Negative / Null Result ReportOpen accessMedicine
Yuan Lin, Fang Zhou, Xihui Wang et al. · 2023 · PeerJ
Purpose: To investigate the prognostic value of the index of cardio-electrophysiological balance (ICEB) and its association with major adverse cardiac events (MACE) and cardiovascular death in diabetic patients complicated with coronary heart disease. Methods: A total of 920 diabetic patients were enrolled in this longitudinal study. Participants were categorized into three groups based on their ICEB levels: normal ICEB, low ICEB, and high ICEB. The primary outcome was the occurrence of MACE, and secondary outcomes included cardiovascular death, coronary heart disease (CHD), heart failure (HF)
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sven E. Weber, Harmeet Singh Chawla, Lennard Ehrig et al. · 2023 · Frontiers in Plant Science
In modern plant breeding, genomic selection is becoming the gold standard to select superior genotypes in large breeding populations that are only partially phenotyped. Many breeding programs commonly rely on single-nucleotide polymorphism (SNP) markers to capture genome-wide data for selection candidates. For this purpose, SNP arrays with moderate to high marker density represent a robust and cost-effective tool to generate reproducible, easy-to-handle, high-throughput genotype data from large-scale breeding populations. However, SNP arrays are prone to technical errors that lead to failed al
View details →Negative / Null Result ReportOpen accessHealth Professions
Hailey Miller, Sandy Askew, Miriam B. Berger et al. · 2024 · Hypertension
BACKGROUND: Dietary Approaches to Stop Hypertension (DASH) is a recommended first-line treatment for adults with hypertension, yet adherence to DASH is low. To evaluate the efficacy of a digital health intervention (DHI), compared with…
View details →Negative / Null Result ReportOpen accessMedicine
Simone Conti, Edmond Y. Lau, Victor Ovchinnikov · 2022 · Antibodies
The accurate and efficient calculation of protein-protein binding affinities is an essential component in antibody and antigen design and optimization, and in computer modeling of antibody affinity maturation. Such calculations remain challenging despite advances in computer hardware and algorithms, primarily because proteins are flexible molecules, and thus, require explicit or implicit incorporation of multiple conformational states into the computational procedure. The astronomical size of the amino acid sequence space further compounds the challenge by requiring predictions to be computed
View details →Negative / Null Result ReportMedicine
William R. Cleek, Nicholas J. Johnson, Bjorn Watsjold et al. · 2019 · Shock
STUDY OBJECTIVE: The quick sequential organ failure assessment (qSOFA) was proposed to identify infected patients at risk for mortality, an indication of sepsis, in nonintensive care unit settings. This study tests whether qSOFA improves…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Mohammed Abdallah, Ke Zhang, Lijun Chao et al. · 2024 · Hydrology and earth system sciences
Abstract. Precipitation is a vital key element in various studies of hydrology, flood prediction, drought monitoring, and water resource management. The main challenge in conducting studies over remote regions with rugged topography is that weather stations are usually scarce and unevenly distributed. However, open-source satellite-based precipitation products (SPPs) with a suitable resolution provide alternative options in these data-scarce regions, which are typically associated with high uncertainty. To reduce the uncertainty of individual satellite products, we have proposed a D-vine copul
View details →Negative / Null Result ReportOpen accessSocial Sciences
Janet Quint, Pei Zhu, Rekha Balu et al. · 2015 · SSRN Electronic Journal
Success for All (SFA) combines a challenging elementary reading program, whole-school reform elements, and an emphasis on continuous improvement. In 2010, the Success for All Foundation (SFAF) received a scale-up grant under the U.S.…
View details →Negative / Null Result Report
Shira Fanti‐Oren, Daphna Birenbaum‐Carmeli, Dan Nemet et al. · 2019 · Acta Paediatrica
Abstract Aim The aim of the study was to examine the effect of information placebo on fitness test results in normal weight, overweight and obese children. Methods Twenty‐four pre‐pubertal children with overweight or obesity and 24 age and…
View details →Failed Experiment Report
Joon Hee Kang, Seon-Hyeong Lee, Jae-Seon Lee et al. · 2020 · Cells
More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog (MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence…
View details →Negative / Null Result Report
Claus Thorn Ekstrøm, Bendix Carstensen · 2024 · The International Journal of Biostatistics
Abstract Agreement between methods for quantitative measurements are typically assessed by computing limits of agreement between pairs of methods and/or by illustration through Bland–Altman plots. We consider the situation where the…
View details →Negative / Null Result Report
Ellen J. Serafini · 2019 · Language Teaching
Abstract Research conducted over the past 15–20 years has revealed significant insights into the nature and role of learner selves in language learning settings, particularly the importance of considering the interaction between situated…
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Andrea Asperti, Franky George, Tiberio Marras et al. · 2025 · Big Data and Cognitive Computing
In recent years, advancements in generative artificial intelligence have led to the development of sophisticated tools capable of mimicking diverse artistic styles, opening new possibilities for digital creativity and artistic expression.…
View details →Negative / Null Result Report
Jonas J. Astrin, Peter E. Stüben · 2010 · Invertebrate Systematics
A molecular phylogeny for the western Palaearctic weevil genus Echinodera Wollaston, 1863 and the former genus Ruteria Roudier, 1954 is presented, combining two mitochondrial genes (CO1 and 16S) in a Bayesian analysis. Special…
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Seyed-Mohammad Fereshtehnejad, Johan Lökk, Anders Wimo et al. · 2018 · Journal of Parkinson’s Disease
