Negative / Null Result ReportOpen accessEngineering
Fengxiang Liu, Shipeng Ning, Xia Wang et al. · 2025 · Science Advances
Cancer stem cells (CSCs) and myeloid-derived suppressor cells (MDSCs) contribute to chemoresistance and immunosuppression, constraining chemoimmunotherapy outcomes. Differentiation therapy, aiming to mature CSCs and MDSCs, shows great promise. However, its efficacy is hindered by limited accessibility in hypoxic deep tumor regions. Inspired by the apoptotic body (ApoBD)-mediated deep tumor penetration, we design a pulsatile sequential drug release system with a core-shell structure. The reversible acid-responsive shell protonates and swells in lysosomes to release doxorubicin, inducing lysosom
View details →Failed Experiment ReportOpen accessMedicine
Sahar Motamedi, Nina Ravoet, Jonas Dehairs et al. · 2025 · Nature Communications
Ferroptosis, a regulated form of cell death driven by lipid peroxidation, holds promise for targeting treatment-resistant cancer cells. Using a panel of melanoma cell lines, we uncover variability in the timing of ferroptosis onset upon…
View details →Negative / Null Result ReportOpen accessMedicine
Golan Carmi · 2025 · Education Sciences
Generative AI technologies are rapidly permeating higher education as innovative tools that support teaching and learning processes. This study investigates the integration of GenAI tools into academic learning and examines their influence on students’ learning effectiveness, attitudes, and satisfaction. A quantitative survey was administered to 485 college students. The findings indicate that students’ attitudes, satisfaction, and accumulated experience with GenAI constitute the most influential factors in promoting effective learning. Perceived advantages and disadvantages also play a substa
View details →Negative / Null Result ReportOpen accessPsychology
Gerui Xu, Shruthi Venkatesha Murthy, Bochen Jia · 2025 · Informatics
As AI decision support systems play a growing role in high-stakes decision making, ensuring effective integration of human intuition with AI recommendations is essential. Despite advances in AI explainability, challenges persist in fostering appropriate reliance. This review explores AI decision support systems that enhance human intuition through the analysis of 84 studies addressing three questions: (1) What design strategies enable AI systems to support humans’ intuitive capabilities while maintaining decision-making autonomy? (2) How do AI presentation and interaction approaches influence
View details →Negative / Null Result ReportOpen accessEngineering
Lihua Liang, Xiaodong Li, Shutong Liu et al. · 2026 · Buildings
This study develops and applies an integrated methodology that combines deep learning-based computer vision and spatial statistics to automate the large-scale identification and analysis of morphological features in vernacular courtyard dwellings. Focusing on Liangshuaixiu dwellings in Wu’an, southern Hebei, we trained an HRNetV2 semantic segmentation model on high-resolution satellite imagery to identify and extract contours for 134,280 courtyard spaces. Core morphological parameters (area, orientation) were calculated and analyzed using GIS spatial statistics and the geographic detector mode
View details →Negative / Null Result ReportOpen accessMedicine
Ruben P. A. van Eijk, Daphne N. Weemering, Sarah Opie-Martin et al. · 2025 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Objective To characterize the natural history of the revised ALS functional rating scale (ALSFRS-R) over a 24-month period following initial assessment, and to assess its associations with survival.Methods Longitudinal ALSFRS-R…
View details →Negative / Null Result ReportOpen accessMedicine
