Negative / Null Result Report
Owino RO, Golding J, Sangale EL et al. · 2026 · Preprint
Giraffes, unlike other large mammals, typically pose minimal risk to humans, their animals, and crops, so they are traditionally not involved in human-wildlife conflict. Tree crops, however, are expanding across Africa, resulting in crop…
View details →Methods Dead-EndOpen accessMedicine
Demnitz-King H, Cooper C, Poppe M et al. · 2026 · Age and ageing
Background Previous studies have modelled long-term cost-effectiveness of dementia prevention but seldom within trials. APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build…
View details →Negative / Null Result ReportOpen accessMedicine
Winstén AK, Langén V, Airaksinen KEJ et al. · 2026 · JAMA network open
Importance Anticoagulation for stroke prevention in subclinical, device-detected atrial fibrillation (AF) remains an area of clinical equipoise, and its cost-effectiveness is unknown. Objective To evaluate the cost-effectiveness of direct…
View details →Failed Experiment ReportMedicine
Bigirimana D, Hu N, Soo J et al. · 2026 · Ophthalmology. Glaucoma
Purpose To assess the cost-effectiveness of Xen45 Gel Stent (XGS) compared with trabeculectomy for the surgical management of open angle glaucoma in the United States Medicare system. Design Cost-utility analysis using safety and efficacy…
View details →Failed Experiment Report
Johansson H, Ponnikas S, Harmoinen J et al. · 2026 · Preprint
Effective management of the wolf ( Canis lupus ) population in Finland requires defining a genetics-based minimum viable population (MVP) to support the national Favourable Reference Population (FRP) reporting under the EU Habitats…
View details →Negative / Null Result ReportMedicine
Thomas CA, Blau S, Neuhalfen H et al. · 2026 · JCO oncology practice
Purpose Biomarker testing, including immunohistochemistry (IHC) and next-generation sequencing, is the standard of care in advanced non-small cell lung cancer (NSCLC) for identifying actionable mutations such as EGFR , ALK , and KRAS .…
View details →Negative / Null Result ReportOpen accessMedicine
Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…
View details →Abandoned HypothesisMedicine
Ni X, Zhou S, He X et al. · 2026 · Toxicology in vitro : an international journal published in association with BIBRA
Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…
View details →Negative / Null Result ReportMedicine
Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology
Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…
View details →Negative / Null Result Report
Juhasz J, DeFeis B, Britton MK et al. · 2026 · Preprint
ABSTRACT Introduction Brain-predicted age, estimated from structural MRI data, is a machine learning biomarker of biological brain aging. Greater brain age gap (BAG) indicates advanced brain aging and is associated with cognitive decline…
View details →Negative / Null Result ReportMedicine
Sochacka K, Kotowska A, Lachowicz-Wiśniewska S · 2026 · Nutrients
Background: This study aimed to compare a limited set of predefined diet-, lifestyle-, knowledge-, and psychosocial indicators across school youth, students, and adults in Poland, and to examine their associations with three predefined…
View details →Negative / Null Result ReportMedicine
Machado EM, Matthews M, Rathleff MS et al. · 2026 · Brazilian journal of physical therapy
Background Clinical functional tests for patellofemoral pain (PFP), such as step-up, step-down and squat, are commonly used in clinic practice, although the extent to which changes in these tests reflect changes in patient-reported outcome…
View details →Negative / Null Result ReportMedicine
Fusco S, Nesseler J, Minn L et al. · 2026 · Diagnostics (Basel, Switzerland)
Background : Crohn's disease-associated intestinal strictures represent a major source of morbidity and frequently require endoscopic or surgical intervention. However, patients with stricturing Crohn's disease demonstrate substantial…
View details →Replication FailureOpen accessMedicine
Sitter TM, Savinen S, Andiné P et al. · 2026 · BMJ mental health
Background Patients in forensic psychiatric care (FPC) are often treated with various psychotropic medications. However, evidence regarding their effectiveness in this setting is lacking. Objective The study aimed to estimate how different…
View details →Negative / Null Result ReportMedicine
Larkio J, Söderström M, Holmström J et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective The aim of this retrospective observational study was to analyse imaging and patient related parameters of splenic artery aneurysms (SAAs) and their impact on SAA growth and rupture. Methods The term "aneurysm" was systematically…
