Negative / Null Result ReportOpen accessMedicine
Somnath Bandyopadhyay, Seán Connolly, Omar Jabado et al. · 2017 · Lupus Science & Medicine
OBJECTIVE: To characterise patients with active SLE based on pretreatment gene expression-defined peripheral immune cell patterns and identify clusters enriched for potential responders to abatacept treatment. METHODS: This post hoc…
View details →Negative / Null Result ReportOpen accessMedicine
Rohit Nathani, Meena B. Bansal · 2023 · PubMed
Tremendous effort has been put forth over the past 2 decades in understanding the pathophysiology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH). Although multiple potential targets for drug development…
View details →Negative / Null Result ReportOpen accessMedicine
Panpan Zhang, Wei Wang, Ming Lu et al. · 2018 · Cancer Medicine
BACKGROUND: Gastroesophageal Junction neuroendocrine neoplasms (GEJ-NENs) are rare and heterogeneous tumors. We aim to analyze the clinicopathlogical features and prognostic factors of GEJ-NENs and to compare the outcome of GEJ-NENs with other gastric NENs. METHODS: A total of 297 GEJ-NENs patients were enrolled from 10 Chinese hospitals and 3152 gastric NENs patients, including 274 GEJ-NENs, were retrieved from Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: The clinical characteristics of GEJ-NENs among different races were different. All Chinese patients had GEJ-NENs o
View details →Negative / Null Result ReportMedicine
Josephine Berger-Groch, Johannes M. Rueger, Patrick Czorlich et al. · 2021 · Prehospital Emergency Care
Background: The role of pelvic circumferential compression devices (PCCD) is to temporarily stabilize the pelvic ring, reduce its volume and to tamponade bleeding. The purpose of this study was to evaluate the effect of PCCDs on mortality…
View details →Negative / Null Result ReportOpen accessMedicine
Bethan Goulden, David Isenberg · 2020 · Expert Opinion on Biological Therapy
INTRODUCTION: The type 1 interferon pathway is known to play a role in the immunopathology of systemic lupus erythematosus (SLE). As a result, biologic agents targeting this pathway have been developed and are currently being investigated…
View details →Negative / Null Result Report
Qihan Ma, Jianbo Wang, Ming Xiong et al. · 2023 · Remote Sensing
The lockdowns from the coronavirus disease of 2019 (COVID-19) have led to a reduction in anthropogenic activities and have hence reduced primary air pollutant emissions, which were reported to have helped air quality improvements. However,…
View details →Negative / Null Result Report
S.F. Hall, R. Griffiths · 2016 · Current Oncology
Background: For oncologists and for patients, no site-specific clinical trial evidence has emerged for the use of concurrent chemotherapy with radiotherapy (ccrt) over radiotherapy (rt) alone for cancer of the hypopharynx (hpc) or for…
View details →Negative / Null Result Report
JAMIE L. BENHAM, JANE E. BOOTH, MARY J. DUNBAR et al. · 2020 · Medicine & Science in Sports & Exercise
ABSTRACT Introduction The Diabetes Aerobic and Resistance Exercise trial found that aerobic training and resistance training alone each reduced hemoglobin A1c (HbA1c) compared with nonexercising controls, and combined aerobic and…
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Aimara Planillo, Juan E. Malo · 2017 · Ecology and Evolution
Abstract Human disturbance is widespread across landscapes in the form of roads that alter wildlife populations. Knowing which road features are responsible for the species response and their relevance in comparison with environmental…
View details →Negative / Null Result Report
Eun-Kyoung Rosa Lee, Colin Phillips · 2022 · Bilingualism: Language and Cognition
Abstract It is well-known that native English speakers sometimes erroneously accept subject-verb agreement violations when there is a number-matching attractor (e.g., *The key to the cabinets were…). Whether bilinguals whose L1 lacks…
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David Winship Taylor, Hongqi Li · 2018 · eLife
The discovery of a fossil that might be the oldest flowering plant will continue the debate on the origin and structure of ancestral flowering plants.
