12,218 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mark W. Becker, Nora M. Bello, Raghav Prashant Sundar et al. · 2015 · Food Policy
OBJECTIVES: 1) To assess whether Front-of-Pack (FOP) nutrition labels garner attention more readily than more complete, mandated nutrition information (the Nutrition Facts Panel (NFP), required in the US), and 2) To determine whether label…
View details →Céline Grégoire, Caroline Ritacco, Muriel Hannon et al. · 2019 · Frontiers in Immunology
Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft-versus-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate their superiority over placebo in the sole phase III trial reported thus far. MSCs from different tissue origins display different characteristics, but their therapeutic benefits have never been directly compared in GVHD. Here, we compared the impact of BM-, umbilical cord (UC-), and adipose-tissue (AT-) derived MSCs on T-cell function in
View details →David C. Wheeler, Gérard M. London, Patrick S. Parfrey et al. · 2014 · Journal of the American Heart Association
BACKGROUND: Premature cardiovascular disease limits the duration and quality of life on long-term hemodialysis. The objective of this study was to define the frequency of fatal and nonfatal cardiovascular events attributable to…
View details →Emily C. LaVoy, Christopher P. Fagundes, Robert Dantzer · 2026 · PubMed
Cancer-related fatigue significantly disrupts normal functioning and quality of life for a substantial portion of cancer survivors, and may persist for years following cancer treatment. While the causes of persistent fatigue among cancer…
View details →Donna R. Rivera, Solange Peters, Orestis A. Panagiotou et al. · 2020 · Cancer Discovery
Abstract Among 2,186 U.S. adults with invasive cancer and laboratory-confirmed SARS-CoV-2 infection, we examined the association of COVID-19 treatments with 30-day all-cause mortality and factors associated with treatment. Logistic…
View details →Priyanka Sharma, William E. Barlow, Andrew K. Godwin et al. · 2017 · Annals of Oncology
Background: Homologous recombination deficiency (HRD)-causing alterations have been reported in triple-negative breast cancer (TNBC). We hypothesized that TNBCs with HRD alterations might be more sensitive to anthracycline plus…
View details →Colin Steer, George Davey Smith, Pauline Emmett et al. · 2010 · PLoS ONE
BACKGROUND: Breastfeeding is important for child cognitive development. A study by Caspi et al has suggested that rs174575 within the FADS2 gene moderates this effect so that children homozygous in the minor allele (GG genotype) have similar IQs irrespective of feeding method. METHODS AND PRINCIPAL FINDINGS: In our study of 5934 children aged 8 years, no genetic main effect with IQ was found for rs174575. However, an interaction with this polymorphism was observed such that breastfed GG children performed better than their formula fed counterparts by an additional 5.8 points [1.4, 10.1] (inter
View details →Sherief Abd‐Elsalam, Eslam Saber Esmail, Mai Khalaf et al. · 2020 · American Journal of Tropical Medicine and Hygiene
The COVID-19 pandemic is showing an exponential growth, mandating an urgent need to develop an effective treatment. Indeed, to date, a well-established therapy is still lacking. We aimed to evaluate the safety and efficacy of…
View details →Stijn van Roessel, Eran van Veldhuisen, Sjors Klompmaker et al. · 2020 · JAMA Oncology
IMPORTANCE: The benefit of adjuvant chemotherapy after resection of pancreatic cancer following neoadjuvant combination treatment with folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) is unclear. OBJECTIVE: To assess…
View details →Amy J. Schuh, Melissa J. Ward, Andrew Brown et al. · 2013 · PLoS neglected tropical diseases
The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts. What is less clear are the factors influencing the distribution of virus-specific lineages. Japanese encephalitis virus (JEV) is the most important etiologic agent of epidemic encephalitis worldwide, and is primarily maintained between vertebrate reservoir hosts (avian and swine) and culicine mosquitoes. There are five genotypes of JEV: GI-V. In recent years, GI has displaced GIII as the dominant JEV genotype and GV has re-emerg
