Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lei Li, Hongchao Huang, Yin He et al. · 2025 · Military Medical Research
Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction. Despite advances in clinical identification and management, both its incidence and mortality have remained persistently high. Emerging evidence indicates that cell-free DNA (cfDNA), as a novel biomarker and molecular therapeutic target, holds promise for improving the clinical management of sepsis. cfDNA refers to DNA fragments present in body fluids, including naked DNA, membrane-coated DNA, nucleosomes, and neutrophil extracellular traps (NETs). cfDNA is released from host cells o
View details →Negative / Null Result ReportOpen accessDentistry
Guowu Gan, Ruonan Chen, Peining Zheng et al. · 2026 · Frontiers in Cellular and Infection Microbiology
The oral-gut axis represents a critical bidirectional pathway linking oral microbiota to systemic health. Dysbiosis of the oral microbiome, driven by pathogens like Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus species, and Helicobacter pylori, disrupts gut ecology via direct translocation, metabolite signaling (e.g., TMAO, SCFAs), and immune crosstalk (e.g., Th17). This leads to gut barrier dysfunction, systemic inflammation, and metabolic disturbances, contributing to diverse diseases beyond the oral cavity. Evidence supports causal links with conditions including rheumato
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tahrim Ramzan, Muhammad Shahbaz, Farooq Ahmad et al. · 2026 · New Zealand Journal of Crop and Horticultural Science
Salinity stress is a major abiotic factor that inhibits plant growth and yield. This study's objective was to evaluate how foliar applications of melatonin and ascorbic acid affected canola varieties under salt stress. The treatments of…
View details →Negative / Null Result ReportOpen accessComputer Science
Ali Raza, Fareeha Hanif, Heba Abdelgader Mohammed · 2026 · Scientific Reports
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, and accurate early diagnosis plays a critical role in improving patient survival. In this study, a comparative analysis of multiple lightweight Convolutional Neural Network (CNN) variants is presented for multi-class lung cancer classification using histopathological images. Four CNN architectures were designed to systematically explore the trade-off between model complexity and classification performance. Each variant was trained and evaluated within a unified experimental framework incorporating data augment
View details →Negative / Null Result ReportOpen accessMedicine
Y. Kanemitsu, Yasuhiro Shimizu, Junki Mizusawa et al. · 2026 · Journal of Clinical Oncology
JCOG0603 demonstrated improved disease-free survival (DFS) with adjuvant mFOLFOX6 after hepatectomy compared with hepatectomy alone in colorectal liver-only metastasis (CRLM), but the overall survival (OS) data were immature. Here, we…
View details →Negative / Null Result ReportOpen accessEngineering
Teevrat Garg, Ryan Hanna, Jeff Myers et al. · 2026 · Journal of Environmental Economics and Management
Aligning electric vehicle (EV) charging with periods of abundant clean energy is essential for decarbonizing transportation. In solar-dominated grids, this requires shifting charging to midday hours – when vehicles are typically parked at workplaces. Yet workplace charging networks operate under institutional constraints such as shared infrastructure, bundled parking and charging services, and limited willingness to require drivers to move vehicles, making time-of-day pricing and active management difficult to implement. In a natural field experiment (n = 629 drivers) across a large workplace
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ashley Rich, Ziqi Li, Alessandro De Simone et al. · 2026 · Nature Physics
Amputated salamander limbs or fish fins precisely regenerate to their pre-injury size, providing a paradigm for positional memory. Although this phenomenon has been appreciated for centuries, how position-dependent cues control tissue…
View details →Negative / Null Result ReportOpen accessPsychology
Isaac Davor, Francis Ohene Boateng, Franco Osei-Wusu et al. · 2026 · Cogent Education
This study examines the mediating and moderating role of metacognitive awareness in the relationship between self-regulated learning and mathematics achievement of university students in Ghana. Although self-regulated learning has attracted attention as a predictor of academic performance, few studies have examined how metacognitive awareness interacts with self-regulated learning to influence mathematics achievement in the Ghanaian context. A quantitative cross-sectional design was employed. Data were collected from 315 university students, representing a population of 3,240, using a structur
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Mohamed T. El‐Saadony, Ahmed Mohamed Saad, Mahmoud Zaki Sitohy et al. · 2026 · Frontiers in Immunology
Probiotics, defined as living microorganisms, are widely recognized for their ability to positively influence the gut microbiota, an effect increasingly linked to a wide array of health benefits. They are claimed to treat or prevent conditions ranging from infant colic to cardiovascular disease, respiratory infections, and certain cancers. Since the beginning of the 21st century, consumer demand for probiotic-enriched foods has risen significantly, propelled by these health assertions. The consumption of such products has been associated with the alleviation of disorders, including irritable b
View details →Negative / Null Result ReportOpen accessMedicine
Megan L. Uhelski, Mandee K. Schaub, Felipe Espinosa et al. · 2026 · Pain
