Negative / Null Result ReportOpen accessEnvironmental Science
Haotian Zhang, Wen‐Yong Guo, Wenting Wang · 2023 · Ecology and Evolution
How to effectively obtain species-related low-dimensional data from massive environmental variables has become an urgent problem for species distribution models (SDMs). In this study, we will explore whether dimensionality reduction on environmental variables can improve the predictive performance of SDMs. We first used two linear (i.e., principal component analysis (PCA) and independent components analysis) and two nonlinear (i.e., kernel principal component analysis (KPCA) and uniform manifold approximation and projection) dimensionality reduction techniques (DRTs) to reduce the dimensionali
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Carlo Russo, Mariarosaria Simeone, Maria Angela Perito · 2020 · Sustainability
In this paper, we investigated educated millennials’ evaluation of credence attributes in food products containing genetically modified organisms (GMO products). Our goal is to assess whether beliefs about GMO products are determined by scientific knowledge alone or if they are affected by other factors such as trust in information providers and use of social media. The focus on millennials is motivated by the increasing relevance of this social group in the public debate and by their extensive use of social media. We surveyed a sample of 215 Italian college students, confronting them with que
View details →Negative / Null Result ReportArts and Humanities
Chris Skurka, Rainer Romero‐Canyas, Helen H. Joo et al. · 2021 · Human Communication Research
Abstract There is much need to verify the robustness of published findings in the field of communication—particularly regarding the effects of persuasive emotional appeals about social issues. To this end, we present the results from a…
View details →Negative / Null Result ReportNeuroscience
Lidia Y. X. Wong, Stephen J. Gray, David A. Gallo · 2018 · Cognitive Neuroscience
We report 4 experiments aiming to replicate and extend the finding that anodal transcranial direct current stimulation (tDCS) over dorsolateral prefrontal cortex after encoding and just prior to retrieval improves accuracy on an episodic…
View details →Negative / Null Result ReportOpen accessEnergy
Adeyemi Ogundipe, Opeyemi Akınyemi, Oluwatomisin Ogundipe · 2016 · Covenant University Repository (Covenant University)
The study examines the relationship between electricity consumption and economic development using an extended neoclassical model for the period 1970-2013. The study incorporates the uniqueness of the Nigerian economy by controlling for…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Muhammad Bilal, Muhammad Aslam Mirza, Muhammad Kaleem et al. · 2016 · Journal of Animal Physiology and Animal Nutrition
The response of broiler chickens to 3 levels of sunflower meal and 2 levels of NSP-ase enzyme combination (with and without) was investigated in 3 × 2 factorial arrangement under complete randomized design (CRD). A total of 240 Hubbard…
View details →Negative / Null Result ReportEngineering
Roland Imhoff, Jens Lange, Markus Germar · 2018 · Cognition & Emotion
Spatial cueing paradigms are popular tools to assess human attention to emotional stimuli, but different variants of these paradigms differ in what participants' primary task is. In one variant, participants indicate the location of the…
View details →Negative / Null Result ReportMedicine
Kenneth H. Mayer, Douglas Krakower · 2012 · Annals of Internal Medicine
During the past 2 years, several pivotal clinical trials have proven that the use of antiretrovirals by HIV-infected and at-risk uninfected persons can decrease the probability of HIV being transmitted sexually. The initial…
View details →Negative / Null Result ReportOpen accessPsychology
Tobias Kopp, Marco Baumgartner, Steffen Kinkel · 2023 · International Journal of Human-Computer Studies
An appropriate level of human-robot trust is widely acknowledged as a crucial factor for successful human-robot interaction (HRI). Previous research has addressed anthropomorphic design but mostly neglected linguistic framing as a means to…
View details →Negative / Null Result ReportOpen accessComputer Science
Tianjiao Cao, Jiahao Lyu, Weichao Zeng et al. · 2024
Scene text detection has seen the emergence of high-performing methods that excel on academic benchmarks. However, these detectors often fail to replicate such success in real-world scenarios. We uncover two key factors contributing to…
View details →Negative / Null Result ReportOpen accessEngineering
Federico Serpe, Carlo Massimo Casciola, Giancarlo Ruocco et al. · 2024 · International Journal of Bioprinting
