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WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
C. Elizabeth Shaaban, Caterina Rosano, Xiaonan Zhu et al. · 2023 · The Journals of Gerontology Series A
BACKGROUND: Older adults with discordant biological and chronological ages (BA and CA) may vary in cognitive and physical function from those with concordant BA and CA. METHODS: To make our approach clinically accessible, we created…
View details →Camille Zaug, John D. Carter · 2021 · Studies in Applied Mathematics
Abstract Ocean swell plays an important role in the transport of energy across the ocean, yet its evolution is not well understood. In the late 1960s, the nonlinear Schrödinger (NLS) equation was derived as a simplified model for the…
View details →David Giguere, Daniel J. Dickson, Michelle K. Tulloch et al. · 2021 · Journal of Experimental Child Psychology
Evidence is mixed regarding whether and why bilingual children might be advantaged in the development of executive functions. Five preregistered hypotheses regarding sources of a bilingual advantage were tested with data from 102 Spanish-English bilingual children and 25 English monolingual children who were administered a test of executive attention, the flanker task, at 7, 8, and 9 years of age. Measures of the children's early and concurrent bilingual exposure and their concurrent English and Spanish skill were available from a larger longitudinal study in which these children participated.
View details →Carlos González‐Alayón, Esteban Porrini, Sergio Luis‐Lima et al. · 2021 · Liver International
BACKGROUND & AIMS: In cirrhosis, the reliability of formulas that estimate renal function, either those specifically developed in this population or the classic equations, has not been properly quantified. We studied the agreement between…
View details →Li Wang, Jiting Zhang, Li Zhang et al. · 2022 · Frontiers in Cellular and Infection Microbiology
Background Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing…
View details →Liza Van der Laan, Kyle Parmley, Mojdeh Saadati et al. · 2025 · The Plant Genome
Developments in genomics and phenomics have provided valuable tools for use in cultivar development. Genomic prediction (GP) has been used in commercial soybean [Glycine max L. (Merr.)] breeding programs to predict grain yield and seed…
View details →Jingxiang Song, Xiaohuang Tu, Bing Wang et al. · 2014 · BMC Gastroenterology
BACKGROUND: To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. METHODS: Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic and operative data, gastrointestinal function, postoperative hospital stays, surgical and general complications and mortality were assessed prospectively. RESULTS: Of the 80 patients (mean age 56.3 years), 10 (12.5%) received proximal subtotal gastrectomy (Billroth I), 38 (47.5%)
View details →Safi U. Khan, Ahmad Naeem Lone, Neal S. Kleiman et al. · 2023 · JACC Advances
The effects of aspirin in adults without atherosclerotic cardiovascular disease (ASCVD), stratified by statin use across different ASCVD risks, remain uncertain. The purpose of this study was to examine the effects of aspirin in adults…
View details →Maureen Reilly, Sunita Vohra, Valeria E. Rac et al. · 2019 · Neonatology
<b><i>Background:</i></b> The treatment effect of occlusive wrap applied immediately after delivery in infants born 24–28 weeks’ gestation has been studied, but the effect is not known in infants born at less than…
View details →Christopher A. Tait, Abtin Parnia, Nishan Zewge-Abubaker et al. · 2020 · BMC Public Health
Abstract Background Child mortality has been reduced by more than 50 % over the past 30 years. A range of secular economic and social developments have been considered to explain this phenomenon. In this paper, we examine the association…
View details →Ian I. Courter, Tom Chance, Ryan Gerstenberger et al. · 2022 · Canadian Journal of Fisheries and Aquatic Sciences
For over 150 years, hatchery-origin anadromous salmon and trout have been reared and released throughout the Pacific Northwest to mitigate for lost habitat and sustain harvest opportunity. Some studies demonstrate that introgression of…
View details →Joanne H. Reed, Gwenny M. Verstappen, Maureen Rischmueller et al. · 2020 · PubMed
Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the precise role of B cells in the pathogenesis is not fully understood. This is exemplified by the failure of multiple clinical trials directed at B cell…
View details →Chandran Ramakrishna, Mari S. Golub, Abby J. Chiang et al. · 2017 · Behavioural Neurology
Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. Anxiety level
View details →Martin S. Weber, Jacqueline Nicholas, Michael R. Yeaman · 2021 · Neurology Neuroimmunology & Neuroinflammation
Bruton tyrosine kinase inhibitors (BTKis) encompass a new class of therapeutics currently being evaluated for the treatment of multiple sclerosis (MS). Whether BTKis affect COVID-19 risk or severity or reduce vaccine efficacy are important…
View details →Mahima Chillakanti, Elaine Young, April Hopcroft et al. · 2024 · touchREVIEWS in Endocrinology
AID systems can achieve near-desired glycaemic targets with minimal hypoglycaemia in pregnant women with T1D. Randomized controlled trials are needed to confirm these findings and to win FDA indications in pregnancy.
