Negative / Null Result ReportOpen accessEnvironmental Science
Xinyi Zhang, Liangjie Wang, Jian Wei et al. · 2026 · Nature Communications
Oxygen vacancies (Ov) on metal oxide surfaces exhibit high catalytic activity for activating peroxymonosulfate (PMS) in wastewater decontamination, yet their in-situ regeneration remains a significant challenge. This study successfully…
View details →Negative / Null Result ReportOpen accessMaterials Science
Sonakshi Gupta, Akhlak Mahmood, Shivank Shukla et al. · 2025 · Macromolecular Rapid Communications
ABSTRACT Machine learning and artificial intelligence have revolutionized polymer science by enhancing the ability to rapidly predict key polymer properties and enabling generative design. The utilization of large language models (LLMs) in polymer informatics may offers additional opportunities for advancement. Unlike traditional methods that depend on large labeled datasets, hand‐crafted representations of the materials, and complex feature engineering, LLM‐based methods utilize natural language inputs via a transfer learning process and eliminate the need for complex representation and finge
View details →Negative / Null Result ReportOpen accessMedicine
Pinar Sargin, Mark F. Roethle, Shuang Jia et al. · 2022 · Gut Microbes
The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. Since Lactiplantibacillus plantarum 299 v (Lp299v) supplementation improves gut barrier function and reduces systemic inflammation, we studied its effects in spontaneously diabetic DRlyp/lyp rats provided a normal cereal diet (ND) or a gluten-free hydrolyzed casein diet (HCD). All rats provided ND developed diabetes (62.5±7.7 days); combining ND with Lp299v did not improve survival. Diabetes was delayed by HCD (72.2±9.4 day
View details →Negative / Null Result ReportOpen accessPsychology
Muhammad Kamal Uddin, Md Tarikul Islam, Muhammad Asaduzzaman · 2026 · Zenodo (CERN European Organization for Nuclear Research)
A large body of research has documented that smoking behavior is associated with a number of psychological variables. Weiss, Mouttapa, Cen, Johnson, and Unger (2011) studied a culturally diverse sample of 1,771 adolescents who reported that the risk of smoking initiation was significantly higher among students who scored higher on hostility and depressive symptoms, and were bully-victims. Mykletun, Overland, Aaro, Liabo, and Stewart (2008) carried out a population-based health survey on 60,814 adults aged between 20 to 89 years and reported that anxiety and depression were the most common in c
View details →Negative / Null Result ReportOpen accessMedicine
Malte L Schmieding, Marvin Kopka, Myrto Bolanaki et al. · 2025 · Journal of Medical Internet Research
BACKGROUND: Symptom checker apps (SCAs) are layperson-facing tools that advise on whether and where to seek care, or possible diagnoses. Previous research has primarily focused on evaluating the accuracy, safety, and usability of their recommendations. However, studies examining SCAs' impact on clinical care, including the patient-physician interaction and satisfaction with care, remain scarce. OBJECTIVE: This study aims to evaluate the effects of an SCA on satisfaction with the patient-physician interaction in acute care settings. Additionally, we examined its influence on patients' anxiety a
View details →Negative / Null Result ReportOpen accessMedicine
Fatemeh Mohammadyari, Amirreza Aflak, Mahta ZareDini et al. · 2025 · Frontiers in Medicine
Background: Gastrointestinal bleeding (GIB), which includes both upper GIB (variceal and non-variceal) and lower GIB, represents a significant cause of emergency department referrals. Main body: Given the potential risks of blood transfusion, re-bleeding, and mortality in these patients, it is essential to establish a system for prioritizing critical patients. Several risk stratification scoring systems have been developed based on patients' clinical characteristics and/or endoscopic findings. However, the optimal scoring system for each clinical scenario remains uncertain. Conclusion: In this
View details →Replication FailureOpen accessMedicine
Julien Vionnet, Jorge P. Torres-Yaguana, Rosa Miquel et al. · 2024 · American Journal of Transplantation
The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multicenter, biomarker-strategy design, IS withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver
View details →Negative / Null Result ReportOpen accessEngineering
Junyi Yin, Jie Zhu, Shaolei Wang et al. · 2026 · Nature Communications
One-dimensional (1D) multifunctional fibers have garnered significant attention due to their advantageous geometry properties, which allows conformal interfacing with soft biological tissues and efficient charge transport. Here, we…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Faisal AlReshaid, Alper Ertürk, Razan Alkhayyat et al. · 2025 · Frontiers in Psychology
Introduction: Leaders' self-awareness is essential to leadership effectiveness. Cognitive styles-how individuals perceive and process information-are key factors in fostering self-awareness. Drawing on Social Identity Theory (SIT), this study explores whether cognitive style congruence between supervisors and subordinates enhances supervisors' self-awareness, and whether Leader-Member Exchange (LMX) mediates this relationship. Methods: We used a time-lagged dyadic design and multilevel polynomial regression to analyze data from 189 subordinates and 36 supervisors. Cognitive styles were measure
View details →Negative / Null Result ReportOpen accessMedicine
