Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Katsiaryna Salavei Bardos, Dev R. Mishra, Hyacinthe Somé · 2025 · Journal of Corporate Finance
In a sample of U.S. firms, we find strong evidence that firms' implied cost of equity is decreasing in a novel proxy of firm-level climate change sentiments of earnings call participants, supporting prior literature that shows investors demand higher returns from their investments in brown firms and lower returns from that in green firms. This effect, however, is particularly pronounced for the firm-years headquartered in the states experiencing higher than median per-capita energy related CO2 emissions, those headquartered in climate related disaster intensive counties and those headquartered
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Eva S. M. van der Heijden, Karin Näsvall, Fernando Seixas et al. · 2025 · Proceedings of the National Academy of Sciences
A central question in evolutionary biology is what drives the diversification of lineages. Rapid, recent radiations are ideal systems for this question because they still show key morphological and ecological adaptations associated with speciation. While most research on recent radiations focuses on those occurring in insular environments, less attention has been given to continental radiations with complex species interactions. Here, we study the drivers of continental radiations of Melinaea and Mechanitis butterflies (Nymphalidae: Ithomiini), which have rapidly radiated in the continental Ne
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Eliza Neights, Eric Burns, Chris L. Fryer et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Gamma-ray bursts are the most luminous electromagnetic events in the Universe. Their prompt gamma-ray emission has typical durations between a fraction of a second and several minutes. A rare subset of these events have durations in excess of a thousand seconds, referred to as ultra-long gamma-ray bursts. Here, we report the discovery of the longest gamma-ray burst ever seen with a $\sim$25 000 s gamma-ray duration, GRB 250702B, and characterize this event using data from four instruments in the InterPlanetary Network and the Monitor of All-sky X-ray Image. We find a hard spectrum, su
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anagha Krishna, Alison Meynert, Karamjit Singh Dolt et al. · 2026 · Nature Genetics
CTNNB1, the gene encoding β-catenin, is a frequent target for oncogenic mutations activating the canonical Wnt signaling pathway, typically through missense mutations within a degron hotspot motif in exon 3. Here, we combine saturation genome editing with a fluorescent reporter assay to quantify signaling phenotypes for all 342 possible missense mutations in the mutation hotspot. Our data define the genetic requirements for β-catenin degron function, refine the consensus motif for substrate recognition by β-TRCP and reveal diverse levels of signal activation among known driver mutations. Tumor
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Lucie E. Rowland, Mauro Stefanon, R. J. Bouwens et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Metallicity is a crucial tracer of galaxy evolution, providing insights into gas accretion, star formation, and feedback. At high redshift, these processes reveal how early galaxies assembled and enriched their interstellar medium. In this work, we present rest-frame optical spectroscopy of 12 massive ($\log (M_*/\mathrm{{\rm M}_{\odot }})>9$) galaxies at $z\sim 6$–8 from the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimetre/submillimetre Array (ALMA) large program, observed with the James Webb Space Telescope (JWST) NIRSpec integral field unit spec
View details →Negative / Null Result ReportMedicine
Manav Raj, Justin M. Berg, Rob Seamans · 2026 · Journal of Experimental Psychology General
= 27,491), we examine how evaluations of creative writing are affected by whether participants believe the content is produced with an AI model. We find consistent evidence of an AI disclosure penalty: Participant evaluations of creative…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Orkhan Ibrahimov, László Vancsura, Anett Parádi-Dolgos · 2025 · Economies
