Negative / Null Result ReportMedicine
Cherenack EM, Larson ME, Roach ME et al. · 2026 · Brain, behavior, and immunity
Background Limited research has examined the longitudinal interplay of depression, substance use, and immune dysregulation among men with HIV. Methods We analyzed longitudinal data from 100 men who have sex with men (MSM) living with HIV…
View details →Negative / Null Result ReportOpen accessMedicine
Hoehne C, Rehling S, Schrenker J et al. · 2026 · Scientific reports
Preclinical simulation is essential for students to practice before clinical treatment. A low-cost 3D-printed model was developed with repositionable mobile maxillary anterior teeth to train periodontal splinting and evaluate learner…
View details →Failed Experiment ReportOpen accessMedicine
Bolder R, King SBS, Zahn RC et al. · 2026 · Vaccines
Background/objectives RSV is a major cause of mortality in infants, and despite recent progress to prevent RSV in the very young, an RSV vaccine for this population is still highly warranted. Clinical studies in infants in the 1960s using…
View details →Failed Experiment Report
Noble C, Geller D, Urs N et al. · 2026 · Preprint
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become defining therapies in the management of type 2 diabetes and obesity. Despite recent interest in the effects of GLP-1RA therapy on skeletal muscle, their influence on muscle…
View details →Failed Experiment ReportOpen accessMedicine
· 2006
Semaglutide was not detectable in the milk of mothers taking the drug subcutaneously. Their breastfed infants experienced no adverse effects. Some brands of oral semaglutide, such as Rybelsus, contain the absorption enhancer salcaprozate…
View details →Negative / Null Result ReportOpen accessMedicine
Tozawa R, Ishii N, Minamoto Y · 2026 · Cureus
Background Medial meniscus extrusion (MME) is a pivotal biomarker for knee osteoarthritis progression. Although ultrasonography offers a dynamic and cost-effective MME assessment, its clinical utility is often limited by the perceived high…
View details →Negative / Null Result Report
Stein A · 2026 · Preprint
Abstract Low-dose radiation epidemiology is contested and inconclusive: confidence intervals span zero, and point estimates shift with the chosen dose range. Part of the contest is structural, not empirical. Under the linear…
View details →Negative / Null Result ReportOpen accessMedicine
Arslan SG, Gultekinler BD · 2026 · BMC sports science, medicine & rehabilitation
Background Force platforms are widely used to assess postural stability and vertical jump performance, yet their cost and limited portability restrict routine clinical and field-based use. The Meloq EasyBase force platform offers a…
View details →Failed Experiment ReportOpen accessMedicine
McMullan RR, McGrath C, Cody N et al. · 2026 · Critical care explorations
Objectives Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared with usual care.…
View details →Failed Experiment ReportOpen accessMedicine
Heinemann FM, Hallensleben M, Althaus K et al. · 2026 · HLA
Single antigen (SA) tests are indispensable for an accurate HLA antibody identification in sera of transplant patients. Three commercial tests using purified single antigens combined with microbead or microarray technology are currently…
View details →Failed Experiment ReportMedicine
Zheng J, Wu M, Wang X et al. · 2026 · Cells
Prime editing (PE) is a precise genome-editing technology that avoids double-strand breaks, holding great promise for clinical and agricultural applications. However, its genome-wide off-target effects are not fully understood, raising…
View details →Negative / Null Result Report
Lindell H, Lehtilä K, Dinnétz P · 2026 · Preprint
Abstract Background Wild boar ( Sus scrofa ) have expanded in northern Europe, yet their role in the ecology of tick-borne pathogens remains poorly understood. This study investigated the occurrence of Anaplasma phagocytophilum and…
View details →Negative / Null Result ReportOpen accessMedicine
Stoff R, Routman DM, Yalon M et al. · 2026 · Therapeutic advances in medical oncology
Background Circulating tumor DNA (ctDNA) is predictive of recurrence in resected stage III melanoma, yet its role in the neoadjuvant setting for clinical stage III (cSIII) is unclear. Objective Assess the association between ctDNA and…
View details →Negative / Null Result ReportMedicine
Chu NH, Le HD, Quach NT et al. · 2026 · Biochemical genetics
The optical purity of lactic acid is a critical parameter for producing high-performance polylactic acid (PLA). To investigate the genetic basis of stereospecific lactic acid biosynthesis, the present study aimed to functionally…
View details →Negative / Null Result ReportMedicine
Sulaiman AR, Bassit GE · 2026 · BMC oral health
Background Primary Hyperoxaluria Type 1 (PH1) is a rare metabolic disorder characterized by systemic oxalate deposition, which may influence bone metabolism through mechanisms such as oxalate accumulation in alveolar bone, renal…
View details →Negative / Null Result ReportOpen accessMedicine
Lu J, Ahmad A, Chomont N et al. · 2026 · Frontiers in immunology
