e-ISSN: Pending

Browse the failure-mode index

21,252 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Sentinel Lymph Node Mapping Compared with Selective Lymph Node Sampling in the Surgical Staging of Endometrial Cancer: A Prospective Observational Study.

Gâta, Ilieș, Mureșan-Bădescu et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Nowadays, lymph node assessment represents a key component in the surgical staging of endometrial cancer, as sentinel lymph node (SLN) mapping increased in adoption as an alternative to lymphadenectomy. This study…

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Negative / Null Result ReportMedicine

Diagnostic Value of Ocular Hemodynamics and Choroidal Thickness in Unilateral Sudden Sensorineural Hearing Loss: Non-Invasive Biomarkers of Systemic Microvascular Disease.

Findik, Kaim, Uzun et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: Although vascular mechanisms are increasingly implicated in the etiology of sudden sensorineural hearing loss (SSNHL), the inability to directly visualize the labyrinthine artery remains a diagnostic obstacle.…

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Negative / Null Result ReportMedicine

Antimicrobial effect of 1064 nm Nd:YAG laser with flat-top homogeneous beam profile on oral fungal and bacterial biofilms: an in vitro study.

Grzech-Leśniak, Pyrkosz, Szwajkowski et al. · 2026 · Lasers in medical science

This in vitro study aimed to evaluate the antimicrobial effects of a 1064 nm Nd:YAG laser delivered through a novel handpiece designed to provide a flat-top, homogeneous energy distribution profile (MarcoM handpiece) against key oral…

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Negative / Null Result ReportMedicine

Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.

Alshaibani, Kamadjaja, Sitalaksmi et al. · 2026 · Journal of molecular histology

Tooth extraction is a common procedure often followed by alveolar bone resorption, which may compromise future implant placement, prosthetic rehabilitation, esthetics, and periodontal support. Hydroxyapatite-chitosan (HA-Chi) scaffolds…

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Negative / Null Result ReportMedicine

Metformin and renal dosimetry in patients undergoing [ 177 Lu]Lu-PSMA therapy: reduced kidney absorbed dose without impact on tumor dosimetry.

Siegmund, Delker, Widjaja et al. · 2026 · European journal of nuclear medicine and molecular imaging

Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy (RPT) is an established treatment for advanced prostate cancer, but renal radiation exposure remains a major safety concern, as no clinically established…

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Negative / Null Result ReportMedicine

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Nomura, Kimata, Ito et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: To directly compare the capabilities of hybrid-type iterative reconstruction (IR) with the newly developed deep learning reconstruction (DLR) for the inner ear on high-definition CT (HDCT) obtained using the…

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Negative / Null Result ReportMedicine

Rural medical disparities in multimodal glioblastoma treatment.

Momii, Hata, Fudaba et al. · 2026 · Scientific reports

Glioblastoma continues to have a poor prognosis, although recent advancements in multimodal treatments have gradually improved outcomes. However, treatment options have become increasingly complex and highly specialized. In rural areas,…

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Negative / Null Result ReportMedicine

Impact of hydrophobic ion pair type and self-nanoemulsifying drug delivery systems composition on the oral delivery of salmon calcitonin.

Al-Maghrabi, Müllertz, Rades · 2026 · Journal of controlled release : official journal of the Controlled Release Society

Salmon calcitonin (sCT) is a peptide with poor enzymatic stability and permeability, limiting its oral delivery. This study investigated how hydrophobic ion pair (HIP) type and self-nanoemulsifying drug delivery systems (SNEDDS)…

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Negative / Null Result ReportMedicine

A multicenter randomized controlled trial comparing metallic stents with 10- versus 14-mm diameter for distal biliary obstruction caused by unresectable pancreatic carcinoma.

Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy

Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…

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Abandoned HypothesisMedicine

Formaldehyde metabolism in the biocatalytic upgrading of lignin.