Measuring financial performance is pivotal not only for assessing a firm’s current health but also for informing strategic decisions that shape its long-term trajectory. This study investigates how macroeconomic volatility affects the firm profitability across five major sectors in Türkiye—industrial manufacturing, food, beverage and tobacco, chemicals and plastics, technology, and energy—during the turbulent period from 2016 to 2023. Using return on assets (ROA) and return on equity (ROE) as performance indicators, we apply panel data regression to test the impact of inflation, interest rates
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sourav Goswami, Alisha Ansari, Chetan Saraf et al. · 2026 · Nature Communications
Bifidobacteria are key health-associated members of the human gut microbiome and are widely used as probiotics, but their colonization success varies substantially between individuals, partly due to baseline microbiome composition. We…
View details →Negative / Null Result ReportOpen accessMedicine
Emanuel J. Novais, Olivia K. Ottone, Sanjana Jagannath et al. · 2026 · Bone Research
Genetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeutic strategies to mitigate it: Navitoclax (Nav.) and a cocktail of Dasatinib and Quercetin (DQ). While Nav. treatment did not improve severe degeneration in SM/J mice or senescence status, DQ-treated mice showed lower grades of degeneration and a decreased abundance of senescence markers, including p19ARF, p21, and the senescence-assoc
View details →Negative / Null Result ReportOpen accessSocial Sciences
Matěj Opatrný, Tomáš Havránek, Zuzana Iršová et al. · 2025 · Journal of Labor Economics
Class size reduction mandates are frequent and invariably justified by studies reporting positive effects on student achievement. Yet other studies report no effects, and the literature as a whole awaits correction for potential…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Forest ISBELL, A. Mori, Michel Loreau et al. · 2026 · Nature
Stability can be desirable for many natural and social systems. Temporal stability, the invariability of a system over time, can be enhanced by resisting displacement during perturbations, accelerating recovery after them, or both1–4.…
View details →Negative / Null Result ReportOpen accessNeuroscience
Louis Roberts, Juho Äijälä, Florian Bürger et al. · 2026 · Nature Communications
The cortex generates diverse neural dynamics, ranging from broadband fluctuations to narrowband oscillations at specific frequencies. Here, we investigated whether broadband and oscillatory dynamics play different roles in the encoding and transmission of visual information. We used information-theoretical measures to dissociate neural signals sharing common information (i.e., redundancy) from signals encoding complementary information (i.e., synergy). We analyzed electrocorticography (ECoG) and local field potentials (LFP) in the visual cortex of human and non-human primates (macaque) to inve
View details →Negative / Null Result ReportOpen accessEngineering
J. Jithish, Nagarajan Mahalingam, Bo Wang et al. · 2025 · Cybersecurity
Abstract The forthcoming 6G technology offers significant potential for the advancement of the smart grid domain. 6G promises ultra-low latency, higher data transfer rates, native Artificial Intelligence (AI) support, enhanced connectivity, and improved security for smart grids. Smart grids are vulnerable to cyberattacks, such as Distributed Denial-of-Service (DDoS) attacks, posing a significant threat to grid functionality. To address security concerns, smart grids implement intrusion detection systems (IDS), but detecting novel attacks such as subtle multi-domain DDoS attacks through traditi
View details →Replication FailureOpen accessMedicine
Sara A. Hurvitz, Rachel M. Layman, Giuseppe Curigliano et al. · 2026 · Journal of Clinical Oncology
PURPOSE Gedatolisib potently targets all four class I PI3K isoforms and mTORC1 and mTORC2 to comprehensively block the PI3K/AKT/mTOR pathway and has shown compelling activity in early clinical trials with palbociclib and fulvestrant.…
View details →Negative / Null Result ReportOpen accessMedicine
Danielle J Sisnett, Katherine B Zutautas, Dan Hoang Nguyet Vo et al. · 2026 · Frontiers in Immunology
Endometriosis is a chronic inflammatory, hormone dependent disorder that affects more than 200 million women worldwide. Immune dysfunction has emerged as one of the predominant mechanisms facilitating endometriosis lesion growth and survival. In particular, T cell subsets are predominant effector immune cells within the complex endometriosis lesion microenvironment. T cell biology encompasses a highly regulated and diverse network of cellular differentiation, antigen recognition, and immune regulation, all of which play critical roles in immune homeostasis. This complexity becomes particularly