Microfluidics is rapidly revolutionizing the scientific panorama, providing unmatched high-throughput platforms that find application in numerous areas of physics, chemistry, biology, and materials science. Recently, microfluidic chips have been proposed, in combination with bioactive materials, as promising tools for spinning cell-laden fibers with on-demand characteristics. However, cells encapsulated in filaments produced via microfluidic spinning technology are confined in a quasi-three-dimensional (3D) environment that fails to replicate the intricate 3D architecture of biological tissues
View details →Negative / Null Result ReportOpen accessMedicine
Natalie A. Prow, Marcus G. Mah, Joshua M. Deerain et al. · 2018 · Journal of General Virology
Liao ning virus (LNV) was first isolated in 1996 from mosquitoes in China, and has been shown to replicate in selected mammalian cell lines and to cause lethal haemorrhagic disease in experimentally infected mice. The first detection of…
View details →Negative / Null Result ReportOpen accessMedicine
Dipender Gill, Marios Arvanitis, Paul Carter et al. · 2020 · Royal Society Open Science
Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to investigate whether these exposures affect lung ACE2 and TMPRSS2 gene expression and circ
View details →Negative / Null Result ReportOpen accessMedicine
Louisa Chan, Christine T. H. Bui, Chris Ka Pun Mok et al. · 2016 · Scientific Reports
Novel avian H7N9 virus emerged in China in 2013 resulting in a case fatality rate of around 39% and continues to pose zoonotic and pandemic risk. Amino acid substitutions in PB2 protein were shown to influence the pathogenicity and transmissibility of H7N9 following experimental infection of ferrets and mice. In this study, we evaluated the role of amino acid substitution PB2-627K or compensatory changes at PB2-591K and PB2-701N, on the tropism and replication competence of H7N9 viruses for human and swine respiratory tracts using ex vivo organ explant cultures. Recombinant viruses of A/Shangh
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Annie Gott, Clare Andrews, María Larriva et al. · 2018 · PeerJ
) found that a marker of biological age predicted the strength of the stress response even in individuals of the same chronological age. Specifically, birds that had experienced greater developmental telomere attrition (DTA) showed a lower peak corticosterone (CORT) response to an acute stressor, and more rapid recovery of CORT levels towards baseline. Here, we performed a follow-up study using the same capture-handling-restraint stressor in a separate cohort of starlings that had been subjected to a developmental manipulation of food availability and begging effort. We measured the CORT respo
View details →Negative / Null Result ReportOpen accessMedicine
Gongxun Zhong, Shufang Fan, Masato Hatta et al. · 2019 · Journal of Virology
Bats are reservoirs for several severe zoonotic pathogens. The genomes of influenza A viruses of the H17N10 and H18N11 subtypes have been identified in bats, but no live virus has been isolated. The characterization of artificially…
View details →Negative / Null Result ReportPsychology
Caitlin Mills, Jennifer Wu, Sidney K. D’Mello · 2017 · Discourse Processes
We investigated how affective states influence expository text comprehension and whether text valence moderates the effects (i.e., mood congruency). In Experiment 1 participants were randomly assigned to a happy or sad affective state…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Satoru Taniguchi, Kohei Ninomiya, Itaru Kushima et al. · 2019 · Psychiatry and Clinical Neurosciences
AIMS: Recent studies have revealed that the interplay between polygenic risk scores (PRS) and large copy number variants (CNV; >500kb) is essential for the etiology of schizophrenia (SCZ). To replicate previous findings, including those for smaller CNV (>10kb), the PRS between SCZ patients with and without CNV were compared. METHODS: The PRS were calculated for 724 patients with SCZ and 1178 healthy controls (HC), genotyped using array-based comparative genomic hybridization and single nucleotide polymorphisms chips, and comparisons were made between cases and HC, or between subjects with and
View details →Negative / Null Result ReportBusiness, Management and Accounting
Noel D. Campbell, David Mitchell, Tammy M. Rogers · 2013 · Journal of Entrepreneurship and Public Policy
Purpose The purpose of this paper is to provide a robustness check of the relationship between entrepreneurial activity and economic freedom. As a deliberate “robustness check,” the authors estimated various spatial measures of…
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Travis J. Matics, Nadia Khan, Priti Jani et al. · 2019 · Pediatric Critical Care Medicine