View details →Failed Experiment ReportMedicine
Ganesh A, Smith EE, Mostert J et al. · 2026 · Neurology
Background and objectives The cost and complexity of phase 2 randomized-controlled trials (RCTs) hinder further development of promising treatment candidates for Alzheimer disease (AD). The Simon Two-Stage futility trial design, originally…
View details →Replication FailureMedicine
Juárez Sarrión C, Armas IR, Torrano Guillamón A et al. · 2026 · Animals : an open access journal from MDPI
Objectives To describe the clinical, clinicopathological and ultrasonographic characteristics of dogs with an acute pancreatitis (AP) and to identify prognostic markers associated with short-term mortality in a referral population. Methods…
View details →Negative / Null Result ReportMedicine
Huang B, Mao C, Xu T et al. · 2026 · Animals : an open access journal from MDPI
Early-life microbial community assembly is important for gastrointestinal development, immune maturation, and feed utilization in young ruminants, but the maternal reservoirs associated with neonatal lamb gut microbial profiles remain…
View details →Negative / Null Result ReportMedicine
Choi JS, Kim KM · 2026 · Healthcare (Basel, Switzerland)
Background The number of long-term care hospitals (LTCHs) in Korea has been increasing. Because LTCHs primarily care for older adults who are vulnerable to infection, strict infection control (IC) practices are essential. This study aimed…
View details →Negative / Null Result ReportMedicine
Qu ZW, Zhang Y, Guo MY · 2026 · The Journal of international medical research
ObjectiveTo investigate the association of preoperative hypoalbuminemia (serum albumin <35 g/L) with clinicopathological characteristics and survival outcomes in patients with gastric cancer undergoing radical gastrectomy and to construct…
View details →Negative / Null Result ReportMedicine
Abdulridha GAO, Fadhel AS, Al-Kinany SQ et al. · 2026 · Journal of neuroimmunology
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by leukocyte infiltration, immune activation, demyelination, and axonal injury. This case-control observational study aimed to investigate…
View details →Negative / Null Result ReportMedicine
Baltu D, Taş N, Alıcı N et al. · 2026 · Pediatric nephrology (Berlin, Germany)
Background Although acetazolamide is the main medical treatment for idiopathic intracranial hypertension (IIH), data on acetazolamide-induced metabolic acidosis and its long-term outcomes are limited. This study aimed to investigate the…
View details →Negative / Null Result ReportOpen accessMedicine
Rinaldi V, Ridolfi F, Finotello R et al. · 2026 · Veterinary medicine and science
Hypertrophic osteopathy (HO) is a paraneoplastic or parainflammatory syndrome characterised by painful periosteal new bone formation and soft tissue swelling, most commonly associated with thoracic neoplasia. The pathogenesis of HO remains…
View details →Negative / Null Result ReportMedicine
Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering
Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…
View details →Negative / Null Result ReportOpen accessMedicine
Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education
This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…
View details →Replication Failure
Allfelt A, Bendahl PO, Alkner S et al. · 2026 · Preprint
Abstract Background Invasive lobular carcinoma (ILC) is a risk factor for positive margins after breast-conserving surgery (BCS). This retrospective observational study examined whether the presence of residual cancer cells in re-excision…
View details →Negative / Null Result ReportMedicine
Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)
Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…
View details →Negative / Null Result ReportMedicine
Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics
Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…
View details →Negative / Null Result ReportMedicine
Liu S, Tan Y, Zang L · 2026 · Healthcare (Basel, Switzerland)
Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether…
View details →Replication FailureMedicine
Fisayo T, Evans C, Mutasa K et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Cytomegalovirus (CMV) co-infection is associated with mortality in adults with HIV, but whether CMV is associated with mortality in children with HIV remains uncertain. Methods In 498 children (median age 6.3 years,…
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