Background: Whether dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are distinct disorders or two subtypes of the same entity, is not yet fully understood. There is a dearth of knowledge on differences in…
View details →Negative / Null Result Report
Xiao-yan Xu, Xiao-cui Nie, Hai-ying Ma et al. · 2014 · Technology in Cancer Research & Treatment
Flow cytometry method (FCM) is a generally accepted tool to analyze apoptosis. Although apoptosis assay kit was applied by many companies, the manufacturers were not consistent with whether using Trypsin with EDTA to collect the adherent…
View details →Negative / Null Result Report
P. Sumithran, K. Purcell, S. Kuyruk et al. · 2017 · Clinical Obesity
Summary Consistent, strong predictors of obesity treatment outcomes have not been identified. It has been suggested that broadening the range of predictor variables examined may be valuable. We explored methods to predict outcomes of a…
View details →Negative / Null Result Report
Richard A. Gallenstein, John P. Dougherty · 2024 · American Journal of Agricultural Economics
Abstract Index insurance programs in developing countries have focused almost entirely on agricultural production risk (i.e., yield) while largely avoiding output marketing risk (i.e., price). This omission may miss an important constraint…
View details →Negative / Null Result Report
Guangming Chen, Xiaoyun Shan, Huabin Wang · 2021 · Nephrology
Abstract Aim Various studies have reported that urinary neutrophil gelatinase‐associated lipocalin (NGAL), an indicator of tubular damage, may be an effective biomarker of renal impairment in patients with diabetes. This study aimed to…
View details →Negative / Null Result Report
Jason West, Maiko Chu, Lincoln Crooks et al. · 2018 · Journal of Business Strategy
Purpose Business wargames represent an alternative approach to challenge organisations to uncover internal capabilities through competitive actions designed to counteract external threats and address strategic mismatches. Internal…
View details →Negative / Null Result Report
Dolores Ruiz-Lupión, Jordi Pascual, Nereida Melguizo-Ruiz et al. · 2019 · Insects
Soil fauna play a key role in nutrient cycling and decomposition, and in recent years, researchers have become more and more interested in this compartment of terrestrial ecosystems. In addition, soil fauna can act as ecosystem engineers…
View details →Negative / Null Result Report
Natsu Sasaki, Reiko Kuroda, Kanami Tsuno et al. · 2022 · Neuropsychopharmacology Reports
Abstract Objectives This study aimed to examine the effectiveness of vaccination to improve mental health among employees in Japan based on a prospective study. Methods The data were retrieved from the Employee Cohort Study conducted…
View details →Negative / Null Result Report
Anna Adamczak-Bugno, Aleksandra Krampikowska · 2020 · Materials
This article proposes to use the acoustic emission (AE) method to evaluate the degree of change in the mechanical parameters of fiber–cement boards. The research was undertaken after a literature review, due to the lack of a methodology…
View details →Negative / Null Result Report
Gengsheng L. Zeng · 2012 · International Journal of Imaging Systems and Technology
Abstract The iterative maximum‐likelihood expectation‐maximization (ML‐EM) algorithm is an excellent algorithm for image reconstruction and usually provides better images than the filtered backprojection (FBP) algorithm. However, a…
View details →Negative / Null Result Report
Jack W. O’Sullivan, John P. A. Ioannidis · 2021 · Scientific Reports
Abstract With the establishment of large biobanks, discovery of single nucleotide variants (SNVs, also known as single nucleotide polymorphisms (SNVs)) associated with various phenotypes has accelerated. An open question is whether…
View details →Negative / Null Result Report
Yui Matsuda, Todd A. Schwartz, YunKyung Chang et al. · 2019 · Journal of the American Psychiatric Nurses Association
BACKGROUND: Mothers’ depressive symptoms affect their children’s growth as well as physical and mental well-being. Moreover, mothers of young children with developmental delay or disability (DD) tend to have higher depressive symptoms.…
View details →Negative / Null Result Report
Mona Almalik, Alice Kiger, Janet Tucker · 2010 · International Journal of Qualitative Methods
Although a few researchers mention that involving interpreters can have an impact on the research process and research findings, little is published regarding methods of assessing the interpretation work's quality and impact. The impact of…
View details →Negative / Null Result Report
Peter N. Chalmers · 2019 · Arthroscopy
Abstract The optimal surgical technique for arthroscopic rotator cuff repair remains controversial, with advantages and disadvantages to each of the most commonly used methods. The pattern as well as number of suture anchors relative to…
View details →Negative / Null Result Report
Gordon Minru Xiong, Kailash Venkatraman, Subbu Venkatraman · 2020 · Progress in Biomedical Engineering
Abstract Ever since the term ‘Magic Bullet’ was coined by Nobel laureate Paul Ehrlich to denote selective activity of a therapeutic medicine against a particular target tissue or organism, researchers have been attempting to develop the…
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Nicholas Smith, Kathleen F. Hunter, Saima Rajabali et al. · 2019 · Journal of Wound, Ostomy & Continence Nursing
PURPOSE: This study aimed to determine from what sources women with urinary and dual urinary and fecal incontinence sought and received information about incontinence and absorbent products. We also evaluated source utility. DESIGN:…
View details →Negative / Null Result Report
Yuriko Adkins, Kevin D. Laugero, Bruce Mackey et al. · 2019 · Lipids
Abstract Recent studies suggest that dietary krill oil leads to higher omega‐3 polyunsaturated fatty acids (n‐3 PUFA) tissue accretion compared to fish oil because the former is rich in n‐3 PUFA esterified as phospholipids (PL), while n‐3…
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