Émilie Le Rhun, Lakshmi Nayak, Mary Jane Lim-Fat et al. · 2024 · Neuro-Oncology
BACKGROUND: There are no validated tools for the clinical neurological assessment of patients with leptomeningeal metastases (LM). However, clinical examination during the course of the disease guides medical management and is part of response assessment in clinical trials. Because neuroimaging may not always be obtained owing to rapid clinical deterioration, clinical neurological assessment of LM is essential, and standardization is important to minimize rater disagreement. METHODS: The Response Assessment in Neuro-oncology-LM group launched a 2-step process, aiming at improving and standardi
View details →Negative / Null Result ReportOpen accessEngineering
Fhysmélia Firmino de Albuquerque, Rodrigo M. Iost, Frank N. Crespilho · 2025 · ACS Measurement Science Au
The development of enzyme-based bioelectronic devices, including biosensors and biomimetic systems, has significantly advanced with the introduction of innovative materials such as hydrogels, deep eutectic solvents (DES), and ionic liquids (ILs). These materials offer unique advantages in enhancing biodevice performance, particularly in enzyme stabilization, biocompatibility, and electrochemical sensitivity. Hydrogels, known for their high water content and flexibility, provide an ideal matrix for enzyme immobilization in biological applications but are limited by low ionic conductivity. DES,
View details →Negative / Null Result ReportOpen accessMedicine
Gustavo Jimenez‐Maggiora, Arndt‐Peter Schulz, Michael Donohue et al. · 2024 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies were conducted between 2014 and 2023, with enrollment completed in 2017 and final study results reported in 2023. The study screening process involved the collection of initial clinical, cognitive, neuroimaging, and genetic measures to determine eligibility. Once randomized, enrolled participants were assessed every four weeks over a 4.5-year follow-up period during which longitudinal clinical, cognitive, and neuroimaging measures wer
View details →Negative / Null Result ReportOpen accessMedicine
Qun Xiao, WeiCheng Huang, Yuheng Zhuang et al. · 2025 · Aging Clinical and Experimental Research
BACKGROUND: Stroke is a significant public health issue, with its risk influenced by various metabolic factors. The Cholesterol, High-Density Lipoprotein, Glucose (CHG) index has been identified as a valid stroke predictor. However, the…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Alina Marculetiu, Çiğdem Ataseven, Injazz J. Chen · 2025 · Business Ethics the Environment & Responsibility
ABSTRACT This study investigates the effectiveness of institutional pressures in motivating two contrasting sustainability strategies, symbolic and substantive, and their subsequent impact on the triple bottom line (TBL). Using data from…
View details →Replication FailureOpen accessSocial Sciences
Cristina Expósito-Álvarez, Manuel Roldán-Pardo, Gail Gilchrist et al. · 2024 · Psychosocial Intervention
Objective: Intimate partner violence (IPV) perpetrators with alcohol and/or other drug use problems (ADUPs) have been identified as one of the main high-risk and highly resistant groups of perpetrators requiring special attention in…
View details →Negative / Null Result ReportOpen accessMedicine
Solveigh C. Koeberle, Maria Thürmer, Fengting Su et al. · 2025 · Theranostics
: Our study deciphers the structural features of silybin contributing to hepatic lipid remodeling and suggests that silymarin/silybin protects the liver in individuals with mild metabolic dysregulation, involving a lipid class switch from triglycerides to phospholipids, whereas it may be less effective in disease states associated with severe metabolic dysregulation.