Due to persistent immune dysfunction, People with HIV (PWH) are at increased risk of more severe infections with SARS-CoV-2 and hospitalizations. In several countries, they were listed as a priority group for receiving anti-SARS-CoV-2…
View details →Methods Dead-EndMedicine
Noey JD, Kearfott KJ · 2026 · Health physics
This study examines the range of methodologies used to determine the minimum detectable dose for LiF:Mg,Ti thermoluminescent dosimeters, emphasizing the importance of incorporating uncertainties when assessing variability in dosimeter…
View details →Negative / Null Result ReportOpen accessMedicine
Kanamaru K, Sakai A, Kobayashi T et al. · 2026 · Clinical journal of gastroenterology
We present a rare case of autoimmune pancreatitis (AIP) confined exclusively to the subepithelial layer in the main pancreatic duct (MPD) without associated pancreatic enlargement or mass formation. A 73-year-old man presented with…
View details →Negative / Null Result ReportOpen accessMedicine
Metwally NKA, de Boer F, Vreeken J et al. · 2025 · Scientific reports
This study compared three multiplex immunoassay platforms, Meso Scale Discovery (MSD), NULISA, and Olink, for detecting protein markers in stratum corneum tape strips, a non-invasive sampling method challenged by low protein yield. We…
View details →Negative / Null Result ReportOpen accessMedicine
Karlina Y, Rizaldy D, Riani C et al. · 2026 · Iranian journal of microbiology
Background and objectives Enzymes are protein biomolecules that act as catalysts, including cellulase and β-glucosidase with extensive applications. Thus, this work aimed to contrast the activity of both enzymes from tempeh fermented by…
View details →Negative / Null Result Report
de la Colina AN, Skaperda Z, Charisis S et al. · 2026 · Preprint
Peripheral blood measurements dominate oxidative stress research, yet whether they reflect central nervous system (CNS) redox status remains untested in humans. We simultaneously profiled five biomarkers, total antioxidant capacity (TAC),…
View details →Negative / Null Result ReportMedicine
Turkmen D, Ucuz I, Altunisik N et al. · 2026 · Cutaneous and ocular toxicology
Objective This exploratory study aimed to evaluate the basic temperament and behavioral characteristics of preschool children diagnosed with vitiligo, alopecia areata (AA), and psoriasis, and to compare them with healthy controls.…
View details →Negative / Null Result ReportOpen accessMedicine
Zhakypbek Y, Toktar M, Kossalbayev BD et al. · 2026 · Biology
Dryland soils of the Caspian region of western Kazakhstan are exposed to environmental stress, including drought, alkalinity, low soil organic matter content, and anthropogenic pressure. In this preliminary study, bacterial communities…
View details →Negative / Null Result ReportMedicine
Shen Y, Li HX, Dai J et al. · 2026 · Journal of affective disorders
Background Light therapy (LT) may improve sleep and affective disorders in Parkinson's disease (PD), but effects of different intensities and underlying mechanisms remain unclear. Methods Thirty-three patients with PD were randomized to…
View details →Null DatasetMedicine
Khalid A, Yasir Ali M, Tul Janat R et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Sorafenib (SB) is a receptor tyrosine kinase inhibitor, currently marketed as an oral dosage form. However, due to severe irritation of the gastrointestinal tract, the drug is facing decreased acceptability as a therapeutic…
View details →Negative / Null Result ReportOpen accessMedicine
Ma Q, Chen K, Wang C et al. · 2026 · PsyCh journal
Previous studies have indicated impaired motor sequence learning in people who stutter (PWS). The present study demonstrates that PWS retain intact sequence learning abilities when motor demands are minimized.
View details →Negative / Null Result ReportOpen accessMedicine
Vockert KL, Winter N, Kirschmann FS et al. · 2026 · Neurological research and practice
Background and aims Hereditary polyneuropathies are rare heterogeneous neurological disorders that cause progressive muscle weakness and disability. As new therapies emerge, sensitive imaging biomarkers to monitor disease progression are…
View details →Negative / Null Result ReportMedicine
Johnson L, Chen ZZ, Marshall JG · 2026 · Analytical biochemistry
The detection of human IgG (hIgG) in tris buffer versus fetal calf serum (FCS) served as a model system to explore the factors that contribute to sensitivity of enzyme-linked immunosorbent assay (ELISA) with and without capture reagents.…
View details →Negative / Null Result Report
Cui H, Wu M, Zhao P · 2026 · Preprint
Abstract Background Myocarditis is a clinically heterogeneous cardiovascular condition that may progress rapidly to severe outcomes, making early recognition and accurate public understanding essential. With the rapid expansion of…
View details →Negative / Null Result ReportMedicine
Ichikawa S, Shimura A, Kikuchi A et al. · 2026 · Scientific reports
Early childhood is a period of rapid brain maturation and gut microbiome assembly, when emerging behavioral difficulties can shape later mental health and learning trajectories. Microbiota-gut-brain communication has been implicated in…
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