →Xu X, Zhang B, Wang X et al. · 2026 · Orthopaedic surgery
Objective There is no consensus on the age restriction for total ankle arthroplasty (TAA) patients. The aim of our study was to analyze the clinical function, radiographic outcomes, patient satisfaction, and complications between patients…
View details →Agarwal P, Kumar P, Chugh VK et al. · 2026 · Cureus
Background and aim Postoperative pain following root canal treatment (RCT) can be influenced by the obturation technique, as variations in apical sealing and material extrusion may affect periapical tissue response. The aim of this study…
View details →Lopresti AL, Smith SJ, Ferdinands FR · 2026 · Frontiers in reproductive health
Background Khaya senegalensis is a tree species that has traditional use for the alleviation of menstrual and hormonal symptoms in women. Moreover, supplementation with a Khaya senegalensis preparation (Khapregesic®) was associated with…
View details →Mousa N, Hasan AK · 2026 · Cureus
Background This study aimed to evaluate nasal morphological characteristics and their relationship with vertical facial growth patterns in a Syrian adult population using lateral cephalometric analysis. Methodology This retrospective…
View details →Atsuta S, Koizumi S, Takahashi SS et al. · 2026 · Dentistry journal
Background/Objectives : Acceleration of orthodontic tooth movement remains a major challenge in clinical orthodontics. Evidence suggests that increased local blood flow around the alveolar bone is key to bone remodeling and potentially…
View details →Yiğit N, Nazlıgül AS, Ülgen NK et al. · 2026 · Geriatric orthopaedic surgery & rehabilitation
Background Distal radius fractures are common among elderly patients and frequently pose management challenges due to advanced age, multiple comorbidities, and increased anesthesia-related risks. In high-risk individuals with limited…
View details →Rogalska E, Stenka W, Kupcewicz E et al. · 2026 · Frontiers in public health
Introduction Breast cancer is the most common malignancy among women worldwide. Mastectomy, often accompanied by breast reconstruction, plays a key role in treatment and prevention among high-risk patients; however, psychological outcomes…
View details →Nowell S, Fantini O, Roman A et al. · 2026 · Veterinary dermatology
Fluorescent light energy (FLE; Phovia, Vetoquinol) is a photobiomodulation therapy that promotes healing and reduces inflammation. Cutaneous epitheliotropic lymphoma (CTCL) is a neoplastic skin disease with limited treatment options.…
View details →Pei Y, Jones L, Minga J · 2026 · American journal of speech-language pathology
Purpose This study investigated patterns of question use in conversation among individuals with traumatic brain injury (TBI) by analyzing the frequency, types, and social actions of the questions. Method Questions from conversational…
View details →Ilbekova K, Ibrayeva D, Saifulina E et al. · 2026 · Journal of clinical medicine
Background/Objectives : Cancer incidence and mortality are key epidemiological indicators for evaluating the long-term biological effects of chronic low-dose radiation exposure. The aim of this study was to assess the incidence, structure,…
View details →Plaikner A, Ploner M, Sewald Z et al. · 2026 · Preprint
Protein Language Models (pLMs) have significantly advanced computational biology. Yet their scale and reliance on redundant training data raise a fundamental question: do pLMs generalize the statistical grammar of proteins, or do they…
View details →Shan J, Yu J, Zhao L et al. · 2026 · BMC cancer
Background Dose reduction during concurrent chemoradiotherapy (cCRT) is frequently required in patients with limited-stage small-cell lung cancer (LS-SCLC) because of treatment-related toxicities or poor tolerance. However, the impact of…
View details →Mohammed S, Kyei L, Okyere F et al. · 2026 · Preprint
Abstract Background: PAM50 molecular subtype is an established prognostic factor in breast cancer, yet unmeasured heterogeneity may persist within and between subtypes. We evaluated whether shared frailty modeling provides additional…
View details →Alkhalifah OF, Ali Shah S, Tareen SUK et al. · 2026 · Cureus
Background Achieving a lifelike color match for anterior restorations is a persistent challenge because tooth appearance is heavily influenced by illumination and observer-dependent choices. While visual matching with VITA-type guides…
View details →Kiplimo D, Sperber S, Nata’ala MK et al. · 2026 · Preprint
Abstract Background Antimicrobial resistance (AMR) in plant-associated microbiomes is increasingly recognized as One-Health concern. Apples are widely consumed, yet little is known about how agricultural practices and geography shape its…
View details →Matsumoto T, Yamamoto Y, Kotaka M et al. · 2024 · Targeted oncology
Background Non-inferiority of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) to irinotecan/fluoropyrimidine plus BEV in metastatic colorectal cancer was investigated in the phase III TRUSTY study, and we conducted a phase II study…
View details →Halpin M, Lerner A, Sagar M et al. · 2023 · Preprint
The systemic inflammatory response seen in patients with severe COVID-19 shares many similarities with the changes observed in hemophagocytic lymphohistiocytosis (HLH); a disease characterized by excessive immune activation. Many patients…
View details →Webers C, Ortolan A, Sepriano A et al. · 2023 · Annals of the rheumatic diseases
Objective To update the evidence on efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of SpondyloArthritis…
View details →Ma XT, Yao GY, Li JL et al. · 2025 · World journal of clinical oncology
Background Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) represents a distinct molecular cancer subtype that is often associated with a poor prognosis. While perioperative chemotherapy regimens are currently…
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