ABSTRACT: Nonselective antagonists of voltage-gated sodium channels (VGSCs) provide effective local analgesia, but systemic administration is fraught with unwanted cardiovascular and central nervous system toxicity. The development of…
View details →Negative / Null Result ReportOpen accessMedicine
Florian Kahles, Andreas L. Birkenfeld, Nikolaus Marx · 2026 · Journal of Clinical Investigation
The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl peptidase 4 (DPP-4) prolong the half-life of endogenous GLP-1 and typically achieve reductions in HbA1c of 0.5%-0.8%. However, large-scale cardiovascular (CV) outcomes trials (CVOTs) with DPP-4 inhibitors demonstrated CV safety but did not show a reduction in CV events. A second incretin-based therapeutic approach was the development of GLP-1R agonists (GLP-1RA
View details →Negative / Null Result ReportOpen accessMedicine
Youying Mao, Weidong Shen, Jiayao Shen et al. · 2025 · Kidney International Reports
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease and approximately 40% of patients with SLE progress to lupus nephritis (LN). The treatment of refractory SLE and LN remains challenging. This clinical study aimed to…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Richard E. Pratley, Douglas Scott Denham, Rupal Trivedi et al. · 2026 · Nature Medicine
Abstract Loss of lean mass in proportion to total weight loss is observed with incretin mimetic therapies such as tirzepatide and has the potential to adversely affect health and function. Apitegromab is an investigational, fully human monoclonal antibody that selectively inhibits myostatin activation and is, thereby, capable of increasing muscle mass. In the randomized, double-blind, placebo-controlled phase 2 EMBRAZE study, adults with overweight or obesity ( n = 102) were randomized 1:1 to receive tirzepatide plus apitegromab (10 mg kg −1 ) or tirzepatide plus placebo. At week 24, apitegrom
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Richard Stiskalek, Harry Desmond, Julien Devriendt et al. · 2025 · Monthly Notices of the Royal Astronomical Society
ABSTRACT The peculiar velocity field of the local Universe provides direct insights into its matter distribution and the underlying theory of gravity, and is essential in cosmological analyses for modelling deviations from the Hubble flow. Numerous methods have been developed to reconstruct the density and velocity fields at $z \lesssim 0.05$, typically constrained by redshift-space galaxy positions or by direct distance tracers such as the Tully–Fisher relation, the Fundamental Plane, or Type Ia supernovae. We introduce a validation framework to evaluate the accuracy of these reconstructions
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Koen H.M. Prange, Gemma Bel-Bordes, MAC Depuydt et al. · 2026 · European Heart Journal
BACKGROUND AND AIMS: Atherosclerosis is a chronic lipid-driven inflammatory disease and one of the leading underlying causes of cardiovascular morbidity and mortality in Western society. Macrophages are key players in atherosclerotic development. Although the cellular composition of carotid atherosclerotic lesions has been determined, macrophage population definitions lack granularity and lineage data. Moreover, to date no direct link has been established between cellular content of atherosclerotic lesions and secondary clinical outcome. This study is aimed at characterization of atherosclerot
View details →Negative / Null Result ReportOpen accessComputer Science
Qiuhan Zhu, Xiangnan Li, Yiang Dong et al. · 2026 · Frontiers in Psychology
Generative AI tools such as ChatGPT now perform core cognitive operations—reasoning, synthesis, evaluation, and creative generation—on users' behalf, raising urgent questions for educational psychology about how AI use relates to cognitive development. Yet research on cognitive offloading has largely treated AI use as a unidimensional phenomenon, obscuring a theoretically consequential distinction: whether AI substitutes for the user's own thinking or scaffolds it. Drawing on the autonomous–dependent help typology and self-determination theory, the present study introduces and examines a disti
View details →Negative / Null Result ReportOpen accessMedicine
Jean‐Christophe Marine, Osnat Bartok, Shira Sagie et al. · 2026 · Cell
Intratumor heterogeneity (ITH) encompasses genetic, epigenetic, transcriptional, proteomic, and immunopeptidomic diversity. Beyond genetic heterogeneity, it is increasingly clear that non-mutational heterogeneity and plasticity generate…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chengjiao Yang, Ruici Yang, Binbin Zheng et al. · 2026 · Cell Death and Disease
Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of "Lactylation Switch in Cancer Vulnerabilities." We dissect the dominant enzymatic pathways (AARS1/2, KATs, HDACs) and non-enzymatic mechanisms (MGO/LGSH), alongside their critical structural underpinnings. Furthermore, we delineate how lactylation signals are interpreted by specific readers (e.g., TRIM33), directly reprogram non-histone protein function through s
View details →Negative / Null Result ReportOpen accessPsychology
Matthew Bourke, Claudia I. Maddren, Franziska Sippel et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Understanding the within-person association between daily screen use and sleep can help clarify whether this association reflects potentially causal effects or confounding factors. Objective: To synthesize evidence on the…
View details →Negative / Null Result ReportOpen accessMedicine
Lyduine Eisa Collij, Gemma Salvadó, Kanta Horie et al. · 2026 · Nature Communications
To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease duration was estimated using Aβ-PET and tau-PET with the SILA algorithm. Bootstrapped LOESS models showed that %p-tau217 changes earliest, increasing just before Aβ-PET positivity. Other p-tau species
