Negative / Null Result ReportOpen accessMedicine
Bommersbach TJ, Saliba M, Gilman CK et al. · 2025 · JAACAP open
Objective Attention-deficit/hyperactivity disorder (ADHD) is a risk factor for future substance use. Stimulant medication has largely failed to demonstrate protection against future substance use, but no studies have assessed whether…
View details →Negative / Null Result ReportMedicine
Wolpe N, Perrottelli A, Giuliani L et al. · 2025 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
The negative symptoms of schizophrenia can determine functional outcome in patients. Despite its clinical significance, no treatment exists to date, as numerous pharmacological and non-pharmacological clinical trials have failed to…
View details →Negative / Null Result ReportMedicine
Imam R, Chastang KM, Olowojesiku R et al. · 2025 · The Pediatric infectious disease journal
Background Multiple clinical trials evaluating therapies for cerebral malaria (CM) have failed to demonstrate improved outcomes. This may derive from inclusion of children at all risk levels, including those at low risk of mortality or…
View details →Negative / Null Result ReportMedicine
Steendam ST, Prutean N, Clybouw F et al. · 2024 · Biological psychology
Previous research suggests that the mere presence of a smartphone can detrimentally affect performance. However, other studies failed to observe such detrimental effects. A limitation of existing studies is that no indexes of (potentially…
View details →Negative / Null Result ReportOpen accessMedicine
Brenner H, Sergeev D, Heisser T et al. · 2025 · Alimentary pharmacology & therapeutics
NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with…
View details →Negative / Null Result ReportMedicine
Deng S, Hu L, Chen G et al. · 2025 · Advanced materials (Deerfield Beach, Fla.)
Although the combination of radiotherapy and immunotherapy is regarded as a promising clinical treatment strategy, numerous clinical trials have failed to demonstrate synergistic effects. One of the key reasons is that conventional…
View details →Negative / Null Result ReportOpen accessMedicine
Murillo-Olaizola A, Rodrigo-Gisbert M, Requena M et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized controlled trials of endovascular treatment (EVT) for distal and medium vessel occlusion (DMVO) stroke did not demonstrate clinical benefit over best medical therapy and suggested potential safety concerns. We…
View details →Negative / Null Result ReportOpen accessMedicine
Hattori Y, Abe S, Kakino Y et al. · 2026 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular…
View details →Negative / Null Result ReportMedicine
Emborg C, Kothari SF, Finnerup NB et al. · 2025 · Handbook of clinical neurology
Over the past decades, a growing number of clinical trials in neurologic conditions have failed to demonstrate superiority of active treatments over placebo. A key question in this context is whether an increase in placebo response can…
View details →Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →Negative / Null Result ReportMedicine
Thery G, Noly PE, Cavayas YA et al. · 2025 · Seminars in thoracic and cardiovascular surgery
ECLS-SHOCK is the largest randomized control trial on Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in Acute Myocardial Infarction-related Cardiogenic Shock (AMI-CS). Unfortunately, ECLS-SHOCK failed to demonstrate a…
View details →Negative / Null Result ReportOpen accessComputer Science
D. Kharzeev, H. Satz, A. Syamtomov et al. · 1996 · arXiv
We extend a recent sum rule calculation for inelastic quarkonium-hadron interactions to realistic parton distribution functions; we also include finite target-mass corrections. Both modifications are shown to have no significant effect on the resulting cross section behaviour but the performed analysis gives useful insights on the sum-rule approach in general.
View details →Negative / Null Result ReportMedicine
Schreiner M, Thien H, Braasch T et al. · 2025 · Abdominal radiology (New York)
Background Many patients are instructed to fast before abdominal ultrasound examinations in order to obtain better image quality. However, the few available studies on this topic have so far failed to demonstrate an advantage of several…
View details →Negative / Null Result Report
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2025 · Preprint
Background Intracranial atherosclerotic disease (ICAD) is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to…
View details →Negative / Null Result ReportMedicine
Endo S, Tanaka R, Yamaguchi T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Large type 3 (≥ 8 cm) and type 4 gastric cancers are associated with extremely poor prognoses. The phase III JCOG0501 trial, which evaluated neoadjuvant S-1 plus cisplatin, failed to demonstrate any survival benefits. Docetaxel,…
View details →Negative / Null Result ReportOpen accessMedicine
Said C, Hayward C, Stevens M et al. · 2026 · Bioengineering (Basel, Switzerland)
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has failed to demonstrate mortality benefit in randomised controlled trials of cardiogenic shock. We aimed to determine whether a novel 'Hemi-ECMO' configuration, involving aortic…
View details →Negative / Null Result ReportOpen accessMedicine
Park HJ, Park S, Heo S et al. · 2026 · Journal of microbiology and biotechnology
Leuconostoc lactis DMLL10 is a novel strain isolated from kimchi. The strain did not exhibit toxicity in genetic tests. This study aims to conduct a preclinical safety assessment by performing repeated-dose toxicity studies in animals. In…
View details →Negative / Null Result ReportOpen accessMedicine
Wang J, Liu LL, Huang L et al. · 2026 · BMC nephrology