Objectives: The Fragility Index measures the number of events on which the statistical significance of a result depends and has been suggested as an adjunct statistical assessment for interpretation of trial results. This study aimed to…
View details →Negative / Null Result ReportOpen accessMedicine
Akio Kôyama, Toshiro Fujita, Fumitake Gejyo et al. · 2015 · BMC Nephrology
BACKGROUND: Evidence increasingly points to the importance of chronic hypoxia in the tubulointerstitium as a final common pathway to end-stage renal disease (ESRD). Beraprost sodium (BPS) is an orally active prostacyclin (PGI2) analogue demonstrating prevention of the progression of chronic kidney disease (CKD) in various animal models by maintaining renal blood flow and attenuating renal ischemic condition. METHODS: This multicenter, randomized, double-blind, placebo-controlled, phase II trial was designed to determine the recommended dose of the sustained-release form of BPS (TRK-100STP 120
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Ian G Barr, Cleve Rynehart, Paul Whitney et al. · 2020 · Eurosurveillance
The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production…
View details →Negative / Null Result ReportOpen accessMedicine
Curtis J. Henry, Rebecca L. Sedjo, Andrii I. Rozhok et al. · 2015 · BMC Cancer
BACKGROUND: Inflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution of inflammatory cytokines to pre-malignant disease, such as the formation of adenomas, is unclear. METHODS: Using the Milliplex® MAP Human Cytokine/ Chemokine Magnetic Bead Panel Immunoassay, serum cytokine and chemokine profiles were assayed among participants without an adenoma (n = 97) and those with an adenoma (n = 97) enrolled in the NCI-funded Insulin Resistance Atherosclerosis Colon Study. The concentrations of interleukin
View details →Negative / Null Result ReportMedicine
Wen-Jyi Lo, Wen Shin Chang, Han-Fang Hsu et al. · 2017 · PubMed
Mounting evidence supports the notion that inflammatory processes play a role in carcinogenesis, and interleukin-10 (IL10) is an important inflammatory cytokine. This study aimed to evaluate the contribution of IL10 A-1082G (rs1800896),…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Caroline R. Amendola, William T. Cordell, Colin M. Kneucker et al. · 2023 · Metabolic Engineering
Pseudomonas putida KT2440 is a robust, aromatic catabolic bacterium that has been widely engineered to convert bio-based and waste-based feedstocks to target products. Towards industrial domestication of P. putida KT2440, rational genome…
View details →Negative / Null Result Report
Jamal T. Maalouf, James Combs, William E. Gillis et al. · 2020 · Journal of Knowledge Management
Purpose The purpose of this paper is to introduce strategy as a factor that explains when franchisors – through the franchisees they select – seek to replicate routines exactly versus allow local adaptation of routines.…
View details →Negative / Null Result ReportOpen accessComputer Science
Shervin Malmasi · 2016 · Figshare
The prediction of an author's native language using only their second language writing -- a task called Native Language Identification (NLI) -- is usually tackled using supervised classification. This is underpinned by the presupposition…
View details →Negative / Null Result ReportOpen accessNeuroscience
Amit Walia, Matthew Shew, Jordan Varghese et al. · 2023 · JAMA Otolaryngology–Head & Neck Surgery
Importance: Cochlear implantation produces remarkable results in postlingual deafness, although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a valuable tool for assessing the cochlear-neural substrate and evaluating…
View details →Negative / Null Result ReportMedicine
Haruo Ohtani, Hiroyasu Ishida, Yuka Ito et al. · 2011 · Pathology International
Autoimmune pancreatitis (AIP) (also called IgG4-related sclerosing pancreatitis (IgG4-SP)) and IgG4-related sclerosing cholangitis (IgG4-SC) are frequently associated with each other. It is generally believed that association of these…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Liza C. Villaruz, Grace Huang, Marjorie Romkes et al. · 2015 · Clinical Epigenetics
BACKGROUND: Carboplatin/paclitaxel (CP), with or without sorafenib, result in objective response rates of 18-20 % in unselected chemotherapy-naïve patients. Molecular predictors of survival and response to CP-based chemotherapy in metastatic melanoma (MM) are critical to improving the therapeutic index. Intergroup trial E2603 randomized MM patients to CP with or without sorafenib. Expression data were collected from pre-treatment formalin-fixed paraffin-embedded (FFPE) tumor tissues from 115 of 823 patients enrolled on E2603. The selected patients were balanced across treatment arms, BRAF stat
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