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WASTE Journal

Browse the failure-mode index

21,778 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Impact of age on the reliability of GE Entropy™ module indices for guidance of maintenance of anaesthesia in adult patients: a single-centre retrospective analysis.

Ebensperger M, Kreuzer M, Kratzer S et al. · 2025 · British journal of anaesthesia

Background The GE Entropy™ module uses frontal EEG to compute the processed indices state entropy (SE), response entropy (RE), and burst suppression ratio (BSR) to guide maintenance of anaesthesia by supposedly minimising overly 'deep' or…

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Negative / Null Result ReportMedicine

Exploring the functional, protective, and transcriptomic effects of GIP on cytokine-exposed human pancreatic islets and EndoC-βH5 cells.

Henriksen K, Jørgensen A, Kaur S et al. · 2025 · Molecular and cellular endocrinology

Immune-mediated beta-cell destruction and lack of alpha-cell responsiveness to hypoglycaemia are hallmarks of type 1 diabetes pathology. The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may hold therapeutic potential…

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Negative / Null Result ReportMedicine

Subthreshold Micropulse Laser for Eyes: With Center Involving Diabetic Macular Edema With Good Visual Acuity: The PULSE Study, a Randomized Clinical Trial.

Feldman S, Basra J, Lawani A et al. · 2025 · Ophthalmic surgery, lasers & imaging retina

Background and objective To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA). Patients and methods Prospective, single-masked,…

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Negative / Null Result Report

Deciphering Fusarium-Banana Interactions in Resistant and Susceptible Banana Cultivars Using a GFP-Tagged Subtropical Race 4 Strain of Fusarium oxysporum f. sp. cubense

Chen A, Chou TY, Chen Y et al. · 2024 · Preprint

Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is a major disease affecting banana production around the globe. To study the movement of Foc in planta and investigate potential physical mechanisms of deterrence, the roots…

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Negative / Null Result ReportOpen accessMedicine

Effect of zoledronate on avascular necrosis of the femoral head according to disease stage and bone resorption activity.

Moksi L, Sissala N, Ojala R et al. · 2026 · Journal of orthopaedic surgery and research

Background Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger…

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Failed Experiment ReportOpen accessMedicine

High-volume lactated Ringer's solution with human albumin versus standard-volume infusion as a prophylactic treatment for post-endoscopic retrograde cholangiopancreatography pancreatitis: randomized clinical trial.

Shatsnimitkul E, Laopeamthong I, Tansawet A et al. · 2024 · BJS open

Background Adverse events after endoscopic retrograde cholangiopancreatography (ERCP) are rare, and post-ERCP pancreatitis is a serious adverse event. This study aimed to determine the role of aggressive intravenous hydration with lactated…

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Negative / Null Result ReportMedicine

Oxidative Stress Parameters are Differentially Regulated in Visceral and Subcutaneous Adipose Tissue by Western Diet and Intermittent Fasting.

Correia de Lima Junior N, Fernandes-Batista T, Ferreira-Serra L et al. · 2025 · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

The consumption of Western diet, characterized by high sugar and saturated fat content, often leads to weight gain and promotes oxidative stress. Intermittent fasting has emerged as a potential strategy to combat obesity, but its effects…

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Negative / Null Result ReportOpen accessMedicine

11β-Hydroxysteroid dehydrogenase type 1 deficiency causes sexual dimorphism in body composition and bone mass in response to caloric restriction.

de Araújo IM, Le PT, de Carvalho Picoli C et al. · 2026 · JBMR plus

Caloric restriction (CR) alters energy metabolism and increases systemic glucocorticoid production, contributing to bone loss and bone marrow adipose tissue (BMAT) expansion. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)…

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Negative / Null Result ReportMedicine

A role in intracellular K<sup>+</sup> in protecting pathogenic dimorphic fungi against induced cell death by bioinspired antimicrobial peptides.

Damica FZ, Lucas DR, Toledo EB et al. · 2025 · Biochimica et biophysica acta. General subjects

Antimicrobial peptides (AMPs) are promising drugs, though their fungal combat mechanisms remain partly unclear. We designed three AMPs (dAMPs) based on the γ-core of the Vu-Def 1 seed defensin from Vigna unguiculata L. Walp. named RR,…

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