Lalande AT, Eltis LD · 2026 · Current opinion in biotechnology

Formaldehyde is a toxic metabolite generated in the bacterial catabolism of lignin-derived aromatic compounds (LDACs) through the oxidative O-demethylation of methoxylated aromatics. Microbial cell factories designed to convert LDACs to…

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Negative / Null Result ReportMedicine

Prognostic markers, quality of life (QoL) and value of health (V-He) in advanced biliary cancers (ABC) treated with second-line active symptom control (ASC) alone or ASC with oxaliplatin-5-FU chemotherapy (ASC + FOLFOX) in the randomised phase III, multicentre, open-label ABC-06 clinical trial.

Lamarca, Palmer, Wasan et al. · 2026 · ESMO open

The ABC-06 trial established FOLFOX as the reference second-line regimen for patients diagnosed with advanced biliary tract cancer (ABC). Here we analysed the prognostic role of tumour markers carbohydrate antigen 19-9 (CA19-9),…

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Negative / Null Result ReportMedicine

Transition practices of patients with inflammatory bowel disease from pediatric to adult healthcare systems. Results from a national survey.

Leruste, Ley, Gottrand et al. · 2026 · Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

Although recommendations for structured transition programs in adolescents with Inflammatory Bowel Diseases (IBD) have been published, few studies have addressed the implementation of transition in real-life settings at a national level.…

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Negative / Null Result ReportMedicine

Impact of testosterone therapy and hypogonadism on treatment outcomes in Peyronie's disease: a multicenter retrospective analysis of collagenase clostridium histolyticum therapy.

Hernandez, Walia, Coady et al. · 2026 · The journal of sexual medicine

Peyronie's disease (PD) is an acquired connective tissue disorder characterized by fibrous plaque formation within the penile tunica albuginea that may be influenced by androgen status. To evaluate whether baseline testosterone levels and…

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Negative / Null Result ReportMedicine

An Internet-Based Mindfulness- and Compassion-Based Intercare Program for Reducing Parental Burnout: Randomized Controlled Trial.

Villalón López, Escaffi-Schwarz · 2026 · Journal of medical Internet research

Parental burnout is an underrecognized syndrome characterized by emotional exhaustion, detachment from children, and reduced parental efficacy. It is associated with sleep disturbance, addictive behaviors, suicidal ideation, and increased…

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Negative / Null Result ReportMedicine

Pancreatitis in Familial Dysautonomia Patients.

Benson, Cohen, Peskin et al. · 2026 · Digestive diseases (Basel, Switzerland)

Introduction Familial Dysautonomia (FD) is characterized by abnormal function of autonomic and sensory nervous systems. Gastrointestinal (GI) symptoms are extremely prevalent in FD patients, but the impact of FD on the pancreas is less…

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Negative / Null Result ReportMedicine

The Impact of Glucagon-Like Peptide 1 Receptor Agonists Versus Diabetes Mellitus on Endoscopic Procedures: A Case-Control Study From a Large Tertiary Care Health System.

Bahdi, Bachu, Aldzhyan et al. · 2026 · Journal of clinical gastroenterology

While glucagon-like peptide 1 receptor agonists (GLP1-RAs) increase the risk of gastric food retention (GFR) and inadequate bowel preparation (IBP), the confounding role of diabetes mellitus is still questioned. Here, we compare the…

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Negative / Null Result ReportMedicine

Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms.

Baskar, Patel, Rose et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

The incidence of neuroendocrine neoplasms (NENs) is rising, particularly among younger patients, but data comparing early-onset (EO-NENs) and average-onset (AO-NENs) remain limited. Using the National Inpatient Sample (2016-2020), we…

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Negative / Null Result ReportMedicine

Minimally invasive stabilisation of anterior pelvic ring injuries through anterior infix versus percutaneous anterior retrograde pubic screw: a prospective comparative cohort study.

Goda El-Hamalawy, Abdelmoneim, Al-Sayed et al. · 2026 · Archives of orthopaedic and trauma surgery

Management of unstable anterior pelvic ring fractures has shifted toward minimally invasive fixation techniques. This prospective randomized cohort study compares anterior subcutaneous internal fixator with percutaneous retrograde pubic…

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