View details →Negative / Null Result ReportOpen accessSocial Sciences
Peter Eshak Nashed Soliman, Reham Beram · 2025 · Journal of the Knowledge Economy
Abstract In the face of escalating unemployment rates and the pressing demand for sustainable development, this paper examines the dynamic interplay between technological innovation, information and communications technology (ICT), financial inclusion, and governance quality—key components of the knowledge-based economy and the Sustainable Development Goals (SDGs) 9 and 16—on unemployment (SDG 8) across diverse regions. Using a panel dataset spanning 2004 to 2020 for five regions (Middle East and North Africa, Sub-Saharan Africa, Latin America, Asia, and Europe), a dynamic two-step system gene
View details →Negative / Null Result ReportOpen accessHealth Professions
Guozheng Wang, Xiaoxia Liu, Yiming Cai et al. · 2025 · Journal of NeuroEngineering and Rehabilitation
BACKGROUND: Tai Chi (TC) is recognized for enhancing balance and postural control. However, studies on its effects on the central nervous system are limited and often involve static experiments despite the dynamic nature of TC. This study…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Himanshu Chaudhary, Vipin Kumar Sharma, Salvatore Capozzıello et al. · 2026 · The Astrophysical Journal Supplement Series
Abstract Observational data play a pivotal role in identifying cosmological models that are both theoretically consistent and empirically viable. In this work, we investigate the level of preference for dynamical dark energy over a cosmological constant using current late-time observational datasets, including cosmic chronometers (CC), baryon acoustic oscillations from Dark Energy Spectroscopic Instrument (DESI) DR2, and different Type Ia supernova catalogs (Pantheon + , DES-Dovekie, Union3). We analyze various dynamical dark-energy models, including ω CDM, o ω CDM, ω 0 ω a CDM, logarithmic, e
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hasan Demirci, Jessica Paola Bahena-López, Смородченко Алина Тихоновна et al. · 2025 · JCI Insight
Kidney thick ascending limb cells reabsorb sodium, potassium, calcium, and magnesium and contribute to urinary concentration. These cells are typically viewed as of a single type that recycles potassium across the apical membrane and generates a lumen-positive transepithelial voltage driving calcium and magnesium reabsorption, although variability in potassium channel expression has been reported. Additionally, recent transcriptomic analyses suggest that different cell types exist along this segment, but classifications have varied and have not led to a new consensus model. We used immunolocal
View details →Negative / Null Result ReportOpen accessHealth Professions
Rachel O’Neill · 2025 · International Journal of Cultural Studies
Medical doctors are central to existing networks for wellness content on Instagram in and beyond the UK, yet remain overlooked within scholarship concerned with this terrain. Taking a case study approach, this article examines three such figures prominent in the UK context. In doing so, it challenges existing conceptualisations of the 'wellness influencer' and argues for an expanded understanding of the category, one that does not assume its representatives are 'lay' persons without recognised expertise in health and well-being. The analysis developed demonstrates that credentials cannot resol
View details →Negative / Null Result ReportOpen accessSocial Sciences
Brooklyn Walker, Paul A. Djupe, Brian Calfano et al. · 2025 · Perspectives on Politics
Popular narratives suggest that the effects of Christian nationalism should be more heavily concentrated among white Americans. The academic literature on Christian nationalism largely reflects this take, often asserting that it is effectively white Christian nationalism. We question such pronouncements, as they have come without systematic analysis across the broad range of issue areas needed to justify subgroup segmentations. Utilizing national oversamples of Black and Latino Christians (alongside white Christians), we assess the relationship between standard measures of Christian nationalis
View details →Negative / Null Result ReportOpen accessComputer Science
