Negative / Null Result ReportOpen accessMedicine
Matthew J. Fisher, Luis A Marcos Raymundo, Melinda Monteforte et al. · 2020 · International Journal of Infectious Diseases
OBJECTIVES: The purpose of this study is to evaluate clinical outcomes in patients with critical COVID-19 pneumonia requiring invasive mechanical ventilation who were treated with tocilizumab DESIGN: Single-center retrospective cohort…
View details →Negative / Null Result Report
Christopher W. Noel, Caitlin McMullen, Christopher Yao et al. · 2018 · The Laryngoscope
Objectives The Fragility Index (FI) is a novel tool for evaluating the robustness of statistically significant findings in a randomized control trial (RCT). It measures the number of events upon which statistical significance depends. We…
View details →Negative / Null Result ReportOpen accessMaterials Science
Qi Li, Rongchao Jin · 2017 · Nanotechnology Reviews
Abstract Silicon nanoparticles (NPs) have long been regarded as a promising alternative for commercial organic dyes and typical quantum dots (e.g. CdSe) for applications in light emitting, bio-imaging, sensing, etc. The photoluminescence…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
L. A. Temitope · 2013 · Journal of Economics and Behavioral Studies
This paper adopts the Toda-Yamamoto technique of causality in order to examine the direction of causality between employment and economic growth. This is to investigate whether the increase in the Gross Domestic Product (GDP) translates into increased employment or not and vice versa, in South Africa, using quarterly data from 2000Q1 to 2012Q3. South Africa has been experiencing high and increased growth for the past decade, yet the rate of employment is not significantly high. Meanwhile, the objective of the government, since the first democratic election in 1994, was to increase economic gro
View details →Negative / Null Result ReportOpen accessPsychology
Jonathan Jarrett, Tyler R. Bonnell, Christopher Young et al. · 2018 · Proceedings of the Royal Society B Biological Sciences
, 12084 (doi:10.1038/ncomms12084)) has demonstrated that network structure can be maintained by a simple process of social inheritance. Here, we ask how juvenile vervet monkeys integrate into their adult grooming networks, using the model…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kirandeep Bhullar, Maryam Zarepour, Hongbing Yu et al. · 2015 · Infection and Immunity
Bacterial pathogens produce a number of autotransporters that possess diverse functions. These include the family of serine protease autotransporters of Enterobacteriaceae (SPATEs) produced by enteric pathogens such as Shigella flexneri…
View details →Negative / Null Result ReportOpen accessNeuroscience
John D. Tompkins, Todd A. Clason, Jean C. Hardwick et al. · 2016 · American Journal of Physiology-Cell Physiology
Pituitary adenylate cyclase (PAC)-activating polypeptide (PACAP) peptides ( Adcyap1) signaling at the selective PAC1 receptor ( Adcyap1r1) participate in multiple homeostatic and stress-related responses, yet the cellular mechanisms…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Sukanta Deb, Harinder P. Singh, Subhash Kumar et al. · 2015 · Monthly Notices of the Royal Astronomical Society
We present a study of three-dimensional structure of the Small Magellanic Cloud (SMC). The V- and I-band light curves of the fundamental mode RR Lyrae (RRab) stars obtained by the Optical Gravitational Lensing Experiment-III project were…
View details →Negative / Null Result ReportNeuroscience
Harrison E. Vieth, Katie L. McMahon, Greig I. de Zubicaray · 2014 · Quarterly Journal of Experimental Psychology
How does the presence of a categorically related word influence picture naming latencies? In order to test competitive and noncompetitive accounts of lexical selection in spoken word production, we employed the picture-word interference…
View details →Negative / Null Result ReportOpen accessNeuroscience
Alejandro Gella, Mònica Segura, Núria Durany et al. · 2011 · BMC Psychiatry
BACKGROUND: Genome wide association studies reported two single nucleotide polymorphisms in ANK3 (rs9804190 and rs10994336) as independent genetic risk factors for bipolar disorder. Another SNP in ANK3 (rs10761482) was associated with schizophrenia in a large European sample. Within the debate on common susceptibility genes for schizophrenia and bipolar disorder, we tried to investigate common findings by analyzing association of ANK3 with schizophrenia, bipolar disorder and unipolar depression. METHODS: We genotyped three single nucleotide polymorphisms (SNPs) in ANK3 (rs9804190, rs10994336,
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Maximilian L. Würstle, Markus Rehm · 2014 · Journal of Biological Chemistry
