Negative / Null Result ReportOpen accessMedicine
Helen M Collins, Susan A. Greenfield · 2024 · International Journal of Molecular Sciences
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no effective treatments, not least due to the lack of authentic animal models. Typically, rodent models recapitulate the effects but not causes of AD, such as cholinergic neuron loss: lesioning of cholinergic neurons mimics the cognitive decline reminiscent of AD but not its neuropathology. Alternative models rely on the overexpression of genes associated with familial AD, such as amyloid precursor protein, or have genetically amplified expression of mutant tau. Yet transgenic rodent models poorly replicate the neuropatho
View details →Negative / Null Result ReportOpen accessPsychology
Simone Di Plinio · 2022 · Frontiers in Psychology
Correlation coefficients are often compared to investigate data across multiple research fields, as they allow investigators to determine different degrees of correlation to independent variables. Even with adequate sample size, such differences may be minor but still scientifically relevant. To date, although much effort has gone into developing methods for estimating differences across correlation coefficients, adequate tools for variable sample sizes and correlational strengths have yet to be tested. The present study evaluated four different methods for detecting the difference between two
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Jiahang Zhang, Shengai Cui · 2023 · Axioms
The number of random fields required to capture the spatial variability of soil properties and their impact on the performance of geotechnical systems is often varied. However, the number of random fields required to obtain higher-order…
View details →Negative / Null Result ReportNeuroscience
Jessica Nicosia, David A. Balota · 2020 · Psychology and Aging
Recent evidence indicates that older adults' decreased ability to inhibit irrelevant information may lead to increased processing and greater memory for distractor information compared with younger adults. The present experiments examine…
View details →Negative / Null Result ReportOpen accessMaterials Science
Suriati Paiman, T. Hui Ling, M. Husham et al. · 2020 · Results in Physics
This paper focused on the growth of zinc oxide nanowires on unannealed and annealed indium tin oxide-coated-coated glass substrates on the structural, optical, and electrical properties towards surface acoustic wave (SAW) piezoelectric…
View details →Negative / Null Result ReportSocial Sciences
Xueqin Qian, Renáta Tichá, Roger J. Stancliffe · 2017 · Journal of Policy and Practice in Intellectual Disabilities
Abstract Although numerous studies in the U.K. and Australia have shown that Active Support (AS) is an effective intervention in increasing staff assistance and engagement for people with intellectual and developmental disabilities (IDD)…
View details →Negative / Null Result ReportOpen accessEnergy
Jingwen Shi, Ning Li, Yan Liang et al. · 2025 · Angewandte Chemie International Edition
Abstract The transfer path of photogenerated charges greatly affects the final photocatalytic performance, but this important fact has not been clearly demonstrated experimentally. Here, we construct an ultrastable crystalline catalytic…
View details →Negative / Null Result ReportOpen accessNeuroscience
Daniel F. Kripke, Caroline M. Nievergelt, Gregory J. Tranah et al. · 2013 · Journal of Circadian Rhythms
BACKGROUND: There are several indications that malfunctions of the circadian clock contribute to depression. To search for particular circadian gene polymorphisms associated with depression, diverse polymorphisms were genotyped in two samples covering a range of depressed volunteers and participants with normal mood. METHODS: Depression mood self-ratings and DNA were collected independently from a sample of patients presenting to a sleep disorders center (1086 of European origin) and from a separate sample consisting of 399 participants claiming delayed sleep phase symptoms and 406 partly-matc
View details →Negative / Null Result ReportOpen accessPsychology
Julia Holzer, Luisa Grützmacher, Marko Lüftenegger et al. · 2024 · Learning and Instruction
Despite broad theoretical consensus on the direct and indirect relevance of teacher emotions for instructional behavior and student outcomes, empirical evidence is inconclusive. Moreover, there is limited research in this area involving disadvantaged and younger student populations, and addressing students’ school well-being as an outcome explicitly. This study investigates associations between teacher emotions (joy, anger, anxiety), teacher-reports of instructional behavior (cognitive and motivational stimulation, classroom management, and social support), and students' reported school well-b
View details →Negative / Null Result ReportPsychology
Sarah E. Whiteman, Lindsay B. Kramer, Madison W. Silverstein et al. · 2020 · Assessment
The Posttraumatic Cognitions Inventory (PTCI) is one of the most widely used measure of posttraumatic cognitions. The original factor analysis of the PTCI provided evidence for a three-factor model of negative cognitions about self, world,…
View details →Negative / Null Result ReportMedicine
Kun Man, Jiafeng Liu, Cindy Liang et al. · 2023 · ACS Applied Materials & Interfaces
Determining the mechanistic causes of lung diseases, developing new treatments thereof, and assessing toxicity whether from chemical exposures or engineered nanomaterials would benefit significantly from a preclinical human lung alveolar…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Rajrani Ruhel, Mohit Mazumder, Prabu Gnanasekaran et al. · 2021 · FEBS Journal
