Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Bo Yang, Fatma Ahmed Hassan, Waqar Ahmad et al. · 2026 · Frontiers in Public Health
Air pollution (AIRP) remains a critical public health and environmental challenge in developing Asia, where rapid industrialization and fossil fuel dependence continue to undermine population health and longevity. This study examines the impact of AIRP on life expectancy (LIFE) and investigates whether renewable energy adoption moderates this relationship. AIRP is proxied by carbon dioxide (CO₂) and nitrous oxide (N₂O) emissions, which capture pollution-intensive energy systems, industrial activity, and agricultural practices that jointly generate health-damaging co-pollutants, particularly in
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Wagner Augusto Müller, Sandro Binsfeld Ferreira, Suse Botelho da Silva · 2026 · Journal of Food Science
Effective cold chain management is crucial for ensuring food safety, but traditional monitoring approaches remain reactive and fragmented. Industry 4.0 technologies, such as the Internet of Things (IoT) and artificial intelligence (AI), offer transformative potential for real-time tracking, automation, and predictive analytics. Many studies have explored the application of IoT and AI in the cold chain, but the existing literature focuses on isolated technologies. This review presents an integrated perspective, examining the synergistic potential of IoT-enabled data acquisition and AI-driven pr
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marco Raffaele Cosenza, Alice Gaiatto, Büşra Erarslan Uysal et al. · 2025 · Nature
, the underlying processes and rates of spontaneous CA formation in human cells are underexplored. Here we introduce machine-learning-assisted genomics and imaging convergence (MAGIC)-an autonomously operated platform that integrates live-cell imaging of micronucleated cells, machine learning on-the-fly and single-cell genomics to systematically investigate CA formation. Applying MAGIC to near-diploid, non-transformed cell lines, we track de novo CAs over successive cell cycles, highlighting the common role of dicentric chromosomes as initiating events. We determine the baseline CA mutation ra
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Gabriele Cristelli, Francesco Lissoni · 2026 · Journal of the European Economic Association
Abstract We study the innovation effects of the Agreement on the Free Movement of Persons, signed by Switzerland and the European Union in 1999. We exploit a quasi-experimental setting created by Switzerland’s implementation of the treaty, which initially eased entry restrictions only for commuters from neighboring countries, thereby inducing a large inflow of “cross-border inventors” in regions close to the border. We find that the treaty increased patenting in such regions relative to comparable ones farther away from the border. We find no evidence indicating the displacement of native inve
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Matthew MacLachlan, Michael K. Adjemian, Xiaoli Etienne et al. · 2025 · Nature Communications
The advent of COVID-19 ended an era of stable US retail food prices that followed the world food price crisis of 2010–2012. Pandemic-related disruptions, avian influenza outbreaks, and the Russia-Ukraine war drove 2022 food-at-home…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Untung Rahardja · 2025 · Journal of Digital Market and Digital Currency.
This study investigates the effectiveness of various digital marketing campaign types—Awareness, Conversion, and Retention—on conversion rates and engagement levels. Using a dataset of 8,000 records, we conducted a comprehensive analysis through ANOVA, Chi-Square tests, and OLS regression to understand the impact of these campaign types. The ANOVA results indicated no significant differences in conversion rates across the campaign types, with an F-statistic of 0.4752 and a p-value of 0.6218. Similarly, the analysis for engagement levels, measured by website visits, yielded an F-statistic of 0.