View details →Weijun Xuan, Fatma Vatansever, Liyi Huang et al. · 2013 · PLoS ONE
Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest in this scope is the use of transcranial LLLT to treat stroke and traumatic brain injury (TBI). We developed a mouse model of severe TBI induced by controlled cortical impact and explored the effect of different treatment schedules. Adult male BALB/c mice were divided into 3 broad groups (a) sham-TBI sham-treatment, (b) real-TBI sham-treatment, and (c) real-TBI active-treatmen
View details →Clarissa Capp, Simone Magagnin Wajner, Débora Rodrigues Siqueira et al. · 2010 · Thyroid
BACKGROUND: Vascular endothelial growth factor (VEGF-A) expression is upregulated in the majority of human tumors, where it stimulates proliferation, migration, and survival of endothelial cells. Studies have suggested that VEGF inhibitors…
View details →Alexis F. Turgeon, Dean A Fergusson, Lucy Clayton et al. · 2024 · New England Journal of Medicine
BACKGROUND: The effect of a liberal transfusion strategy as compared with a restrictive strategy on outcomes in critically ill patients with traumatic brain injury is unclear. METHODS: We randomly assigned adults with moderate or severe…
View details →Nohra Chalouhi, Robert M. Starke, Steven Yang et al. · 2013 · Stroke
BACKGROUND AND PURPOSE: Flow diverters are currently indicated for treatment of large and complex intracranial aneurysms. The purpose of this study was to determine whether the indications of flow diversion can be safely extended to…
View details →Leonie S. Penner, Sean P. Gavan, Darren M. Ashcroft et al. · 2022 · British Journal of Clinical Pharmacology
AIMS: To examine the risk of gastrointestinal (GI) bleeding, major bleeding, stroke and systemic embolism associated with prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) to adults receiving oral anticoagulant (OAC) therapy. METHODS: We conducted a population-based cohort study in adults receiving OAC therapy using linked primary care (Clinical Practice Research Datalink GOLD) and hospital (Hospital Episodes Statistics) electronic health records. We used cause-specific Cox regression models with time-dependent NSAID treatment in a propensity score matched population to estimate the in
View details →Irene H. Flønes, Erika Fernández‐Vizarra, Maria Lykouri et al. · 2017 · Acta Neuropathologica
Mitochondrial complex I deficiency occurs in the substantia nigra of individuals with Parkinson's disease. It is generally believed that this phenomenon is caused by accumulating mitochondrial DNA damage in neurons and that it contributes to the process of neurodegeneration. We hypothesized that if these theories are correct, complex I deficiency should extend beyond the substantia nigra to other affected brain regions in Parkinson's disease and correlate tightly with neuronal mitochondrial DNA damage. To test our hypothesis, we employed a combination of semiquantitative immunohistochemical an
View details →Steven Boonen, Dennis M. Black, Cathleen Colón‐Emeric et al. · 2010 · Journal of the American Geriatrics Society
OBJECTIVES: To determine the efficacy of once-yearly intravenous zoledronic acid (ZOL) 5 mg in reducing risk of clinical vertebral, nonvertebral, and any clinical fractures in elderly osteoporotic postmenopausal women. DESIGN: A post hoc…
View details →T.J. Karpanen, A.L. Casey, Peter A. Lambert et al. · 2011 · Infection Control and Hospital Epidemiology
OBJECTIVE: To determine whether copper incorporated into hospital ward furnishings and equipment can reduce their surface microbial load. DESIGN: A crossover study. SETTING: Acute care medical ward with 19 beds at a large university…
View details →Rogier M. Thurlings, Marie Boumans, Janneke Tekstra et al. · 2010 · Arthritis & Rheumatism
OBJECTIVE: To analyze the relationship between the type I interferon (IFN) signature and clinical response to rituximab in rheumatoid arthritis (RA) patients. METHODS: Twenty RA patients were treated with rituximab (cohort 1). Clinical…