View details →Silvia Park, Emma Langley, Jong‐Mu Sun et al. · 2015 · Oncotarget
// Silvia Park 1, * , Emma Langley 2, * , Jong-Mu Sun 1 , Steve Lockton 2 , Jin Seok Ahn 1 , Anjali Jain 2 , Keunchil Park 1 , Sharat Singh 2 , Phillip Kim 2 , Myung-Ju Ahn 1 1 Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Prometheus Laboratories Inc, A Nestlé Health Science Company, Department of Research and Development, San Diego, CA, USA * These authors have contributed equally to this work Correspondence to: Myung-Ju Ahn, e-mail: silkahn@skku.edu Phillip Kim, e-mail: pkim@prometheuslabs.co
View details →Ciara Conduit, Ian D. Davis, Jeffrey C. Goh et al. · 2023 · British Journal of Urology
OBJECTIVE: To evaluate the efficacy of sequential treatment with ipilimumab and nivolumab following progression on nivolumab monotherapy in individuals with advanced, non-clear-cell renal cell carcinoma (nccRCC). MATERIALS AND METHODS:…
View details →Tomoki Makino, Hiroshi Miyata, Takushi Yasuda et al. · 2024 · Esophagus
BACKGROUND: S-588410, a cancer peptide vaccine (CPV), comprises five HLA-A*24:02-restricted peptides from five cancer-testis antigens. In a phase 2 study, S-588410 was well-tolerated and exhibited antitumor efficacy in patients with urothelial cancer. Therefore, we aimed to evaluate the efficacy, immune response, and safety of S-588410 in patients with completely resected esophageal squamous cell carcinoma (ESCC). METHODS: This phase 3 study involved patients with HLA-A*24:02-positive and lymph node metastasis-positive ESCC who received neoadjuvant therapy followed by curative resection. After
View details →Michal Mego, Barbora Judita Kasperová, Jozef Chovanec et al. · 2024 · Frontiers in Oncology
Background: Probiotics could decrease irinotecan-induced diarrhea due to the reduction of intestinal beta-d-glucuronidase activity. This study included a combined analysis of two clinical trials aimed to determine the effectiveness of the probiotics in the prophylaxis of irinotecan-induced diarrhea in metastatic colorectal cancer (CRC) patients. Methods: This combined analysis included 46 patients with CRC enrolled in the Probio-SK-003 (NCT01410955) and 233 patients from Probio-SK-005 (NCT02819960) starting a new line of irinotecan-based therapy with identical eligibility criteria. Patients we
View details →Lien Anh Ha Do, Zheng Quan Toh, Paul Vincent Licciardi et al. · 2021 · The Lancet Global Health
Measles virus and respiratory syncytial virus (RSV) are two important global health pathogens causing substantial morbidity and mortality worldwide. The current measles vaccination schedule has the first dose given at 9-12 months of age…
View details →Zhongwei Liu, Shuang Shi, Haitao Zhu et al. · 2018 · International Heart Journal
The phenotype shifting of vascular smooth muscle cells (VSMCs) was indicated to play a role during the initial stage of atherosclerotic plaque formation by facilitating extracellular matrix deposition. This study was aimed at investigating…
View details →Adrian K. Davison, Ashma Krishan, Robert P New et al. · 2024 · Lara D. Veeken
OBJECTIVES: To test the hypothesis that photographs (in addition to self-reported data) can be collected daily by patients with SSc using a smartphone app designed specifically for digital lesions, and could provide an objective outcome measure for use in clinical trials. METHODS: An app was developed to collect images and patient-reported outcome measures including Pain score and the Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU) questionnaire. Participants photographed their lesion(s) each day for 30 days and uploaded images to a secure repository. Lesions were analysed both