Christian Basil Omeh, Musa Adekunle Ayanwale, Lindelani Mnguni et al. · 2025 · Journal of New Approaches in Educational Research
Abstract Despite the increasing emphasis on computational literacy in higher education, we observed that many undergraduate students particularly in developing contexts struggle to master fundamental programming skills and develop critical thinking. Conventional instructional approaches often lack interactivity and personalized scaffolding, which are essential for teaching abstract programming concepts. In response to this challenge, we examined the effect of artificial intelligence (AI)-assisted problem-based learning (PBL) on students’ programming skills, critical thinking, and problem-solvi
View details →Negative / Null Result ReportOpen accessDentistry
Patrick Golletz, Sissel Damsbo Jensen, Madeline Collignon et al. · 2025 · Journal of Oral Microbiology
Introduction: Coaggregation may reduce the abundance of bacteria in physiological fluids, such as saliva, as aggregated bacteria are cleared more easily than planktonic cells. This study aimed to identify Lactobacillus strains that…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Simone Taddeo, Andrea Regoli, O. Weber et al. · 2026 · Business Strategy and the Environment
ABSTRACT This study investigates the financial consequences of greenwashing, operationalized as the misalignment between ESG disclosure and actual ESG performance. While prior research has explored the reputational and ethical dimensions…
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Gonzalez‐Robles, Oliver Bandmann, Anthony H.V. Schapira · 2025 · Neurology and Therapy
Parkinson disease (PD) is a progressive neurodegenerative condition characterised by tremor, bradykinesia and rigidity, as well as other motor and non-motor symptoms, for which no effective disease-modifying treatments have been…
View details →Replication FailureOpen accessMedicine
PierFranco Conte, Maria Vittoria Dieci, Giancarlo Bisagni et al. · 2025 · Annals of Oncology
BACKGROUND: The A-BRAVE trial evaluated the efficacy of avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody, as adjuvant treatment of patients with early triple-negative breast cancer (TNBC) at high risk. PATIENTS AND METHODS:…
View details →Negative / Null Result ReportOpen accessMedicine
Annefleur C. Langedijk, Floris van den Dungen, Lisette M. Harteveld et al. · 2025 · Human Vaccines & Immunotherapeutics
The European Medicines Agency has authorized two interventions to prevent lower respiratory tract disease due to respiratory syncytial virus (RSV-LRTD) in infants: nirsevimab, a monoclonal antibody, and bivalent stabilized prefusion F…
View details →Negative / Null Result ReportOpen accessEngineering
Fengxiang Liu, Shipeng Ning, Xia Wang et al. · 2025 · Science Advances
Cancer stem cells (CSCs) and myeloid-derived suppressor cells (MDSCs) contribute to chemoresistance and immunosuppression, constraining chemoimmunotherapy outcomes. Differentiation therapy, aiming to mature CSCs and MDSCs, shows great promise. However, its efficacy is hindered by limited accessibility in hypoxic deep tumor regions. Inspired by the apoptotic body (ApoBD)-mediated deep tumor penetration, we design a pulsatile sequential drug release system with a core-shell structure. The reversible acid-responsive shell protonates and swells in lysosomes to release doxorubicin, inducing lysosom
View details →Replication FailureOpen accessMedicine
Zehua Dong, Lianlian Wu, Hongliu Du et al. · 2026 · Gastroenterology
BACKGROUND & AIMS: Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lacking. We aimed to explore whether AI can enhance gastric neoplasm detection. METHODS: Participants from 24 hospitals in China from December 21, 2021, to November 11, 2023, were randomized to AI-assisted or nonassisted esophagogastroduodenoscopy. Primary outcome was detection rate of gastric neoplasms after pathologic review. Secondary outcomes included detection rate of gastric neoplasms before review, relative early gastric cancer detection ratio,
View details →Negative / Null Result ReportOpen accessMedicine
Michael Harrison Storandt, Frank A. Sinicrope · 2026 · BMJ Oncology
The treatment paradigm for deficient mismatch repair (dMMR) colorectal cancer (CRC) has evolved substantially in recent years. Universal mismatch repair testing and broad use of next-generation sequencing have increased the detection of…
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