The protease caspase-9 is activated on the apoptosome, a multiprotein signal transduction platform that assembles in response to mitochondria-dependent apoptosis initiation. Despite extensive molecular research, the assembly of the holo-apoptosome and the process of caspase-9 activation remain incompletely understood. Here, we therefore integrated quantitative data on the molecular interactions and proteolytic processes during apoptosome formation and apoptosis execution and conducted mathematical simulations to investigate the resulting biochemical signaling, quantitatively and kinetically. I
View details →Negative / Null Result ReportMedicine
Steven Masson, Benjamin Marrow, Stuart Kendrick et al. · 2014 · Transplant International
Return to drinking after liver transplantation for alcoholic liver disease (ALD) remains a source of unease with varying reported rates of return to drinking and impact this has on graft function. In 2005, the UK Transplant liver advisory…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Michael N. Stagnaro, Ben M Tappin, David G. Rand · 2023 · Proceedings of the National Academy of Sciences
The highly influential theory of "Motivated System 2 Reasoning" argues that analytical, deliberative ("System 2") reasoning is hijacked by identity when considering ideologically charged issues-leading people who are more likely to engage in such reasoning to be more polarized, rather than more accurate. Here, we fail to replicate the key empirical support for this theory across five contentious issues, using a large gold-standard nationally representative probability sample of Americans. While participants were more accurate in evaluating a contingency table when the outcome aligned with thei
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Yuan Gao, Dokyun Lee, Gordon Burtch et al. · 2025 · Proceedings of the National Academy of Sciences
Recent studies suggest large language models (LLMs) can generate human-like responses, aligning with human behavior in economic experiments, surveys, and political discourse. This has led many to propose that LLMs can be used as surrogates…
View details →Negative / Null Result ReportOpen accessMedicine
Sara Lindström, Fredrick R. Schumacher, Daniele Campa et al. · 2012 · Cancer Epidemiology Biomarkers & Prevention
BACKGROUND: A recent genome-wide association study (GWAS) of prostate cancer in a Japanese population identified five novel regions not previously discovered in other ethnicities. In this study, we attempt to replicate these five loci in a…
View details →Negative / Null Result ReportOpen accessMedicine
Linda Zaharenko, Ineta Kalniņa, Kristine Geldnere et al. · 2016 · European Journal of Endocrinology
Objective(s) High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of…
View details →Negative / Null Result ReportOpen accessMedicine
Cerissa L. Blaney, Mark L. Robbins, Andrea L. Paiva et al. · 2012 · American Journal of Health Promotion
PURPOSE: African-Americans have high rates of physical inactivity-related morbidity and mortality, thus effective interventions to increase exercise are necessary. Tailored interventions show promise, but measures need validation in this…
View details →Negative / Null Result ReportOpen accessMathematics
Mathieu Guillaumé, Christine Schiltz, Amandine Van Rinsveld · 2020 · Journal of Numerical Cognition
Basic numerical abilities are generally assumed to influence more complex cognitive processes involving numbers, such as mathematics. Yet measuring non-symbolic number abilities remains challenging due to the intrinsic correlation between numerical and non-numerical dimensions of any visual scene. Several methods have been developed to generate non-symbolic stimuli controlling for the latter aspects but they tend to be difficult to replicate or implement. In this study, we describe the NASCO method, which is an extension to the method popularized by Dehaene, Izard, and Piazza (2005). Their pro
View details →Negative / Null Result ReportOpen accessPsychology
Matt Field, Lisa Di Lemma, Paul Christiansen et al. · 2016 · Psychology of Addictive Behaviors
Alcohol dependence is characterized by conflict between approach and avoidance motivational orientations for alcohol that operate in automatic and controlled processes. This article describes the first study to investigate the predictive validity of these motivational orientations for relapse to drinking after discharge from alcohol detoxification treatment in alcohol-dependent patients. One hundred twenty alcohol-dependent patients who were nearing the end of inpatient detoxification treatment completed measures of self-reported (Approach and Avoidance of Alcohol Questionnaire; AAAQ) and auto
View details →Negative / Null Result ReportOpen accessMedicine
Camila S. Halal, Diego G. Bassani, Iná S. Santos et al. · 2020 · Journal of Sleep Research
This study used data from 2,222 mothers and infants participating in a population-based birth cohort to verify whether maternal depression in the perinatal period was associated with poor infant sleep. Mothers who scored ≥13 points on the…
View details →Replication FailureOpen accessMedicine
