TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
Astrid Feiten; Kilian Dahm; Kai Schlepckow; Bettina van Lengerich; Jung H. Suh; Anika Reifschneider; Benedikt Wefers; Laura M. Bartos · 2026 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer's disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. In APP transgenic animals, bulk RNA-sequencing of isolated microglia sorted based on reporter expression highlighted TREM2 level-related changes in major immunometabolic pathways, and enrichment of genes in oxidative phosphorylation and cholesterol met
Abstract by Astrid Feiten; Kilian Dahm; Kai Schlepckow; Bettina van Lengerich; Jung H. Suh; Anika Reifschneider; Benedikt Wefers; Laura M. Bartos, Nature Communications (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-026-68706-8