Negative / Null Result ReportOpen accessMedicine
Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal
Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…
View details →Negative / Null Result ReportOpen accessMedicine
Meyer DB, Gifford A, Bradley T et al. · 2026 · Journal of gastrointestinal oncology
Background Prior studies have reported solid organ transplant (SOT) recipients have increased rates of colorectal cancer (CRC). While this increased incidence is established, the recurrence risk following curative-intent treatment for…
View details →Negative / Null Result ReportOpen accessMedicine
Huber A, Pasquier T, Demarchi M et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is…
View details →Negative / Null Result ReportOpen accessMedicine
Sanghvi K, Todorova B, Sepil I · 2025 · Ecology and evolution
Sexual selection operates across pre- and post-mating episodes, driven by intra-sexual competition and inter-sexual choice for mates or gametes. While these episodes can act in the same direction, this is not always the case; for example,…
View details →Negative / Null Result ReportOpen accessMedicine
Al Shboul S, Abu Al Karsaneh O, Alrjoub M et al. · 2025 · International journal of immunopathology and pharmacology
Objective The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introduction Cellular senescence and its secretory phenotype (the SASP) are implicated in…
View details →Negative / Null Result ReportOpen accessMedicine
Arato CVB, Guerra LM, Probst LF et al. · 2025 · Revista de saude publica
Objective To investigate the impact of prenatal care on the reduction of maternal-child mortality in Brazilian municipalities following the new primary health care financing model, the Previne Brasil program. Methods This study comprised a…
View details →Negative / Null Result ReportOpen accessMedicine
Gatterer C, Allmer D, Beitzke D et al. · 2026 · Journal of clinical medicine
Background/Objectives: Fabry disease (FD) is a lysosomal storage disorder characterized by progressive renal and cardiac involvement and an increased burden of cardiovascular and cerebrovascular events. While cardiac magnetic resonance…
View details →Negative / Null Result ReportOpen accessMedicine
Kamian S, Azadeh P, Anbiaee R et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Anthracyclines are widely used in the treatment of breast cancer but are associated with myocardial injury that may progress to cardiac dysfunction. Surveillance has traditionally relied on left ventricular ejection fraction…
View details →Negative / Null Result ReportMedicine
Kim H, Kipp K · 2025 · Computer methods in biomechanics and biomedical engineering
The purpose of this study was to calculate and compare (1) knee loads, (2) muscle-specific contributions to knee loads, and (3) effects of knee flexion angle on knee loads and muscle-specific load contributions during a forward…
View details →Negative / Null Result ReportOpen access
Brolin KA, Bäckström D, Wallenius J et al. · 2024 · Preprint
Variants in GBA1 are important genetic risk factors in Parkinson’s disease (PD). GBA1 T369M has been linked to an ∼80% increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A…
View details →Negative / Null Result ReportOpen accessMedicine
Nakamura T, Hatanaka KC, Kawamoto Y et al. · 2025 · Journal of cancer research and clinical oncology
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Despite the use of aggressive combination chemotherapy regimens, outcomes remain unsatisfactory. Schlafen family member 11 (SLFN11) has been reported to regulate the DNA…
View details →Negative / Null Result ReportOpen accessMedicine
Tsui ST, Zhou N, Tan KS et al. · 2025 · JTCVS open
Objectives The study objectives were to determine whether diagnostic laparoscopy improves staging accuracy in selected patients with distal esophageal adenocarcinoma and to identify clinicopathologic features associated with positive…
View details →Negative / Null Result ReportMedicine
Tabara Y, Shoji-Asahina A, Ogawa A et al. · 2024 · International journal of obesity (2005)
Background Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy…
View details →Negative / Null Result ReportOpen accessMedicine
Tseng YT, Chen II, Wang CH · 2025 · Healthcare (Basel, Switzerland)
Background : The long-term effects of hormone replacement therapy (HRT) on inflammatory bowel disease (IBD) remain unclear, necessitating further investigations of the association between HRT and the development of ulcerative colitis and…
View details →Negative / Null Result ReportMedicine
Schiff DM, Wheeler A, Lewis D et al. · 2026 · Journal of substance use and addiction treatment
Objective Identify sociodemographic and substance use characteristics associated with pregnancy intention and explore the relationship between pregnancy intent and postpartum contraception interest among pregnant individuals with opioid…
View details →Negative / Null Result ReportOpen accessMedicine
Reda B, Zanon G, Contardo L et al. · 2025 · Orthodontics & craniofacial research
