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WASTE Journal

Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Characteristics of systemic growth activation by 9,10-ketol-12(<i>Z</i>),15(<i>Z</i>)-octadecadienoic acid (KODA) in <i>Populus alba</i> cultured in vitro.

Yokoyama M, Kaida R, Miyamoto K et al. · 2024 · Plant biotechnology (Tokyo, Japan)

α-Ketol octadecadienoic acid (KODA), an oxylipin, is generated from linolenic acid by 9-specific lipoxygenase, while jasmonic acid is ultimately synthesized from the same linolenic acid by 13-specific lipoxygenase. KODA has a unique action…

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Negative / Null Result ReportOpen accessMedicine

Moderate-Intensity Aerobic Exercise Induces Ambulatory Hypotension in Young Adults with a Family History of Hypertension.

Queiroz MG, Tobar KDL, Damazo AS et al. · 2026 · International journal of environmental research and public health

This randomized crossover study aimed to evaluate the effect of a single session of aerobic exercise on 24 h ambulatory blood pressure (BP) and heart rate variability (HRV) in young adults with a family history of hypertension, FHH +…

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Failed Experiment ReportOpen accessMedicine

Preoperative Intravenous Desmopressin and Perioperative Blood Loss in Patients Undergoing Major Spine Surgery : Preoperative Intravenous Desmopressin and Perioperative Blood Loss in Spine Surgery Patients.

Alizadeh A, Moradi M, Vafaeimastanabad M et al. · 2025 · Galen medical journal

Background Major spine surgeries often involve significant blood loss, increasing transfusion risks and postoperative complications. Desmopressin, a synthetic vasopressin analog, may reduce bleeding by enhancing clotting factor release,…

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Negative / Null Result ReportOpen accessMedicine

Discovery of Small-Molecule Inhibitors of the KCNQ1/Kv7.1 Potassium Channel with Virtual Screening and Functional Validation in Electrophysiological Assays and KCNQ1-Knockout Neural Stem Cells.

Alam KA, Martí-Solans J, Schall D et al. · 2026 · ACS chemical neuroscience

Voltage-gated potassium channel KCNQ1 (Kv7.1) plays a critical role in electrical excitability in the heart, gut, and brain. Together with the auxiliary subunit KCNE1, KCNQ1 generates a slow delayed rectifier current ( I Ks ) that is…

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Negative / Null Result ReportOpen accessMedicine

Resolution rate of prescribing errors after advice from a specialised hospital pharmacist or a substitute hospital pharmacist: a retrospective cross-sectional study.

Wilkes S, Kalfsvel L, van Rosse F et al. · 2026 · European journal of hospital pharmacy : science and practice

Objectives Specialised hospital pharmacists, integrated in medical teams on the ward, can improve medication safety. When a specialised hospital pharmacist is temporarily not available, the pharmaceutical care will be conducted by a…

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Negative / Null Result ReportOpen accessMedicine

Effects of Luteolin and Apigenin on Adipogenesis Markers PPARγ and FABP4 and Thermogenesis Marker UCP1 in 3T3-L1 Preadipocyte Cell Line.

Uysal Yeler G, Sivaslıoğlu A, Gülsün T et al. · 2025 · International journal of molecular sciences

Peroxisome proliferator-activated receptor γ (PPARγ) plays a crucial role in the differentiation and maturation of preadipocytes. PPARγ promotes adipogenesis by inducing the expression of fatty acid-binding protein 4 (FABP4). Uncoupling…

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Negative / Null Result ReportOpen accessMedicine

The administration of proton pump inhibitors with the CDK4/6 inhibitor abemaciclib does not affect the clinical outcome of metastatic breast cancer patients.

