Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Kateryn Rochon, Rodney B. Baker, Glen W. Almond et al. · 2015 · Journal of Medical Entomology
We investigated the acquisition of porcine reproductive and respiratory syndrome (PRRS) virus by the stable fly (Diptera: Muscidae; Stomoxys calcitrans (L.)) through a bloodmeal, and virus persistence in the digestive organs of the fly…
View details →Negative / Null Result ReportOpen accessMedicine
Marie Lefebvre, Michael P. Hengartner, Enrico Tronci et al. · 2022 · Physiology & Behavior
BACKGROUND: As eating behavior changes in relation to the menstrual cycle and weight changes with menopausal transition, ovarian hormones appear to be involved in regulating eating behavior. However, observations are contradictory and are difficult to compare, due to methodological problems related to nutritional epidemiology. To better understand the relationship between ovarian steroid hormones and eating behavior, our study evaluates women's responses to visual food cues at different points in the menstrual cycle with their specific serum estrogen/progesterone levels and women's responses i
View details →Negative / Null Result ReportOpen accessHealth Professions
Nasser Lubega, Abigail Anderson, Nicole Nelson · 2023 · PLoS ONE
High rates of irreproducibility and of poor mental health in graduate students have been reported in the biomedical sciences in the past ten years, but to date, little research has investigated whether these two trends interact. In this study, we ask whether the experience of failing to replicate an expected finding impacts graduate students' mental health. Using an online survey paired with semi-structured qualitative interviews, we examined how often biomedical science doctoral students at a large American public university experienced events that could be interpreted as failures to replicat
View details →Negative / Null Result ReportOpen accessNeuroscience
Nicholas Murphy, Alison Killen, Rajnish Kumar Gupta et al. · 2021 · Frontiers in Neurology
Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% of cases. Integrative models of their etiology posit that a decline in executive control of the visuo-perceptual system is a primary mechanism of VH generation. The role of bottom-up processing in the manifestation of VH in this condition is still not clear although visual evoked potential (VEP) differences have been associated with VH at an earlier stage of PD. Here we compared the amplitude and latency pattern reversal VEPs in healthy controls ( n = 21) and PDD patients ( n = 34) w
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriele Meyer, Jeffrey R. Leipprandt, Jianwei Xie et al. · 2012 · Endocrinology
Mammary organoids from adult mice produce tubules, analogous to mammary ducts in vivo, in response to hepatocyte growth factor (HGF) when cultured in collagen gels. The combination of HGF plus progestin (R5020) causes reduced tubule number…
View details →Negative / Null Result ReportOpen accessHealth Professions
Ann‐Marie Towers, Stacey Rand, Stephen Allan et al. · 2025 · BMJ Open
OBJECTIVES: To assess the feasibility of capturing older care home residents' quality of life (QoL) in digital social care records and the construct validity (hypothesis testing) and internal consistency (Cronbach's alpha) of four QoL measures. DESIGN: doption) study, a mixed-methods pilot of a prototype minimum dataset (MDS). SETTING: Care homes (with or without nursing) registered to provide care for older adults (>65 years) and/or those living with dementia. All homes used a digital record system from one of two suppliers. PARTICIPANTS: Data were extracted from 748 residents. All permanent
View details →Negative / Null Result Report
Loet Leydesdorff, Caroline S. Wagner, Lin Zhang · 2021 · Journal of Data and Information Science
Abstract Purpose Building on Leydesdorff, Bornmann, and Mingers (2019), we elaborate the differences between Tsinghua and Zhejiang University as an empirical example. We address the question of whether differences are statistically…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jeanne M. McCaffery, George D. Papandonatos, Lucy F. Faulconbridge et al. · 2015 · Psychosomatic Medicine
OBJECTIVES: Numerous studies have found elevated depressive symptoms among individuals with Type 2 diabetes, yet the mechanisms remain unclear. We examined whether genetic loci previously associated with depressive symptoms predict…
View details →Negative / Null Result ReportOpen accessNeuroscience
Christopher J. Wertz, Faith M Hanlon, Nicholas A. Shaff et al. · 2018 · Schizophrenia Bulletin