Geminivirus replication initiator protein (Rep) is a multifunctional viral protein required for replication. During the process of viral replication, Rep acts as a site- and strand-specific endonuclease, ligase, ATPase, and helicase. B'…
View details →Negative / Null Result ReportOpen accessEngineering
Amlan Jyoti Kalita, Maibam Pooya Chanu, Nayan M. Kakoty et al. · 2025 · Wearable Technologies
Electromyogram (EMG)-controlled prosthetic hands have advanced significantly during the past two decades. However, most of the currently available prosthetic hands fail to replicate human hand functionality and controllability. To measure the emulation of the human hand by a prosthetic hand, it is important to evaluate the functional characteristics. Moreover, incorporating feedback from end users during clinical testing is crucial for the precise assessment of a prosthetic hand. The work reported in this manuscript unfolds the functional characteristics of an EMG-CoNtrolled PRosthetIC Hand ca
View details →Negative / Null Result ReportOpen accessMedicine
Ruijuan Liu, Xia Li, Jingyao Wei et al. · 2019 · Frontiers in Pharmacology
Despite its narrow therapeutic window and large inter-individual variability, cyclosporine A (CsA) is the first-line therapy following organ transplantation. Metabolized mainly by CYP3A and being a substrate of P-glycoprotein (P-gp), CsA is susceptible to drug-drug interactions. Baicalin (BG) is a drug used for adjuvant therapy of hepatitis in traditional Chinese medicine. Since its aglycone Baicalein (B) inhibits CYP3A and P-gP, co-administration might affect CsA pharmacokinetics. This study investigated the effect of BG on CsA pharmacokinetics. In a two-period study, 16 healthy volunteers re
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Animamalar Mayavannan, Emily Shantz, Ian D. Haidl et al. · 2023 · Frontiers in Immunology
Introduction Chlamydia trachomatis ( C. trachomatis ) is a Gram-negative obligate intracellular bacterium that causes reproductive tract complications in women, including ectopic pregnancies and tubal factor infertility. We hypothesized that mast cells, which are common at mucosal barriers, may contribute to responses to Chlamydia infection and aimed to define human mast cell responses to C. trachomatis . Methods Human cord blood-derived mast cells (CBMCs) were exposed to C. trachomatis to assess bacterial uptake, mast cell degranulation, gene expression, and production of inflammatory mediato
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miruna C. Barbu, Carmen Amador, Alex S. F. Kwong et al. · 2022 · EBioMedicine
BACKGROUND: DNA methylation (DNAm) is associated with time-varying environmental factors that contribute to major depressive disorder (MDD) risk. We sought to test whether DNAm signatures of lifestyle and biochemical factors were associated with MDD to reveal dynamic biomarkers of MDD risk that may be amenable to lifestyle interventions. METHODS: , N=565), using CpG sites reported in previous well-powered methylome-wide association studies. We also compared their predictive accuracy for MDD to a MDD MS in an independent GS sub-sample (N=4,432). FINDINGS: =-0.069-0.083) remained significantly a
View details →Negative / Null Result ReportOpen accessMedicine
Christine L. Nelson, Roderick S. Tang, Elizabeth A. Stillman · 2013 · Vaccine
MEDI-534 is the first live, attenuated and vectored respiratory syncytial virus (RSV) vaccine to be evaluated in seronegative children. It consists of a bovine/human parainfluenza virus type 3 (PIV3) backbone with the RSV fusion…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Yusuf Wanjala Musi, Elegwa Mukulu, Margaret Oloko · 2018 · Journal of Management and Sustainability
Strategic planning is a very crucial phenomenon in all organisations. It is the tool that determines the destiny of the firm. The objective of this study was to investigate the influence of financial resource strategic planning on firm performance, to determine influence of human capital strategic planning on firm performance, to analyze the influence of material resource strategic planning on firm performance and to determine influence of information resource strategic planning on firm performance in agriculture research based institutions of Kenya. Although there had been previous internatio
View details →Negative / Null Result ReportOpen accessComputer Science
Nikunj Arora, Markku Suomalainen, Matti Pouke et al. · 2022 · IEEE Transactions on Visualization and Computer Graphics
We propose augmenting immersive telepresence by adding a virtual body, representing the user's own arm motions, as realized through a head-mounted display and a 360-degree camera. Previous research has shown the effectiveness of having a virtual body in simulated environments; however, research on whether seeing one's own virtual arms increases presence or preference for the user in an immersive telepresence setup is limited. We conducted a study where a host introduced a research lab while participants wore a head-mounted display which allowed them to be telepresent at the host's physical loc
View details →Negative / Null Result ReportOpen accessPsychology
Annika Gunst, Marlene Werner, Lourens Waldorp et al. · 2018 · Scientific Reports