Bilal A. Siddiqui, Sumit K. Subudhi, Padmanee Sharma · 2022 · Cell Reports Medicine
The addition of atezolizumab (anti-PD-L1) to enzalutamide (androgen receptor antagonist) did not prolong survival in metastatic prostate cancer.1Powles T. Yuen K.C. Gillessen S. Kadel 3rd, E.E. Rathkopf D. Matsubara N. Drake C.G. Fizazi K.…
View details →Negative / Null Result ReportOpen accessMedicine
Carlen Yuen, Michelle Zheng, Max Saint-Germain et al. · 2025 · Biomedicines
Background/Objectives: Meningiomas are the most common intracranial tumors. Surgery and radiation therapy are the cornerstones of treatment and no standard of care therapy exists for refractory meningiomas. This manuscript aims to provide a comprehensive review of novel diagnostic and therapeutic approaches against these tumors. Methods: A search for the existing literature on systemic therapies for meningiomas was performed on PubMed and a search for presently accruing clinical trials was performed on ClinicalTrials.gov. Results: Systemic treatments, including chemotherapy, somatostatin analo
View details →Negative / Null Result ReportOpen accessMedicine
Giordano Fiorentù, Nicol Bernardinello, Giacomo Giulianelli et al. · 2025 · Advances in Therapy
Pulmonary hypertension (PH) is a progressive syndrome characterized by increased pulmonary artery pressure. PH often complicates chronic lung diseases, thus contributing to a substantial disease burden and poor prognosis. The WHO Group 3…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Muhammad Asif, Long Yun-rong, Muhammad Azam Zia et al. · 2025 · Energy & Environment
Climate change, caused by the burning of fossil fuels, has emerged as an acute world problem, especially in the Group of Twenty (G20), where CO 2 emissions and other greenhouse gases are accumulating. This research examines how energy…
View details →Negative / Null Result ReportOpen accessMedicine
Judith Charbit, Jean‐Sébastien Vidal, Olivier Hanon · 2025 · Nutrients
Cognitive aging is a complex, multifactorial process influenced by genetic, metabolic, and environmental factors. Among modifiable risk factors, nutrition has emerged as a promising target to preserve cognitive function. This review provides a comprehensive overview of the impact of dietary interventions-including specific nutrients and dietary patterns-on cognitive domains (memory, executive function, global cognition) and mental health. Recent findings: multinutrient supplementation, particularly combinations of B vitamins and omega-3 fatty acids, appears beneficial for episodic memory, espe
View details →Negative / Null Result ReportOpen accessEngineering
Cao Zhengzheng, Xie Mengqi, Rong Tao et al. · 2026 · Scientific Reports
With the development of underground engineering and oil and gas exploitation, the problem of fluid-solid interaction in fractured rock mass has become increasingly prominent, and its complex coupling mechanism has a profound impact on the…
View details →Negative / Null Result ReportOpen accessPsychology
Zachary J. Williams, Hannah Barnett, Balázs Szigeti · 2026 · JAMA Psychiatry
Importance: Psychedelic-assisted therapy (PAT) trials have high levels of functional unblinding, which biases results when comparing PAT with blinded interventions. Because PAT is effectively always open label, treatment results should be…
View details →Negative / Null Result ReportOpen accessMedicine
Ewelina Młynarska, Wiktoria Lisińska, Katarzyna Hossa et al. · 2025 · Pharmaceuticals
Vitamin D, long recognized for its essential role in calcium-phosphate balance and bone health, has increasingly been identified as a pleiotropic regulator of metabolic, cardiovascular, and renal function. Deficiency of vitamin D is widespread worldwide and has been linked to a higher risk of insulin resistance, type 2 diabetes, atherosclerosis, hypertension, and chronic kidney disease. Meta-analyses suggest that each 10 nmol/L (≈4 ng/mL) increase in serum 25-hydroxyvitamin D [25(OH)D] is associated with about a 4% lower risk of type 2 diabetes, whereas other analyses indicate an approximately
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
T. Zhang, Chuan Qin, Zhaoying Lu · 2025 · International Review of Economics & Finance
This study investigates the relationship between firm-level market competitiveness and corporate environmental, social, and governance (ESG) performance, with a particular focus on the underlying mechanisms and moderating factors…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Sieun Kim · 2025 · Scientific Reports
This study investigated the neurophysiological and affective responses elicited by nature-inspired indoor design elements, including curvilinear forms (CL), nature views (N), and wooden interiors (W), in a virtual environment, and their…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Karina Gutiérrez-Moreno, Ana Isabel Olguín-Martínez, Amelia C. Montoya-Martínez et al. · 2025 · Diversity
Fungi from the genus Trichoderma have been extensively studied and used as biological control agents (BCAs) because of their versatile mechanisms of action. These include triggering systemic resistance, directly inhibiting pathogens, promoting plant growth, enhancing tolerance to abiotic stress, and producing auxins. However, the widespread application of the most studied Trichoderma strains has been limited by discrepancies between their potential results observed in controlled environments and the outcomes in greenhouses and field conditions. These differences are associated with context dep
