e-ISSN: Pending

Browse the failure-mode index

21,770 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Can we refute a role for infections in Alzheimer's disease pathogenesis?

Chatila ZK, Duggan MR, Silberberg E et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association

While a growing body of literature suggests a role for infections in Alzheimer's disease (AD), microbial contributions to AD remains a contentious topic, in part due to challenges in reconciling the positive evidence with studies reporting…

View details →
Negative / Null Result ReportOpen accessMedicine

Mendelian randomization analysis reveals no causal association between non-alcoholic fatty liver disease and hepatocellular carcinoma: implications for lipid metabolomics and shared pathophysiological mechanisms.

Wei Y, Li J · 2025 · Discover oncology

Background Non-alcoholic fatty liver disease (NAFLD) has been increasingly associated with hepatocellular carcinoma (HCC) risk in observational studies, yet the causal nature of this relationship and its impact on systemic lipid metabolism…

View details →
Negative / Null Result ReportMedicine

Gastrointestinal tract exposure to particles and DNA damage in animals: A review of studies before, during and after the peak of nanotoxicology.

Møller P, Roursgaard M · 2024 · Mutation research. Reviews in mutation research

Humans ingest particles and fibers on daily basis. Non-digestible carbohydrates are beneficial to health and food additives are considered safe. However, titanium dioxide (E171) has been banned in the European Union because the European…

View details →
Negative / Null Result ReportOpen accessMedicine

Pro-inflammatory dietary patterns and their association with cardiovascular disease and pancreatic cancer in a hospital population: a cross-sectional study.

Jin Q, Liu Y, Tong Q et al. · 2025 · Frontiers in nutrition

Objective To examine whether a concise, clinic-feasible Patient Inflammatory Diet Score (PIDS) relates to prevalent pancreatic cancer and cardiovascular disease (CVD) in a hospital population, and to explore associations with systemic…

View details →
Negative / Null Result ReportMedicine

Learning to draw parametric faces.

Davidenko N, Day J · 2025 · Memory & cognition

Humans' ability to draw faces accurately from memory is extremely rare. One source of difficulty is the drawing process itself, which requires converting a complex, three-dimensional mental representation to a two-dimensional drawing. To…

View details →
Negative / Null Result ReportOpen accessMedicine

No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis.

Liu P, Zeng Q · 2025 · Journal of multidisciplinary healthcare

Background The causal relationship between HIV infection and insulin resistance, as well as diabetes mellitus, remains uncertain. This study explores these associations using genome-wide association study data and Mendelian randomization…

View details →
Negative / Null Result ReportOpen accessMedicine

In the eastern Mediterranean, the rat lungworm Angiostrongylus cantonensis is absent or extremely rare according to recent surveys.

Anettová L, Šipková A, Cibulka P et al. · 2025 · Parasitology research

This study summarizes the findings of a comprehensive field investigation into the presence of Angiostrongylus cantonensis, a zoonotic nematode responsible for meningitis, in selected regions of the eastern Mediterranean. Samples were…

View details →
Negative / Null Result ReportOpen accessMedicine

Musical groove listening does not enhance primary motor cortex activation.

O'Connell SR, Wilson GE, Berkowitz DH et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Groove is the pleasurable urge to move to the beat of music, a universally experienced human phenomenon. Because listeners are often inspired to move to music with groove, we asked whether high-groove music would promote greater motor…

View details →
Negative / Null Result ReportOpen accessMedicine

Psychobehavioral profiles of eating risk: schema-emotion regulation patterns differ in central adiposity with genotype (FTO rs9939609) as external validator-a pilot study.

Obara-Gołębiowska M · 2026 · Eating and weight disorders : EWD

Purpose To identify person-centered psychological profiles of eating-related risk based on early maladaptive schemas (EMS), emotion regulation difficulties, and eating behaviors, and to examine their external validation using…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of a Pragmatic eHealth Behavioral Gestational Weight Gain Intervention on Household Chaos in Pregnant People of Lower Socioeconomic Status: Randomized Controlled Trial.

Kracht CL, Falkenhain K, Flanagan EW et al. · 2026 · JMIR mental health

Background Household chaos is an emerging risk factor for childhood obesity development, especially in families with lower socioeconomic status (SES). It is unclear if changes in household chaos, especially in pregnancy, may mediate the…

View details →