Objective Orthodontic treatment is a common approach for correcting malocclusion but is often associated with discomfort. The aim of this study was to assess the longitudinal changes in oral behaviours, temporomandibular disorder…
View details →Negative / Null Result ReportOpen accessMedicine
Kholili U, Hidayat AA, Bintoro UY et al. · 2026 · Cancers
Introduction Mounting evidence indicates that the p53 Pro72Arg single-nucleotide polymorphisms (SNPs) may play a role in modulating hepatocarcinogenesis in the setting of chronic HBV infection. However, there is currently a lack of studies…
View details →Negative / Null Result ReportMedicine
Petzke TM, Köteles F, Pohl A et al. · 2024 · Journal of psychosomatic research
Objective (Cardiac) interoception was long considered a key mechanism behind symptom perception in persistent somatic symptoms (PSS). In this study, we aimed to extend earlier findings to clarify this potential interoceptive mechanisms of…
View details →Negative / Null Result ReportMedicine
Kohno C, Higuchi A, Miyagawa E et al. · 2026 · Modern rheumatology
Objectives Low-dose aspirin (LDA) is widely recommended to prevent hypertensive disorders of pregnancy (HDP). However, the evidence of its effectiveness in pregnancies with systemic lupus erythematosus (SLE) remains limited. This study…
View details →Negative / Null Result ReportOpen accessMedicine
· 2006
Lurasidone is more than 99% bound to plasma proteins, so it is unlikely that the drug would be excreted into milk in sufficient amounts to affect a breastfed infant. Data from one mother-infant pair appears to support the poor excretion…
View details →Negative / Null Result ReportMedicine
Kishinevsky M, Ferrer-Suay M, Ives AR · 2026 · Biol Invasions.
The enemy release hypothesis—that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range—can be an important explanation for successful invasions. Testing this…
View details →Negative / Null Result Report
Sebbag A, SAKDAVONG J · 2025 · Preprint
In the scientific literature, avatars are representations that can take various forms and fulfill multiple functions and roles for learners. The recent emergence of ultra-realistic avatars generated by artificial intelligence presents new…
View details →Negative / Null Result ReportOpen accessMedicine
Neal RA, Corbett J, Costello JT et al. · 2026 · European journal of sport science
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterised by chronic hyperglycaemia, whereas obesity is a major risk factor which increases morbidity and mortality. Treatments that alter white adipose tissue to express a…
View details →Negative / Null Result ReportMedicine
Abbasi H, Ashtiani MN · 2026 · Journal of motor behavior
This study investigated the impact of real-time laser-guided visual cues on spatiotemporal gait parameters during initiation and termination in people with Parkinson's (PwP). Fifteen PwP walked a 5-m path under uncued and laser-cued…
View details →Negative / Null Result ReportMedicine
DeGrado J, Devlin JW · 2025 · Critical care clinics
Antipsychotics are an attractive option for adjunctive sedation in critically ill adults given their sedating effects, short duration of action, lack of effect on respiratory drive, and multiple routes of administration but high-quality…
View details →Replication FailureMedicine
Mirsharifi MS, Shirdel S, Ghaderi E et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)
OBJECTIVE: This study aimed to evaluate the effect of vitamin D supplementation on in vitro fertilization (IVF) outcomes in poor responder women with vitamin D deficiency, focusing on fertilization rates, oocyte quality, and pregnancy…
View details →Replication FailureMedicine
Gaul C, Ferreira S, Johansen T · 2026 · Headache
Objective Evaluate the efficacy and safety of a novel partial rebreathing device for early treatment of acute attacks of migraine with aura. Background Earlier clinical studies have indicated a potential for CO 2 -enriched gas to be…
View details →Negative / Null Result ReportOpen accessMedicine
Singier A, Jarne Munoz A, Maumus-Robert S et al. · 2025 · JAMA network open
Importance Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further…
View details →Negative / Null Result ReportOpen accessMedicine
Ellis K, Moss J, Dziwisz M et al. · 2025 · Oxford open neuroscience
It has been suggested that mentalizing abilities underlie the distinct profiles of autism characteristics observed between Cornelia de Lange (CdLS) and fragile X syndromes (FXS) and autistic people without a genetic syndrome. However,…
View details →Negative / Null Result ReportOpen accessMedicine
Turmanbayeva A, Sadykova K, Nuskabayeva G et al. · 2026 · Journal of clinical medicine
Background : Metabolic syndrome (MetS) is influenced by behavioral and genetic factors, yet evidence on eating behavior patterns and related genetic polymorphisms in Central Asian populations remains limited. Aim: The aim of this study was…
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