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Browse the failure-mode index

21,247 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

State Anxiety after Exergame Beach Volleyball Did Not Differ between the Single and Multiplayer Modes in Adult Men

Vinnycius de Oliveira, Ricardo Viana, Naiane Morais et al. · 2021 · International Journal of Environmental Research and Public Health

This study compared the exergame beach volleyball’s acute effects on state anxiety level in single vs. multiplayer mode in adult men. Sixty adult men (age: 21.98 [4.58] years, body mass: 75.40 [15.70] kg, height: 1.77 [0.09] m, and body…

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Negative / Null Result Report

Normocalcaemic hyperparathyroidism and primary hyperparathyroidism: least significant change for adjusted serum calcium

Marian Schini, Richard Jacques, Eleanor Oakes et al. · 2021 · European Journal of Endocrinology

Introduction The least significant change (LSC) is a term used in individuals in order to evaluate whether one measurement has changed significantly from the previous one. It is widely used when assessing bone mineral density (BMD) scans.…

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Negative / Null Result Report

Biological variation of thiopurine methyltransferase enzyme activity: when has a significant change taken place?

Remco van Egmond, Murray L Barclay, Paul KL Chin et al. · 2013 · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

Background Thiopurine methyltransferase (TPMT) enzyme activity is measured before initiating thiopurine therapy to reduce the risk of severe drug-associated myelotoxicity in patients with low enzyme activity. TPMT activity may vary over…

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Negative / Null Result Report

No significant association of repeated messages with changes in health compliance in the COVID-19 pandemic: a registered report on the extended parallel process model

Jingwen Yang, Xue Wu, Kyoshiro Sasaki et al. · 2021 · PeerJ

When people are confronted with health proposals during the coronavirus disease 2019 (COVID-19) pandemic, it has been suggested that fear of COVID-19 can serve protective functions and ensure public health compliance. However, health…

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Negative / Null Result Report

Acutely increased workload is correlated with significant injuries among national basketball association players

Matthew J Orringer, Nirav K Pandya · 2021 · International Journal of Sports Science & Coaching

Background Particularly at the level of professional athletics, injury prevention is of critical importance. We hypothesized that elevated in-game statistics over a period of 3-10 games places increased cumulative stress on players’ joints…

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Negative / Null Result Report

Significant Improvement of Somatic Symptom Disorder With Brief Psychoeducational Intervention by PMHNP in Primary Care

Kim K. Johnson, Carole Bennett, Haresh Rochani · 2020 · Journal of the American Psychiatric Nurses Association

Objective: Patients with somatic symptom disorders (SSD) are prevalent in primary care, urgent care, and emergency rooms and present with reduced quality of life, increased disability, and suicidality . Criteria for SSD include (1) somatic…

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Negative / Null Result Report

Drug‐target Mendelian randomization revealed a significant association of genetically proxied metformin effects with increased prostate cancer risk

Xiaohui Sun, Jie Ping, Xingyi Guo et al. · 2024 · Molecular Carcinogenesis

Abstract The association between metformin use and risk of prostate cancer remains controversial, while data from randomized trials is lacking. We aim to evaluate the association of genetically proxied metformin effects with prostate…

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Negative / Null Result Report

Randomized trial within a trial of yellow ‘post‐it notes’ did not improve questionnaire response rates among participants in a trial of treatments for neck pain

Helen E Tilbrook, Taeko Becque, Hannah Buckley et al. · 2014 · Journal of Evaluation in Clinical Practice

Abstract Rationale Attrition is a threat to the validity of randomized trials. Few randomized studies have been conducted within randomized trials to test methods of reducing attrition. Aim To test whether using yellow post‐it notes on…

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Negative / Null Result Report

Long‐chain alcohols did not improve predictions of the composition of tall fescue and red clover mixtures over n ‐alkanes alone