View details →Brendan McMullan, Catriona Halliday, Tania C. Sorrell et al. · 2012 · PLoS ONE
BACKGROUND: Cryptococcus neoformans causes life-threatening meningitis. A recently introduced lateral flow immunoassay (LFA) to detect cryptococcal antigen (CRAG) is reportedly more rapid and convenient than standard latex agglutination (LA), but has not yet been evaluated in a diagnostic laboratory setting. METHODS: One hundred and six serum, 42 cerebrospinal fluid (CSF), and 20 urine samples from 92 patients with known or suspected cryptococcosis were tested by LA and LFA, and titres were compared. Results were correlated with laboratory-confirmed cryptococcosis. Serial samples were tested i
View details →Man‐Fung Yuen, Ingolf Schiefke, Jung‐Hwan Yoon et al. · 2019 · Hepatology
BACKGROUND AND AIMS: ARC-520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived from covalently closed circular DNA, leading to a reduction in viral antigens and hepatitis B virus (HBV)…
View details →Jordan Spatz, E. E. Fields, Elaine W Yu et al. · 2012 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Animal models and human studies suggest that osteocytes regulate the skeleton's response to mechanical unloading in part by an increase in sclerostin. However, few studies have reported changes in serum sclerostin in humans…
View details →Jochen Klucken, Anne-Maria Poehler, Darius Ebrahimi‐Fakhari et al. · 2012 · Autophagy
Synucleinopathies like Parkinson disease and dementia with Lewy bodies (DLB) are characterized by α-synuclein aggregates within neurons (Lewy bodies) and their processes (Lewy neurites). Whereas α-synuclein has been genetically linked to…
View details →Kevin C. Huoh, David W. Eisele · 2011 · Otolaryngology
OBJECTIVES: The purpose of this study was to investigate etiologic factors for sialolithiasis in a population of patients from the United States. STUDY DESIGN: Retrospective, cohort study. SETTING: Tertiary university. MATERIALS AND…
View details →Catalina Medina, Sı́món Barquera, Ian Janssen · 2013 · PubMed
OBJECTIVE: To determine the test-retest reliability and validity of the Spanish version of the short-form International Physical Activity Questionnaire (IPAQ) among adults in Mexico. METHODS: This was a cross-sectional study of a…
View details →Teruko Tashiro, Sorin V. Pislaru, Jodi M Blustin et al. · 2014 · European Heart Journal
AIMS: Severe aortic stenosis (SAS) is a major risk factor for death after non-cardiac surgery, but most supporting data are from studies over a decade old. We evaluated the risk of non-cardiac surgery in patients with SAS in contemporary…
View details →Kevin W. Eva, Harold Reiter, Jack Rosenfeld et al. · 2012 · JAMA
CONTEXT: There has been difficulty designing medical school admissions processes that provide valid measurement of candidates' nonacademic qualities. OBJECTIVE: To determine whether students deemed acceptable through a revised admissions…
View details →Alan K. Burnett, Nigel H. Russell, Ann E. Hunter et al. · 2013 · Blood
Better treatment is required for older patients with acute myeloid leukemia (AML) not considered fit for intensive chemotherapy. We report a randomized comparison of low-dose Ara-C (LDAC) vs the novel nucleoside, clofarabine, in untreated…
View details →Li‐Tzong Chen, Miin-Fu Chen, Lung-An Li et al. · 2011 · Annals of Surgery
OBJECTIVE: To investigate the clinical efficacy of adjuvant interferon alfa-2b (IFNα-2b) therapy on recurrence-free survival (RFS) of patients with postoperative viral hepatitis-related hepatocellular carcinoma (HCC). BACKGROUND: Despite…
View details →Jin Kim, Se Jin Baek, Dong-Woo Kang et al. · 2017 · Diseases of the Colon & Rectum
BACKGROUND: Robotic total mesorectal excision for rectal cancer has rapidly increased and has shown short-term outcomes comparable to conventional laparoscopic total mesorectal excision. However, data for long-term oncologic outcomes are…
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