Inhibitory failure represents a core dysfunction in patients with schizophrenia (SP), which has predominantly been tested in the literature using reactive (ie, altering behavior after a stimulus) rather than proactive (ie, purposefully…
View details →Negative / Null Result ReportMedicine
Leon Veryard, Emma Jones, Gary Weaving et al. · 2013 · Current Alzheimer Research
Increased concentrations of pro-inflammatory blood cytokines and plasma homocysteine (Hcy) are frequently reported in Alzheimer's disease (AD). Hcy appears to have immunomodulating and pro-inflammatory activities. Further, emerging…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Shaoyuan Tan, Weixin Wu, Xinna Ge et al. · 2023 · One Health Advances
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Although modified live virus (MLV) vaccines are commonly used for PRRSV prevention and control, they still carry a risk of infecting the host and replicating in target cells, thereby increasing the likehood of virus recombination and reversion to virulence. In this study, we inserted the target sequence of miR-142 into the nsp2 hypervariable region of PRRSV to inhibit viral replication in its host cells of pigs, with the aim of achieving virus attenuation. The chimeri
View details →Negative / Null Result ReportPsychology
Jeannette Fuller, James Tapp, Simon Draycott · 2019 · Criminal Behaviour and Mental Health
BACKGROUND: Motivation and readiness to change are important drives for forensic patients accessing interventions. It is thought that guilt and shame influence these drives, but to date, their relationship has not been empirically tested.…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Benatar, Christopher McDermott, Martin R. Turner et al. · 2024 · Brain
There is a long history in amyotrophic lateral sclerosis (ALS) of promoting therapies based on phase 2 data, which then fail in phase 3 trials. Experience suggests that studies of 6 months in duration are too short, especially with…
View details →Negative / Null Result Report
Yusuke Okada · 2010 · JALT Journal
While the pedagogical value of teachers’ questioning in classrooms has been well studied, what exactly teachers do if a question fails to obtain an adequate response has not yet been sufficiently addressed from an interactional…
View details →Negative / Null Result Report
N. Naef, T. Steiner, J. Wehrlin · 2015 · International Journal of Sports Medicine
Abstract Duplicate haemoglobin mass (Hbmass) measurements are recommended before and after altitude training sojourns to identify individual adaptations in athletes with a high level of certainty. Duplicate measurements reduce typical…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Peipei Ma, Mogens Sandø Lund, Xiangdong Ding et al. · 2014 · Journal of Animal Breeding and Genetics
This study investigated the effect of including Nordic Holsteins in the reference population on the imputation accuracy and prediction accuracy for Chinese Holsteins. The data used in this study include 85 Chinese Holstein bulls genotyped…
View details →Negative / Null Result ReportOpen accessMedicine
Eun-Ju Kim, Chan Kyo Kim, Hyun Soo Kim et al. · 2020 · British Journal of Radiology
Objective: To evaluate the usefulness of histogram analysis of stretched exponential model (SEM) on diffusion-weighted imaging in evaluating clinically significant prostate cancer (CSC). Methods: A total of 85 patients with prostate cancer…
View details →Negative / Null Result Report
C Länger, P Ernst, M Bender et al. · 2021 · New Journal of Physics
Abstract Hydrogen-covered Si(001) surfaces were exposed to swift heavy ions (SHI) and slow highly charged ions (HCI). Using scanning tunneling microscopy as analysis tool, the ion-induced modifications on the surface were resolved on the…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Cedric Popa, Karel Holvoet, Tessa Van Montfort et al. · 2018 · Frontiers in Pharmacology
Background: Profits in the biopharmaceutical industry have been scrutinized in social debate. However, drawing conclusions based on industry profitability only is inappropriate as such an analysis does not account for risks faced by investors. This study aims to measure risks and returns in the biopharmaceutical industry and investigates whether risk-adjusted return on investment in the biopharmaceutical industry is higher than that in other industries. Methods: To enable appropriate comparison, we identified six benchmark industries with characteristics that match those of the biopharmaceutic
View details →Negative / Null Result ReportOpen accessMedicine
Jacobien H. F. Oosterhoff, Anne de Hond, Rinne M Peters et al. · 2024 · Clinical Orthopaedics and Related Research