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Mohammad Nourani, Qian Long Kweh, Wen-Min Lu et al. · 2022 · Financial Innovation
Abstract This study examines the efficiency of investment trust companies (ITCs) from 2011 to 2020 using a meta-frontier two-stage network data envelopment analysis (DEA) based on the directional distance function (DDF). We improved the…
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Henry W. Caplan, Karthik S. Prabhakara, Naama E. Toledano Furman et al. · 2021 · PLOS ONE
Traumatic brain injury (TBI) causes both physical disruption of the blood brain barrier (BBB) and altered immune responses that can lead to significant secondary brain injury and chronic inflammation within the central nervous system…
View details →Methods Dead-End
Till Francke, Gabriele Baroni, Arlena Brosinsky et al. · 2018 · Water Resources Research
Abstract Modelers can improve a model by addressing the causes for the model errors (data errors and structural errors). This leads to implementing model enhancements (MEs), for example, meteorological data based on more monitoring…
View details →Negative / Null Result Report
Elysia Larson, Godfrey M Mbaruku, Jessica Cohen et al. · 2019 · International Journal for Quality in Health Care
Abstract Objective To test the success of a maternal healthcare quality improvement intervention in actually improving quality. Design Cluster-randomized controlled study with implementation evaluation; we randomized 12 primary care…
View details →Negative / Null Result ReportOpen accessNeuroscience
Shao-Chin Hung, Aaron R. Seitz · 2011 · PLoS ONE
Consolidation, a process that stabilizes memory trace after initial acquisition, has been studied for over a century. A number of studies have shown that a skill or memory must be consolidated after acquisition so that it becomes resistant to interference from new information. Previous research found that training on a peripheral 3-dot hyperacuity task could retrogradely interfere with earlier training on the same task but with a mirrored stimulus configuration. However, a recent study failed to replicate this finding. Here we address the controversy by replicating both patterns of results, ho
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Raissa Relator, Aika Terada, Jun Sese · 2018 · BMC Medical Genomics
BACKGROUND: Survival analysis methods have been widely applied in different areas of health and medicine, spanning over varying events of interest and target diseases. They can be utilized to provide relationships between the survival time of individuals and factors of interest, rendering them useful in searching for biomarkers in diseases such as cancer. However, some disease progression can be very unpredictable because the conventional approaches have failed to consider multiple-marker interactions. An exponential increase in the number of candidate markers requires large correction factor
View details →Negative / Null Result ReportOpen accessComputer Science
Robert Ranisch, Joschka Haltaufderheide · 2025 · Digital Society
Abstract Conversational agents are increasingly used in healthcare, with Large Language Models (LLMs) significantly enhancing their capabilities. When integrated into social robots, LLMs offer the potential for more natural interactions. However, while LLMs promise numerous benefits, they also raise critical ethical concerns, particularly regarding hallucinations and deceptive patterns. In this case study, we observed a critical pattern of deceptive behavior in commercially available LLM-based care software integrated into robots. The LLM-equipped robot falsely claimed to have medication remin
View details →Negative / Null Result ReportOpen accessMedicine
Dominik Lewandowski, Mateusz Konieczny, Agata Różycka et al. · 2025 · International Journal of Molecular Sciences
Cathepsins, a family of lysosomal proteases, play critical roles in maintaining cellular homeostasis through protein degradation and modulation of immune responses. In the central nervous system (CNS), their functions extend beyond classical proteolysis, influencing neuroinflammation, synaptic remodeling, and neurodegeneration. Emerging evidence underscores the crucial role of microglial cathepsins in the pathophysiology of several neurological disorders. This review synthesizes current knowledge on the involvement of cathepsins in a spectrum of CNS diseases, including Parkinson's disease, Alz
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Sean Myers · 2026 · The Review of Economic Studies
Abstract This paper studies how municipal governments jointly manage spending, credit market borrowing, and a public employee pension system. I model governments as levered investors who must meet non-defaultable pension obligations and…
View details →Negative / Null Result ReportOpen accessMaterials Science
Dylan M. Anstine, Qiyuan Zhao, R.I. Zubatyuk et al. · 2026 · Science Advances
Mechanistic modeling of chemical transformations offers a compelling basis for understanding reactivity and allows for prediction of reaction outcomes before attempting experiments. Despite progress in machine-learned interatomic…
View details →Negative / Null Result ReportOpen accessMedicine
Ryota Nishio, Tomotaka Dohi, Miho Yokoyama et al. · 2025 · JMIR mhealth and uhealth