View details →Negative / Null Result ReportOpen accessMedicine
Mateja Napravnik, Franko Hržić, Martin Urschler et al. · 2025 · Scientific Reports
Deep learning models require large amounts of annotated data, which are hard to obtain in the medical field, as the annotation process is laborious and depends on expert knowledge. This data scarcity hinders a model's ability to generalise…
View details →Negative / Null Result ReportOpen accessNursing
Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer et al. · 2025 · Pharmaceutics
Selenium nanoparticles (SeNPs) have emerged as promising metal-based nanoparticles for drug delivery due to their unique physicochemical properties, intrinsic bioactivity, and biocompatibility. SeNPs offer a lower toxicity, higher bioavailability, and flexibility to be customized for surface chemistry compared to traditional selenium compounds. Advances in synthetic strategies, including chemical reduction, green biosynthesis, and surface functionalization with polymers, peptides, or ligands, have improved their stability, targeting capability, and circulation time. SeNP-based systems have dem
View details →Negative / Null Result ReportOpen accessDecision Sciences
Pablo Ruiz‐Palomino, Juliana Toro‐Arias, María del Pilar Rodríguez‐Córdoba et al. · 2025 · Business Ethics the Environment & Responsibility
ABSTRACT A supportive ethical culture (EC) can encourage moral behavior among employees and help them avoid wrongdoing. One option for fostering EC is ethics training; its longer‐term effectiveness, however, has rarely been examined,…
View details →Negative / Null Result ReportOpen accessEnergy
Haisheng Zhang, Jiawei Li, Haijing Yan et al. · 2025 · Advanced Materials
Proton exchange membrane water electrolysis (PEMWE) is a promising blueprint for the industrial production of green hydrogen in the short term, but its large-scale deployment is extremely constrained by the high cost and low storage of…
View details →Negative / Null Result ReportOpen accessMedicine
Bekir Enes Koca, Sümeyye Sarıtaş, Mikhaël Bechelany et al. · 2025 · International Journal of Molecular Sciences
Polyphenols are bioactive molecules that occur naturally in plants and exhibit a diverse array of properties, including antioxidant, anti-inflammatory, and anti-obesity effects, all of which have been supported by numerous studies. They are categorized into four main groups: flavonoids, phenolic acids, stilbenes, and lignans. Polyphenols demonstrate a wide range of health-promoting effects throughout human life, from the womb to old age. They can exert these effects by modulating signaling pathways, regulating gut microbiota, influencing gene expression, and regulating epigenetic pathways. Thi
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Ming Yi, Tianye Li, Yinhui Gu et al. · 2026 · Nature Communications
Antibodies targeting TGF-β and PD-L1 initially showed promise as second-generation PD-L1 agents. However, consecutive trial failures have limited their clinical success. Our study reveals that the efficacy of the TGF-β×PD-L1 bispecific…
View details →Negative / Null Result ReportOpen accessComputer Science
M. Said Doğru, Emily Faulconer · 2025 · Research in Science Education
Abstract The emergence of ChatGPT brings an opportunity to lighten the workload of in-person teaching assistance in science laboratory courses. We investigated the use of the language model developed by OpenAI as a virtual teaching assistant for an introductory undergraduate biology laboratory course. Student-generated questions related to a laboratory exercise on enzyme activity were separately provided to ChatGPT and a cohort of graduate teaching assistants (TAs). Responses were evaluated for content accuracy and teaching effectiveness. Results revealed that human TAs were more accurate in t
View details →Replication FailureOpen accessMedicine
Nicholas A. Marston, Erin A. Bohula, Ajay Bhatia et al. · 2026 · JAMA
Importance: Intensive lowering of low-density lipoprotein cholesterol (LDL-C) levels with PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors for cardiovascular event reduction has largely been reserved for patients with…
View details →Negative / Null Result ReportOpen accessMedicine
Nina Boskovic, Marilin Ivask, Gamze Yazgeldi Gunaydin et al. · 2025 · Scientific Reports
Abstract Mammalian preimplantation embryo development is a complex sequence of events. This period of development is sensitive to oxygen (O 2 ) levels that can affect various cellular processes. We compared the influence of O 2 tension by culturing embryos either in normoxic (20% O 2 ) or physiological hypoxic (6% O 2 ) conditions, or sequential low O 2 concentration starting with 6% O 2 until 16-cell stage and then switching to ultrahypoxic conditions (2% O 2 ). Due to ethical concerns, we used bovine as an animal model with a good similarity of embryogenesis to human. We found that the cleav
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Paul Behrens, Catherine M. Champagne, Jason C. G. Halford et al. · 2025 · Frontiers in Science