View details →Negative / Null Result ReportOpen accessPsychology
Hae Won Kim, Jee In Kang, Eunhee Hwang et al. · 2018 · PLoS ONE
Accumulating evidence suggests that the glutamatergic system plays a major role in the pathophysiology of obsessive compulsive disorder (OCD) and empathic processing. Particularly, genetic influence of glutamate transporter gene (SLC1A1) on OCD has been frequently replicated in previous studies, but several studies did not replicate the result. Therefore, we aimed to replicate the associations between the SLC1A1 and OCD in a Korean population. In addition, we investigated the influence of SLC1A1 on trait empathy, impairments in which are characteristic of OCD. Six single-nucleotide polymorphis
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Zhendong Zhao, Huiwang Dai, Tiantian Nie et al. · 2025 · Nature Communications
High-valent iron-oxo species (FeIV=O) have garnered increasing attention for water purification, while the selective generation of FeIV = O in Fenton-like reactions still lacks an effective control protocol at the atomic level. Here, we…
View details →Negative / Null Result ReportOpen accessNeuroscience
Madhur Mangalam · 2025 · European Journal of Applied Physiology
The Bayesian brain hypothesis-the idea that neural systems implement or approximate Bayesian inference-has become a dominant framework in cognitive neuroscience over the past two decades. While mathematically elegant and conceptually unifying, this paper argues that the hypothesis occupies an ambiguous territory between useful metaphor and testable, biologically plausible mechanistic explanation. We critically examine the key claims of the Bayesian brain hypothesis, highlighting issues of unfalsifiability, biological implausibility, and inconsistent empirical support. The framework's remarkabl
View details →Negative / Null Result ReportOpen accessMedicine
Athina Trachalaki, Anna Lindahl, Simone Petrarulo et al. · 2025 · Breathe
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with limited treatment options. Despite the approval of pirfenidone and nintedanib that slow disease progression, IPF remains a disease with poor survival. Promising therapeutic…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ali Derakhshan, Gurpinder Singh Lalli, Yujong Park · 2026 · Language Testing in Asia
While Artificial Intelligence (AI) has significantly transformed L2 testing and assessment, empirical research into how EFL practitioners perceive the specific opportunities and challenges of these tools remains limited. To address this…
View details →Negative / Null Result ReportOpen accessMedicine
Tara L. Alvarez, Mitchell Scheiman, Farzin Hajebrahimi et al. · 2025 · British Journal of Sports Medicine
OBJECTIVE: The CONCUSS randomised clinical trial compared the effectiveness of immediate office-based vergence/accommodative therapy with movement (OBVAM) to delayed therapy for the treatment of concussion-related convergence insufficiency…
View details →Negative / Null Result ReportOpen accessMedicine
Yu Jun Wong, Laurent Lam, Pierre‐Antoine Soret et al. · 2025 · Journal of Hepatology
BACKGROUND & AIMS: Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis (PBC). However, the frequency and clinical relevance of discordant biochemical and LSM changes remain unclear. We aim to determine the performance of the most recent or current LSM (LSMc) in predicting first hepatic decompensation (HD) in the setting of discordant biochemical and LSM responses. METHODS: In this international, multicenter study, we included patients with at least two reliable LSM performed at least 6 months apart. Patients
View details →Negative / Null Result ReportOpen accessMedicine
Iñaki Eguren‐Santamaría, Ignacio Melero, Inmaculada Rodríguez et al. · 2025 · Journal for ImmunoTherapy of Cancer
Almost every successful anticancer treatment has been preceded by preclinical scientific breakthroughs that encouraged clinical development. However, therapeutic strategies showing promising preclinical results often fail to confirm…
View details →Negative / Null Result ReportOpen accessNeuroscience
Yanyu Bao, Guoying Miao, Nannan He et al. · 2026 · Biology
Mitochondrial dysfunction is a key early pathological process in neurodegenerative diseases (NDs), leading to oxidative stress, impaired energy metabolism, and neuronal apoptosis prior to the onset of clinical symptoms. Although mitochondria represent important therapeutic targets, effective interventions targeting mitochondrial function remain limited. This review summarizes current evidence regarding the mechanisms by which melatonin protects mitochondria and evaluates its therapeutic relevance, with a primary focus on Alzheimer's disease, Parkinson's disease, and Huntington's disease-the ma
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Zahra Ghorbanzadeh, Bahman Panahi, Leila Purhang et al. · 2025 · Agronomy
Developing climate-resilient and high-quality cotton cultivars remains an urgent challenge, as the key target traits yield, fibre properties, and stress tolerance are highly polygenic and strongly influenced by genotype–environment interactions. Recent advances in chromosome-scale genome assemblies, pan-genomics, and haplotype-resolved resequencing have greatly enhanced the capacity to identify causal variants and recover non-reference alleles linked to fibre development and environmental adaptation. Parallel progress in functional genomics and precision genome editing, particularly CRISPR/Cas
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