View details →Shiho Arima, Kyoko Shimizu, Tomoyoshi Okamoto et al. · 2017 · Anticancer Research
BACKGROUND: Gemcitabine (GEM) plus cisplatin (CDDP) chemotherapy has been used worldwide as the standard first-line treatment for advanced biliary tract cancer (BTC). A phase II trial has also suggested promising activity of GEM plus S-1…
View details →Xiao Xuan Xing, Chen Zhu, Yan Chu et al. · 2021 · BMC Gastroenterology
BACKGROUND: Perioperative patients are at risk of developing stress ulcers (SU), which can cause clinically important bleeding. Stress ulcer prophylaxis (SUP) is widely applied to the patients in Intensive care unit (ICU) as well as the general ward, so it may lead to overmedication. However, there have been no surveys regarding SUP knowledge or prescribing habits. OBJECTIVE: Our study assessed the knowledge, attitudes, and prescribing behavior of the surgeons toward perioperative patients regarding SUP and determined factors associated with low knowledge and high level of prescribing behavior
View details →Shih-Hong Chen, Wing-Sum Chan, Chih‐Min Liu et al. · 2020 · Annals of Intensive Care
Abstract Background Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and…
View details →Yudan Wang, Litian Liu, Xinning Li et al. · 2022 · Journal of Interventional Cardiology
Background: Mortality after percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients with cardiogenic shock (CS) remains high. However, the real-world risk factors for mortality in these patients are poorly defined. Objective: The aim of this study is to establish a clinical prognostic nomogram for predicting in-hospital mortality after primary PCI in STEMI patients with CS. Methods: This retrospective, multicenter, observational study included STEMI patients with CS who underwent PCI at 39 hospitals in Hebei Province from January 2018 to December 2019. A
View details →Kazuhiro Yamamoto · 2017 · Yonago acta medica
Heart failure with preserved ejection fraction is a socioeconomic burden in Japan as well as other developed countries. Diuretics are widely used to attenuate symptoms and signs of congestion in both heart failure with preserved and…
View details →İpek Komşuoğlu Çelikyurt · 2011 · Pharmaceutica Analytica Acta
Affirmative influence of antioxidant vitamins may be observed in atherosclerosis and endothelial dysfunction, male infertility, Parkinson's disease (especially via lipoic acid), diabetes, brain tumors and skin maturation There is not yet…
View details →Qiang Tang, Yanwei Liu, Yingfeng Fu et al. · 2021 · Scientific Reports
The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that adv
View details →Zachary Veitch, Alona Zer, Herbert H. Loong et al. · 2019 · Scientific Reports
ENMD-2076, an aurora-A kinase inhibitor with anti-angiogenic properties, has shown activity in solid and hematologic malignancies. We investigated oral ENMD-2076 in an open-label, single-arm phase II study using 275 mg daily on a 28-day cycle in patients with advanced soft-tissue sarcomas (STS) receiving ≤1 line of prior therapy. Primary endpoint was 6-month progression-free survival (PFS) with ≤15% indicating no interest, and ≥40% indicating further interest in ENMD-2076. Secondary/exploratory endpoints included clinical benefit (CBR ≥6-months) and objective response (ORR) rates, PFS, OS, saf
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