Background The European STOP study showed that glucocorticoids (with/without immunosuppressants) did not delay disease progression in adults with IgA nephropathy (IgAN). However, pediatric IgAN is characterized by more severe acute…
View details →Negative / Null Result ReportOpen access
Robert Ladouceur, Marie Mayrand · 1987
The perceptions of control regarding an objectively uncontrollable task (American Roulette) by depressive and nondepressive subjects were compared. Monetary risk behavior and subjective control did not differ significantly between the two…
View details →Negative / Null Result ReportOpen access
Vilela, Judith M · 1984
The activity of beta-amylase in crosses of Saccharum spontaneum L. and S. officinarum L. and their hybrids was determined. Results showed that the parents did not differ significantly in their enzyme activity. Variability in enzyme…
View details →Negative / Null Result ReportOpen accessMedicine
Le J, Patel M, Atschinow A et al. · 2026 · Cureus
The platelet-rich plasma in achilles tendon healing 2 (PATH-2) trial is the largest randomized study of platelet-rich plasma (PRP) in acute Achilles tendon rupture. While the original frequentist analysis showed no significant benefit,…
View details →Negative / Null Result ReportMedicine
Janz C, Timpka J, Storch A et al. · 2026 · Journal of Parkinson's disease
BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient…
View details →Replication FailureMedicine
Ramphul R, McCurdy SA, Lee J et al. · 2026 · Drug and alcohol dependence
Background In 2023, an estimated 39.6 million adults aged ≥ 18 years had a substance use disorder (SUD) and 94.7 % did not seek treatment. Recovery residences provide essential support for individuals recovering from SUD, yet their…
View details →Negative / Null Result ReportMedicine
Mazdarani, Miles · 2026 · Veterinary research communications
Cranial cruciate ligament (CCL) rupture is uncommon in cats but may cause persistent stifle instability. Previous ex vivo assessments of tibial plateau levelling osteotomy and tibial tuberosity advancement have failed to restore stability…
View details →Negative / Null Result ReportOpen accessPhysics
Benjamin Poole, Bartosz Barzdajn, Daniele Dini et al. · 2019 · arXiv
The thermal effects of plastic and frictional heat generation and elevated temperature were examined along with the role of adhesion in the context of galling wear, using a representative crystal plasticity, normally loaded, sliding surface model. Galling frequency behaviour was predicted for 316L steel. Deformation of the surfaces was dominated by the surface geometry, with no significant effect due to variations in frictional models. Plastic and frictional heating were found to have a minimal effect on the deformation of the surface, with the rapid conduction of heat preventing any highly lo
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Markus Dertwinkel-Kalt, Max R. P. Grossmann · 2025 · arXiv
When environmental regulations are unpopular, policymakers often attribute resistance to information frictions and poor communication. We test this idea in the context of a major climate policy: Germany's Heating Law of 2023, which mandates the phase-out of fossil fuel heating. Through a survey experiment with property owners, we examine whether providing comprehensive information about the regulation's costs, requirements, and timeline affects adoption decisions and policy support. Despite successfully increasing factual knowledge, information provision has no significant effect on intended t
View details →Negative / Null Result ReportOpen accessChemistry
Yu Jia, Cao Yu, Song Hang et al. · 2012 · Journal of the Serbian Chemical Society
Ab initio Hartree-Fock (HF) method and Density Functional Theory (DFT) were used to calculate the optical rotation of 26 chiral compounds. The effects of theory and basis sets used for calculation, solvents influence on the geometry and values of calculated optical rotation were all discussed. The polarizable continuum model, included in the calculation, did not improve the accuracy effectively, but it was superior to γs. Optical rotation of five or sixmembered of cyclic compound has been calculated and 17 pyrrolidine or piperidine derivatives which were calculated by HF and DFT methods gave a
View details →Negative / Null Result ReportOpen accessEcology
Sánchez-Ledesma Judith A., Águila Bernardo, Garibay-Orijel Roberto et al. · 2025 · Folia Oecologica
Using ITS1-based metabarcoding, we investigated the structure of the soil fungal communities in the central and peripheral zones of a 25-hectare pecan nut (Carya illinoinensis) orchard located in the arid region of Coahuila, Mexico. While environmental conditions such as soil moisture and temperature varied between zones, physicochemical soil properties (pH, organic carbon, total carbon, organic matter, electrical conductivity, and zinc) remained homogeneous. A total of 4,443 fungal OTUs were detected at 97% similarity. Alpha diversity indices did not differ significantly between zones. The fu
View details →Negative / Null Result Report
Creamer MS, Leifer AM, Pillow JW · 2024 · Preprint
A fundamental goal of neuroscience is to understand how anatomy determines the functional properties of the nervous system. However, previous work has failed to show how the functional connections between neurons are derived from the…
View details →Negative / Null Result ReportOpen accessMedicine
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2026 · Stroke (Hoboken, N.J.)
Background Intracranial atherosclerotic disease is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to demonstrate…
View details →