View details →Replication FailureOpen accessMedicine
Jean‐Christophe Rozé, Gilles Cambonie, Cyril Flamant et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Controversies persist about management of the ductus arteriosus by nonsteroidal anti-inflammatory drugs in extremely preterm infants. Acetaminophen (paracetamol) appears to be a promising alternative with possibly fewer adverse…
View details →Negative / Null Result ReportOpen accessMaterials Science
Ran Dong, Yingao Ru, Xi Zhang et al. · 2026 · ACS Omega
Abstract Batch nanofabrication of complex nanostructures remains a critical challenge, restricting their translation from laboratory design to industrial application. To address this, we report a conceptual and methodological advance by…
View details →Replication FailureOpen accessMedicine
Hideaki Bando, Jun Watanabe, Yusuke Takahashi et al. · 2026 · Nature Medicine
Tumor-informed circulating tumor DNA (ctDNA) enables detection of molecular residual disease (MRD) after curative resection of colorectal cancer (CRC), but whether early intervention improves outcomes remains uncertain. ALTAIR was a…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Gongwei Guo, Zhihui Tang, Honggang Liu · 2026 · European Journal of Education
ABSTRACT Although the proliferation of artificial intelligence (AI) and digital tools has facilitated AI‐enhanced and informal digital learning of English, traditional classroom ecology remains a central context for adolescent English‐as‐a‐foreign‐language (EFL) learners' language learning and development. Additionally, while the importance of achievement emotions among tertiary‐level EFL learners has been well established, research on retrospective outcome emotions (e.g., pride and shame) among non‐tertiary EFL learners remains scarce. As such, the study investigated whether and how language
View details →Negative / Null Result ReportOpen accessMathematics
Michelle Pistner Nixon, Kyle C. McGovern, Maxwell A. Konnaris et al. · 2026 · The Annals of Applied Statistics
Many scientific fields, including human gut microbiome science, collect multivariate count data where the sum of the counts is unrelated to the scale of the underlying system being measured (e.g., total microbial load in a subject’s…
View details →Failed Experiment ReportOpen accessAgricultural and Biological Sciences
Irene Dini · 2026 · Molecules
Fermented foods and probiotics represent complementary yet distinct components of human nutrition. Fermented foods are shaped by biochemical transformations driven by microbial metabolism, whereas probiotics are live microorganisms that may confer health benefits to the host. In both cases, bacteria, yeasts, and filamentous fungi mediate key metabolic activities that generate bioactive compounds and modulate host-microbiota interactions. During fermentation, microbial communities synthesize organic acids, peptides, exopolysaccharides, vitamins, and other metabolites that enhance food safety, s
View details →Negative / Null Result ReportOpen accessEnergy
Ahmed M. Khalil, Samir M. Kamel, Mohamed S. Mohy Eldin · 2026 · Scientific Reports
This work used a simple technique to prepare a novel cerium titanate nano-rods embedded in a cellulose-based hydrogel with high photo catalytic degradation activity. The composite hydrogel was prepared by embedding different amounts of cerium titanate nano-rods (Ce/Ti-NRs) into a crosslinked carboxymethyl cellulose/polyacrylamide polyelectrolyte complex (CMC/PAM) as a matrix material. The physico-chemical properties of the Ce/Ti-NRs, CMC/PAM, and cerium titanate nano-rods embedded in a cellulose-based hydrogel (Ce/Ti-NRs/CMC/PAM) were investigated by FT-IR, XRD, BET, TEM, SEM, and EDX techniqu
View details →Negative / Null Result ReportOpen accessEngineering
Lorenzo Tamboia, Giorgio Montinaro, Elisa Ravesio et al. · 2026 · Journal of Cleaner Production
The growing demand for sustainable energy solutions has highlighted the crucial role of lithium-ion batteries (LIBs) in the global energy transition. However, the conventional use of polyvinylidene fluoride (PVDF) binders combined with…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ingvild Almås, Alexander W. Cappelen, Erik Ø. Sørensen et al. · 2026 · The Quarterly Journal of Economics
Abstract This article provides the first comprehensive global evidence on people’s fairness and efficiency preferences, beliefs about the sources of inequality and the efficiency cost of redistribution, and policy attitudes toward redistribution. Using a globally harmonized consequential experiment with more than 65,000 individuals across 60 countries, we show that the source of inequality plays a substantially larger role for inequality acceptance than the efficiency cost of redistribution. At the global level, implemented inequality increases by 85% when inequality is caused by merit rather
View details →Negative / Null Result ReportOpen accessMedicine
Marta Młodawska, Anna Zmelonek-Znamirowska, Grzegorz Świercz et al. · 2026 · Journal of Clinical Medicine
Background and Objectives: Placenta accreta spectrum (PAS) complicating placenta praevia is associated with increased maternal morbidity; however, neonatal respiratory burden may be underappreciated. We compared neonatal outcomes between pregnancies complicated by placenta praevia with and without histopathologically confirmed PAS, with additional adjustment of respiratory outcomes for gestational age at delivery. Materials and Methods: We conducted a retrospective single-centre cohort study (n = 82). Based on placental histopathology, women were classified as PAS (n = 37; accreta/increta/perc
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