Problems related to low sexual desire in women are common clinical complaints, and the aetiology is poorly understood. We investigated predictors of change in levels of sexual desire using a novel network approach, which assumes that mental disorders arise from direct interactions between symptoms. Using population-based data from 1,449 Finnish women, we compared between-subject networks of women whose sexual desire decreased, increased, or remained stable over time. Networks were estimated and analyzed at T1 (2006) and replicated at T2 (2013) using R. Domains included were, among others, sexu
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Heido Trofimov, Nicolas Bellouin, Velle Toll · 2020 · Journal of Geophysical Research: Atmospheres
Abstract Aerosols offset a poorly quantified fraction of anthropogenic greenhouse gas warming, and the aerosol impact on clouds is the most uncertain mechanism of anthropogenic climate forcing. Here observations of a relatively weak…
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Kärt Simre, Oivi Uibo, Aleksandr Peet et al. · 2019 · Acta Paediatrica
Abstract Aim Our aim was to compare the presence of various common viruses (rhinovirus, enterovirus, adenovirus, Epstein–Barr virus, cytomegalovirus, norovirus, parechovirus) in stool and nasal swab samples as well as virus‐specific…
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Jonas Ziegenhorn, Julia Kirschberg, Markus Heinecke et al. · 2024 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose The purpose of this study was to find out whether the torsions of the femur and tibia are dependent on the coronal plane alignment of the knee (CPAK) type. Methods Five hundred patients (1000 legs) were included, who…
View details →Negative / Null Result ReportOpen accessMedicine
Brian Hitsman, George D. Papandonatos, Jackie K. Gollan et al. · 2023 · Addiction
BACKGROUND AND AIMS: Treatment of depression-related psychological factors related to smoking behavior may improve rates of cessation among adults with major depressive disorder (MDD). This study measured the efficacy and safety of 12…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
David García Alonso, Ignacio Buesa, Luis Flor et al. · 2025 · Frontiers in Plant Science
The intensification of drought conditions due to climate change poses a major challenge to sustainable grape production. Rootstocks are essential in supporting grapevine water uptake and drought resilience; however, their physiological responses to water stress are not fully understood. Under the hypothesis that root morphology and anatomy may be key traits in grapevine tolerance to water deficit, this study aimed to investigate these traits across diverse rootstocks under progressive water deficit and recovery phases. Thirteen genotypes, including commercial rootstocks and recently bred RG-se
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Catherine S. Jarnevich, Helen R. Sofaer, Pairsa Belamaric et al. · 2022 · NeoBiota
Aim : Species distribution models can guide invasive species prevention and management by characterizing invasion risk across space. However, extrapolation and transferability issues pose challenges for developing useful models for invasive species. Previous work has emphasized the importance of including all available occurrences in model estimation, but managers attuned to local processes may be skeptical of models based on a broad spatial extent if they suspect the captured responses reflect those of other regions where data are more numerous. We asked whether species distribution models fo
View details →Negative / Null Result ReportOpen accessMedicine
Alessandro Rabiolo, Federico Fantaguzzi, Riccardo Sacconi et al. · 2021 · Translational Vision Science & Technology
Purpose: Compare the ability of peripapillary and macular structural parameters, vascular parameters, and their integration to discriminate among glaucoma, suspected glaucoma (GS), and healthy controls (HCs). Methods: In this study, 196…
View details →Negative / Null Result Report
Suman Prasad, Triptish Bhatia, Prachi Kukshal et al. · 2017 · npj Schizophrenia
Abstract Schizophrenia is a chronic, severe, heritable disorder. Genome-wide association studies, conducted predominantly among Caucasians, have indicated > 100 risk alleles, with most significant SNPs on chromosome 6. There is growing…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marlee R. Labroo, Jessica Rutkoski · 2022 · BMC Genomics
BACKGROUND: Recurrent selection is a foundational breeding method for quantitative trait improvement. It typically features rapid breeding cycles that can lead to high rates of genetic gain. Usually, generations are discrete in recurrent selection, which means that breeding candidates are evaluated and considered for selection for only one cycle. Alternately, generations can overlap, with breeding candidates considered for selection as parents for multiple cycles. With recurrent genomic selection but not phenotypic selection, candidates can be re-evaluated by using genomic estimated breeding v
View details →Negative / Null Result ReportOpen accessNeuroscience
Daniel Griffiths-King, Amanda Wood, Jan Novák · 2023 · Scientific Reports
Brain development is regularly studied using structural MRI. Recently, studies have used a combination of statistical learning and large-scale imaging databases of healthy children to predict an individual's age from structural MRI. This data-driven, predicted 'Brainage' typically differs from the subjects chronological age, with this difference a potential measure of individual difference. Few studies have leveraged higher-order or connectomic representations of structural MRI data for this Brainage approach. We leveraged morphometric similarity as a network-level approach to structural MRI t
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