BACKGROUND: Estimating the risk of revision after arthroplasty could inform patient and surgeon decision-making. However, there is a lack of well-performing prediction models assisting in this task, which may be due to current conventional…
View details →Negative / Null Result Report
Jan Reinhard, Melanie Schindler, Franziska Leiss et al. · 2023 · Archives of Orthopaedic and Trauma Surgery
Abstract Introduction Enhanced recovery after surgery (ERAS) leads to less morbidity, faster recovery, and, therefore, shorter hospital stays. The expected increment of primary total hip arthroplasty (THA) in the U.S. highlights the need…
View details →Negative / Null Result Report
Amanda Sundberg, Anna Carin Wahlberg, Niklas Zethraeus et al. · 2021 · BMJ Open
Objectives Telephone advice nursing is introduced in many countries with one key aim being a reduction of avoidable healthcare visits. The aim of this study was to explore whether callers to a telephone advice nursing service followed the…
View details →Negative / Null Result ReportOpen accessComputer Science
Conor Hanrahan · 2019 · ARROW@Dublin Institute of Technology (Dublin Institute of Technology)
The presence of noise in electroencephalography (EEG) signals can significantly reduce the accuracy of the analysis of the signal. This study assesses to what extent stacked autoencoders designed using one-dimensional convolutional neural…
View details →Negative / Null Result Report
Youn-Goo Kang, Taeyoung Lee, Jaeyoung Ro et al. · 2023 · Nutrients
Obesity is a major global health problem which is associated with various diseases and psychological conditions. Increasing understanding of the relationship between obesity and gut microbiota has led to a worldwide effort to use…
View details →Negative / Null Result Report
Rae Morris, Fiona Lewis, Nancy Baker et al. · 2021 · Health & Social Work
Abstract Homelessness is a long-standing issue at the forefront of healthcare globally, and discharge of homeless patients from hospital settings can exacerbate gaps and burdens in healthcare systems. In hospitals, social workers often…
View details →Negative / Null Result Report
Kaoru Ochi, Tamaki Mizuno, Prosenjit Samanta et al. · 2021 · mSphere
Cholera is an acute diarrheal disease caused by pathogenic strains of V. cholerae generated by lysogenization of the filamentous cholera toxin phage CTXΦ. The analysis revealed that recent isolates possessed altered CTXΦ prophage array of…
View details →Negative / Null Result ReportComputer Science
Pertti Vakkari · 2011 · Online Information Review
Purpose This paper seeks to evaluate to what extent Google retrieved correct answers to queries inferred from factual and topical requests in a digital Ask‐a‐Librarian service. Design/methodology/approach In total, 100 factual and 100…
View details →Replication FailureOpen accessMedicine
Daniela Achkova, Richard Beatson, John Maher · 2022 · Cells
Macrophage colony-stimulating factor receptor (M-CSFR) is found in cells of the mononuclear phagocyte lineage and is aberrantly expressed in a range of tumours, in addition to tumour-associated macrophages. Consequently, a variety of cancer therapies directed against M-CSFR are under development. We set out to engineer chimeric antigen receptors (CARs) that employ the natural ligands of this receptor, namely M-CSF or interleukin (IL)-34, to achieve specificity for M-CSFR-expressing target cells. Both M-CSF and IL-34 bind to overlapping regions of M-CSFR, although affinity of IL-34 is significa
View details →Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology
Dennis Poel, Elske C. Gootjes, Lotte Bakkerus et al. · 2020 · Cancer Medicine
BACKGROUND: Palliative systemic therapy is currently standard of care for patients with extensive metastatic colorectal cancer (mCRC). A biomarker predicting chemotherapy benefit which prevents toxicity from ineffective treatment is urgently needed. Therefore, a previously developed tissue-derived microRNA profile to predict clinical benefit from chemotherapy was evaluated in tissue biopsies and serum from patients with mCRC. METHODS: Samples were prospectively collected from patients (N = 132) who were treated with capecitabine or 5-FU/LV with oxaliplatin ± bevacizumab. Response evaluation wa
View details →Negative / Null Result ReportOpen accessMedicine
Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · PubMed
BACKGROUND: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. SETTING: Two urban clinics in Kigali, Rwanda. METHODS: A 2-arm individual randomized controlled trial compared…
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