Background: Cardiac rehabilitation (CR) is effective in preventing cardiovascular diseases; however, participation in CR programs remains limited due to the associated challenges. The integration of wearable devices and real-time monitoring offers a potential solution to enhance adherence to remote CR programs and their outcomes. Objective: This study aimed to evaluate the efficacy of a remote CR program using wearable devices and real-time monitoring with or without online coaching (OLC) in improving exercise capacity in patients with coronary artery disease (CAD). Methods: We enrolled 50 pat
View details →Negative / Null Result ReportOpen accessEngineering
Kyung Seo Joo, Sun Jin Sym, Kwangmin Kim et al. · 2025 · International Journal of Nanomedicine
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, largely because of its profoundly hypoxic and desmoplastic tumor microenvironment (TME), which hinders drug delivery and promotes resistance to…
View details →Negative / Null Result ReportOpen accessMedicine
Yusuke Kamatsuki, Marie Synnøve Qvale, Kathrin Steffen et al. · 2024 · The American Journal of Sports Medicine
Background: Anterior cruciate ligament (ACL) injury is one of the most severe injuries for athletes. It is important to identify risk factors because a better understanding of injury causation can help inform athletes about risk and increase their understanding of and motivation for injury prevention. Purpose: To investigate the relationship between anatomic factors and risk for future noncontact ACL injuries. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 870, excluding 9 players with a new contact ACL injury and a player with a new noncontact ACL injury just before the
View details →Negative / Null Result ReportOpen accessMedicine
Tanayott Thaweethai, Sarah E. Donohue, Jeffrey N. Martin et al. · 2025 · Nature Communications
Longitudinal trajectories of Long COVID remain ill-defined, yet are critically needed to advance clinical trials, patient care, and public health initiatives for millions of individuals with this condition. Long COVID trajectories were…
View details →Negative / Null Result ReportOpen accessMaterials Science
Wenwen Zhang, Qilin Wang, Wei Yi et al. · 2026 · Biomolecules
To overcome the limitations of traditional motion sickness medications—slow onset of action, short duration of efficacy, and poor patient compliance—this study employed coaxial electrospinning technology. Poly(lactic acid) (PLA) and polyvinylpyrrolidone K90 (PVP K90) were used as composite carrier materials. The sheath layer is composed of highly hydrophilic PVP K90, loaded with the antihistamine diphenhydramine (DPH). The core layer, composed of biodegradable PLA with excellent sustained-release properties, carries the anticholinergic drug scopolamine hydrobromide (SH). This core–sheath nanos
View details →Negative / Null Result ReportOpen accessComputer Science
Sarah Kettley · 2026 · Edinburgh Napier Research Repository (Edinburgh Napier University)
The purpose of the research described in this thesis was to develop a design methodology for Wearable Computing concepts that could potentially embody authenticity. The Wearables community, still firmly rooted in the disciplines of engineering and ergonomics, had made clear its aspirations to the mainstream market (DeVaul et al 2001). However, at this point, there was a distinct lack of qualitative studies on user perceptions of Wearable products. A review of the market research literature revealed significant consumer demand for authenticity in goods and services, and it was this need that dr
View details →Negative / Null Result ReportOpen accessMedicine
Shu-Shu Han, Qin Liu, Zhiming Zeng et al. · 2026 · Cardiovascular Diabetology
BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome imposes a substantial global health burden, with most adults clustered in early stages 0-3. Insulin resistance (IR), as a core manifestation of metabolic dysfunction, is thought to…
View details →Negative / Null Result ReportOpen accessMedicine
Ulla Lång, Johanna Metsälä, Hugh Ramsay et al. · 2025 · American Journal of Psychiatry
OBJECTIVE: As many as half of individuals who develop psychosis had attended child and adolescent psychiatric services at some stage in childhood, highlighting substantial opportunities for prevention within these services if an effective preventive intervention were identified. The authors hypothesized that adolescent psychiatric patients exposed to doxycycline, an antibiotic with putative neuroprotective properties, would have a lower risk of developing schizophrenia. METHODS: This was an emulated target trial using nationwide Finnish health register data on all individuals born between 1987
View details →Negative / Null Result ReportOpen accessPsychology
Nobel Glas · 2026 · Zenodo (CERN European Organization for Nuclear Research)
EA-GLAS-02 v1.0. A self-contained empirical white paper presenting the measurement program for the Semantic Deviation Principle (Sharks 2026). Defines meaning as the time-integrated divergence a sign induces from the most probable trajectory of a semantic field, extending the Bar-Hillel and Carnap (1953) program into distributional and temporal domains. Two primary operationalizations. (F1) Closed-system trajectory deviation within a frozen language model, where the counterfactual baseline is read from logits, building on surprisal theory (Hale 2001; Levy 2008) and decomposing it into signed d
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