Päivi Merjonen, Liisa Keltikangas‐Järvinen, Markus Jokela et al. · 2011 · Translational Psychiatry
Hostility is a multidimensional personality trait with changing expression over the life course. We performed a genome-wide association study (GWAS) of the components of hostility in a population-based sample of Finnish men and women for…
View details →Negative / Null Result ReportOpen accessDecision Sciences
Anton Olsson-Collentine, Robbie C. M. van Aert, Marjan Bakker et al. · 2023 · Psychological Methods
-hacking) from this "multiverse" of outcomes can inflate effect size estimates and false positive rates. We studied the effects of researcher degrees of freedom and selective reporting using empirical data from extensive multistudy…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ismaïl Ahmed, Pei‐Chen Lee, Christina M. Lill et al. · 2014 · PLoS Genetics
The etiology of Parkinson disease (PD) involves both genetic susceptibility and environmental exposures. In particular, coffee consumption is inversely associated with PD but the mechanisms underlying this intriguing association are unknown. According to a recent genome-wide gene-environment interaction study, the inverse coffee-PD association was two times stronger among carriers of the T allele of SNP rs4998386 in gene GRIN2A than in homozygotes for the C allele. We attempted to replicate this result in a similarly sized pooled analysis of 2,289 cases and 2,809 controls from four independent
View details →Negative / Null Result ReportOpen accessPsychology
Paweł A. Atroszko, Bartosz Atroszko, Edyta Charzyńska · 2021 · International Journal of Environmental Research and Public Health
Background: Relatively strong theoretical assumptions and previous studies concerning co-occurring addictive behaviors suggest a subpopulation representing general proclivity to behavioral addictions (BAs), and there are gender-specific subpopulations. This study aimed to compare latent profile analysis (LPA) and latent class analysis (LCA) as the methods of investigating different clusters of BAs in the general student population and among students positively screened for at least one BA. Participants and procedure: Analyses of six BAs (study, shopping, gaming, Facebook, pornography, and food
View details →Negative / Null Result ReportOpen accessMedicine
David Baumeister, Wolfgang Eich, Silvia Saft et al. · 2019 · Scientific Reports
There has been a surging interest in the putative role of peripheral growth factors in the pathophysiology of fibromyalgia, specifically in the peripheral sensitization that occurs in chronic pain disorders. This cross-sectional study set out to assess and compare brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in plasma samples from fibromyalgia patients and healthy controls. Plasma BDNF and NGF were measured in 89 fibromyalgia patients and 36 pain-free controls, and compared using ANCOVA controlling for potential confounders, as well as Bayesian methods for parameter e
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
William R. Scott, Weihua Zhang, Marie Loh et al. · 2016 · PLoS ONE
South Asians are 1/4 of the world's population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on genome-wide association studies of common SNPs in Europeans. To evaluate the contribution of DNA sequence variation to the higher levels of central obesity (defined as waist hip ratio adjusted for body mass index, WHR) among South Asians compared to Europeans we carried out: i) a genome-wide association analysis of >6M genetic variants in 10,318 South Asians with focused analy
View details →Negative / Null Result ReportOpen accessEngineering
Nour El Din El Sheikh, Esteban Paz, Juan Pinto et al. · 2021
The blocking performance of a heuristic and a deep reinforcement learning approach for resource provisioning in a dynamic multi-band elastic optical network is evaluated. The heuristic is based on a previous proposal that prioritises the…
View details →Negative / Null Result ReportPsychology
Natalie L. Wilver, Jesse R. Cougle · 2018 · Journal of Consulting and Clinical Psychology
OBJECTIVE: The current study extended upon previous research efforts by evaluating the utility and feasibility of an 8-session Internet-based interpretation bias modification (IBM) training protocol targeting evaluation- and…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Patrick J. McIntyre, Sharon Y. Strauss · 2017 · Evolution
The geographic distributions of polyploids suggest they can have distinct and sometimes broader niches compared to diploids. However, relatively few field experiments have investigated whether range differences are associated with local…
View details →Negative / Null Result ReportNeuroscience
Tong He, Ru Kong, Avram J. Holmes et al. · 2018
In recent years, deep learning has transformed the field of machine learning. In the field of neuroimaging, there are increasing interests in adopting deep learning techniques. However, deep neural networks (DNNs) usually need large…
View details →