The global obesity crisis involves an unprecedented and rapid change to the human phenotype. Conferring vast levels of avoidable morbidity and mortality at enormous cost, it has proved refractory to previous policy-led action. This article reviews recent developments in our understanding of obesity and its links to the climate co-crisis, aiming to inform evidence-based, societal-level actions to address both. Recent therapeutic developments now offer transformative interventions for millions of people living with obesity. However, treating all affected adults and children with major bariatric
View details →Negative / Null Result ReportOpen accessEngineering
J. Jithish, Nagarajan Mahalingam, Bo Wang et al. · 2025 · Cybersecurity
Abstract The forthcoming 6G technology offers significant potential for the advancement of the smart grid domain. 6G promises ultra-low latency, higher data transfer rates, native Artificial Intelligence (AI) support, enhanced connectivity, and improved security for smart grids. Smart grids are vulnerable to cyberattacks, such as Distributed Denial-of-Service (DDoS) attacks, posing a significant threat to grid functionality. To address security concerns, smart grids implement intrusion detection systems (IDS), but detecting novel attacks such as subtle multi-domain DDoS attacks through traditi
View details →Negative / Null Result ReportOpen accessEngineering
Lina Maria Ellegård, Gustav Kjellsson, Linn Mattisson · 2026 · The Economic Journal
Abstract The emergence of markets for on-demand online physician consultations —direct-to-consumer telemedicine (DCT) — is currently transforming many healthcare settings. DCT may be a cost-effective substitute for in-person consultations, but the convenience of seeking DCT may increase the demand for the service and consequently also the costs for health insurers. To causally assess the degree to which DCT consultations substitute for in-person primary care consultations, we exploit exogenous changes in patient fees in a fuzzy difference-in-discontinuities analysis of young adults in Sweden.
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
A. J. Nayana, R. Margutti, Eli Wiston et al. · 2025 · The Astrophysical Journal Letters
Abstract We present X-ray (0.3–79 keV) and radio (0.25–203 GHz) observations of the most luminous fast blue optical transient (LFBOT) AT 2024wpp at z = 0.0868, spanning 2–280 days after first light. AT 2024wpp shows luminous ( L X ≈ 1.5 × 10 43 erg s −1 ), variable X-ray emission with a Compton hump peaking at δt ≈ 50 days. The X-ray spectrum evolves from a soft ( F ν ∝ ν −0.6 ) to an extremely hard state ( F ν ∝ ν 1.26 ) accompanied by a rebrightening at δt ≈ 50 days. The X-ray emission properties favor an embedded high-energy source shining through asymmetric expanding ejecta. We detect radi
View details →Negative / Null Result ReportOpen accessSocial Sciences
Matěj Opatrný, Tomáš Havránek, Zuzana Iršová et al. · 2025 · Journal of Labor Economics
Class size reduction mandates are frequent and invariably justified by studies reporting positive effects on student achievement. Yet other studies report no effects, and the literature as a whole awaits correction for potential…
View details →Negative / Null Result ReportOpen accessEngineering
Bianca Menzani, Priscille De Gea, Xavier Gidrol et al. · 2026 · Lab on a Chip
models for studying human physiology, development and disease. Their potential is very important and they have broad applications, but their impact is currently limited by persistent challenges such as incomplete maturation, batch…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Orkhan Ibrahimov, László Vancsura, Anett Parádi-Dolgos · 2025 · Economies
Measuring financial performance is pivotal not only for assessing a firm’s current health but also for informing strategic decisions that shape its long-term trajectory. This study investigates how macroeconomic volatility affects the firm profitability across five major sectors in Türkiye—industrial manufacturing, food, beverage and tobacco, chemicals and plastics, technology, and energy—during the turbulent period from 2016 to 2023. Using return on assets (ROA) and return on equity (ROE) as performance indicators, we apply panel data regression to test the impact of inflation, interest rates
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Amalie Kjær Andresen, Mathilde Sophie Felding, Margarida M. A. Sacramento et al. · 2025 · Journal of Controlled Release
Bacterial biofilms pose a significant clinical challenge due to their intrinsic resistance to antibiotics and immune clearance. Traditional systemic antibiotic therapies are often ineffective against the structured microbial communities, emphasizing the urgent need for localized and targeted drug delivery systems. Hydrogels are three-dimensional, water-rich polymeric networks, and have emerged as a versatile platform for localized delivery of antimicrobial agents, offering controlled release, biocompatibility and the potential for functionalization with bioactive components. This review explor
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