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Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Use of oXiris<sup>®</sup> vs standard AN69ST filters in sepsis-associated acute kidney injury requiring continuous renal replacement therapy: a retrospective matched cohort study.

Yepes Gómez D, Moreno-Bedoya S, Lohle-Rueda S et al. · 2026 · Frontiers in nephrology

Background Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and carries high short-term mortality despite timely antimicrobials and organ support. Adsorptive hemofilters such as the oXiris ® membrane have…

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Negative / Null Result ReportMedicine

Diverging paths: Modeling the relation between adverse effects, attitudes, perceived adherence, and treatment effect in an internet-based cognitive-behavioral intervention for obsessive-compulsive disorder.

Baumeister A, Schuurmans L, Schultz J et al. · 2025 · Behaviour research and therapy

Background and aim The efficacy of internet-based interventions (IBI) for various psychiatric disorders is widely established, but little is known about the mechanisms or possible influencing factors. One of the most prominent problems in…

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Negative / Null Result ReportMedicine

Efficacy of Molding Helmet Therapy following Suturectomy for Craniosynostosis: A Single-center, Retrospective Analysis in Japan.

Kurimoto M, Nawashiro T, Nagakura M et al. · 2025 · The Journal of craniofacial surgery

Craniosynostosis limits normal cranial growth, significantly affecting the growth and development of children. This increase in intracranial pressure results in significant cosmetic and functional losses. This study investigated the…

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Negative / Null Result Report

Embryonic exposure to valproic acid and neonicotinoid deteriorates the developmental GABA switch and impairs long-term potentiation in the local circuit of intermediate medial mesopallium of chick telencephalon

Matsushima T, Toji N, Wada K et al. · 2024 · Preprint

Embryonic exposure to valproic acid (VPA) and imidacloprid (IMI, a neonicotinoid insecticide) impairs filial imprinting in hatchlings, and the deteriorating effects of VPA are mitigated by post-hatch injection of bumetanide, a blocker of…

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Negative / Null Result ReportMedicine

Is it personality or genes? - A secondary analysis on a randomized controlled trial investigating responsiveness to placebo analgesia.

van Lennep JPA, van Middendorp H, Leong OV et al. · 2025 · Scandinavian journal of pain

Objectives To understand how different individuals respond to placebo effects, it is relevant to disentangle the influence of someone's personality and genetic variations. The aim of this exploratory study was to investigate the role of…

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Negative / Null Result ReportOpen accessMedicine

Bioavailability of and US Infant Exposure to Arsenic, Cadmium, Lead, Mercury, and Per- and Polyfluoroalkyls from Human Milk and Infant Formula: Results from a Series of Systematic Reviews.

O'Connor LE, Thoerig RC, Leta CN et al. · 2026 · Advances in nutrition (Bethesda, Md.)

Infants may be exposed to contaminants from environmental and food sources, including human milk (HM) or infant formula (IF). The objective of this series of systematic reviews (PROSPERO: CRD42024530332, CRD42024530336, CRD42024530339, and…

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Failed Experiment ReportMedicine

Investigation of malondialdehyde as a trait marker associated with familial risk in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives - A longitudinal cohort study.

Coello K, Stanislaus S, Forman JL et al. · 2025 · Free radical biology & medicine

Aims Increased oxidative stress-generated tissue damage seems to play a pivotal role in the pathophysiology and progression of bipolar disorder (BD). Malondialdehyde (MDA), a product of lipid oxidation, may represent a trait marker in BD…

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Failed Experiment Report

Venetoclax and azacitidine compared with intensive chemotherapy for adverse-risk acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation in first complete remission: a multicenter study of TROPHY group.

Mo X, Wen Q, Jiang C et al. · 2024 · Preprint

Abstract It was commonly accepted that adverse-risk acute myeloid leukemia patients should receive allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission (CR1). In this multicenter study, we aimed to…

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Negative / Null Result ReportOpen accessMedicine

Are KLIC and CRIME-80 scores useful to assist decision-making initially or at the moment of repeat DAIR? - a retrospective study.

Contente J, Ferreira C, Silva M et al. · 2025 · Journal of bone and joint infection

Introduction : Debridement, antibiotics, and implant retention (DAIR) is recommended for early acute postoperative and late acute periprosthetic joint infections (PJIs). The KLIC and CRIME-80 scores have been proposed to predict DAIR…

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Negative / Null Result ReportMedicine

Elevational pattern of species range size of vascular plants in Changbai Mountain, China:A test of Rapo-port's rule.

Li MS, Wu XQ, Zhou YJ et al. · 2024 · Ying yong sheng tai xue bao = The journal of applied ecology

Species range size is closely related to its ability to migrate and adapt to environmental change. Rapoport's rule predicts that species range size would become larger with increasing latitude or elevation. Empirical evidence for…

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