View details →Negative / Null Result ReportOpen accessMedicine
Fiona McPhee, Joseph Ueland, Vincent Vellucci et al. · 2019 · Antimicrobial Agents and Chemotherapy
[tested DAAs] of >5,000 nM) and were detected in evaluated GT-6b and -6f sequences. NS5A-L28A-R30A, observed in GT-6r, did not replicate. In conclusion, HCV GT-6b, GT-6f, and GT-6r sequences harbored highly resistant RASs to all evaluated…
View details →Negative / Null Result ReportOpen accessNeuroscience
Astrid Feiten, Kilian Dahm, Kai Schlepckow et al. · 2026 · Nature Communications
Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer's disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. In APP transgenic animals, bulk RNA-sequencing of isolated microglia sorted based on reporter expression highlighted TREM2 level-related changes in major immunometabolic pathways, and enrichment of genes in oxidative phosphorylation and cholesterol met
View details →Negative / Null Result ReportOpen accessEngineering
Naman Gupta, Rantong Gong, Y. Wu et al. · 2025 · Nature Communications
The discovery of superconductivity in La3Ni2O7 under pressure has motivated the investigation of a parent spin density wave (SDW) state, which could provide the underlying pairing interaction. Here, we employ resonant soft x-ray scattering…
View details →Negative / Null Result ReportOpen accessMedicine
Alexandra Irma Gabriela Bauşic, Francesca Scurtu, Andrei Manu et al. · 2025 · International Journal of Molecular Sciences
Endometriosis is a complex gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus, leading to chronic inflammation, pain, and infertility. Recent research suggests that gut microbiota may play a crucial role in the pathogenesis and progression of endometriosis by modulating immune responses and oestrogen metabolism. This study investigates the intestinal microbiota composition in women with endometriosis and its potential as a disease diagnosis and severity biomarker. Stool samples from nine patients diagnosed with endometriosis were analysed using
View details →Replication FailureOpen accessMedicine
S Bangalore, Santosh Kumar Sinha, Rakendra Singh et al. · 2026 · JAMA Cardiology
Importance: The optimal dual antiplatelet therapy after percutaneous coronary intervention (PCI) in patients with diabetes is not clearly defined. Although both ticagrelor and prasugrel are potent inhibitors of P2Y purinergic receptor 12…
View details →Replication FailureOpen accessChemistry
Farhan Sheth, Ishika Chatter, Manvendra Jasra et al. · 2025 · Plant Methods
Herbs have historically been central to medicinal practices, representing one of the earliest forms of therapeutic intervention. While synthetic drugs are often highly effective in treating acute conditions, their use is frequently…
View details →Negative / Null Result ReportMedicine
Han Sang Kim, Jung Yong Hong, Jaekyung Cheon et al. · 2020 · Journal of Clinical Oncology
4584 Background: Previously, two phase III clinical trials of immune checkpoint inhibitors (ICI) failed to meet their primary endpoints, leading to doubts regarding the clinical activity of ICI monotherapy in patients with aHCC. Here, we…
View details →Negative / Null Result ReportOpen accessMedicine
Martin G Schultz, Petr Otahal, Philip Roberts-Thomson et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: A hypertensive response to exercise is independently associated with cardiovascular disease (CVD), but clinical interpretation may be confounded by aerobic capacity (fitness). The aim of this study was to determine the relationship between exercise blood pressure (BP) relative to fitness and CVD events. METHODS: Clinical exercise test records were analysed from 12 743 people (aged 53 ± 13 years, 60% male) who completed a standard exercise stress test (Bruce treadmill protocol, stages 1-4) at six Australian hospitals. Records were linked to administrative datasets (hospital
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Andrei Kudriashov, Xiong Zhou, Razmik A. Hovhannisyan et al. · 2025 · Science Advances
Josephson junctions (JJs) are key to superconducting quantum technologies and the search for self-conjugate quasiparticles potentially useful for fault-tolerant quantum computing. In topological insulator (TI)–based JJs, measuring the current-phase relation (CPR) can reveal unconventional effects such as Majorana bound states (MBS) and nonreciprocal transport. However, reconstructing CPR as a function of magnetic field has not been attempted. Here, we present a platform for field-dependent CPR measurements in planar JJs made of NbSe 2 and few-layer Bi 2 Se 3 . When a flux quantum Φ 0 thr