N. Vargas Jurado, A. E. Tanner, S. R. Blevins et al. · 2014 · Grass and Forage Science

Abstract Feed intake and diet choice affect production efficiency in livestock. Plant waxes, in particular n ‐alkanes, have been used as markers to predict intake and diet preferences. Still, when n ‐alkane profiles of plants within mixed…

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Negative / Null Result Report

Ethanol Extract of Fructus ligustri lucidi Increased Circulating 1,25(OH) 2 D 3 Levels, but Did Not Improve Calcium Balance in Mature Ovariectomized Rats

Xiao-Li Dong, Si-Si Cao, Li-Ping Zhou et al. · 2016 · The American Journal of Chinese Medicine

Our previous studies found that different extracts or fractions of Fructus ligustri lucidi (FLL) played different roles in altering the regulation of bone and mineral metabolism in different animal models. The present study was designed to…

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Negative / Null Result Report

Shared miRNA landscapes of COVID-19 and neurodegeneration confirm neuroinflammation as an important overlapping feature

Sara Redenšek Trampuž, David Vogrinc, Katja Goričar et al. · 2023 · Frontiers in Molecular Neuroscience

Introduction Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, have been associated with COVID-19 However, the mechanisms associated with…

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Negative / Null Result Report

Gum Guar fiber associated with fructose reduces serum triacylglycerol but did not improve the glucose tolerance in rats

Caio SM Motoyama, Mônica JS Pinto, Fabio S Lira et al. · 2010 · Diabetology & Metabolic Syndrome

Abstract Introduction The increased intake of dietary fructose can be associated with alterations on energy homeostasis and lipid/carbohydrate metabolism, such as insulin resistance and dislipidemia. On the other hand, the ingestion of…

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Negative / Null Result Report

Did School Meal Programs and SNAP Participation Improve Diet Quality of US Children from Low-Income Households: Evidence from NHANES 2013–2014?

Tzuan A. Chen, Lorraine R. Reitzel, Ezemenari M. Obasi et al. · 2021 · Nutrients

Nutrition assistance programs such as school meals and the Supplemental Nutrition Assistance Program (SNAP) are designed to provide a safety net for the dietary intake of children from low-income families. However, compared with eligible…

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Negative / Null Result Report

An attachment‐based program for parents of youth with clinically significant mental health problems: Scaling up and drilling down to mechanisms of change

Marlene M. Moretti, Sebastian P. Dys, Stephanie G. Craig et al. · 2024 · JCPP Advances

Abstract Background Given the prevalence and recent increases in youth mental health problems, there is a pressing need for interventions that target transdiagnostic protective factors that could be targeted as mechanisms of change in…

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Negative / Null Result Report

Confirm Rx insertable cardiac monitor for primary atrial fibrillation detection in high‐risk heart failure patients ( Confirm‐AF trial)

Mehmet K. Aktas, Wojciech Zareba, Javed Butler et al. · 2022 · Annals of Noninvasive Electrocardiology

Abstract Background Patients with heart failure (HF) represent a large population of patients who are at high risk for complications related to undiagnosed atrial fibrillation (AF). However, currently there are limited modalities available…

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Negative / Null Result Report

The most significant change for Colombian medical trainees going transformative learning on cultural safety: qualitative results from a randomised controlled trial

Juan Pimentel, Paola López, Anne Cockcroft et al. · 2022 · BMC Medical Education

Abstract Background Cultural safety training is not yet standard in Colombian medical education. If incorporated, it could address currently adversarial interactions between health professionals and the 40% of people who use traditional…

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Negative / Null Result Report

Incidence and time trends of herpes zoster among patients with head and neck cancer who did and did not undergo radiotherapy: A population-based cohort study

Peng-Yi Lee, Jung-Nien Lai, Lu-Ting Chiu et al. · 2021 · PLOS ONE

Purpose This study aimed to determine the risk and time trends of herpes zoster among patients with head and neck cancer, with or without radiotherapy. Methods A total of 2160 patients with head and neck cancer were enrolled. The…

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