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Browse the failure-mode index

21,247 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Does SLOPE outperform bridge regression?

Shuaiwen Wang, Haolei Weng, Arian Maleki · 2021 · Information and Inference: A Journal of the IMA

Abstract A recently proposed SLOPE estimator [6] has been shown to adaptively achieve the minimax $\ell _2$ estimation rate under high-dimensional sparse linear regression models [25]. Such minimax optimality holds in the regime where the…

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Negative / Null Result Report

Significant individual change should be used as a lower bound for anchor based estimates of meaningful change on patient-reported outcome scores

John Devin Peipert, David Cella, Ron D. Hays · 2024 · Quality of Life Research

Abstract Interpretation of patient-reported outcome (PRO) scores has been supported by identifying score thresholds or ranges that indicate clinical importance. There has been a recent focus on the estimation of meaningful within patient…

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Negative / Null Result Report

Association between Intraoperative Blood Pressure Drop and Clinically Significant Hypoperfusion in Abdominal Surgery: A Cohort Study

Zbigniew Putowski, Szymon Czajka, Łukasz J. Krzych · 2021 · Journal of Clinical Medicine

The recent consensus by the Perioperative Quality Initiative (POQI) on intraoperative hypotension (IOH) stated that mean arterial pressure (MAP) below 60–70 mmHg is associated with myocardial infarction (MI), acute kidney injury (AKI),…

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Negative / Null Result Report

Do Bilinguals Outperform Monolinguals in Switching Tasks? Contrary Evidence for Nonlinguistic and Linguistic Switching Tasks

Ernest Mas-Herrero, Daniel Adrover-Roig, María Ruz et al. · 2021 · Neurobiology of Language

Abstract The benefits of bilingualism in executive functions are highly debated. Even so, in switching tasks, these effects seem robust, although smaller than initially thought (Gunnerud et al., 2020; Ware et al., 2020). By handling two…

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Negative / Null Result Report

Education Finance Reform and the Great Recession: Did State Policy and Fiscal Federalism Improve Education Spending, School Resources, and Student Achievement in Pennsylvania?

Matthew P. Steinberg, Rand Quinn, J. Cameron Anglum · 2020 · Journal of Education Finance

abstract: We estimate the impact of school finance reform on adequate and equitable district spending, school resources and student achievement in Pennsylvania. From the 2008-09 to the 2010-11 school years, amid the Great Recession,…

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Negative / Null Result Report

Another Brick to Confirm the Efficacy of Rigosertib as Anticancer Agent

Alessio Malacrida, Marie Deschamps-Wright, Roberta Rigolio et al. · 2023 · International Journal of Molecular Sciences

Rigosertib is a small molecule in preclinical development that, due to its characteristics as a dual PLK1 and PI3K inhibitor, is particularly effective in counteracting the advance of different types of tumors. In this work, we evaluated…

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Negative / Null Result Report

No significant difference between Australian heat wave impacts of Modoki and eastern Pacific El Niño

Tammas F. Loughran, Sarah E. Perkins‐Kirkpatrick, Lisa V. Alexander et al. · 2017 · Geophysical Research Letters

Abstract The influence of two El Niño types on the frequency of summer heat wave days in Australia is investigated using both observations and an atmospheric climate model. The two basic spatial variants of El Niño are the traditional…

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Negative / Null Result Report

A Meta-Epidemiological Study of Positive Results in Clinical Nutrition Research: The Good, the Bad and the Ugly of Statistically Significant Findings

Konstantinos Gkiouras, Maria-Eleftheria Choleva, Aikaterini Verrou et al. · 2022 · Nutrients

Positive (statistically significant) findings are easily produced in nutrition research when specific aspects of the research design and analysis are not accounted for. To address this issue, recently, a pledge was made to reform nutrition…

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Negative / Null Result Report

Extracting statistically significant eddy signals from large Lagrangian datasets using wavelet ridge analysis, with application to the Gulf of Mexico

Jonathan M. Lilly, Paula Pérez-Brunius · 2021 · Nonlinear Processes in Geophysics

Abstract. A method for objectively extracting the displacement signals associated with coherent eddies from Lagrangian trajectories is presented, refined, and applied to a large dataset of 3770 surface drifters from the Gulf of Mexico. The…

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Negative / Null Result Report

The Continuous Fragility Index of Statistically Significant Findings in Studies Based on High Levels of Evidence Comparing Interventions for Femoroacetabular Impingement Syndrome

Juan Bernardo Villarreal-Espinosa, Zeeshan A. Khan, Kyleen Jan et al. · 2025 · The American Journal of Sports Medicine

Background: Critical analysis of studies with high level of evidence has relied on the significance set by the reported P values. However, this strategy steers readers toward categorical interpretation of the data; therefore, a more…

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Negative / Null Result Report

Photobiomodulation therapy in dogs undergoing TPLO after cranial cruciate ligament rupture shows promise but no statistically significant difference in a randomized trial

Oscar A. Chavez, Walter Renberg, Natalia Cernicchiaro · 2024 · American Journal of Veterinary Research

Abstract OBJECTIVE Effect of photobiomodulation therapy (PBMT) in patients with CCLR after TPLO surgery by measuring C-reactive protein (CRP), percentage weight bearing, lameness using a short form of a composite measure pain scale,…

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Negative / Null Result Report

Did an urban perinatal health programme in Rotterdam, the Netherlands, reduce adverse perinatal outcomes? Register-based retrospective cohort study

Hendrik CC de Jonge, Jacqueline Lagendijk, Unnati Saha et al. · 2019 · BMJ Open

Objectives To study the effect of an urban perinatal health programme in Rotterdam, the Netherlands, on perinatal outcomes. Design A retrospective cohort study with difference-in-differences analysis using individual-level perinatal…

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Negative / Null Result Report

Combination pretest probability assessment and D-dimer did not reduce outpatient imaging for venous thromboembolism in a tertiary care hospital emergency department

Sarah Ingber, Rita Selby, Jacques Lee et al. · 2014 · CJEM

ABSTRACT Introduction: Venous thromboembolism (VTE) is difficult to diagnose yet potentially life threatening. A low-risk pretest probability (PTP) assessment combined with a negative Ddimer can rule out VTE in two-thirds of outpatients,…

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Negative / Null Result Report

Did the ACA reduce job-lock and spur entrepreneurship?

Simon Condliffe, Matt B. Saboe, Sabrina Terrizzi · 2017 · Journal of Entrepreneurship and Public Policy

Purpose The purpose of this paper is to assess the effect of the recent Affordable Care Act’s (ACA) Dependent Mandate (DM) that requires health insurers to extend dependent coverage to the children of their insured, up to age 26. The DM…

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