View details →Negative / Null Result ReportOpen accessMedicine
André Zimerman, Alexander Dal Forno, Luis E. Rohde et al. · 2026 · JAMA Cardiology
Importance: Conduction system pacing (CSP) is a promising and potentially cost-effective alternative to biventricular pacing (BiVP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle-branch block (LBBB), but its impact on heart failure (HF) outcomes remains uncertain. Objective: To compare CSP vs BiVP on an HF-related outcome in patients with HFrEF and LBBB. Design, Setting, and Participants: PhysioSync-HF (Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure) was an investigator-initiated, multicenter, noninf
View details →Negative / Null Result ReportMedicine
Mélissa De Regge, Koenraad G. Monsieurs, K. Vandewoude et al. · 2012 · PubMed
Automated external defibrillators (AEDs) have shown to improve survival after cardiopulmonary arrest (CPA) in many, but not all clinical settings. A recent study reported that the use of AEDs in-hospital did not improve survival. The…
View details →Negative / Null Result ReportOpen accessNeuroscience
Olivier Senn, Florian Hoesl, Toni Bechtold et al. · 2024 · PLoS ONE
There is a broad consensus in groove research that the experience of groove, understood as a pleasurable urge to move in response to music, is to some extent related to the complexity of the rhythm. Specifically, music with medium rhythmic complexity has been found to motivate greater urge to move compared to low or high complexity music (inverted-U hypothesis). Studies that confirmed the inverted-U hypothesis usually based their measure of complexity on the rhythmic phenomenon of syncopation, where rhythms with more and/or stronger syncopation are considered to be more complex than less synco
View details →Negative / Null Result ReportOpen accessMedicine
Igor Strahovnik, Andrej Strahovnik, Samo K. Fokter · 2025 · Bioengineering
Whole-leg radiographs (WLRs) are widely used to assess coronal alignment before total knee arthroplasty (TKA), but may be inaccurate in patients with atypical morphotypes or malrotation. This study evaluated the discrepancy between WLR and 3D computed tomography (CT) scans across coronal plane alignment of the knee (CPAK) morphotypes and introduced a novel projection index—the femoral notch projection ratio (FNPR). In CPAK III knees, 19% of cases exceeded a clinically relevant threshold (>3° difference), prompting investigation of underlying projection factors. In 187 knees, coronal angles—
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dingya Sun, Jialu Wang, Xin Li et al. · 2026 · Antioxidants
Curcumin, a natural polyphenol derived from turmeric, functions as a potent exogenous antioxidant and exhibits a range of benefits in the prevention and management of metabolic diseases. Despite its extremely low systemic bioavailability, curcumin demonstrates significant bioactivity in vivo, a phenomenon likely attributable to its accumulation in the intestines and subsequent modulation of systemic oxidative stress and inflammation. This article systematically reviews the comprehensive regulatory effects of curcumin on systemic metabolic networks-including glucose metabolism, amino acid metab
View details →Negative / Null Result ReportOpen accessMaterials Science
Rosalie Cresswell, Parveen Kumar Deralia, Yoshihisa Yoshimi et al. · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide The structure of plant cellulose microfibrils remains elusive, despite the abundance of cellulose and its utility in industry. Using 2D solid-state NMR of 13 C-labeled never-dried plants, six major glucose environments are resolved, which are common to the cellulose of softwood, hardwood, and grasses. These environments are maintained in isolated holocellulose nanofibrils, allowing more detailed microfibril characterization. We show that there are only two glucose environments that reside within the microfibril core. These have the same NMR 13
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Marcello Candelli, Marta Sacco Fernandez, Gloria Rozzi et al. · 2025 · Diagnostics
Background and Objectives: Despite major advances in medical science and critical care, sepsis remains a leading cause of morbidity and mortality worldwide: it arises from dysregulated host response to infections and may culminate in organ dysfunction. A hallmark of its pathogenesis is the cytokine storm, in which interleukins (ILs) serve as central mediators of both protective and deleterious immune responses. This review summarizes the current knowledge on the role of ILs in sepsis, emphasizing their potential as biomarkers and therapeutic targets. Material and Methods: We analyzed recent cl