Crucitta S, Cinacchi P, Bargagna I et al. · 2026 · Therapeutic advances in drug safety

Background CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib have rapidly become an established oral treatment for patients with ER+, HER2- locally advanced or metastatic breast cancer. The use of the oral route offers convenience…

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Negative / Null Result ReportOpen accessMedicine

In vitro and in vivo acaricidal properties of orally delivered ivermectin against the blacklegged tick, Ixodes scapularis.

van Oosterwijk JG, Richer L, Beimfohr-Griffing LK et al. · 2026 · Parasites & vectors

Background The lack of effective and affordable new environmental tick control products is one of the major challenges to the existing control strategies against the blacklegged tick (Ixodes scapularis), the vector of Lyme disease…

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Negative / Null Result ReportOpen accessMedicine

A Dominant Mutation in G<sub>α</sub>s-Protein Increases Hair Pigmentation.

Goff PS, Budd P, Logan DW et al. · 2025 · Pigment cell & melanoma research

We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the G α s subunit of…

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Negative / Null Result ReportMedicine

Electrical stimulation of the dorsal motor nucleus of the vagus in male mice can regulate inflammation without affecting the heart rate.

Falvey A, Palandira SP, Chavan SS et al. · 2024 · Brain, behavior, and immunity

Background The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal…

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Negative / Null Result ReportOpen accessMedicine

Effects of a Mat Pilates Exercise Program Associated with Photobiomodulation Therapy in Patients with Chronic Nonspecific Low Back Pain: A Randomized, Double-Blind, Sham-Controlled Trial.

Merlo JK, da Silva AV, Casonatto J et al. · 2024 · Healthcare (Basel, Switzerland)

Objective To investigate the effects of combining a Pilates program with photobiomodulation therapy (PBMT) in patients with chronic nonspecific low back pain (CNLBP). Methods Thirty-eight adults with CNLBP were randomly assigned to two…

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Negative / Null Result ReportMedicine

The Effects of Recovery Sleep on Experimental Pain.

Stroemel-Scheder C, Lautenbacher S · 2023 · The journal of pain

Recent research suggests that recovery sleep (RS) has the potential to restore pain sensitivity and modulation after hyperalgesia due to preceding sleep deprivation. However, it has not yet been systematically examined whether the…

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Negative / Null Result ReportOpen accessMedicine

Adjuvant denosumab for early breast cancer-Evidence and controversy.

Moretti L, Richelmi L, Cosentini D et al. · 2024 · Breast (Edinburgh, Scotland)

The efficacy of adjuvant denosumab in combination with hormonotherapy in breast cancer patients was investigated in two randomized trials, ABCSG-18 and D-Care, but the results were mixed with respect to the impact of this drug on…

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Negative / Null Result ReportOpen accessMedicine

Association of the rs2814778 variant in the ACKR1 gene, responsible for the Duffy erythrocyte antigen "null" phenotype, with COVID-19 severity in Southern Brazil.

Góis KS, Braga M, Souza VH et al. · 2026 · Einstein (Sao Paulo, Brazil)

Objective This study aimed to analyze the possible association between rs2814778, rs12075 ( ACKR1 gene), and rs4073 ( CXCL8 gene) single nucleotide variants and COVID-19 severity. Methods This cross-sectional study included 319 COVID-19…

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Negative / Null Result ReportMedicine

Beneficial effect of omega-3 fatty acids supplementation on leaky gut, inflammation and oxidative stress in propionic acid-induced autism in aged rats.

Aloud A, Alzahrani H, Arzoo S et al. · 2026 · Acta pharmaceutica (Zagreb, Croatia)

This study examined the effects of omega-3 fatty acids supplementation on gut barrier integrity, systemic inflammation, neurotrans-mission and oxidative stress, in an aged rat model of propionic acid (PPA)-induced neurotoxicity.…

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Negative / Null Result ReportMedicine

Pleiotropic effects of renal denervation beyond blood pressure reduction.

Vakka A, Kyriakoulis KG, Tatakis F et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension

Overactivation of sympathetic nervous system (SNS) has a key role in the pathophysiology of hypertension, as well as in chronic kidney disease, heart failure, atrial fibrillation, type 2 diabetes mellitus, obstructive sleep apnea, and…

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