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Suelen Gauna Trindade, Fernando Bonin Okasaki, Ashley P. Williams et al. · 2025 · Journal of Colloid and Interface Science
The self-assembly of glycyrrhizic acid (GA) in aqueous solutions has significant implications for soft matter science and material design. Here, we describe the self-assembly of GA under well-defined conditions, focusing on measurements of the critical aggregation concentration (CAC) - when GA dimers start stacking into nanofibrils, and of the critical gel concentration (CGC) - when nanofibrils entangle into a viscoelastic network. We examine in detail the structure at low concentrations and its evolution into a viscoelastic hydrogel, addressing the kinetic pathway. We highlight the dependence
View details →Negative / Null Result ReportOpen accessMedicine
Kenta Watanabe, Sho Fukuda, Dai Kubota et al. · 2026 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: In Japan, gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) account for nearly all fatal upper gastrointestinal malignancies. A unified model that simultaneously predicts the incidence of these two…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Buhari Doğan, Mohammad Razib Hossain, Rabeh Khalfaoui et al. · 2026 · Financial Innovation
Abstract Drawing from the recent COP28, which espouses a boom in clean energy transition through technological forwardness, and the framework of the SDG, we address critical questions related to green investment, energy investment, and environmental sustainability. We scrutinize whether green technology genuinely leads to green investment and energy investment in China and whether the causal nexus between these variables holds amid an EKC postulation. We use Chinese provincial data from 1998 to 2020 and deploy the quantile moment-based non-parametric regression technique and the newly develope
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Martin Olsson, Joacim Tå̊g · 2025 · The Journal of Finance
ABSTRACT Privatization of state‐owned enterprises is on the agenda across the globe. Using Swedish data covering two decades, we show that productivity gains and headcount reductions are associated with economic costs for incumbent…
View details →Negative / Null Result ReportOpen accessMedicine
Xinyi Chen, Mu Yang, Yongbiao Huang et al. · 2025 · Therapeutic Advances in Medical Oncology
Abscopal immunity—the regression of distant, non-irradiated lesions after localized radiotherapy (RT)—signals conversion of focal DNA damage into systemic antitumor immunity. This review advances a unifying three-stage…
View details →Negative / Null Result ReportOpen accessNeuroscience
Ola Ozernov‐Palchik, Amanda O’Brien, Elizabeth Jiachen Lee et al. · 2026 · Nature Communications
In adults, left hemisphere (LH) damage often leads to aphasia, but many cases of early damage leave linguistic processing intact, with a functional language system developing in the right hemisphere. To explain this early apparent equipotentiality of the two hemispheres for language, some have proposed that the language system is more bilateral during early development and becomes increasingly left-lateralized with age. We examined language lateralization using fMRI in two large developmental cohorts (total n=273 children aged 4-16 years; n=107 adults). Strong, adult-like LH lateralization (in
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Andrei Teodor Matei, Anita Ioana Vișan · 2025 · Antibiotics
The growing ineffectiveness of common antibiotics against multidrug-resistant pathogens has made antimicrobial resistance (AMR) a serious global health concern. This review emphasizes that natural antibiotics from animals, bacteria, fungi, and plants are worthy alternatives for combating this crisis. Evolutionary pressure has shaped these molecules, leading to antibiotic-resistant bacteria that can withstand single-target synthetic drugs but are vulnerable to multiple attack pathways (e.g., cell wall disruption, protein synthesis inhibition, biofilm interference) from natural compounds. Natura
View details →Negative / Null Result ReportOpen accessNeuroscience
Eric A. Finkel, Yi-Ting Chang, Rajan Dasgupta et al. · 2024 · Cell Reports
The brain receives constant tactile input, but only a subset guides ongoing behavior. Actions associated with tactile stimuli thus endow them with behavioral relevance. It remains unclear how the relevance of tactile stimuli affects…
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